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Tozawa Takenori  戸澤 雄紀

ORCIDConnect your ORCID iD *help
Researcher Number 30804950
Other IDs
Affiliation (Current) 2025: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Affiliation (based on the past Project Information) *help 2025: 京都府立医科大学, 医学(系)研究科(研究院), 助教
2023: 京都府立医科大学, 医学(系)研究科(研究院), 学内講師
2018 – 2022: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords
Principal Investigator
細胞内輸送障害 / STXBP1脳症 / 神経変性 / Myosin-Va / Munc18-1 / 発達性てんかん性脳症 / BMPシグナル / 神経筋接合部 / SMN非依存的治療 / BMP活性 … More / Lrp4 / 神経筋接合部異常 / SMN / 脊髄性筋萎縮症 / 蛋白質異常凝集 / 膜輸送障害 / syntaxin1A / STX1A / MyosinVa / Syntaxin1A / ミトコンドリア機能異常 / αシヌクレイン / STXBP1関連てんかん性脳症 / タンパク質異常凝集 / STXBP1 / てんかん性脳症 / 細胞死 / 軸索輸送障害 / STXBP1 encephalopathy Less
  • Research Projects

    (4 results)
  • Research Products

    (5 results)
  • Co-Researchers

    (4 People)
  •  脊髄性筋萎縮症の神経筋接合部形成不全の分子病態の解明と新規治療ターゲットの探索Principal Investigator

    • Principal Investigator
      戸澤 雄紀
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  SMN-independent therapy for spinal muscular atrophy focused on BMP signalingPrincipal Investigator

    • Principal Investigator
      戸澤 雄紀
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  STXBP1 haploinsufficiency impairs membrane trafficking and dendrite growthPrincipal Investigator

    • Principal Investigator
      Tozawa Takenori
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Impaired membrane trafficking in STXBP1 encephalopathyPrincipal Investigator

    • Principal Investigator
      Tozawa Takenori
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Kyoto Prefectural University of Medicine

All 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons2021

    • Author(s)
      Ichise Eisuke、Chiyonobu Tomohiro、Ishikawa Mitsuru、Tanaka Yasuyoshi、Shibata Mami、Tozawa Takenori、Taura Yoshihiro、Yamashita Satoshi、Yoshida Michiko、Morimoto Masafumi、Higurashi Norimichi、Yamamoto Toshiyuki、Okano Hideyuki、Hirose Shinichi
    • Journal Title

      Human Molecular Genetics

      Volume: - Issue: 14 Pages: 1337-1348

    • DOI

      10.1093/hmg/ddab113

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17347, KAKENHI-PROJECT-20K16898, KAKENHI-PROJECT-21K07780, KAKENHI-PROJECT-21K07855, KAKENHI-PROJECT-21K07873
  • [Journal Article] Early infantile-onset Leigh syndrome complicated with infantile spasms associated with the m.9185?T?>?C variant in the MT-ATP6 gene: Expanding the clinical spectrum2020

    • Author(s)
      Takada Rei、Tozawa Takenori、Kondo Hidehito、Kizaki Zenro、Kishita Yoshihito、Okazaki Yasushi、Murayama Kei、Ohtake Akira、Chiyonobu Tomohiro
    • Journal Title

      Brain and Development

      Volume: 42 Issue: 1 Pages: 69-72

    • DOI

      10.1016/j.braindev.2019.08.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03624, KAKENHI-PROJECT-18K15724
  • [Presentation] Impaired activity and differential gene expression in STXBP1 encephalopathy patient iPS-derived GABAergic neurons.2021

    • Author(s)
      Eiske Ichise, Tomohiro Chiyonobu, Mitsuru Ishikawa, Yasuyoshi Tanaka, Mami Shibata, Takenori Tozawa, Satoshi Yamashita, Michiko Yoshida, Masafumi Morimoto, Norimichi Higurashi, Toshiyuki Yamamoto, Hideyuki Okano, Shinichi Hirose.
    • Organizer
      日本人類伝学会第66回大会 第28回日本遺伝子診療学会大会 合同開催
    • Data Source
      KAKENHI-PROJECT-20K16898
  • [Presentation] Functional and transcriptomic analysis of STXBP1 encephalopathy iPS-derived GABAergic neuron.2021

    • Author(s)
      Eiske Ichise, Tomohiro Chiyonobu, Mitsuru Ishikawa, Yasuyoshi Tanaka, Takenori Tozawa, Satoshi Yamashita, Michiko Yoshida, Norimichi Higurashi, Toshiyuki Yamamoto, Hideyuki Okano, Shinichi Hirose.
    • Organizer
      第63回日本小児神経学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K16898
  • [Presentation] A case of early infantile-onset Leigh syndrome with a m.9185T>C in the MT-ATP6 gene mutation complicated with infantile spasms.2019

    • Author(s)
      Takada R, Tozawa T, Kondo H, Kizaki Z, Kishita Y, Okazaki Y, Murayama K, Ohtake A, Chiyonobu T.
    • Organizer
      The 20th Annual meeting of infantile seizure society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15724
  • 1.  吉田 英樹 (30570600)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  木下 善仁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  岡崎 康司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  柴田 磨己
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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