Hata Tatsuo 畠達夫

Researcher Number	30806237
Other IDs
Affiliation (Current)	2025: 東北大学, 医学系研究科, 大学院非常勤講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 東北大学, 医学系研究科, 大学院非常勤講師 2018 – 2019: 東北大学, 医学系研究科, 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 膵癌 / TP53遺伝子 / KRAS遺伝子 / 次世代シーケンス / デジタルPCR / メチル化DNA / リキッドバイオプシー / 膵管内乳頭粘液性腫瘍 Except Principal Investigator 膵癌 / 免疫療法 … More / クロモスリプシス / 染色体不安定性 / 胆道癌 / テロメア / バイオマーカー / 胆嚢癌 / 胆管癌 / 集学的治療 / プレシジョン医療 / 循環腫瘍細胞 / 血中循環腫瘍細胞 / 膵神経内分泌腫瘍 / 神経内分泌腫瘍 / CNPY2 / 膵・消化管神経内分泌腫瘍 / qMSP / デジタルPCR / リキッドバイオプシー / DNAメチル化 / 遺伝子 / ゲノム / 癌 Less

人工知能を用いた医用画像と膵液バイオマーカーの統合解析による小膵癌診断技法の構築Principal Investigator
- Principal Investigator
  
  畠達夫
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Early detection and precision medicine for hepatobiliiary cancer targeting chromosomal instability
- Principal Investigator
  
  Hayashi Hiroki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Development of diagnostic technique of pancreatic cancer by using liquid biopsy targeted DNA methylation markers
- Principal Investigator
  
  Gu Zhaodi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
Elucidation of liver metastasis-related mechanisms in CNPY2 for gastroenteropancreatic neuroendocrine tumor
- Principal Investigator
  
  Mizuma Masamichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Molecular signature-based classification of circulating tumor cells and its clinical application for refinement of multidisciplinary treatment of pancreatic cancer.
- Principal Investigator
  
  Motoi Fuyuhiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Yamagata University
Development of the novel diagnostic panel by liquid-biopsy for predicting the early-stage pancreatic cancer.Principal Investigator
- Principal Investigator
  
  Hata Tatsuo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Simultaneous and sequential combination of genetic and epigenetic biomarkers for the presence of high-grade dysplasia in patients with pancreatic cyst: Discovery in cyst fluid and test in pancreatic juice2023
- Author(s)
  Hata T, Mizuma M, Kusakabe T, Amano H, Furukawa T, Iwao T, Unno M.
- Journal Title
  
  Pancreatology
  
  Volume: 23 Issue: 2 Pages: 218-226
- DOI
  10.1016/j.pan.2023.01.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08765
[Journal Article] Impact of Tumor-Derived DNA Testing in Peritoneal Lavage of Pancreatic Cancer Patients with and Without Occult Intra-Abdominal Metastases.2022
- Author(s)
  Chiba K, Hata T, Mizuma M, Masuda K, Aoki S, Takadate T, Kawaguchi K, Nakagawa K, Morikawa T, Motoi F, Furukawa T, Unno M.
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 29 Issue: 4 Pages: 2685-2697
- DOI
  10.1245/s10434-021-10997-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09209, KAKENHI-PROJECT-21K20823
[Journal Article] Circulating tumor DNA as a predictive marker for occult metastases in pancreatic cancer patients with radiographically non-metastatic disease.2021
- Author(s)
  Hata T, Mizuma M, Iseki M, Takadate T, Ishida M, Nakagawa K, Hayashi H, Morikawa T, Motoi F, Unno M.
- Journal Title
  
  J Hepatobiliary Pancreat Sci.
  
  Volume: 28 Issue: 8 Pages: 648-658
- DOI
  10.1002/jhbp.993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09209
[Journal Article] Germline DNA damage repair gene mutations in pancreatic cancer patients with personal/family histories of pancreas/breast/ovarian/prostate cancer in a Japanese population.2021
- Author(s)
  Hata T, Mizuma M, Motoi F, Ishida M, Ohtsuka H, Nakagawa K, Morikawa T, Furukawa T, Unno M.
- Journal Title
  
  Ann Gastroenterol Surg.
  
  Volume: 5 Issue: 6 Pages: 853-864
- DOI
  10.1002/ags3.12482
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09209
[Journal Article] MicroRNA-593-3p Expression in Peritoneal Lavage Fluid as a Prognostic Marker for Pancreatic Cancer Patients Undergoing Staging Laparoscopy.2021
- Author(s)
  Hata T, Mizuma M, Masuda K, Chiba K, Ishida M, Ohtsuka H, Nakagawa K, Morikawa T, Kamei T, Unno M.
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 28 Issue: 4 Pages: 2235-2245
- DOI
  10.1245/s10434-020-09440-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09209
[Journal Article] An integrated analysis of host- and tumor-derived markers for predicting high-grade dysplasia and associated invasive carcinoma of intraductal papillary mucinous neoplasms of the pancreas.2020
- Author(s)
  Hata T, Nakagawa K, Hayashi H, Kanno A,et al.
- Journal Title
  
  Surg Today.
  
  Volume: - Issue: 9 Pages: 1039-1048
- DOI
  10.1007/s00595-020-01982-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07897, KAKENHI-PROJECT-16H05410, KAKENHI-PROJECT-18K16338
[Journal Article] GNAS mutation detection in circulating cell-free DNA is a specific predictor for intraductal papillary mucinous neoplasms of the pancreas, especially for intestinal subtype.2020
- Author(s)
  Hata T, Mizuma M, Motoi F, Omori Y, Ishida M, Nakagawa K, Hayashi H, Morikawa T, Kamei T, Furukawa T, Unno M.
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Issue: 1 Pages: 17761-17761
- DOI
  10.1038/s41598-020-74868-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09209, KAKENHI-PROJECT-18K16338
[Journal Article] Methylation-mediated Silencing of the LIM Homeobox 6 (LHX6) Gene Promotes Cell Proliferation in Human Pancreatic Cancer2020
- Author(s)
  Yakefujiang Abudurexiti, Zhaodi Gu, Kanchan Chakma, Tatsuo Hata, Fuyuhiko Motoi, Michiaki Unno, Akira Horii, Shinichi Fukushige
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: - Issue: 3 Pages: 626-632
- DOI
  10.1016/j.bbrc.2020.03.120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07771
[Journal Article] Epigenetic inactivation of IRX4 is responsible for acceleration of cell growth in human pancreatic cancer2020
- Author(s)
  Kanchan Chakma, Zhaodi Gu, Yakefujiang Abudurexiti, Tatsuo Hata, Fuyuhiko Motoi, Michiaki Unno, Akira Hori, Shinichi Fukushige
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 12 Pages: 4594-4604
- DOI
  10.1111/cas.14644
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07771
[Journal Article] Serum Anti-p53 Antibody Can Serve as a Predictive Marker for Histological Grade of Intraductal Papillary Mucinous Neoplasms of the Pancreas.2020
- Author(s)
  Hata T, Mizuma M, Motoi F, Iseki M, Omori Y, Hayashi H, Nakagawa K, Morikawa T, Kamei T, Naitoh T, Furukawa T, Unno M.
- Journal Title
  
  Pancreas.
  
  Volume: 49 Issue: 6 Pages: 768-773
- DOI
  10.1097/mpa.0000000000001570
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09209, KAKENHI-PROJECT-18K16338
[Journal Article] Prognostic impact of intraoperative peritoneal cytology after neoadjuvant therapy for potentially resectable pancreatic cancer.2020
- Author(s)
  Aoki S, Mizuma M, Hayashi H, Yoshimachi S, Hata T, Miura T, Takadate T, Maeda S, Ariake K, Kawaguchi K, Masuda K, Ishida M, Ohtsuka H, Nakagawa K, Morikawa T, Motoi F, Unno M.
- Journal Title
  
  Pancreatology.
  
  Volume: 20 Issue: 8 Pages: 1711-1717
- DOI
  10.1016/j.pan.2020.08.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09209
[Presentation] 膵病変の診断・リスク評価における連続膵液細胞診と膵液中のKRAS/GNAS遺伝子測定の有用性2022
- Author(s)
  畠達夫, 水間正道, 天野穂高, 日下部崇, 岩尾年康, 海野倫明
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-22K08765
[Presentation] 連続膵液細胞診と膵液中のKRAS/GNAS遺伝子変異測定を併用した膵病変の診断・リスク評価の有用性2022
- Author(s)
  畠達夫, 岩尾年康, 海野倫明
- Organizer
  第108回日本消化器病学会総会（ワークショップ）
- Data Source
  KAKENHI-PROJECT-22K08765
[Presentation] Impact of genome/epigenome biomarker testing using serially harvested pancreatic juice samples in patients with IPMN2022
- Author(s)
  Tatsuo Hata, Masamichi Mizuma, Hodaka Amano, Takashi Kusakabe, Toshiyasu Iwao, Michiaki Unno
- Organizer
  Joint Congress of the 26th Meeting of International Association of Pancreatology (IAP) and the 53th Annual Meeting of Japan Pancreas Society (JPS)（シンポジウム）
- Data Source
  KAKENHI-PROJECT-22K08765
[Presentation] Usefulness of genome/epigenome markers in pancreatic juice to detect high-grade dysplastic lesions.2022
- Author(s)
  Tatsuo Hata, Masamichi Mizuma, Hodaka Amano, Toshiyasu Iwao, Michiaki Unno
- Organizer
  第77回消化器外科学会総会（シンポジウム）
- Data Source
  KAKENHI-PROJECT-22K08765
[Presentation] MicroRNA-593-3p expression in peritoneal lavage fluid as a prognostic marker for pancreatic cancer patients undergoing staging laparoscopy2021
- Author(s)
  Tatsuo Hata, Masamichi Mizuma, Kunihiro Masuda, Kazuharu Chiba, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Hiroki Hayashi, Takanori Morikawa, Michiaki Unno
- Organizer
  第33回日本肝胆膵外科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09209
[Presentation] BRCA関連腫瘍の既往歴と家族歴に着目した生殖細胞系列変異陽性膵癌の特徴2021
- Author(s)
  畠達夫, 水間正道, 元井冬彦, 石田晶玄, 大塚英郎, 中川圭, 森川孝則, 古川徹, 海野倫明
- Organizer
  第52回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-19K09209
[Presentation] 膵病変の鑑別診断における膵液中のKRAS遺伝子変異の検出と連続膵液細胞診の併用の有用性2021
- Author(s)
  畠達夫, 水間正道, 大沼忍, 江川新一, 海野倫明
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09209
[Presentation] 切除企図膵癌に対する血中循環DNAのKRAS変異は画像診断で検出困難な微小病変の存在を予測しうるか？2019
- Author(s)
  畠達夫, 水間正道, 元井冬彦, 高舘達之, 伊関雅裕, 有明恭平, 川口桂, 益田邦洋, 石田晶玄, 大塚英郎, 中川圭, 森川孝則, 林洋毅, 亀井尚, 内藤剛, 海野倫明
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-18K16338
[Presentation] Cell-free KRAS mutant allele predicts the micrometastasis in pancreatic cancer patients with curative-intent resection2019
- Author(s)
  Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Tatsuyuki Takadate, Kyohei Ariake, Shuichi Aoki, Kei Kawaguchi, Hideo Ohtsuka, Hiroki Hayashi, Michiaki Unno
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K16338
[Presentation] 切除企図膵癌における血中遊離DNAのKRAS変異測定の意義ー切除可能性分類に基づいたスクリーニングの有用性ー2018
- Author(s)
  畠　達夫
- Organizer
  第77回日本癌学会
- Data Source
  KAKENHI-PROJECT-18K16338

1. Motoi Fuyuhiko (30343057)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. Mizuma Masamichi (80578675)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. Gu Zhaodi (40451520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. Hayashi Hiroki (30422124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 福重真一 (90192723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 川口桂 (10700164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 高舘達之 (50772216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 古川徹 (30282122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. 青木修一 (30844451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KANNO Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hata Tatsuo 畠 達夫

Research Projects

Research Products

Co-Researchers

人工知能を用いた医用画像と膵液バイオマーカーの統合解析による小膵癌診断技法の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Early detection and precision medicine for hepatobiliiary cancer targeting chromosomal instability

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of diagnostic technique of pancreatic cancer by using liquid biopsy targeted DNA methylation markers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of liver metastasis-related mechanisms in CNPY2 for gastroenteropancreatic neuroendocrine tumor

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular signature-based classification of circulating tumor cells and its clinical application for refinement of multidisciplinary treatment of pancreatic cancer.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the novel diagnostic panel by liquid-biopsy for predicting the early-stage pancreatic cancer.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Simultaneous and sequential combination of genetic and epigenetic biomarkers for the presence of high-grade dysplasia in patients with pancreatic cyst: Discovery in cyst fluid and test in pancreatic juice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of Tumor-Derived DNA Testing in Peritoneal Lavage of Pancreatic Cancer Patients with and Without Occult Intra-Abdominal Metastases.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating tumor DNA as a predictive marker for occult metastases in pancreatic cancer patients with radiographically non-metastatic disease.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Germline DNA damage repair gene mutations in pancreatic cancer patients with personal/family histories of pancreas/breast/ovarian/prostate cancer in a Japanese population.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MicroRNA-593-3p Expression in Peritoneal Lavage Fluid as a Prognostic Marker for Pancreatic Cancer Patients Undergoing Staging Laparoscopy.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An integrated analysis of host- and tumor-derived markers for predicting high-grade dysplasia and associated invasive carcinoma of intraductal papillary mucinous neoplasms of the pancreas.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GNAS mutation detection in circulating cell-free DNA is a specific predictor for intraductal papillary mucinous neoplasms of the pancreas, especially for intestinal subtype.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Methylation-mediated Silencing of the LIM Homeobox 6 (LHX6) Gene Promotes Cell Proliferation in Human Pancreatic Cancer2020

Author(s)

Journal Title

DOI

Data Source

Hata Tatsuo 畠達夫

[Presentation] 切除企図膵癌に対する血中循環DNAのKRAS変異は画像診断で検出困難な微小病変の存在を予測しうるか？2019