Kobayakawa Takuya 小早川拓也

Researcher Number	30801526
Other IDs	https://orcid.org/0000-0001-9786-2608
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 東京医科歯科大学, 生体材料工学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator 中分子創薬 / アミロイドβペプチド / クロロアルケン型ジペプチドイソスター / ペプチドミメティック / アルツハイマー型認知症 / 環状ペプチド / Fmoc-固相合成法 / 収束的合成 / アミロイドβ Except Principal Investigator ケモカイン受容体CXCR4 … More / ペプチドミメティック / 環状ペプチド / 薬物送達 / 中分子化合物 / コンジュゲート分子 / 上皮成長因子受容体 / 創薬リード / 中分子 / コンジュゲート / 上皮成長因子受容体EGFR Less

環状ペプチド誘導体を活用した標的選択的ハイブリッド型中分子医薬品の創製
- Principal Investigator
  
  玉村啓和
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo Medical and Dental University
Development of inhibitors for amyloid peptide aggregation based on peptidomimeticsPrincipal Investigator
- Principal Investigator
  
  小早川拓也
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tokyo Medical and Dental University
Development of target-selective mid-size drugs using cyclic peptide derivatives
- Principal Investigator
  
  Tamamura Hirokazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tokyo Medical and Dental University
Elucidation of aggregation mechanism of amyloid-Beta utilizing chloroalkene type peptidomimetic and its drug discoveryPrincipal Investigator
- Principal Investigator
  
  Kobayakawa Takuya
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] 医薬品モダリティの特許戦略と技術開発動向～核酸医薬・ペプチド・次世代抗体・遺伝子治療・再生医療・細胞治療など～第3章ペプチド医薬に関連した今後の特許戦略と開発動向　５節ペプチドミメティクス技術の現状と今後の動向2019
- Author(s)
  小早川拓也, 玉村啓和
- Total Pages
  676
- Publisher
  株式会社技術情報協会
- ISBN
  9784861047497
- Data Source
  KAKENHI-PROJECT-19K16312
[Book] ペプチド創薬の最前線第6章ペプチドミメティックを活用した中分子型創薬リードの創製2019
- Author(s)
  小早川拓也, 玉村啓和
- Total Pages
  265
- Publisher
  シーエムシー出版
- ISBN
  9784781314174
- Data Source
  KAKENHI-PROJECT-19K16312
[Journal Article] Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups2024
- Author(s)
  Kobayakawa Takuya、Takano Hikaru、Ishii Takahiro、Bolah Peter、Tsuji Kohei、Ohashi Nami、Nomura Wataru、Furuta Toshiaki、Tamamura Hirokazu
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 3 Pages: 311-312
- DOI
  10.1248/cpb.c24-00013
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-03-16
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-23K14318, KAKENHI-PROJECT-23K23468
[Journal Article] Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins2024
- Author(s)
  Kobayakawa Takuya、Yokoyama Masaru、Tsuji Kohei、Boku Sayaka、Kurakami Masaki、Fujino Masayuki、Ishii Takahiro、Miura Yutaro、Nishimura Soshi、Shinohara Kouki、Yamamoto Kenichi、Bolah Peter、Kotani Osamu、Murakami Tsutomu、Sato Hironori、Tamamura Hirokazu
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 1 Pages: 41-47
- DOI
  10.1248/cpb.c23-00618
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-01-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-23K14318, KAKENHI-PROJECT-23K08062
[Journal Article] Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity2023
- Author(s)
  Ishii Takahiro、Kobayakawa Takuya、Matsuda Kouki、Tsuji Kohei、Ohashi Nami、Nakahata Shingo、Noborio Airi、Yoshimura Kazuhisa、Mitsuya Hiroaki、Maeda Kenji、Tamamura Hirokazu
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 256 Pages: 115449-115449
- DOI
  10.1016/j.ejmech.2023.115449
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-23K14318, KAKENHI-PROJECT-23K15385
[Journal Article] Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties2023
- Author(s)
  Tsuji Kohei、Ishii Takahiro、Kobayakawa Takuya、Higashi-Kuwata Nobuyo、Shinohara Kouki、Azuma Chika、Miura Yutaro、Nakano Hiroki、Wada Naoya、Hattori Shin-ichiro、Bulut Haydar、Mitsuya Hiroaki、Tamamura Hirokazu
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 66 Issue: 19 Pages: 13516-13529
- DOI
  10.1021/acs.jmedchem.3c00777
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-23K14318
[Journal Article] Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement2023
- Author(s)
  Tsuji Kohei、Kobayakawa Takuya、Ishii Takahiro、Higashi-Kuwata Nobuyo、Azuma Chika、Shinohara Kouki、Miura Yutaro、Yamamoto Kenichi、Nishimura Soshi、Hattori Shin-ichiro、Bulut Haydar、Mitsuya Hiroaki、Tamamura Hirokazu
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 71 Issue: 12 Pages: 879-886
- DOI
  10.1248/cpb.c23-00562
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2023-12-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-23K14318
[Journal Article] Sensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C2023
- Author(s)
  Matsuura Kanako、Yamaura Mizuki、Sakawaki Hiromi、Himeno Ai、Pisil Yalcin、Kobayakawa Takuya、Tsuji Kohei、Tamamura Hirokazu、Matsushita Shuzo、Miura Tomoyuki
- Journal Title
  
  Virology
  
  Volume: 578 Pages: 171-179
- DOI
  10.1016/j.virol.2022.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-21H02970
[Journal Article] Dimerized fusion inhibitor peptides targeting the HR1?HR2 interaction of SARS-CoV-22023
- Author(s)
  Tsuji Kohei、Baffour-Awuah Owusu Kofi、Miura Yutaro、Ishii Takahiro、Shinohara Kouki、Kobayakawa Takuya、Emi Akino、Nakano Takashi、Suzuki Youichi、Tamamura Hirokazu
- Journal Title
  
  RSC Advances
  
  Volume: 13 Issue: 13 Pages: 8779-8793
- DOI
  10.1039/d2ra07356k
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362
[Journal Article] Development of anti-HBV agents targeting HBV capsid proteins2023
- Author(s)
  Kobayakawa Takuya、Amano Masayuki、Nakayama Miyuki、Tsuji Kohei、Ishii Takahiro、Miura Yutaro、Shinohara Kouki、Yamamoto Kenichi、Matsuoka Masao、Tamamura Hirokazu
- Journal Title
  
  RSC Medicinal Chemistry
  
  Volume: 14 Issue: 10 Pages: 1973-1980
- DOI
  10.1039/d3md00258f
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-23K14318, KAKENHI-PROJECT-23K24379
[Journal Article] Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates2023
- Author(s)
  Matsumoto Kaho、Kuwata Takeo、Tolbert William D.、Richard Jonathan、Ding Shilei、Prevost Jeremie、Takahama Shokichi、Judicate George P.、Ueno Takamasa、Nakata Hirotomo、Kobayakawa Takuya、Tsuji Kohei、Tamamura Hirokazu、Smith Amos B.、Pazgier Marzena、Finzi Andres、Matsushita Shuzo
- Journal Title
  
  Journal of Virology
  
  Volume: 97 Issue: 1
- DOI
  10.1128/jvi.01638-22
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-21K19657
[Journal Article] Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-22023
- Author(s)
  Higashi-Kuwata Nobuyo、Tsuji Kohei、Hayashi Hironori、Bulut Haydar、Kiso Maki、Imai Masaki、Ogata-Aoki Hiromi、Ishii Takahiro、Kobayakawa Takuya、Nakano Kenta、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1076-1076
- DOI
  10.1038/s41467-023-36729-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-20K07134, KAKENHI-PROJECT-23H05465
[Journal Article] Potent and biostable inhibitors of the main protease of SARS-CoV-22022
- Author(s)
  Tsuji Kohei、Ishii Takahiro、Kobayakawa Takuya、Higashi-Kuwata Nobuyo、Azuma Chika、Nakayama Miyuki、Onishi Takato、Nakano Hiroki、Wada Naoya、Hori Miki、et al.
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 11 Pages: 105365-105365
- DOI
  10.1016/j.isci.2022.105365
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-20K07134
[Journal Article] Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors2022
- Author(s)
  Tsuji Kohei、Kobayakawa Takuya、Konno Kiju、Masuda Ami、Takahashi Kohei、Ohashi Nami、Yoshimura Kazuhisa、Kuwata Takeo、Matsushita Shuzo、Harada Shigeyoshi、Tamamura Hirokazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 56 Pages: 116616-116616
- DOI
  10.1016/j.bmc.2022.116616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-20H03362
[Journal Article] Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors2022
- Author(s)
  Wang Rongyi、Tsuji Kohei、Kobayakawa Takuya、Liu Yishan、Yoshimura Kazuhisa、Matsushita Shuzo、Harada Shigeyoshi、Tamamura Hirokazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 76 Pages: 117083-117083
- DOI
  10.1016/j.bmc.2022.117083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-21H02970
[Journal Article] Fluorescence Resonance Energy Transfer-based Screening for Protein Kinase C Ligands Using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones2021
- Author(s)
  Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, Hirokazu Tamamura
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 19 Issue: 38 Pages: 8264-8271
- DOI
  10.1039/d1ob00814e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21253, KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-19H02827
[Journal Article] Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application2021
- Author(s)
  Kobayakawa Takuya、Azuma Chika、Watanabe Yuki、Sawamura Shunsuke、Taniguchi Atsuhiko、Hayashi Yoshio、Tsuji Kohei、Tamamura Hirokazu
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 86 Issue: 7 Pages: 5091-5101
- DOI
  10.1021/acs.joc.0c03019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19K16312, KAKENHI-PROJECT-20H03362
[Journal Article] A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators2021
- Author(s)
  Matsuda Kouki、Kobayakawa Takuya、Kariya Ryusho、Tsuchiya Kiyoto、Ryu Shoraku、Tsuji Kohei、Ishii Takahiro、Gatanaga Hiroyuki、Yoshimura Kazuhisa、Okada Seiji、Hamada Akinobu、Mitsuya Hiroaki、Tamamura Hirokazu、Maeda Kenji
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 12 Pages: 636276-636276
- DOI
  10.3389/fmicb.2021.636276
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-20K17480, KAKENHI-PROJECT-19K22488, KAKENHI-PROJECT-20H03362
[Journal Article] Development for Peptidomimetic Chemistry based on Chloroalkene Structures2019
- Author(s)
  Kobayakawa Takuya、Tamamura Hirokazu
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 77 Issue: 9 Pages: 904-911
- DOI
  10.5059/yukigoseikyokaishi.77.904
- NAID
  130007705928
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2019-09-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16312
[Presentation] HIV侵入阻害剤としてのポリエチレングリコールと低分子CD4ミミックのハイブリッド化合物の創製2024
- Author(s)
  黒田悠貴, 小早川拓也, 辻耕平, 紺野奇重, 大橋南美, 増田亜美, 三浦裕太郎, 桑田岳夫, 吉村和久, 三浦智行, 原田恵嘉, 松下修三, 玉村啓和
- Organizer
  日本薬学会第144回年会
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] アミロイドbeta凝集阻害剤を指向したクロロアルケン型ペプチドミメティックの創製2024
- Author(s)
  山本賢一、小早川拓也、東知佳、渡邉優基、辻耕平、玉村啓和
- Organizer
  日本薬学会第144回年会
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] HIV-1カプシドタンパク質の構造を起点とした低分子型抗HIV-1剤の創製2024
- Author(s)
  町田沙穂, 小早川拓也, 横山勝, 藤野真之, 金子萌美, 倉上真樹, 朴清香, 大西立人, 小谷治, 辻耕平, 村上努, 佐藤裕徳, 玉村啓和
- Organizer
  日本薬学会第144回年会
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] HIV-1外被タンパク質gp41を標的とする二価型膜融合阻害剤の創製2024
- Author(s)
  西村壮史, 小早川拓也, 辻耕平, 村上努, 玉村啓和
- Organizer
  日本薬学会第144回年会
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] SARS-CoV-2メインプロテアーゼを標的とした高抗ウイルス活性を有する低分子阻害剤の創製2024
- Author(s)
  篠原功紀，鍬田伸好，辻耕平，石井貴大，小早川拓也，服部真一朗，岸本直樹，高宗暢暁，三隅将吾，Haydar Bulut，林宏典，満屋裕明，玉村啓和
- Organizer
  日本薬学会第144回年会
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] Combinational use of CD4 mimic with other anti-HIV agents and development of these hybrid molecules2023
- Author(s)
  Yutaro Miura, Rongyi Wang, Kohei Tsuji, Yishan Liu, Takuya Kobayakawa, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura
- Organizer
  14th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] クロロアルケン型ジペプチドイソスターの新規合成法の開発とその応用研究2023
- Author(s)
  山本賢一, 小早川拓也, 東知佳, 辻耕平, 玉村啓和
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] HIV-1カプシドタンパク質の構造を基盤とした低分子型抗HIV-1剤の創製研究2023
- Author(s)
  小早川拓也，横山勝，藤野真之，金子萌美，倉上真樹，朴清香，大西立人，小谷治，辻耕平，村上努，佐藤裕徳，玉村啓和
- Organizer
  第40回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] Development of synthetic strategies for peptidomimetic based on a chloroalkene dipeptide isostere and its application to a cyclic peptide2023
- Author(s)
  Takuya Kobayakawa, Chika Azuma, Kenichi Yamamoto, Kohei Tsuji, Hirokazu Tamamura
- Organizer
  The 15th International Kyoto Conference on New Aspects of Organic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] Double target inhibitors of HIV-1 entry based on hybrid molecules of CD4 mimics and HIV-1 gp41-related peptides2023
- Author(s)
  Yutaro Miura, Rongyi Wang, Kohei Tsuji, Yishan Liu, Takuya Kobayakawa, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura
- Organizer
  26th Korean Peptide Protein Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] フッ素化及びチオアミド置換を活用した新規SARs-CoV-2メインプロテアーゼ阻害剤の創製2023
- Author(s)
  篠原功紀, 鍬田伸好, 辻耕平, 石井貴大, 小早川拓也, 服部真一郎, 岸本直樹, 高宗暢暁, 三隅将吾, Haydar Bulit, 林宏典, 満屋裕明, 玉村啓和
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] Development of convergent synthesis for peptidomimetic based on a chloroalkene dipeptide isostere and its application to a cyclic peptide2023
- Author(s)
  Takuya Kobayakawa, Chika Azuma, Kenichi Yamamoto, Kohei Tsuji, Hirokazu Tamamura
- Organizer
  The 60th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] COVID-19の治療薬として強力な抗ウイルス活性を有する新規SARS-CoV-2メインプロテアーゼ阻害剤の構造活性相関研究2023
- Author(s)
  篠原功紀，鍬田伸好，辻耕平，石井貴大，小早川拓也，服部真一朗，岸本直樹，高宗暢暁，三隅将吾，Haydar Bulut，林宏典，満屋裕明，玉村啓和
- Organizer
  第40回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] Structure-Activity Relationship Studies of DAG-lactone Derivatives with HIV-1 Latancy Reversing Activity2023
- Author(s)
  Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Nami Ohashi, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda, Hirokazu Tamamura
- Organizer
  14th AFMC International Medicinal Chemistry Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] フッ素置換を基盤としたSARS-CoV-2メインプロテアーゼ阻害剤の創製2023
- Author(s)
  篠原功紀, 鍬田伸好, 辻耕平, 石井貴大, 小早川拓也, 服部真一朗, 岸本直樹, 高宗暢暁, 三隅将吾、Haydar Bulut, 林宏典, 満屋裕明, 玉村啓和
- Organizer
  創薬懇話会2023 湯河原
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] Structure-activity relationship studies of novel SARS-CoV-2 main protease inhibitors with potent antiviral activity2023
- Author(s)
  Kouki Shinohara, Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Yutaro Miura, Chika Azuma, Hironori Hayashi, Shin-ichiro Hattori, Haydar Bulut, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura
- Organizer
  The 60th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] Hybrid molecules of CD4 mimic and HIV-1 fusion inhibitors2023
- Author(s)
  Yutaro Miura, Rongyi Wang, Kohei Tsuji, Yishan Liu, Takuya Kobayakawa, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura
- Organizer
  14th AFMC International Medicinal Chemistry Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] クロロアルケン型ジペプチドイソスターの合成法の開発とその応用研究2023
- Author(s)
  山本賢一, 小早川拓也, 東知佳, 渡邉優基, 辻耕平, 玉村啓和
- Organizer
  創薬懇話会2023 湯河原
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] HIV-1外被タンパク質gp41を標的とする二価型膜融合阻害剤の創製2023
- Author(s)
  西村壮史, 小早川拓也, 辻耕平, 村上努, 玉村啓和
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] クロロアルケン骨格を基盤としたペプチドミメティックの新規合成法の開発とその応用2023
- Author(s)
  小早川拓也，東知佳，山本賢一，渡邉優基，辻耕平，玉村啓和
- Organizer
  第49回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] クロロアルケン型ジペプチドイソスターの合成法とその生物学的応用2023
- Author(s)
  山本賢一, 小早川拓也, 東知佳, 辻耕平, 玉村啓和
- Organizer
  第55回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] 抗HIV剤から抗SARS-CoV-2阻害剤へーメインプロテアーゼ阻害剤の創製2023
- Author(s)
  辻耕平, 石井貴大, 小早川拓也, 鍬田伸好, 篠原功紀, 東知佳, 林宏典, 三隅将吾, Haydar Bulut, 岡村匡史, 満屋裕明, 玉村啓和
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] Design and Synthesis of SARS-CoV-2 Mpro Inhibitors Containing Flurine Atoms and Amide Surrogates2023
- Author(s)
  Takahiro Ishii, Kohei Tsuji, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Hironori Hayashi, Haydar Bulut, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura
- Organizer
  26th Korean Peptide Protein Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14318
[Presentation] Exploration of novel class anti-HIV-1 agents derived from a viral capsid protein2022
- Author(s)
  K. Tsuji; R. Wang; K. B.-A. Owusu; T. Kobayakawa; T. Murakami; H. Tamamura
- Organizer
  The 12th International Peptide Symposium/The 36th European Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03362
[Presentation] Development of HIV-1 fusion inhibitors based on dimeric derivatives of the C34 peptide and its peptidomimetics2021
- Author(s)
  Tamamura H, Kobayakawa T, Ebihara K, Murakami T, Tsuji K
- Organizer
  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03362
[Presentation] A FRET-BASED ASSAY SYSTEM FOR PROTEIN KINASE C LIGAND SCREENING USING 1,2-DIACYLGLYCEROL-LACTONE DERIVATIVE2021
- Author(s)
  Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, Hirokazu Tamamura
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-20H03362
[Presentation] ペプチドミメティックを指向したクロロアルケン型ジペプチドイソスターの新規合成法の開発2020
- Author(s)
  東知佳, 小早川拓也, 辻耕平, 玉村啓和
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16312
[Presentation] A convergent synthesis of chloroalkene dipeptide isosteres as peptidomimetics2020
- Author(s)
  Chika Azuma, Takuya Kobayakawa, Kohei Tsuji, Hirokazu Tamamura
- Organizer
  The 57th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-19K16312
[Presentation] ペプチドミメティックを指向したクロロアルケン型ジペプチドイソスターの合成研究2019
- Author(s)
  東知佳, 小早川拓也, 玉村啓和
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19K16312

1. Tamamura Hirokazu (80217182)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 辻耕平 (50866639)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. NOMURA Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. HARADA Shigeyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. KUWATA Takeo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 谷口敦彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayakawa Takuya 小早川 拓也

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環状ペプチド誘導体を活用した標的選択的ハイブリッド型中分子医薬品の創製

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Development of inhibitors for amyloid peptide aggregation based on peptidomimeticsPrincipal Investigator

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Development of target-selective mid-size drugs using cyclic peptide derivatives

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Elucidation of aggregation mechanism of amyloid-Beta utilizing chloroalkene type peptidomimetic and its drug discoveryPrincipal Investigator

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[Book] ペプチド創薬の最前線 第6章 ペプチドミメティックを活用した中分子型創薬リードの創製2019

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[Journal Article] Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups2024

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[Journal Article] Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins2024

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[Journal Article] Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity2023

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[Journal Article] Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties2023

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[Journal Article] Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement2023

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[Journal Article] Sensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C2023

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[Journal Article] Dimerized fusion inhibitor peptides targeting the HR1?HR2 interaction of SARS-CoV-22023

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Kobayakawa Takuya 小早川拓也

[Book] ペプチド創薬の最前線第6章ペプチドミメティックを活用した中分子型創薬リードの創製2019