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Shimba Akihiro  榛葉 旭恒

ORCIDConnect your ORCID iD *help
Researcher Number 30812242
Other IDs
Affiliation (Current) 2025: 京都大学, 医学研究科, 特定助教
Affiliation (based on the past Project Information) *help 2025: 京都大学, 医学研究科, 特定助教
2019 – 2024: 京都大学, 医学研究科, 助教
2018: 京都大学, ウイルス・再生医科学研究所, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 49070:Immunology-related
Except Principal Investigator
Basic Section 49070:Immunology-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords
Principal Investigator
ヘルパーT細胞 / 炎症性腸疾患 / 大腸炎 / ストレス / 関節リウマチ / マトリックスメタロプロテアーゼ / 関節炎 / 好中球 / MMP25 / TH17 … More / TH17細胞 / 精神的ストレス / レニン / TH17 / ステロイドホルモン / ILC3 / Th17細胞 / グルココルチコイド … More
Except Principal Investigator
腫瘍免疫 / IL-15 / 微小環境 / サイトカイン / 自然免疫 / メラノプシン網膜神経節細胞 / 照明機器 / 看護ケア / 概日リズム / 条件等色 / 抗ウイルス免疫応答 / 関節リウマチ / 実験的自己免疫性脳脊髄炎 / Th17細胞 / 自己免疫疾患 / グルココルチコイド Less
  • Research Projects

    (8 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (12 People)
  •  リソソーム機能の概日リズムがCD8T細胞の抗がん免疫応答を制御する機構の解明Principal Investigator

    • Principal Investigator
      榛葉 旭恒
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Kyoto University
  •  Control of immune response and tissue homeostasis by novel IL-15-dependent innate lymphocytes

    • Principal Investigator
      生田 宏一
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Kyoto University
  •  Development of nighttime lighting to promote patient sleep under metameric conditions

    • Principal Investigator
      若村 智子
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 58:Society medicine, nursing, and related fields
    • Research Institution
      Kyoto University
  •  ストレスがTH17細胞のプロテアーゼの発現上昇と関節炎増悪に寄与する機構の解明Principal Investigator

    • Principal Investigator
      榛葉 旭恒
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Kyoto University
  •  Induction of autoimmune diseases by glucocorticoids

    • Principal Investigator
      IKUTA Koichi
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      Kyoto University
  •  Stress-induced renin causes intestinal inflammation via helper T cellsPrincipal Investigator

    • Principal Investigator
      Shimba Akihiro
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Kyoto University
  •  IL-15-producing microenvironment supporting innate lymphoid cells and its role in diseases

    • Principal Investigator
      Ikuta Koichi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Kyoto University
  •  Glucocorticoids enhance the differentiation and function of Th17 cells and cause colitisPrincipal Investigator

    • Principal Investigator
      Shimba Akihiro
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Kyoto University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches2023

    • Author(s)
      Asahi Takuma、Abe Shinya、Cui Guangwei、Shimba Akihiro、Nabekura Tsukasa、Miyachi Hitoshi、Kitano Satsuki、Ohira Keizo、Dijkstra Johannes M、Miyazaki Masaki、Shibuya Akira、Ohno Hiroshi、Ikuta Koichi
    • Journal Title

      eLife

      Volume: 12 Pages: 1-22

    • DOI

      10.7554/elife.84209

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-22K19430, KAKENHI-PROJECT-23K27425, KAKENHI-PROJECT-23K27426
  • [Journal Article] Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow2023

    • Author(s)
      Abe Shinya、Asahi Takuma、Hara Takahiro、Cui Guangwei、Shimba Akihiro、Tani-ichi Shizue、Yamada Kohei、Miyazaki Kazuko、Miyachi Hitoshi、Kitano Satsuki、Nakamura Naotoshi、Kikuta Junichi、Vandenbon Alexis、Miyazaki Masaki、Yamada Ryo、Ohteki Toshiaki、Ishii Masaru、Sexl Veronika、Nagasawa Takashi、Ikuta Koichi
    • Journal Title

      Cell Reports

      Volume: 42 Issue: 9 Pages: 113127-113127

    • DOI

      10.1016/j.celrep.2023.113127

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-21K08370, KAKENHI-PROJECT-22K19430, KAKENHI-PUBLICLY-22H05627, KAKENHI-PROJECT-23K24152, KAKENHI-PROJECT-23K27425, KAKENHI-PROJECT-23K27426
  • [Journal Article] Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation2023

    • Author(s)
      Takami Daichi、Abe Shinya、Shimba Akihiro、Asahi Takuma、Cui Guangwei、Tani-ichi Shizue、Hara Takahiro、Miyata Keishi、Ikutani Masashi、Takatsu Kiyoshi、Oike Yuichi、Ikuta Koichi
    • Journal Title

      International Immunology

      Volume: 35 Issue: 11 Pages: 513-530

    • DOI

      10.1093/intimm/dxad029

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-21H04825, KAKENHI-PROJECT-23K27426
  • [Journal Article] CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s2023

    • Author(s)
      Cui Guangwei、Shimba Akihiro、Jin Jianshi、Hojo Nozomi、Asahi Takuma、Abe Shinya、Ejima Aki、Okada Shinri、Ohira Keizo、Kato Ryoma、Tani-ichi Shizue、Yamada Ryo、Ebihara Takashi、Shiroguchi Katsuyuki、Ikuta Koichi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 120 Issue: 36

    • DOI

      10.1073/pnas.2215941120

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-21K19368, KAKENHI-PROJECT-23K27426
  • [Journal Article] A circulating subset of iNKT cells mediates antitumor and antiviral immunity2022

    • Author(s)
      Cui G, Shimba A, et.al
    • Journal Title

      Science Immunology

      Volume: 7 Issue: 76 Pages: 8760-8760

    • DOI

      10.1126/sciimmunol.abj8760

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-22K07086, KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-22K08187, KAKENHI-PROJECT-20K21522, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-20K17580, KAKENHI-PROJECT-20H03501, KAKENHI-PROJECT-21J15058
  • [Journal Article] Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks2022

    • Author(s)
      Akter Salma、Shimba Akihiro、Ikuta Koichi、Mahmud Md. Rasel Al、Yamada Shintaro、Sasanuma Hiroyuki、Tsuda Masataka、Sone Masakatsu、Ago Yukio、Murai Kenichi、Tanaka Hisashi、Takeda Shunichi
    • Journal Title

      Genes to Cells

      Volume: 28 Issue: 1 Pages: 53-67

    • DOI

      10.1111/gtc.12993

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07148, KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-20H03501, KAKENHI-PROJECT-20K09539
  • [Journal Article] Control of immunity and allergy by steroid hormones2022

    • Author(s)
      Ikuta Koichi、Ejima Aki、Abe Shinya、Shimba Akihiro
    • Journal Title

      Allergol. Int.

      Volume: 71 Issue: 4 Pages: 432-436

    • DOI

      10.1016/j.alit.2022.07.006

    • ISSN
      1323-8930, 1440-1592
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K07133
  • [Journal Article] Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells2022

    • Author(s)
      Ejima Aki、Abe Shinya、Shimba Akihiro、Sato Susumu、Uehata Takuya、Tani-ichi Shizue、Munakata Satoru、Cui Guangwei、Takeuchi Osamu、Hirai Toyohiro、Kato Shigeaki、Ikuta Koichi
    • Journal Title

      The Journal of Immunology

      Volume: 209 Issue: 6 Pages: 1083-1094

    • DOI

      10.4049/jimmunol.2200294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-20H03501
  • [Journal Article] Pleiotropic Effects of Glucocorticoids on the Immune System in Circadian Rhythm and Stress2021

    • Author(s)
      Akihiro Shimba, Aki Ejima, Koichi Ikuta
    • Journal Title

      Front Immunol

      Volume: 706951

    • DOI

      10.3389/fimmu.2021.706951

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K16280
  • [Journal Article] Control of immunity by glucocorticoids in health and disease.2020

    • Author(s)
      Shimba A. and Ikuta K.
    • Journal Title

      Semin. Immunopathol.

      Volume: 42 Issue: 6 Pages: 669-680

    • DOI

      10.1007/s00281-020-00827-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K21525, KAKENHI-PROJECT-20K16280
  • [Journal Article] Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice2020

    • Author(s)
      Inokawa Hitoshi, Umemura Yasuhiro, Shimba Akihiro, Kawakami Eiryo, Koike Nobuya, Tsuchiya Yoshiki, Ohashi Munehiro, Minami Yoichi, Cui Guangwei, Asahi Takuma, Ono Ryutaro, Sasawaki Yuh, Konishi Eiichi, Yoo Seung-Hee, Chen Zheng, Teramukai Satoshi, Ikuta Koichi, Yagita Kazuhiro
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 2569-2569

    • DOI

      10.1038/s41598-020-59541-y

    • NAID

      120006799241

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22516, KAKENHI-PROJECT-18H02600, KAKENHI-PROJECT-17K11021, KAKENHI-PROJECT-17KT0129, KAKENHI-PROJECT-18K15184
  • [Journal Article] Immune-enhancing effects of glucocorticoids in response to day-night cycles and stress.2020

    • Author(s)
      Shimba A. and Ikuta K.
    • Journal Title

      Int. Immunol.

      Volume: 32 Issue: 11 Pages: 703-708

    • DOI

      10.1093/intimm/dxaa048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K21525, KAKENHI-PROJECT-20K16280
  • [Journal Article] Glucocorticoids regulate circadian rhythm of innate and adaptive immunity.2020

    • Author(s)
      Shimba A. and Ikuta K.
    • Journal Title

      Front. Immunol.

      Volume: 11 Pages: 2143-2143

    • DOI

      10.3389/fimmu.2020.02143

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21525, KAKENHI-PROJECT-20K16280
  • [Journal Article] Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intra-epithelial lymphocytes in the intestine2019

    • Author(s)
      Zhu Yuanbo、Cui Guangwei、Miyauchi Eiji、Nakanishi Yuki、Mukohira Hisa、Shimba Akihiro、Abe Shinya、Tani-ichi Shizue、Hara Takahiro、Nakase Hiroshi、Chiba Tsutomu、Sehara-Fujisawa Atsuko、Seno Hiroshi、Ohno Hiroshi、Ikuta Koichi
    • Journal Title

      International Immunology

      Volume: 32 Issue: 5 Pages: 307-319

    • DOI

      10.1093/intimm/dxz082

    • NAID

      120006846480

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05907, KAKENHI-PROJECT-19K07604, KAKENHI-PROJECT-19K16687, KAKENHI-PROJECT-19K16712, KAKENHI-PROJECT-20K16280, KAKENHI-PROJECT-20H03501, KAKENHI-PROJECT-18K07958
  • [Presentation] (Pro)renin receptor controls immune responses by promoting the survival of naive T and iNKT cells2024

    • Author(s)
      宗像悟、榛葉旭恒、生田宏一
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K27426
  • [Presentation] Stress-induced glucocorticoids exacerbate inflammatory diseases by promoting Th17 cell differentiation2024

    • Author(s)
      榛葉旭恒、生田宏一
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K27426
  • [Presentation] グルココルチコイドが制御する 免疫の日内変動2024

    • Author(s)
      榛葉旭恒
    • Organizer
      日本生理人類学会・日本時間生物学会ジョイントセミナー 「シフトワークへの適応:生体リズム・睡眠と健康」
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K07133
  • [Presentation] Bone marrow microenvironment for NK cell differentiation and localization2024

    • Author(s)
      阿部真也、榛葉旭恒、谷一靖江、長澤丘司、生田宏一
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K27426
  • [Presentation] Stress-induced glucocorticoids promote the differentiation of Th17 cells exacerbating inflammatory diseases.2024

    • Author(s)
      榛葉旭恒、生田宏一
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K07133
  • [Presentation] グルココルチコイドが制御するIL-4/IL-17産生を介したがんの増悪機構の解析2023

    • Author(s)
      榛葉旭恒、生田宏一
    • Organizer
      Kyoto T Cell Conference 第31回学術集会
    • Data Source
      KAKENHI-PROJECT-23K27426
  • [Presentation] Lung local IL-7 affect the maintenance, distribution, and activation of ILC2 in allergic airway inflammations2022

    • Author(s)
      Daichi Takami, Shinya Abe, Akihiro Shimba, Takuma Asahi, Guangwei Cui, Shizue Tani-ichi, Takahiro Hara, and Koichi Ikuta
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H03501
  • [Presentation] ステロイドホルモンによる免疫機能とアレルギーの制御2021

    • Author(s)
      生田宏一、榛葉旭恒、江島亜希
    • Organizer
      日本アレルギー学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03501
  • [Presentation] 胎児肝臓に由来する1型自然リンパ球の同定2021

    • Author(s)
      旭拓真、阿部真也、崔広為、榛葉旭恒、生田宏一
    • Organizer
      Kyoto T Cell Conference 第30回学術集会
    • Data Source
      KAKENHI-PROJECT-20H03501
  • [Presentation] Control of T cell immunity by glucocorticoids2021

    • Author(s)
      榛葉旭恒、生田宏一
    • Organizer
      第28回日本時間生物学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K16280
  • [Presentation] ストレスはグルココルチコイドを介してTh17細胞の分化を促進し腸炎を増悪させる2021

    • Author(s)
      榛葉旭恒、生田宏一
    • Organizer
      Kyoto T Cell Conference 第30回学術集会
    • Data Source
      KAKENHI-PROJECT-20K21525
  • [Presentation] ステロイドホルモンによる免疫機能とアレルギーの制御2021

    • Author(s)
      生田宏一、榛葉旭恒、江島亜希
    • Organizer
      日本アレルギー学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K21525
  • [Presentation] 胎児肝臓に由来する1型自然リンパ球の同定2021

    • Author(s)
      旭拓真、阿部真也、崔広為、榛葉旭恒、生田宏一
    • Organizer
      Kyoto T Cell Conference 第30回学術集会
    • Data Source
      KAKENHI-PROJECT-20K21525
  • [Presentation] ストレスはグルココルチコイドを介してTh17細胞を活性化する2021

    • Author(s)
      榛葉旭恒、生田宏一
    • Organizer
      第30回Kyoto T Cell Conference
    • Data Source
      KAKENHI-PROJECT-20K16280
  • [Presentation] ストレスはグルココルチコイドを介してTh17細胞の分化を促進し腸炎を増悪させる2021

    • Author(s)
      榛葉旭恒、生田宏一
    • Organizer
      Kyoto T Cell Conference 第30回学術集会
    • Data Source
      KAKENHI-PROJECT-20H03501
  • [Presentation] Glucocorticoids enhance T cell immune response.2019

    • Author(s)
      榛葉旭恒
    • Organizer
      日本免疫学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K15184
  • [Presentation] Control of immunity by glucocorticoids2019

    • Author(s)
      Shimba Akihiro
    • Organizer
      第48回日本免疫学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K15184
  • 1.  IKUTA Koichi (90193177)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 14 results
  • 2.  崔 广為 (70791276)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  谷一 靖江 (50432331)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 4.  阿部 真也 (70972678)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  若村 智子 (40240452)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  中本 五鈴 (30966966)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  福田 裕美 (50551412)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  高雄 元晴 (90408013)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  高江洲 義和 (90421015)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  八木田 和弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  山田 真太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  宮内 栄治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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