Sasaki Hajime 佐々木基

Researcher Number	30784441
Affiliation (Current)	2025: 札幌医科大学, 医学部, 訪問研究員
Affiliation (based on the past Project Information) *help	2019 – 2023: 札幌医科大学, 医学部, 訪問研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator エピゲノム / ヒストン修飾 / viral mimicry / G9a / EZH2 / エピゲノム標的治療 / 多発性骨髄腫 / スーパーエンハンサー / BRD4 / 肝細胞癌 … More / BRD4阻害剤 / BET阻害剤 / がん治療 / エピジェネティクス / 肝細胞がん Less

ヒストンメチル化酵素阻害による抗腫瘍効果とviral mimicryの解析Principal Investigator
- Principal Investigator
  
  佐々木基
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Sapporo Medical University
Analysis of the anti-tumor mechanism of BRD4 inhibition in hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  Sasaki Hajime
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Sapporo Medical University

All 2023 2022 2021 2019 2018

All Journal Article Presentation

[Journal Article] Serum amyloid A1 recruits neutrophils to the invasive front of T1 colorectal cancers.2023
- Author(s)
  Yoshido A, Sudo G, Takasawa A, Aoki H, Kitajima H, Yamamoto E, Niinuma T, Harada T, Kubo T, Sasaki H, Ishiguro K, Yorozu A, Kai M, Katanuma A, Yamano HO, Osanai M, Nakase H, Suzuki H.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 38 Issue: 2 Pages: 301-310
- DOI
  10.1111/jgh.16055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-22K07964, KAKENHI-PROJECT-21K15556, KAKENHI-PROJECT-21K16846, KAKENHI-PROJECT-22K16001, KAKENHI-PROJECT-20K07409, KAKENHI-PROJECT-20K07662, KAKENHI-PROJECT-20K08335, KAKENHI-PROJECT-23K24186, KAKENHI-PROJECT-23K06445, KAKENHI-PROJECT-23K07420
[Journal Article] Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis.2021
- Author(s)
  Ishiguro K, Kitajima H, Niinuma T, Maruyama R, Nishiyama N, Ohtani H, Sudo G, Toyota M, Sasaki H, Yamamoto E, Kai M, Nakase H, Suzuki H.
- Journal Title
  
  Cell Death Discovery
  
  Volume: 7 Issue: 1 Pages: 7-7
- DOI
  10.1038/s41420-020-00400-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17836, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-19K17468, KAKENHI-PROJECT-20K17057, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-21K15556
[Journal Article] Immunoglobulin G4-related autoimmune hepatitis simultaneously concomitant with autoimmune pancreatitis: a case report2021
- Author(s)
  Yokoyama Yoshihiro、Akutsu Noriyuki、Numata Yasunao、Okuda Keiko、Morita Rena、Masaki Yoshiharu、Sasaki Hajime、Suzuki Ryo、Yabana Takashi、Arimura Yoshiaki、Kondo Yoshihiro、Nakase Hiroshi
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 14 Issue: 6 Pages: 1740-1745
- DOI
  10.1007/s12328-021-01509-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08312, KAKENHI-PROJECT-21K15556
[Journal Article] UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells2019
- Author(s)
  Niinuma Takeshi、Kitajima Hiroshi、Kai Masahiro、Yamamoto Eiichiro、Yorozu Akira、Ishiguro Kazuya、Sasaki Hajime、Sudo Gota、Toyota Mutsumi、Hatahira Tomo、Maruyama Reo、Tokino Takashi、Nakase Hiroshi、Sugai Tamotsu、Suzuki Hiromu
- Journal Title
  
  Clinical Epigenetics
  
  Volume: 11 Issue: 1 Pages: 70-70
- DOI
  10.1186/s13148-019-0668-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-19K17468, KAKENHI-PROJECT-19K18736, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K08700
[Journal Article] DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling2018
- Author(s)
  Ishiguro Kazuya、Kitajima Hiroshi、Niinuma Takeshi、Ishida Tadao、Maruyama Reo、Ikeda Hiroshi、Hayashi Toshiaki、Sasaki Hajime、Wakasugi Hideki、Nishiyama Koyo、Shindo Tetsuya、Yamamoto Eiichiro、Kai Masahiro、Sasaki Yasushi、Tokino Takashi、Nakase Hiroshi、Suzuki Hiromu
- Journal Title
  
  Haematologica
  
  Volume: 104 Issue: 1 Pages: 155-165
- DOI
  10.3324/haematol.2018.191262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-17K15959, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19K17438, KAKENHI-PROJECT-19K17468, KAKENHI-PROJECT-19H03518
[Presentation] 多発性骨髄腫においてDOT1L阻害は自然免疫シグナルを活性化し、免疫調節薬の効果を増強する.2023
- Author(s)
  石黒一也, 北嶋洋志, 新沼猛, 丸山玲緒, 塚原智英, 廣橋良彦, 粂川昂平, 関口翔平, 佐々木基, 甲斐正広, 五十嵐哲祥, 鳥越俊彦, 仲瀬裕志, 鈴木拓.
- Organizer
  第85回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15556
[Presentation] 多発性骨髄腫においてDOT1L阻害は自然免疫シグナルを活性化する．2023
- Author(s)
  石黒一也，北嶋洋志，新沼猛，丸山玲緒，塚原智英，粂川昴平，関口翔平，佐々木基，甲斐正広，仲瀬裕志，鈴木拓．
- Organizer
  第16回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-21K15556
[Presentation] 大腸鋸歯状病変のDNAメチル化は正常大腸粘膜の抑制的なヒストン修飾と相関する．2023
- Author(s)
  鈴木拓，山本英一郎，須藤豪太，青木敬則，久保俊之，佐々木基，新沼猛，北嶋洋志，甲斐正広，山野泰穂，仲瀬裕志，菅井有．
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15556
[Presentation] 多発性骨髄腫においてDOT1L阻害は自然免疫シグナルを活性化し，免疫調整津薬の効果を増強する．2023
- Author(s)
  石黒一也，北嶋洋志，新沼猛，丸山玲緒，塚原智英，廣橋良彦，粂川昂平，関口翔平，佐々木基，甲斐正広，鳥越俊彦，仲瀬裕志，鈴木拓．
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15556
[Presentation] 大腸粘膜の抑制的ヒストン修飾はCIMP陽性の大腸腫瘍リスクと相関する．2022
- Author(s)
  山本英一郎，須藤豪太，久保俊之，原田拓，佐々木基，青木敬則，北嶋洋志，新沼猛，甲斐正広，山野泰穂，菅井有，仲瀬裕志，鈴木拓．
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15556
[Presentation] DOT1L阻害は乳がん細胞のトランスクリプトームおよびエピゲノムシグネチャーを変化させる．2021
- Author(s)
  鈴木拓，丸山玲緒，北嶋洋志，新沼猛，石黒一也，粂川昴平，吉戸文乃，佐々木基，山本英一郎，甲斐正広，仲瀬裕志．
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15556
[Presentation] 新規頭頸部癌関連long non-coding RNAの同定と機能解析．2021
- Author(s)
  新沼猛，北嶋洋志，畠中柚衣，関口翔平，萬顕，久保俊之，佐々木基，原田拓，甲斐正広，仲瀬裕志，鈴木拓．
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15556
[Presentation] エピジェネティック阻害剤のGIST細胞におけるエピゲノム修飾，遺伝子発現への影響の統合解析．2021
- Author(s)
  吉戸文乃，須藤豪太，北嶋洋志，新沼猛，甲斐正広，原田拓，佐々木基，久保俊之，仲瀬裕志，菅井有，鈴木拓．
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15556

1. NAKASE Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 石黒一也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 佐々木茂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 阿久津典之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 時野隆至

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山本英一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Sasaki Hajime 佐々木 基

Research Projects

Research Products

Co-Researchers

ヒストンメチル化酵素阻害による抗腫瘍効果とviral mimicryの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the anti-tumor mechanism of BRD4 inhibition in hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Serum amyloid A1 recruits neutrophils to the invasive front of T1 colorectal cancers.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunoglobulin G4-related autoimmune hepatitis simultaneously concomitant with autoimmune pancreatitis: a case report2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] 多発性骨髄腫においてDOT1L阻害は自然免疫シグナルを活性化し、免疫調節薬の効果を増強する.2023

Author(s)

Organizer

Data Source

[Presentation] 多発性骨髄腫においてDOT1L阻害は自然免疫シグナルを活性化する．2023

Author(s)

Organizer

Data Source

[Presentation] 大腸鋸歯状病変のDNAメチル化は正常大腸粘膜の抑制的なヒストン修飾と相関する．2023

Author(s)

Organizer

Data Source

[Presentation] 多発性骨髄腫においてDOT1L阻害は自然免疫シグナルを活性化し，免疫調整津薬の効果を増強する．2023

Author(s)

Organizer

Data Source

[Presentation] 大腸粘膜の抑制的ヒストン修飾はCIMP陽性の大腸腫瘍リスクと相関する．2022

Author(s)

Organizer

Data Source

[Presentation] DOT1L阻害は乳がん細胞のトランスクリプトームおよびエピゲノムシグネチャーを変化させる．2021

Author(s)

Organizer

Data Source

[Presentation] 新規頭頸部癌関連long non-coding RNAの同定と機能解析．2021

Author(s)

Organizer

Data Source

[Presentation] エピジェネティック阻害剤のGIST細胞におけるエピゲノム修飾，遺伝子発現への影響の統合解析．2021

Author(s)

Organizer

Data Source

Sasaki Hajime 佐々木基