Watanabe Tsubasa 渡邉翼

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Tsubasa Watanabe 渡邉翼

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Researcher Number	30804348
Other IDs	https://orcid.org/0000-0002-2058-335X
Affiliation (Current)	2025: 京都大学, 複合原子力科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 京都大学, 複合原子力科学研究所, 准教授 2020 – 2022: 京都大学, 複合原子力科学研究所, 特定准教授 2017 – 2019: 京都大学, 複合原子力科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science Except Principal Investigator Basic Section 56010:Neurosurgery-related / Basic Section 52040:Radiological sciences-related / Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator ホウ素中性子捕捉療法 / 中性子捕捉療法 / BNCT / 放射線生物 / 免疫反応 / 腫瘍免疫 / 放射線治療 / 免疫療法 / 粒子線治療 / 癌 / ホウ素中性子補足療法 / 腫瘍組織内薬剤不均一分布 / L-BPA … More Except Principal Investigator … More がん治療 / ホウ素 / 薬剤相互作用 / 脳腫瘍 / 中性子捕捉療法 / 免疫チェックポイント阻害薬 / 放射線治療 / アブスコパル効果 / 疾患診断 / 即発ガンマ線 / 高速中性子 Less

Development of innovative radioimmunotherapy utilizing the abscopal effect and exploration of novel biomarkers
- Principal Investigator
  
  坂中克行
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyoto University
Framework for Implementing Multi-Target Neutron Capture Therapy for Brain Tumors
- Principal Investigator
  
  川端信司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
免疫細胞のホウ素薬剤取込能を評価しホウ素中性子捕捉療法後の免疫への影響を解明するPrincipal Investigator
- Principal Investigator
  
  渡邉翼
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyoto University
Development of challenging new disease diagnostic methods using fast neutron beams
- Principal Investigator
  
  田中浩基
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kyoto University
Boron Drug Development to Expand the Indication of Boron Neutron Capture Therapy to Refractory Non-neoplastic DiseasesPrincipal Investigator
- Principal Investigator
  
  Watanabe Tsubasa
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyoto University
Investigation of Novel Host Tumor Immunostimulatory Effects Induced by Boron Neutron Capture TherapyPrincipal Investigator
- Principal Investigator
  
  Watanabe Tsubasa
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyoto University
Elucidating the cause of the heterogeneous distribution of boron drugs used for boron neutron capture therapyPrincipal Investigator
- Principal Investigator
  
  Tsubasa Watanabe
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Multi-Targeted Neutron Capture Therapy Combined with an 18 kDa Translocator Protein-Targeted Boron Compound Is an Effective Strategy in a Rat Brain Tumor Model2023
- Author(s)
  Kashiwagi Hideki、Hattori Yoshihide、Kawabata Shinji、Kayama Ryo、Yoshimura Kohei、Fukuo Yusuke、Kanemitsu Takuya、Shiba Hiroyuki、Hiramatsu Ryo、Takami Toshihiro、Takata Takushi、Tanaka Hiroki、Watanabe Tsubasa、Suzuki Minoru、Hu Naonori、Miyatake Shin-Ichi、Kirihata Mitsunori、Wanibuchi Masahiko
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 4 Pages: 1034-1034
- DOI
  10.3390/cancers15041034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16698, KAKENHI-PROJECT-20H03797, KAKENHI-PROJECT-20K05753, KAKENHI-PROJECT-21K15805, KAKENHI-PROJECT-22K09270
[Journal Article] Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated closo-Dodecaborate on a Rat Brain Tumor Model2023
- Author(s)
  Fujikawa Yoshiki、Fukuo Yusuke、Nishimura Kai、Tsujino Kohei、Kashiwagi Hideki、Hiramatsu Ryo、Nonoguchi Naosuke、Furuse Motomasa、Takami Toshihiro、Hu Naonori、Miyatake Shin-Ichi、Takata Takushi、Tanaka Hiroki、Watanabe Tsubasa、Suzuki Minoru、Kawabata Shinji、Nakamura Hiroyuki、Wanibuchi Masahiko
- Journal Title
  
  Biology
  
  Volume: 12 Issue: 9 Pages: 1240-1240
- DOI
  10.3390/biology12091240
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09270, KAKENHI-PROJECT-23K27715
[Journal Article] Proposal of recommended experimental protocols for <i>in vitro</i> and <i>in vivo</i> evaluation methods of boron agents for neutron capture therapy2023
- Author(s)
  Hattori Yoshihide、Andoh Tooru、Kawabata Shinji、Hu Naonori、Michiue Hiroyuki、Nakamura Hiroyuki、Nomoto Takahiro、Suzuki Minoru、Takata Takushi、Tanaka Hiroki、Watanabe Tsubasa、Ono Koji
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 64 Issue: 6 Pages: 859-869
- DOI
  10.1093/jrr/rrad064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07080, KAKENHI-PROJECT-23K07119, KAKENHI-PROJECT-19K08134, KAKENHI-PROJECT-20K08094, KAKENHI-PROJECT-21K09176, KAKENHI-PROJECT-23K27715
[Journal Article] Pharmacokinetic Study of 14C-Radiolabeled p-Boronophenylalanine (BPA) in Sorbitol Solution and the Treatment Outcome of BPA-Based Boron Neutron Capture Therapy on a Tumor-Bearing Mouse Model2023
- Author(s)
  Watanabe Tsubasa、Yoshikawa Tomohiro、Tanaka Hiroki、Kinashi Yuko、Kashino Genro、Masunaga Shin-ichiro、Hayashi Toshimitsu、Uehara Koki、Ono Koji、Suzuki Minoru
- Journal Title
  
  European Journal of Drug Metabolism and Pharmacokinetics
  
  Volume: 48 Issue: 4 Pages: 443-453
- DOI
  10.1007/s13318-023-00830-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08171, KAKENHI-PROJECT-23K07080
[Journal Article] The mutual relationship between the host immune system and radiotherapy2022
- Author(s)
  Tsubasa Watanabe, Genki Edward Sato, Michio Yoshimura, Minoru Suzuki, Takashi Mizowaki
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 0 Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15805
[Journal Article] The mutual relationship between the host immune system and radiotherapy: stimulating the action of immune cells by irradiation2022
- Author(s)
  Watanabe Tsubasa、Sato Genki Edward、Yoshimura Michio、Suzuki Minoru、Mizowaki Takashi
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 28 Issue: 2 Pages: 201-208
- DOI
  10.1007/s10147-022-02172-2
- Data Source
  KAKENHI-PROJECT-21K15805
[Journal Article] Correlation between the expression of LAT1 in cancer cells and the potential efficacy of boron neutron capture therapy2022
- Author(s)
  Watanabe Tsubasa、Sanada Yu、Hattori Yoshihide、Suzuki Minoru
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 64 Issue: 1 Pages: 91-98
- DOI
  10.1093/jrr/rrac077
- Data Source
  KAKENHI-PROJECT-21K15805
[Journal Article] Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model2022
- Author(s)
  Arima Jun、Taniguchi Kohei、Yamamoto Masashi、Watanabe Tsubasa、Suzuki Yusuke、Hamamoto Hiroki、Inomata Yosuke、Kashiwagi Hideki、Kawabata Shinji、Tanaka Keitaro、Uchiyama Kazuhisa、Suzuki Minoru、Lee Sang-Woong
- Journal Title
  
  Biomedicine & Pharmacotherapy
  
  Volume: 154 Pages: 113632-113632
- DOI
  10.1016/j.biopha.2022.113632
- Data Source
  KAKENHI-PROJECT-21K15805
[Journal Article] Quantitative autoradiography in boron neutron capture therapy considering the particle ranges in the samples2021
- Author(s)
  Takeno Satoshi、Tanaka Hiroki、Watanabe Tsubasa、Mizowaki Takashi、Suzuki Minoru
- Journal Title
  
  Physica Medica
  
  Volume: 82 Pages: 306-320
- DOI
  10.1016/j.ejmp.2021.02.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17231
[Journal Article] Characteristic evaluation of the thermal neutron irradiation field using a 30 MeV cyclotron accelerator for basic research on neutron capture therapy2020
- Author(s)
  Tanaka H, Takata T, Watanabe T, Suzuki M, Mitsumoto T, Kawabata S, Masunaga S, Kinashi Y, Sakurai Y, Maruhashi A, Ono K.
- Journal Title
  
  Nuclear Inst. And Methods in Physics Research, A
  
  Volume: 983 Pages: 164533-164533
- DOI
  10.1016/j.nima.2020.164533
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07750, KAKENHI-PROJECT-19K08171, KAKENHI-PROJECT-19H04485, KAKENHI-PROJECT-20H03797, KAKENHI-PROJECT-19K17231
[Journal Article] Deep abscopal response to radiotherapy and anti-PD-1 in an oligometastatic melanoma patient with unfavorable pretreatment immune signature2020
- Author(s)
  Watanabe Tsubasa、Firat Elke、Scholber Jutta、Gaedicke Simone、Heinrich Corinne、Luo Ren、Ehrat Nicolas、Multhoff Gabriele、Schmitt-Graeff Annette、Grosu Anca-Ligia、Abdollahi Amir、Hassel Jessica C.、von Bubnoff Dagmar、Meiss Frank、Niedermann Gabriele
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 69 Issue: 9 Pages: 1823-1832
- DOI
  10.1007/s00262-020-02587-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17231
[Journal Article] Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8+ T-Cell?Dependent Tumor Activity2020
- Author(s)
  Watanabe Tsubasa、Gaedicke Simone、Guffart Elena、Firat Elke、Niedermann Gabriele
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 26 Issue: 4 Pages: 945-956
- DOI
  10.1158/1078-0432.ccr-19-0476
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17231
[Presentation] シンポジウム4 「高精度放射線治療における放射線生物学」「免疫療法時代における高精度放射線治療の役割」2021
- Author(s)
  渡邉翼
- Organizer
  第34回高精度放射線外部照射部会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17231
[Presentation] 良好なアブスコパル効果を認めた転移性悪性黒色腫患者の末梢血免疫反応の解析2020
- Author(s)
  渡邉翼
- Organizer
  第2回生体量子捕獲反応研究会
- Data Source
  KAKENHI-PROJECT-19K17231
[Presentation] 硼素中性子捕捉療法により誘導される宿主免疫を介した照射後抗腫瘍効果増感作用の研究2020
- Author(s)
  渡邉翼
- Organizer
  第22回癌治療増感シンポジウム
- Data Source
  KAKENHI-PROJECT-19K17231
[Presentation] 臓器別シンポジウム「免疫療法時代における局所療法の意義」「放射線治療と免疫療法併用における放射線治療の役割と可能性」2020
- Author(s)
  渡邉翼
- Organizer
  第58回癌治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17231
[Presentation] Indoleamine 2,3-deoxygenase阻害剤は放射線治療と免疫チェックポイント阻害剤の効果を増強する2020
- Author(s)
  渡邉翼
- Organizer
  第22回癌治療増感シンポジウム
- Data Source
  KAKENHI-PROJECT-19K17231
[Presentation] Indoleamine 2,3-deoxygenase阻害剤は放射線治療と免疫チェックポイント阻害剤の効果を増強する2020
- Author(s)
  渡邉翼、吉村通央、溝脇尚志、鈴木実、Gabriele Niedermann
- Organizer
  第22回癌治療増感シンポジウム
- Data Source
  KAKENHI-PROJECT-19K17231
[Presentation] 放射線照射と免疫療法併用における腫瘍組織内代謝競合の役割2020
- Author(s)
  渡邉翼
- Organizer
  日本放射線腫瘍学会第33回学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17231
[Presentation] 良好なアブスコパル効果を認めた転移性悪性黒色腫患者の末梢血免疫反応の解析2020
- Author(s)
  渡邉翼
- Organizer
  第58回癌治療学会
- Data Source
  KAKENHI-PROJECT-19K17231
[Presentation] トリプトファン代謝酵素阻害剤は放射線と抗PD-1抗体併用による治療効果を増強する2019
- Author(s)
  渡邉翼、溝脇尚志、鈴木実、Gabriele Niedermann
- Organizer
  第32回日本放射線腫瘍学会
- Data Source
  KAKENHI-PROJECT-19K17231
[Presentation] IDO inhibition strongly enhances effects of combined hRT and PD1/PD-L1 checkpoint blockade2019
- Author(s)
  渡邉翼
- Organizer
  ESTRO 38 (European SocietTy for Radiotherapy & Oncology), Italy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06811

1. 田中浩基 (70391274)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 坂中克行 (90637208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 竹内裕也 (20265838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 加藤健 (50501855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 對馬隆浩 (70763514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 川端信司 (20340549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 中村浩之 (30274434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 熊田博明 (30354913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 呼尚徳 (90846908)

# of Collaborated Projects: 1 results

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10. 古瀬元雅 (70340560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 平松亮 (40609707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 福村匡央 (00826290)

# of Collaborated Projects: 1 results

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13. 斯波宏行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 高見俊宏

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# of Collaborated Products: 1 results
15. 鰐渕昌彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 野々口直助

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 木梨友子

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# of Collaborated Products: 1 results
18. 増永慎一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Tsubasa 渡邉 翼

Tsubasa Watanabe 渡邉 翼

Research Projects

Research Products

Co-Researchers

Development of innovative radioimmunotherapy utilizing the abscopal effect and exploration of novel biomarkers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Framework for Implementing Multi-Target Neutron Capture Therapy for Brain Tumors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫細胞のホウ素薬剤取込能を評価しホウ素中性子捕捉療法後の免疫への影響を解明するPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of challenging new disease diagnostic methods using fast neutron beams

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Boron Drug Development to Expand the Indication of Boron Neutron Capture Therapy to Refractory Non-neoplastic DiseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of Novel Host Tumor Immunostimulatory Effects Induced by Boron Neutron Capture TherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the cause of the heterogeneous distribution of boron drugs used for boron neutron capture therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Multi-Targeted Neutron Capture Therapy Combined with an 18 kDa Translocator Protein-Targeted Boron Compound Is an Effective Strategy in a Rat Brain Tumor Model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated closo-Dodecaborate on a Rat Brain Tumor Model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proposal of recommended experimental protocols for <i>in vitro</i> and <i>in vivo</i> evaluation methods of boron agents for neutron capture therapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pharmacokinetic Study of 14C-Radiolabeled p-Boronophenylalanine (BPA) in Sorbitol Solution and the Treatment Outcome of BPA-Based Boron Neutron Capture Therapy on a Tumor-Bearing Mouse Model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The mutual relationship between the host immune system and radiotherapy2022

Author(s)

Journal Title

Data Source

[Journal Article] The mutual relationship between the host immune system and radiotherapy: stimulating the action of immune cells by irradiation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correlation between the expression of LAT1 in cancer cells and the potential efficacy of boron neutron capture therapy2022

Author(s)

Journal Title

DOI

Watanabe Tsubasa 渡邉翼

Tsubasa Watanabe 渡邉翼

[Presentation] 臓器別シンポジウム「免疫療法時代における局所療法の意義」「放射線治療と免疫療法併用における放射線治療の役割と可能性」2020

[Presentation] 良好なアブスコパル効果を認めた転移性悪性黒色腫患者の末梢血免疫反応の解析2020