Hino Hirotsugu 日野浩嗣

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HINO Hirotsugu 日野浩嗣

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Researcher Number	30793468
Other IDs
Affiliation (Current)	2025: 日本大学, 医学部, 助教 2025: 東京医科大学, 医学部, ポストドクター
Affiliation (based on the past Project Information) *help	2019 – 2021: 日本大学, 医学部, 助教 2018: 東京医科大学, 医学部, ポストドクター
Review Section/Research Field	Principal Investigator Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator 分子スイッチ / オートリソソーム / リソソーム / 細胞死 / 自食胞形成 / CDK4/6 / abemaciclib

Analysis of the molecular basis of atypical cell-death induction with vacuolar formation in cancer cells by CDK4/6 inhibitorsPrincipal Investigator
- Principal Investigator
  
  HINO Hirotsugu
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Nihon University
  Tokyo Medical University

All 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Cytonuclear Estrogen Receptor Alpha Regulates Proliferation and Migration of Endometrial Carcinoma Cells2021
- Author(s)
  Mierxiati Saimi, Shota Moriya, Zhong-Lian Li, Hidenobu Miyaso, Kenta Nagahori, Shinichi Kawata, Takuya Omotehara, Yuki Ogawa, Hirotsugu Hino, Keisuke Miyazawa, Kou Sakabe, Masahiro Itoh
- Journal Title
  
  The Tokai Journal of Experimental and Clinical Medicine
  
  Volume: 46 Pages: 7-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15031
[Journal Article] Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics2021
- Author(s)
  Miyazaki Masaya、Hiramoto Masaki、Takano Naoharu、Kokuba Hiroko、Takemura Jun、Tokuhisa Mayumi、Hino Hirotsugu、Kazama Hiromi、Miyazawa Keisuke
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: 48 Issue: 4 Pages: 195-195
- DOI
  10.3892/ijmm.2021.5028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-21K07106
[Journal Article] Age-related exacerbation of hematopoietic organ damage induced by systemic hyper-inflammation in senescence-accelerated mice2021
- Author(s)
  Harada Tomonori、Tsuboi Isao、Hino Hirotsugu、Yuda Miyuki、Hirabayashi Yoko、Hirai Shuichi、Aizawa Shin
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 23250-23250
- DOI
  10.1038/s41598-021-02621-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07053, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-21K06743
[Journal Article] Kana Miyahara, Naoharu Takano, Yumiko Yamada, Hiromi Kazama, Mayumi Tokuhisa, Hirotsugu Hino, Koji Fujita, Edward Barroga, Masaki Hiramoto, Hiroshi Handa, Masahiko Kuroda, Takashi Ishikawa & Keisuke Miyazawa BRCA1 degradation in response to mitochondrial damage in breast cancer cells2021
- Author(s)
  Kana Miyahara, Naoharu Takano, Yumiko Yamada, Hiromi Kazama, Mayumi Tokuhisa, Hirotsugu Hino, Koji Fujita, Edward Barroga, Masaki Hiramoto, Hiroshi Handa, Masahiko Kuroda, Takashi Ishikawa, Keisuke Miyazawa
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 8735-8735
- DOI
  10.1038/s41598-021-87698-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-21H02706, KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-21K07106
[Journal Article] Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization?associated cell death2020
- Author(s)
  Takeda Atsuo、Takano Naoharu、Kokuba Hiroko、Hino Hirotsugu、Moriya Shota、Abe Akihisa、Hiramoto Masaki、Tsukahara Kiyoaki、Miyazawa Keisuke
- Journal Title
  
  International Journal of Oncology
  
  Volume: 57 Issue: 6 Pages: 1280-1292
- DOI
  10.3892/ijo.2020.5138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-18K06901
[Journal Article] Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin2020
- Author(s)
  Tanaka Hideki、Hino Hirotsugu、Moriya Shota、Kazama Hiromi、Miyazaki Masaya、Takano Naoharu、Hiramoto Masaki、Tsukahara Kiyoaki、Miyazawa Keisuke
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 22 Pages: 100750-100750
- DOI
  10.1016/j.bbrep.2020.100750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-17K15031
[Journal Article] Abemaciclib induces atypical cell death in cancer cell characterized by formation of cytoplasmic vacuoles derived from lysosomes2020
- Author(s)
  Hino Hirotsugu, Iriyama Noriyoshi, Kokuba Hiroko, Kazama Hiromi, Moriya Shota, Takano Naoharu, Hiramoto Masaki, Aizawa Shin, Miyazawa Keisuke
- Journal Title
  
  Cancer Science
  
  Volume: － Issue: 6 Pages: 2132-2145
- DOI
  10.1111/cas.14419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-18K06846, KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-17K15031
[Journal Article] Sequestosome 1 (p62) accumulation in breast cancer cells suppresses progesterone receptor expression via argonaute 22020
- Author(s)
  Yokota Ayuka、Hiramoto Masaki、Hino Hirotsugu、Tokuhisa Mayumi、Miyazaki Masaya、Kazama Hiromi、Takano Naoharu、Miyazawa Keisuke
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 531 Issue: 2 Pages: 256-263
- DOI
  10.1016/j.bbrc.2020.07.058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-18K06901
[Journal Article] Fingolimod/FTY720 sensitizes EGFR wild-type non-small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest.2019
- Author(s)
  Ohta　K, Ohkuma T, Lorenzo AD, Yokota A, Hino H, Kazama H, Moriya S, Takano N, Hiramoto M, Miyazawa K.
- Journal Title
  
  Oncol Rep.
  
  Volume: - Pages: 231-242
- DOI
  10.3892/or.2019.7140
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21388, KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-17K15031
[Journal Article] Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines2019
- Author(s)
  Miyazawa Shinsuke、Moriya Shota、Kokuba Hiroko、Hino Hirotsugu、Takano Naoharu、Miyazawa Keisuke
- Journal Title
  
  Breast Cancer
  
  Volume: 27 Issue: 2 Pages: 225-235
- DOI
  10.1007/s12282-019-01012-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-17K15031
[Presentation] CDK4/6阻害薬abemaciclibが誘導する空胞形成の機序及び細胞死との関連の検討2022
- Author(s)
  日野浩嗣、田中良法、竹谷浩介、高野直治、平本正樹、相澤信、宮澤啓介、江藤真澄、平井宗一
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-18K15031
[Presentation] CDK4/6阻害薬abemaciclibが誘導する空胞の形成メカニズムの検討2021
- Author(s)
  日野浩嗣、田中良法、竹谷浩介、高野直治、平本正樹、相澤信、宮澤啓介、江藤真澄、平井宗一
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K15031
[Presentation] CDK4/6 inhibitor abemaciclib induces non-apoptotic cell-death with cytoplasmic vacuolar formation derived from lysosomes2020
- Author(s)
  Hirotsugu Hino, Noriyoshi Iriyama, Hiroko Kokuba, Hiromi Kazama, Shota Moriya, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa
- Organizer
  14th International Conference on Protein Phosphatase
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15031
[Presentation] CDK4/6阻害薬abemaciclibはリソソームの酸性化、膨化により空胞形成を起こし、新規形式の細胞死を誘導する2020
- Author(s)
  日野浩嗣、入山規良、國場寛子、風間宏美、森谷昇太、高野直治、平本正樹、相澤信、宮澤啓介
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K15031
[Presentation] CDK4/6阻害薬abemaciclibはリソソーム機能障害を介した空胞形成を伴う新規細胞死を誘導する2020
- Author(s)
  日野浩嗣、風間宏美、森谷昇太、高野直治、平本正樹、宮澤啓介
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15031
[Presentation] 阻害薬abemaciclibはリソソームの酸性化、膨化による空胞形成を伴った新規細胞死を誘導する2020
- Author(s)
  日野浩嗣、入山規良、國場寛子、風間宏美、森谷昇太、高野直治、平本正樹、相澤信、宮澤啓介
- Organizer
  第125回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-18K15031
[Presentation] CDK4/6阻害薬abemaciclibのリソソームを標的とした空胞形成を伴う新規細胞死2019
- Author(s)
  日野浩嗣、風間宏美、森谷昇太、高野直治、平本正樹、宮澤啓介
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15031
[Presentation] CDK4/6阻害薬abemaciclibによるリソソーム由来の空胞形成を伴った新規細胞死誘導2019
- Author(s)
  日野浩嗣、入山規良、國場寛子、風間宏美、森谷昇太、高野直治、平本正樹、相澤信、宮澤啓介
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K15031
[Presentation] Development of luminescent probes for real-time detection of phosphorylation balance by CDK/PP2A in cell cycle2019
- Author(s)
  Hino Hirotsugu, Nagai Takeharu, Takaki Kaori, Kobe Mika, Mochida Satoru
- Organizer
  The 4th Taiwan-Japan Bilateral Conference on Protein Phosphatase
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15031
[Presentation] CDK4/6阻害薬abemaciclibのリソソームを標的とした細胞死誘導効果2018
- Author(s)
  日野浩嗣、風間宏美、森谷昇太、高野直治、平本正樹、宮澤啓介
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15031
[Presentation] CDK4/6阻害薬abemaciclibはリソソーム由来の空胞形成を伴った細胞死を誘導する2018
- Author(s)
  日野浩嗣、入山規良、國場寛子、風間宏美、森谷昇太、高野直治、平本正樹、宮澤啓介
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K15031

1. 森谷昇太

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 平本正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 宮澤啓介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 平林容子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 風間宏美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hino Hirotsugu 日野 浩嗣

HINO Hirotsugu 日野 浩嗣

Research Projects

Research Products

Co-Researchers

Analysis of the molecular basis of atypical cell-death induction with vacuolar formation in cancer cells by CDK4/6 inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cytonuclear Estrogen Receptor Alpha Regulates Proliferation and Migration of Endometrial Carcinoma Cells2021

Author(s)

Journal Title

Data Source

[Journal Article] Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Age-related exacerbation of hematopoietic organ damage induced by systemic hyper-inflammation in senescence-accelerated mice2021

Author(s)

Journal Title

DOI

Data Source

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization?associated cell death2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Abemaciclib induces atypical cell death in cancer cell characterized by formation of cytoplasmic vacuoles derived from lysosomes2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sequestosome 1 (p62) accumulation in breast cancer cells suppresses progesterone receptor expression via argonaute 22020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fingolimod/FTY720 sensitizes EGFR wild-type non-small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] CDK4/6阻害薬abemaciclibが誘導する空胞形成の機序及び細胞死との関連の検討2022

Author(s)

Organizer

Data Source

[Presentation] CDK4/6阻害薬abemaciclibが誘導する空胞の形成メカニズムの検討2021

Author(s)

Organizer

Data Source

[Presentation] CDK4/6 inhibitor abemaciclib induces non-apoptotic cell-death with cytoplasmic vacuolar formation derived from lysosomes2020

Author(s)

Organizer

Data Source

[Presentation] CDK4/6阻害薬abemaciclibはリソソームの酸性化、膨化により空胞形成を起こし、新規形式の細胞死を誘導する2020

Author(s)

Organizer

Data Source

[Presentation] CDK4/6阻害薬abemaciclibはリソソーム機能障害を介した空胞形成を伴う新規細胞死を誘導する2020

Author(s)

Organizer

Data Source

[Presentation] 阻害薬abemaciclibはリソソームの酸性化、膨化による空胞形成を伴った新規細胞死を誘導する2020

Hino Hirotsugu 日野浩嗣

HINO Hirotsugu 日野浩嗣