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UESUGI Shota  上杉 祥太

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Shota Uesugi  上杉 祥太

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Researcher Number 30795901
Other IDs
Affiliation (Current) 2025: 公益財団法人岩手生物工学研究センター, 生物資源研究部, 主任研究員
Affiliation (based on the past Project Information) *help 2020 – 2023: 公益財団法人岩手生物工学研究センター, 生物資源研究部, 主任研究員
2019: 公益財団法人岩手生物工学研究センター, 生物資源研究部, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 08030:Family and consumer sciences, and culture and living-related
Except Principal Investigator
Basic Section 39040:Plant protection science-related / Basic Section 38050:Food sciences-related
Keywords
Principal Investigator
化学分類 / 健康機能性 / 山菜 / フキ属 / 成分育種 / 成分多様性 / 機能性物質 / 単離精製 / 作用機序 / アレルギー / interleukin-2 / カルシウムシグナル / キク科植物 … More
Except Principal Investigator
… More 病原菌 / システミック / リンドウ / シロイヌナズナ / 糸状菌 / 細菌 / 抵抗性誘導 / 感受性誘導 / TMPRSS2 / カリン / ナリンゲニン / 甘茶 / ガレート型カテキン / 緑茶 / Withanolides / Physalis peruviana L. / IL-6 / Dihydroisocoumarin / Hydrangea macrophylla / Hydroxywithanlide E / Whithanolide E / Phyllodulcin / Hydrangenol / IL-6 amplification / ACE2 / SARS-CoV-2 / 4b-hydroxywithanolide E / withanolide E / phyllodulcin / hydrangenol Less
  • Research Projects

    (5 results)
  • Research Products

    (43 results)
  • Co-Researchers

    (8 People)
  •  Design of functionality and safety by molecular bleeding in Petasites japonicusPrincipal Investigator

    • Principal Investigator
      上杉 祥太
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 08030:Family and consumer sciences, and culture and living-related
    • Research Institution
      Iwate Biotechnology Research Center
  •  気孔侵入型病原菌による宿主の気孔密度操作を伴うシステミックな感受性誘導機構の解明

    • Principal Investigator
      舘田 知佳
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 39040:Plant protection science-related
    • Research Institution
      Iwate University
      Nara Institute of Science and Technology
  •  Investigation on viral inhibitory effects of food ingredients.

    • Principal Investigator
      Yano Akira
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38050:Food sciences-related
    • Research Institution
      Iwate Biotechnology Research Center
  •  The chemical diversity and health functionality of Petasites japonicus focused on "chemotaxonomy"Principal Investigator

    • Principal Investigator
      Uesugi Shota
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 08030:Family and consumer sciences, and culture and living-related
    • Research Institution
      Iwate Biotechnology Research Center
  •  Identification and functional analysis of Ca2+-signaling inhibitors derived from edible Asteraceae plantsPrincipal Investigator

    • Principal Investigator
      Shota Uesugi
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 08030:Family and consumer sciences, and culture and living-related
    • Research Institution
      Iwate Biotechnology Research Center

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Golden berry leaf extract containing withanolides suppresses TNF-α and IL-17 induced IL-6 expression in HeLa Cells2023

    • Author(s)
      Yano A, Yuki S, Shiraishi A, Hakozaki M, Kanno Y, Kimura K, Uesugi S
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 87 Issue: 9 Pages: 972-980

    • DOI

      10.1093/bbb/zbad070

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K02000, KAKENHI-PROJECT-21K05433
  • [Journal Article] 3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation2023

    • Author(s)
      Usukhbayar Narandulam、Takano Yukie、Uesugi Shota、Muroi Makoto、Osada Hiroyuki、Kimura Ken-ichi
    • Journal Title

      Free Radical Research

      Volume: 57 Issue: 3 Pages: 208-222

    • DOI

      10.1080/10715762.2023.2229005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-23K02000, KAKENHI-PROJECT-22H04922
  • [Journal Article] 3,6-Epidioxy-1,10-bisaboladiene and sulfasalazine synergistically induce ferroptosis-like cell death in human breast cancer cell lines2023

    • Author(s)
      Usukhbayar N, Uesugi S, Kimura K
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 87 Issue: 11 Pages: 1336-1344

    • DOI

      10.1093/bbb/zbad117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K02000
  • [Journal Article] Dihydroisocoumarins of Hydrangea macrophylla var. thunbergia inhibit binding of the SARS-CoV-2 spike protein to ACE22023

    • Author(s)
      Yano A, Yuki S, Kanno Y, Shiraishi A, Onuma H, Uesugi S
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 87 Issue: 9 Pages: 1045-1055

    • DOI

      10.1093/bbb/zbad078

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K02000, KAKENHI-PROJECT-21K05433
  • [Journal Article] The Functional Ingredients in Asteraceae Edible Wild Plants2023

    • Author(s)
      上杉祥太
    • Journal Title

      KAGAKU TO SEIBUTSU

      Volume: 61 Issue: 10 Pages: 468-476

    • DOI

      10.1271/kagakutoseibutsu.61.468

    • ISSN
      0453-073X, 1883-6852
    • Year and Date
      2023-10-01
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K02000
  • [Journal Article] Production of yellow-flowered gentian plants by genetic engineering of betaxanthin pigments2023

    • Author(s)
      Nishihara M, Hirabuchi A, Goto F, Nishizaki Y, Uesugi S, Watanabe A, Tasaki K, Washiashi R, Sasaki N
    • Journal Title

      New Phytologist

      Volume: 240 Issue: 3 Pages: 1177-1188

    • DOI

      10.1111/nph.19218

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K02000
  • [Journal Article] 岩手生物工学研究センター2023

    • Author(s)
      上杉祥太
    • Journal Title

      Seibutsu-kogaku Kaishi

      Volume: 101 Issue: 12 Pages: 646-646

    • DOI

      10.34565/seibutsukogaku.101.12_646

    • ISSN
      0919-3758, 2435-8630
    • Year and Date
      2023-12-25
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K02000
  • [Journal Article] Anti-melanogenic effect of furanoeremophilanes identified from edible wild plants belonging to the genus Cacalia2022

    • Author(s)
      Uesugi S, Hakozaki M, Kanno Y, Takahashi Y, Shindo K, Kimura K, Yano A
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 86 Issue: 10 Pages: 1462-1466

    • DOI

      10.1093/bbb/zbac124

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Journal Article] Bidysoxyphenols A-C, dimeric sesquiterpene phenols from the leaves of Dysoxylum parasiticum (Osbeck) Kosterm2022

    • Author(s)
      Sofian FF, Subarnas A, Hakozaki M, Uesugi S, Koseki T, Shiono Y
    • Journal Title

      Fitoterapia

      Volume: 158 Pages: 105157-105157

    • DOI

      10.1016/j.fitote.2022.105157

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Journal Article] Petasin is the main component responsible for the anti-adipogenic effect of Petasites japonicus2022

    • Author(s)
      Uesugi S, Hakozaki M, Kanno Y, Shiraishi A, Suzuki M, Kimura K, Shiono Y, Yano A
    • Journal Title

      Fitoterapia

      Volume: 157 Pages: 105130-105130

    • DOI

      10.1016/j.fitote.2022.105130

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Journal Article] Tridysoxyphenols A and B, two new trimeric sesquiterpene phenols from Dysoxylum parasiticum leaves2022

    • Author(s)
      Sofian FF, Subarnas A, Hakozaki M, Uesugi S, Koseki T, Shiono Y
    • Journal Title

      Phytochemistry Letters

      Volume: 50 Pages: 134-140

    • DOI

      10.1016/j.phytol.2022.06.004

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Journal Article] Antioxidant p-terphenyl compound, isolated from edible mushroom, Boletopsis leucomelas2022

    • Author(s)
      Sofian FF, Kikuchi N, Koseki T, Kanno Y, Uesugi S, Shiono Y
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 86 Issue: 3 Pages: 300-304

    • DOI

      10.1093/bbb/zbab224

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Journal Article] A yeast-based screening system identified bakkenolide B contained in Petasites japonicus as an inhibitor of interleukin-2 production in a human T cell line2021

    • Author(s)
      Uesugi S, Hakozaki M, Kanno Y, Takahashi H, Kudo Y, Kimura K, Yamada H, Yano A
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Issue: 10 Pages: 2153-2160

    • DOI

      10.1093/bbb/zbab130

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Journal Article] Inhibition of Calcineurin and Glycogen Synthase Kinase‐3β by Ricinoleic Acid Derived from Castor Oil2020

    • Author(s)
      Yoshida Jun、Okawa Yusuke、Oyama Takuya、Shimoda Nozomu、Uesugi Shota、Takagi Hiroshi、Ito Yoshiaki、Kimura Ken‐ichi
    • Journal Title

      Lipids

      Volume: 55 Issue: 2 Pages: 89-99

    • DOI

      10.1002/lipd.12208

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K13036, KAKENHI-PROJECT-19K14046
  • [Journal Article] Isolation of a spirolactone norditerpenoid as a yeast Ca^2+ signal transduction inhibitor from Kuji amber and evaluation of its effects on PPM1A activity2019

    • Author(s)
      Shimizu Eisaku、Koshino Hiroyuki、Noro Aoi、Maruyama Miku、Shimoda Nozomu、Uesugi Shota、Ohnishi Motoko、Kimura Ken-ichi
    • Journal Title

      Fitoterapia

      Volume: 134 Pages: 290-296

    • DOI

      10.1016/j.fitote.2019.02.027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H04910, KAKENHI-PROJECT-15K01810, KAKENHI-PROJECT-16K07724, KAKENHI-PROJECT-19K14046
  • [Journal Article] Identification of neomacrophorins isolated from Trichoderma sp. 1212-03 as proteasome inhibitors2019

    • Author(s)
      Uesugi S, Honmura Y, Nishiyama M, Kusakabe K, Tonouchi A, Yamashita T, Hashimoto M, Kimura K
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 27 Issue: 24 Pages: 115161-115161

    • DOI

      10.1016/j.bmc.2019.115161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K14046
  • [Presentation] 食用ほおずきに含まれる新規withanolide硫酸エステルの同定と生物学的役割2024

    • Author(s)
      上杉祥太、越野広雪、箱崎真友佳、菅野裕子、菅原英範、鈴木瑞季、白石朗子、結城彩花、木村賢一、矢野明
    • Organizer
      日本農芸化学会2024年度大会
    • Data Source
      KAKENHI-PROJECT-23K02000
  • [Presentation] アレルギー症状原因因子ロイコトリエンの産生を抑制する農林水産物の探索2023

    • Author(s)
      箱崎真友佳、菅野裕子、結城彩花、矢野明、木村賢一、上杉祥太
    • Organizer
      日本農芸化学会東北支部第158回大会
    • Data Source
      KAKENHI-PROJECT-23K02000
  • [Presentation] 山菜由来の3,6-Epidioxy-1,10-bisaboladiene(EDBD)はフェロトーシス様細胞死を誘導する2023

    • Author(s)
      Uskhbayar Narandulam、髙野侑恵、上杉祥太、室井誠、長田裕之、木村賢一
    • Organizer
      第96回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-23K02000
  • [Presentation] 農林水産物や未利用資源の高度利用に向けた機能性成分研究2023

    • Author(s)
      上杉祥太
    • Organizer
      2023年度日本農芸化学会東北支部シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K02000
  • [Presentation] 甘茶に含まれるウイルス-受容体結合阻害成分2023

    • Author(s)
      矢野明、結城彩花、菅野裕子、白石朗子、上杉祥太
    • Organizer
      日本農芸化学会2023年度大会
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Presentation] 3,6-Epidioxy-1,10-bisaboladiene(EDBD)とスルファサラジンは乳がん細胞に相乗的に細胞死を誘導する2023

    • Author(s)
      Uskhbayar Narandulam、上杉祥太、木村賢一
    • Organizer
      日本農芸化学会2023年度大会
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Presentation] 甘茶に含まれるウイルス-受容体結合阻害成分2023

    • Author(s)
      矢野明、結城彩花、菅野裕子、白石朗子、上杉祥太
    • Organizer
      日本農芸化学会2023年度大会
    • Data Source
      KAKENHI-PROJECT-21K05433
  • [Presentation] 焙煎漆種子熱水抽出物(漆茶)の血圧上昇抑制作用2023

    • Author(s)
      上杉祥太、杉山育美、箱崎真友佳、菅野裕子、丹場晴也、木村賢一、松沢卓生、佐塚泰之、矢野明
    • Organizer
      日本農芸化学会2023年度大会
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Presentation] ヤマブドウの多機能性未利用資源「梗」の成分特性2023

    • Author(s)
      上杉祥太、箱崎真友佳、菅野裕子、及川和宏、小浜恵子、佐々木茂、矢野明
    • Organizer
      日本農芸化学会東北支部第158回大会
    • Data Source
      KAKENHI-PROJECT-23K02000
  • [Presentation] 月山で採取された落枝から分離されたAlternaria alternata SI-694株が生産する二次代謝産物について2023

    • Author(s)
      髙橋怜央、一色新之助、上杉祥太、箱崎真友佳、菅野裕子、小関卓也、塩野義人
    • Organizer
      日本農芸化学会東北支部第158回大会
    • Data Source
      KAKENHI-PROJECT-23K02000
  • [Presentation] フキ・フキノトウにおける新規ケモタイプの発見と主成分による抗ヒスタミン薬抵抗性克服戦略2023

    • Author(s)
      上杉祥太、箱崎真友佳、菅野裕子、丹場晴也、木村賢一、矢野明
    • Organizer
      日本農芸化学会2023年度大会
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Presentation] 新型コロナウイルススパイクタンパク質と受容体の結合を阻害する食品成分の探索2022

    • Author(s)
      矢野明、結城彩花、上杉祥太、菅野裕子、箱崎真友佳
    • Organizer
      第76回日本栄養・食糧学会大会
    • Data Source
      KAKENHI-PROJECT-21K05433
  • [Presentation] Undescribed dimeric- and trimeric-sesquiterpene phenols and a bicoumarin derivative isolated from the leaves of Dysoxylum caulostachyum Miq., a primate-consumed plant2022

    • Author(s)
      Ferry Ferdiansyah Sofian, Anas Subarnas, Mayuka Hakozaki, Shota Uesugi, Takuya Koseki, Yoshihito Shiono
    • Organizer
      日本農芸化学会2022年度大会
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Presentation] 農林水産物に含まれる機能性成分の理解と活用に向けた基礎・応用研究2022

    • Author(s)
      上杉祥太
    • Organizer
      2022年度日本農芸化学会東北支部シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Presentation] Identification of a cytokine storm inhibitor from a golden berry leaf.2022

    • Author(s)
      矢野明、上杉祥太、結城彩花、箱崎真友佳、菅野裕子、白石朗子
    • Organizer
      22nd International Congress of Nutrition in Tokyo
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K05433
  • [Presentation] ウニの消化管および生殖巣中のβ-カロテンとβ-エキネノンの定量および相関分析2022

    • Author(s)
      佐野真生、濱遥香、上杉祥太、結城彩花、矢野明、下荢坪之典、今村聖祐、井戸篤史、都木靖彰、浦和寛
    • Organizer
      令和4年度日本水産増殖学会第20回大会
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Presentation] Cacalia属山菜に含まれるメラニン産生抑制物質の同定2022

    • Author(s)
      上杉祥太、箱崎真友佳、菅野裕子、髙橋優太、新藤一敏、木村賢一、矢野明
    • Organizer
      令和4年度日本農芸化学会北海道・東北支部合同支部会
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Presentation] 肝細胞糖産生を抑制するヒドロキシ脂肪酸ricinoleic acid類の構造活性相関研究2021

    • Author(s)
      吉田潤、上杉祥太、箱崎真友佳、藤澤日土美、伊藤芳明、木村賢一
    • Organizer
      日本農芸化学会2021年度大会
    • Data Source
      KAKENHI-PROJECT-19K14046
  • [Presentation] Bioactive properties of non-methylene-interrupted dienoic fatty acids in eukaryotic cells2021

    • Author(s)
      Jun Yoshida, Shota Uesugi, Tetsuaki Kawamura, Ken-ichi Kimura, Dawei Hu, Shuang Xia, Naoki Toyooka, Masao Ohnishi, Hideki Kawashima
    • Organizer
      Pacifichem2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Presentation] フキ属山菜の化学系統分類規定成分bakkenolide類によるinterleukin-2産生阻害作用2021

    • Author(s)
      上杉祥太、箱崎真友佳、菅野裕子、高橋穂乃香、工藤唯、木村賢一、山田秀俊、矢野明
    • Organizer
      日本農芸化学会2021年度大会
    • Data Source
      KAKENHI-PROJECT-19K14046
  • [Presentation] Elucidation of a partial polymer structure of Kuji amber2021

    • Author(s)
      Junpei Abe, Hiroyuki Koshino, Kazuyoshi Oikawa, Yuka Miura, Shota Uesugi, Masayuki Shirai, Ken-ichi Kimura
    • Organizer
      Pacifichem2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Presentation] Analysis of functional mechanism and target molecules of ricinoleic acid derived from castor oil2021

    • Author(s)
      Jun Yoshida, Yusuke Okawa, Takuya Oyama, Nozomu Shimoda, Shota Uesugi, Hiroshi Takagi, Yoshiaki Ito, Ken-ichi Kimura
    • Organizer
      Pacifichem2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Presentation] フキ・フキノトウに含まれる脂肪蓄積抑制成分petasinの同定と作用機序解析2021

    • Author(s)
      上杉祥太、箱崎真友佳、菅野裕子、白石朗子、鈴木瑞季、木村賢一、塩野義人、矢野明
    • Organizer
      日本農芸化学会東北支部第156回大会
    • Data Source
      KAKENHI-PROJECT-21K13508
  • [Presentation] ヒマシ油由来のヒドロキシ脂肪酸ricinoleic acidのcalcineurinとGSK-3βに対する阻害作用2020

    • Author(s)
      吉田潤、大川佑介、小山卓矢、下田希、上杉祥太、高木博史、伊藤芳明、木村賢一
    • Organizer
      日本農芸化学会2020年度大会
    • Data Source
      KAKENHI-PROJECT-19K14046
  • [Presentation] モミジガサに含まれるinterleukin-2産生阻害物質2020

    • Author(s)
      上杉祥太、箱崎真友佳、植村亜衣子、熊谷加奈子、木村賢一、山田秀俊、矢野明
    • Organizer
      日本農芸化学会2020年度大会
    • Data Source
      KAKENHI-PROJECT-19K14046
  • [Presentation] 食品に含まれるウイルス-受容体結合阻害成分の探索2020

    • Author(s)
      矢野明、上杉祥太
    • Organizer
      日本農芸化学会東北支部第155回大会
    • Data Source
      KAKENHI-PROJECT-19K14046
  • [Presentation] フキ属山菜の化学分類規定成分bakkenolide BによるIL-2産生阻害作用2020

    • Author(s)
      上杉祥太、箱崎真友佳、菅野裕子、高橋穂乃香、工藤唯、木村賢一、山田秀俊、矢野明
    • Organizer
      日本農芸化学会東北支部第155回大会
    • Data Source
      KAKENHI-PROJECT-19K14046
  • 1.  Yano Akira (50312286)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 2.  生内 和哉 (70881514)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  大沼 広宜 (90891028)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  舘田 知佳 (30774111)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  藤崎 恒喜 (30626510)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  木村 賢一 (30344625)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 7.  室井 誠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  吉田 潤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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