Hasegawa Kana 長谷川佳那

Researcher Number	30793989
Affiliation (Current)	2025: 九州大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2024 – 2025: 九州大学, 大学病院, 助教 2017 – 2023: 九州大学, 歯学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 57020:Oral pathobiological science-related / Pathobiological dentistry/Dental radiology Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Basic Section 57020:Oral pathobiological science-related / Medium-sized Section 57:Oral science and related fields / Morphological basic dentistry
Keywords	Principal Investigator 口腔癌 / 細胞・組織 / 機械侵害受容器 / 異型 / 細胞内シグナル伝達経路 / YAPシグナル / 上皮間葉転換 / 細胞異型 / 機械感受性イオンチャネル / Hippoシグナル … More / PIEZO1 / 口腔扁平上皮癌 / 膜タンパク / Piezo1 / 機械受容器 … More Except Principal Investigator 歯胚 / 発生 / 歯 / 再生 / 歯乳頭 / 分化 / 耐性獲得 / BET阻害剤 / BETファミリー蛋白 / スーパーエンハンサー（SE） / 口腔扁平上皮癌（OSCC） / 細胞競合 / Field cancerization / 早期発見 / 扁平上皮癌 / 口腔癌 / 唾液腺悪性腫瘍 / Semaphorin3A (Sema3A) / 形態形成 / 癌形質 / 細胞増殖 / Wnt/β-カテニン経路 / Sema3A / 腺様嚢胞癌 / 唾液腺 / 細胞内シグナリング / 癌細胞間相互作用 / 癌周囲微小環境 / 細胞集団浸潤 / 口腔扁平上皮癌 / 癌形質変化 / 癌微小環境 / 間葉系幹細胞 / 上皮間葉相互作用 / 器官形成 / 間葉細胞 / 器官培養 / 歯の再生 / メカノセンサー Less

口腔癌をモデルとした癌転移機構の解明 ~新規YAP下流因子によるEMT誘導機構の解明~Principal Investigator
- Principal Investigator
  
  長谷川佳那
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Kyushu University
Elucidation of the mechanism of resistance acquisition to super-enhancer-targeted anticancer therapies and novel strategies based on this mechanism
- Principal Investigator
  
  清島保
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
Study of the instability among mutant epithelial cells, adjacent normal epithelial cells and stromal cells to develop strategies for screening and very early detection of cancer.
- Principal Investigator
  
  清島保
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
Elucidation of differentiation regulating mechanism by SPARC-related factors expressed in the dental papilla, and attempt of tooth regeneration
- Principal Investigator
  
  和田裕子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Kyushu University
Investigation of the effect of the Hippo-YAP signaling on atypia in oral squamos cell carcinomaPrincipal Investigator
- Principal Investigator
  
  Hasegawa Kana
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Kyushu University
Identification of odontogenic mesenchymal stem cell-inducing factors and application to tooth regeneration
- Principal Investigator
  
  Wada Hiroko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Kyushu University
Analysis of the signal pathways between oral squamous cell carcinoma cells and surrounding microenvironment as novel therapeutic target for novel anti-cancer therapy
- Principal Investigator
  
  Kiyoshima Tamotsu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
Functional analysis and development of novel adenoid cystic carcinoma therapy targeting Wnt signaling
- Principal Investigator
  
  Higuchi Yoshinori
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Fukuoka Dental College
Investigation of the mechanism of oral squamous cell carcinoma tumorigenesis through PIEZO1Principal Investigator
- Principal Investigator
  
  Hasegawa Kana
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Kyushu University
Mechanism of tooth development based on mechanosensor
- Principal Investigator
  
  Wada Hiroko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Kyushu University
Development of novel oral cancer therapy through the anti tumor effect of Piezo1Principal Investigator
- Principal Investigator
  
  Hasegawa Kana
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Kyushu University

All 2024 2023 2022 2021 2020 2018

All Journal Article Presentation

[Journal Article] Wnt/β-catenin-C-kit axis may play a role in adenoid cystic carcinoma prognostication2024
- Author(s)
  Fujii Shinsuke、Hasegawa Kana、Maehara Takashi、Kurppa Kari J.、Heikinheimo Kristiina、Warner Kristy A.、Maruyama Satoshi、Tajiri Yudai、Nor Jacques E.、Tanuma Jun-ichi、Kawano Shintaro、Kiyoshima Tamotsu
- Journal Title
  
  Pathology - Research and Practice
  
  Volume: 254 Pages: 155148-155148
- DOI
  10.1016/j.prp.2024.155148
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0262, KAKENHI-PROJECT-20K10096, KAKENHI-PROJECT-23K27792
[Journal Article] Arl4c is involved in tooth germ development through osteoblastic/ameloblastic differentiation2023
- Author(s)
  Truong Thinh Thi Kim、Fujii Shinsuke、Nagano Ryoko、Hasegawa Kana、Kokura Megumi、Chiba Yuta、Yoshizaki Keigo、Fukumoto Satoshi、Kiyoshima Tamotsu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 679 Pages: 167-174
- DOI
  10.1016/j.bbrc.2023.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KK0262, KAKENHI-PROJECT-21K09843, KAKENHI-PROJECT-21K19610, KAKENHI-PROJECT-23K21498
[Journal Article] Stepwise activation of p63 and the MEK/ERK pathway induces the expression of ARL4C to promote oral squamous cell carcinoma cell proliferation.2023
- Author(s)
  Alkhatib DZR, Thi Kim Truong T, Fujii S, Hasegawa K, Nagano R, Tajiri Y, Kiyoshima T.
- Journal Title
  
  Pathol Res Pract.
  
  Volume: 246 Pages: 154493-154493
- DOI
  10.1016/j.prp.2023.154493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K10096, KAKENHI-PROJECT-21K09843, KAKENHI-PROJECT-22K17017, KAKENHI-PROJECT-23K27792
[Journal Article] Wnt signaling promotes tooth germ development through YAP1-TGF-β signaling.2022
- Author(s)
  Nagano R, Fujii S, Hasegawa K, Maeda H, Kiyoshima T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 630 Pages: 64-70
- DOI
  10.1016/j.bbrc.2022.09.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K10096, KAKENHI-PROJECT-21K09843, KAKENHI-PROJECT-20K09906, KAKENHI-PROJECT-23K24528
[Journal Article] Clear cell squamous cell carcinoma of the tongue exhibits characteristics as an undifferentiated squamous cell carcinoma.2022
- Author(s)
  Hasegawa K, Fujii S, Kurppa KJ, Maehara T, Oobu K, Nakamura S, Kiyoshima T.
- Journal Title
  
  Pathol Res Pract.
  
  Volume: 235 Pages: 153909-153909
- DOI
  10.1016/j.prp.2022.153909
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K10096, KAKENHI-PROJECT-21K09843, KAKENHI-PROJECT-20K09906
[Journal Article] The Semaphorin 3A-AKT axis-mediated cell proliferation in salivary gland morphogenesis and adenoid cystic carcinoma pathogenesis.2022
- Author(s)
  Fujii S, Fujimoto T, Hasegawa K, Nagano R, Ishibashi T, Kurppa KJ, Mikami Y, Kokura M, Tajiri Y, Kibe T, Wada H, Wada N, Kishida S, Higuchi Y, Kiyoshima T.
- Journal Title
  
  Pathol Res Pract.
  
  Volume: 236 Pages: 153991-153991
- DOI
  10.1016/j.prp.2022.153991
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K10096, KAKENHI-PROJECT-21K09843, KAKENHI-PROJECT-19K19235, KAKENHI-PROJECT-22K17017, KAKENHI-PROJECT-20K09906, KAKENHI-PROJECT-20K10107
[Journal Article] YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation2020
- Author(s)
  Hasegawa Kana、Fujii Shinsuke、Matsumoto Shinji、Tajiri Yudai、Kikuchi Akira、Kiyoshima Tamotsu
- Journal Title
  
  The Journal of Pathology
  
  Volume: 253 Issue: 1 Pages: 80-93
- DOI
  10.1002/path.5553
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09906, KAKENHI-PROJECT-20K10096, KAKENHI-PROJECT-19K18966, KAKENHI-PROJECT-21K19407, KAKENHI-PROJECT-21H04797, KAKENHI-PROJECT-21K07121
[Journal Article] The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation.2020
- Author(s)
  Fujii S., Tajiri, Y., Hasegawa, K., Matsumoto,S., Yoshimoto, RU., Wada, H., Kishida, S., Kido, MA., Yoshikawa, H., Ozeki, S., Kiyoshima, T.
- Journal Title
  
  Lab Invest.
  
  Volume: 100(2) Issue: 2 Pages: 311-323
- DOI
  10.1038/s41374-019-0357-z
- NAID
  120006938538
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11616, KAKENHI-PROJECT-19K10302, KAKENHI-PROJECT-18J11575, KAKENHI-PROJECT-19K18966
[Presentation] 口腔扁平上皮癌におけるp63とMAPKシグナルによる低分子量Gタンパク質ARL4Cの発現制御機構解明2023
- Author(s)
  藤井　慎介、Dania Zuhier Ragheb Alkhatib、Thinh Thi-Kim Truong、長谷川佳那、長野　良子、清島　保
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K27792
[Presentation] CHARACTERIZATION OF CLEAR CELL SQUAMOUS CELL CARCINOMA OF THE TONGUE, INCLUDING INTRACELLULAR SIGNALING PATHWAYS AND DNA METHYLATION2023
- Author(s)
  Kana Hasegawa, Shinsuke Fujii, Tamotsu Kiyoshima
- Organizer
  IAOP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09843
[Presentation] 口腔扁平上皮癌におけるp63とMAPKシグナルによる低分子量Gタンパク質ARL4Cの発現制御機構解明2023
- Author(s)
  藤井　慎介、Dania Zuhier Ragheb Alkhatib、Thinh Thi-Kim Truong、長谷川佳那、長野　良子、清島　保
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-20K10096
[Presentation] 未分化な扁平上皮癌の特徴を有する舌に生じた clear cell squamous cell carcinoma2022
- Author(s)
  長谷川佳那、藤井慎介、清島保
- Organizer
  第33回日本臨床口腔病理学会（3学会合同学術大会）
- Data Source
  KAKENHI-PROJECT-20K10096
[Presentation] 口腔癌においてYAPシグナルは異型性および上皮間葉転換を誘導する2022
- Author(s)
  長谷川佳那、藤井慎介、清島保
- Organizer
  第111回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-20K10096
[Presentation] 口腔癌においてYAPシグナルは異型性および上皮間葉転換を誘導する2022
- Author(s)
  長谷川　佳那、藤井慎介、清島保
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-21K09843
[Presentation] 口腔扁平上皮癌においてp63シグナルはYAPシグナルと協調的に細胞内シグナルおよびDNAメチル化を制御する2022
- Author(s)
  長谷川佳那、藤井慎介、清島保
- Organizer
  第64回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K10096
[Presentation] YAP-PIEZO1シグナルは口腔扁平上皮癌の細胞増殖を促進する2022
- Author(s)
  長谷川　佳那
- Organizer
  歯科基礎医学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09843
[Presentation] 口腔扁平上皮癌においてp63シグナルはYAPシグナルと協調的に細胞内シグナルおよびDNAメチル化を制御する2022
- Author(s)
  長谷川　佳那、藤井慎介、清島保
- Organizer
  歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-21K09843
[Presentation] 未分化な扁平上皮癌の特徴を有する舌に生じたclear cell squamous cell carcinoma2022
- Author(s)
  長谷川　佳那、藤井慎介、清島保
- Organizer
  日本臨床口腔病理学会
- Data Source
  KAKENHI-PROJECT-21K09843
[Presentation] YAP-PIEZO1シグナルは口腔扁平上皮癌の細胞増殖を促進する2021
- Author(s)
  長谷川佳那、藤井慎介、清島保
- Organizer
  歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-21K09843
[Presentation] YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation2021
- Author(s)
  長谷川佳那、藤井慎介、清島保
- Organizer
  Kyudai Oral Bioscience & OBT Research Center 5th Joint International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09843
[Presentation] YAP-PIEZO1シグナルは口腔扁平上皮癌の細胞増殖を制御する2021
- Author(s)
  藤井慎介、長谷川佳那、清島保
- Organizer
  第110回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-20K10096
[Presentation] YAP-PIEZO1シグナルは口腔扁平上皮癌の細胞増殖を促進する2021
- Author(s)
  長谷川佳那、藤井慎介、清島保
- Organizer
  第63回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K10096
[Presentation] Hippo-PIEZO1 signal regulates cell proliferation in oral squamous cell carcinoma2020
- Author(s)
  長谷川佳那、藤井慎介、清島保
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-19K18966
[Presentation] Hippo-PIEZO1 signal regulates cell proliferation in oral squamous cell carcinoma2020
- Author(s)
  長谷川佳那、藤井慎介、清島保
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-20K10096
[Presentation] 機械感受性イオンチャネルPiezo1の発現は口腔扁平上皮癌の細胞増殖を制御する2018
- Author(s)
  長谷川佳那、藤井慎介、清島保
- Organizer
  歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-17K17103

1. Kiyoshima Tamotsu (20264054)

# of Collaborated Projects: 8 results

# of Collaborated Products: 20 results
2. 藤井慎介 (60452786)

# of Collaborated Projects: 7 results

# of Collaborated Products: 22 results
3. Wada Hiroko (70380706)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
4. 自見英治郎 (40276598)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 田尻祐大 (30820659)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Higuchi Yoshinori (70117224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 城戸瑞穂 (60253457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 永田健吾 (90189134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 川野真太郎 (00398067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 和田尚久 (60380466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 御手洗裕美 (60801660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hasegawa Kana 長谷川 佳那

Research Projects

Research Products

Co-Researchers

口腔癌をモデルとした癌転移機構の解明 ~新規YAP下流因子によるEMT誘導機構の解明~Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of resistance acquisition to super-enhancer-targeted anticancer therapies and novel strategies based on this mechanism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the instability among mutant epithelial cells, adjacent normal epithelial cells and stromal cells to develop strategies for screening and very early detection of cancer.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of differentiation regulating mechanism by SPARC-related factors expressed in the dental papilla, and attempt of tooth regeneration

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the effect of the Hippo-YAP signaling on atypia in oral squamos cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of odontogenic mesenchymal stem cell-inducing factors and application to tooth regeneration

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the signal pathways between oral squamous cell carcinoma cells and surrounding microenvironment as novel therapeutic target for novel anti-cancer therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis and development of novel adenoid cystic carcinoma therapy targeting Wnt signaling

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the mechanism of oral squamous cell carcinoma tumorigenesis through PIEZO1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of tooth development based on mechanosensor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel oral cancer therapy through the anti tumor effect of Piezo1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Wnt/β-catenin-C-kit axis may play a role in adenoid cystic carcinoma prognostication2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Arl4c is involved in tooth germ development through osteoblastic/ameloblastic differentiation2023

Author(s)

Journal Title

DOI

Data Source

Hasegawa Kana 長谷川佳那

[Presentation] 口腔扁平上皮癌においてp63シグナルはYAPシグナルと協調的に細胞内シグナルおよびDNAメチル化を制御する2022