NAGAI HIROTAKA 永井裕崇

… Alternative Names

Nagai Hirotaka 永井裕崇

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Researcher Number	30814587
Other IDs	https://orcid.org/0000-0003-0983-8670
Affiliation (Current)	2024: 神戸大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 神戸大学, 医学研究科, 助教 2018: 神戸大学, 医学研究科, 特命助教
Review Section/Research Field	Principal Investigator Basic Section 48030:Pharmacology-related Except Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
Keywords	Principal Investigator シナプス / ストレス / 中央代謝系 / マウス / 社会ストレス / 膨張顕微鏡法 / 三次元電顕 / 内側前頭前皮質 / うつ病モデルマウス / 細胞死 … More / 細胞内小器官 / 神経突起 / ミトコンドリア / うつ病 / 樹状突起 / 前頭前皮質 / 神経グリア相互作用 / 電子顕微鏡 / 軸索 / ミクログリア … More Except Principal Investigator ストレスモデルマウス / チロシン水酸化酵素 / グルタミン酸脱炭酸酵素 / 酵素活性 / 質量分析イメージング Less

社会ストレスによる脳代謝リモデリングの実態と機序、意義の解明Principal Investigator
- Principal Investigator
  
  永井裕崇
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kobe University
Development of enzyme histochemistry for elucidating brain function using mass microscope and its application to stress model brains
- Principal Investigator
  
  新間秀一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Osaka University
Elucidation of the molecular mechanisms responsible for social stress-induced dendritic atrophy and establishment of its control methodsPrincipal Investigator
- Principal Investigator
  
  Nagai Hirotaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kobe University
Ultrastructural analysis of social stress-induced neuron-glia interaction underlying neuronal morphological alterationsPrincipal Investigator
- Principal Investigator
  
  Nagai Hirotaka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kobe University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice2022
- Author(s)
  Akiyama Satoshi、Nagai Hirotaka、Oike Shota、Horikawa Io、Shinohara Masakazu、Lu Yabin、Futamura Takashi、Shinohara Ryota、Kitaoka Shiho、Furuyashiki Tomoyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 11385-11385
- DOI
  10.1038/s41598-022-15461-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06576, KAKENHI-PROJECT-22K06859, KAKENHI-PROJECT-21H04812, KAKENHI-PROJECT-20K07288, KAKENHI-PROJECT-20K08422, KAKENHI-PLANNED-18H05429
[Journal Article] Single-Shot 10K Proteome Approach: Over 10,000 Protein Identifications by Data-Independent Acquisition-Based Single-Shot Proteomics with Ion Mobility Spectrometry2022
- Author(s)
  Kawashima Yusuke、Nagai Hirotaka、Konno Ryo、Ishikawa Masaki、Nakajima Daisuke、Sato Hironori、Nakamura Ren、Furuyashiki Tomoyuki、Ohara Osamu
- Journal Title
  
  Journal of Proteome Research
  
  Volume: - Issue: 6 Pages: 1418-1427
- DOI
  10.1021/acs.jproteome.2c00023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07288, KAKENHI-PROJECT-21H04812, KAKENHI-PLANNED-18H05429
[Journal Article] Effects of Severe Sleep Disruption on the Synaptic Ultrastructure of Young Mice2021
- Author(s)
  Nagai Hirotaka、de Vivo Luisa、Marshall William、Tononi Giulio、Cirelli Chiara
- Journal Title
  
  eneuro
  
  Volume: 8 Issue: 4 Pages: ENEURO.0077-21.2021
- DOI
  10.1523/eneuro.0077-21.2021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07288
[Journal Article] Stress-induced sleep-like inactivity modulates stress susceptibility in mice2020
- Author(s)
  Nagai Midori、Nagai Hirotaka、Numa Chisato、Furuyashiki Tomoyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 19800-19800
- DOI
  10.1038/s41598-020-76717-8
- NAID
  120006950335
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07288, KAKENHI-PLANNED-18H05429, KAKENHI-PROJECT-20J21853, KAKENHI-PROJECT-18K15028
[Journal Article] Social defeat stress induces phosphorylation of extracellular signal-regulated kinase in the leptomeninges in mice2019
- Author(s)
  Okamura Satoshi、Nagai Hirotaka、Numa Chisato、Nagai Midori、Shinohara Ryota、Furuyashiki Tomoyuki
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: - Issue: 2 Pages: 134-139
- DOI
  10.1002/npr2.12051
- NAID
  120006713572
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15028, KAKENHI-ORGANIZER-18H05428, KAKENHI-PLANNED-18H05429, KAKENHI-PROJECT-16H05132, KAKENHI-PROJECT-17K19457
[Journal Article] ocial defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex2019
- Author(s)
  Numa Chisato, Nagai Hirotaka, Taniguchi Masayuki, Nagai Midori, Shinohara Ryota, Furuyashiki Tomoyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 16670-16670
- DOI
  10.1038/s41598-019-52997-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15028, KAKENHI-PROJECT-19K16372, KAKENHI-PLANNED-18H05429, KAKENHI-PROJECT-16H06276
[Presentation] Chronic social stress alters synaptic central metabolism for depression2023
- Author(s)
  Nagai H, Nagai M, Numa C, Ota K, Yamashita T, Kawashima Y, Ohno N, Kataoka Y, Shimma S, Mimori-Kiyosue Y, Kato T, Soga T, Furuyashiki T
- Organizer
  第128回日本解剖学会全国学術集会
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] 社会ストレスによる脳代謝リモデリング2022
- Author(s)
  永井　裕崇
- Organizer
  第16回メタボロームシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Roles of synaptic mitochondrial regulations for stress susceptibility2022
- Author(s)
  Numa C, Nagai H, Nagai M, Yamashita T, Kawashima Y, Ohno N, Kataoka Y, Mimori-Kiyosue Y, Kato T, Furuyashiki T
- Organizer
  第95回日本薬理学会
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] 慢性社会ストレスによるシナプス構造変化とその分子機序の解析2022
- Author(s)
  永井　裕崇、古屋敷　智之
- Organizer
  第127回日本解剖学会全国学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] 社会ストレスによる脳組織の超微細な細胞生物学的変化の解析とその機序・役割の解明2022
- Author(s)
  永井　裕崇
- Organizer
  関西共創の場　第6回若手人材育成セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] 慢性社会ストレスによるシナプス構造変化とその分子機序の解析2022
- Author(s)
  永井　裕崇、古屋敷　智之
- Organizer
  国立研究開発法人日本医療研究開発機構　精神・神経疾患領域/マルチセンシング連携推進ワークショップ
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Chronic social stress alters synaptic central metabolism for depression2022
- Author(s)
  Nagai H, Nagai M, Numa C, Yamashita T, Kawashima Y, Ohno N, Kataoka Y, Shimma S, Mimori-Kiyosue Y, Kato T, Soga T, Furuyashiki T
- Organizer
  第95回日本薬理学会
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] 慢性社会ストレスはシナプスの中央代謝系を変化して抑うつを誘導する2022
- Author(s)
  Nagai H, Nagai M, Numa C, Yamashita T, Kawashima Y, Ohno N, Kataoka Y, Shimma S, Mimori-Kiyosue Y, Kato T, Soga T, Furuyashiki T
- Organizer
  NEURO 2022
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Analysis of aging-induced neural dysfunctions and their biological basis2022
- Author(s)
  Yamada R, Nagai H, Numa C, Horikawa I, Nagai M, Kawashima Y, Furuyashiki T
- Organizer
  第95回日本薬理学会
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] 慢性社会ストレスによるシナプス構造変化とその分子機序の解析2022
- Author(s)
  永井　裕崇
- Organizer
  BPCNPNPPP 4学会合同年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] 慢性社会ストレスによるシナプス構造変化とその分子機序の解析2022
- Author(s)
  Nagai H, Nagai M, Numa C, Yamashita T, Kawashima Y, Ohno N, Kataoka Y, Shimma S, Mimori-Kiyosue Y, Kato T, Soga T, Furuyashiki T
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Multiomic analyses of subcellular mechanisms underlying social stress-induced depressive-like behaviors in mice2021
- Author(s)
  Nagai H and Furuyashiki T
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] 質量分析イメージング法を用いた毛髪成分可視化によるストレスモニタリング手法の開発2021
- Author(s)
  植木瞭生, 永井裕崇，古屋敷智之，福崎英一郎, 新間秀一
- Organizer
  第73回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Social stress induces subcellular degeneration preceding dendritic loss of prefrontal pyramidal neurons in mice.2021
- Author(s)
  Numa C、 Nagai H、 Nagai M、 Ohno N、 Mimori-Kiyosue Y、 Kataoka Y、 Furuyashiki T
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] Social stress induces subcellular degeneration preceding dendritic loss of prefrontal pyramidal neurons in mice.2021
- Author(s)
  Numa C、 Nagai H、 Nagai M、 Ohno N、 Mimori-Kiyosue Y、 Kataoka Y、 Furuyashiki T
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Multiple individual variabilities in cognitive aging2021
- Author(s)
  Yamada R, Nagai H, Numa C, Furuyashiki T
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Multiple individual variabilities in cognitive aging2021
- Author(s)
  Yamada R, Nagai H, Numa C, Furuyashiki T
- Organizer
  The 23rd Korea-Japan Joint Seminar on Pharmacology (23rd KJJSP)
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Subcellular mechanisms of social stress2021
- Author(s)
  Nagai H、 Furuyashiki T
- Organizer
  第94回日本薬理学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] マウスの社会ストレスは前頭前皮質錐体神経細胞の樹状突起消失に先行して細胞内変性を誘導する2021
- Author(s)
  Numa C, Nagai H, Nagai M, Ohno N, Mimori-Kiyosue Y, Kataoka Y, Furuyashiki T
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Subcellular mechanisms of social stress2021
- Author(s)
  Nagai H、 Furuyashiki T
- Organizer
  第94回日本薬理学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Social defeat stress altered microglia-neuron interaction in the medial prefrontal cortex of mice2020
- Author(s)
  Nagai M、 Nagai H、 Furuyashiki T
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Social defeat stress altered microglia-neuron interaction in the medial prefrontal cortex of mice2020
- Author(s)
  Nagai M、 Nagai H、 Furuyashiki T
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] Analysis of ultrastructural alterations in the mouse medial prefrontal cortex toward the understanding of pathophysiology of social stress-induced depressive-like behaviors2020
- Author(s)
  Nagai H、 Furuyashiki T
- Organizer
  新学術領域「マルチスケール精神病態の構成的理解」第三回領域会議
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] Analysis of ultrastructural alterations in the mouse medial prefrontal cortex toward the understanding of pathophysiology of social stress-induced depressive-like behaviors2020
- Author(s)
  永井裕崇、古屋敷智之
- Organizer
  第125回日本解剖学会全国学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] Analysis of ultrastructural alterations in the mouse medial prefrontal cortex toward the understanding of pathophysiology of social stress-induced depressive-like behaviors2020
- Author(s)
  Nagai H、 Furuyashiki T
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] 三次元電子顕微鏡法2020
- Author(s)
  永井裕崇
- Organizer
  文部科学省新学術領域研究「マルチスケール精神病態の構成的理解」第3回若手育成セミナー「神経回路の可視化・操作・モデリングのための最先端技術」
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] 社会ストレスによる神経細胞の微細構造変化とその役割2020
- Author(s)
  永井裕崇、古屋敷智之
- Organizer
  AMED-CREST、PRIME研究開発領域「画期的医薬品等の創出をめざす脂質の生理活性と機能の解明」令和２年度PRIME会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Social stress-induced ultrastructural alterations of prefrontal neurons in mice2020
- Author(s)
  永井裕崇、古屋敷智之
- Organizer
  第50回日本神経精神薬理学会年会、第42回日本生物学的精神医学会年会、第4回日本精神薬学会総会・学術集会　合同年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] Analysis of ultrastructural alterations in the mouse medial prefrontal cortex toward the understanding of pathophysiology of social stress-induced depressive-like behaviors2020
- Author(s)
  永井裕崇、古屋敷智之
- Organizer
  第125回日本解剖学会全国学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Analysis of ultrastructural alterations in the mouse medial prefrontal cortex toward the understanding of pathophysiology of social stress-induced depressive-like behaviors2020
- Author(s)
  Nagai H、 Furuyashiki T
- Organizer
  新学術領域「マルチスケール精神病態の構成的理解」第三回領域会議
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Analysis of ultrastructural alterations in the mouse medial prefrontal cortex toward the understanding of pathophysiology of social stress-induced depressive-like behaviors2020
- Author(s)
  Nagai H、 Furuyashiki T
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] Social stress-induced ultrastructural alterations of prefrontal neurons in mice2020
- Author(s)
  永井裕崇、古屋敷智之
- Organizer
  第50回日本神経精神薬理学会年会、第42回日本生物学的精神医学会年会、第4回日本精神薬学会総会・学術集会　合同年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] 社会ストレスによる神経細胞の微細構造変化とその役割2020
- Author(s)
  永井裕崇、古屋敷智之
- Organizer
  AMED-CREST、PRIME研究開発領域「画期的医薬品等の創出をめざす脂質の生理活性と機能の解明」令和２年度PRIME会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] 三次元電子顕微鏡法2020
- Author(s)
  永井裕崇
- Organizer
  文部科学省新学術領域研究「マルチスケール精神病態の構成的理解」第3回若手育成セミナー「神経回路の可視化・操作・モデリングのための最先端技術」
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07288
[Presentation] Elucidating neuronal projections from the medial prefrontal cortex responsible for the resilience to social defeat stress in mice2019
- Author(s)
  Numa C, Nagai H, Furuyashiki T
- Organizer
  NEURO2019
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] 断眠ストレスや社会ストレスによる脳組織の超微細な細胞生物学的変化の解析2019
- Author(s)
  永井　裕崇、古屋敷　智之
- Organizer
  生理研研究会「情動の生起と変容の多面的理解に向けて」
- Invited
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference2019
- Author(s)
  Hirotaka Nagai, Shu Higashida, Kazuki Nakayama, Ryota Shinohara, Masayuki Taniguchi, Midori Nagai, Takatoshi Hikida, Satoshi Yawata, Yukio Ago, Shiho Kitaoka, Shuh Narumiya, Tomoyuki Furuyashiki
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] Ultrastructural analysis of microglia-neuron interaction following social defeat stress using serial electron microscopy2019
- Author(s)
  Nagai H, Ueyama J, Nagai M, Numa C, Ohno N, Furuse M, Furuyashiki T
- Organizer
  NEURO2019
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] 社会ストレスによる脳組織の超微細細胞生物学的解析の解析2019
- Author(s)
  永井裕崇, 古屋敷智之
- Organizer
  第124回日本解剖学会総会・全国学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] Sleep Consolidates Motor Learning of Complex Movement Sequences in Mice2018
- Author(s)
  Hirotaka Nagai, Luisa De Vivo, Michele Bellesi, Maria F Ghilardi, Giulio Tononi, Chiara Cirelli
- Organizer
  WCP2018 - 18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15028
[Presentation] 断眠ストレスや社会ストレスによる脳組織の超微細細胞生物学的解析の解析2018
- Author(s)
  永井裕崇
- Organizer
  次世代脳プロジェクト冬のシンポジウム2018
- Invited
- Data Source
  KAKENHI-PROJECT-18K15028

1. 新間秀一 (30515896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 古屋敷智之 (20362478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KITAOKA Shiho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGAI HIROTAKA 永井 裕崇

Nagai Hirotaka 永井 裕崇

Research Projects

Research Products

Co-Researchers

社会ストレスによる脳代謝リモデリングの実態と機序、意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of enzyme histochemistry for elucidating brain function using mass microscope and its application to stress model brains

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanisms responsible for social stress-induced dendritic atrophy and establishment of its control methodsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Ultrastructural analysis of social stress-induced neuron-glia interaction underlying neuronal morphological alterationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-Shot 10K Proteome Approach: Over 10,000 Protein Identifications by Data-Independent Acquisition-Based Single-Shot Proteomics with Ion Mobility Spectrometry2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Severe Sleep Disruption on the Synaptic Ultrastructure of Young Mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stress-induced sleep-like inactivity modulates stress susceptibility in mice2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Social defeat stress induces phosphorylation of extracellular signal-regulated kinase in the leptomeninges in mice2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] ocial defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Chronic social stress alters synaptic central metabolism for depression2023

Author(s)

Organizer

Data Source

[Presentation] 社会ストレスによる脳代謝リモデリング2022

Author(s)

Organizer

Data Source

[Presentation] Roles of synaptic mitochondrial regulations for stress susceptibility2022

Author(s)

Organizer

Data Source

[Presentation] 慢性社会ストレスによるシナプス構造変化とその分子機序の解析2022

Author(s)

Organizer

Data Source

[Presentation] 社会ストレスによる脳組織の超微細な細胞生物学的変化の解析とその機序・役割の解明2022

Author(s)

Organizer

NAGAI HIROTAKA 永井裕崇

Nagai Hirotaka 永井裕崇