Shimizu Mikito 清水幹人

Researcher Number	30817507
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 招へい教員 2025: 地方独立行政法人大阪府立病院機構大阪急性期・総合医療センター(臨床研究支援センター), 脳神経内科, 医長 2025: 地方独立行政法人大阪府立病院機構大阪急性期・総合医療センター(臨床研究支援センター), 臨床研究支援センター, 特別研究者
Affiliation (based on the past Project Information) *help	2025: 地方独立行政法人大阪府立病院機構大阪急性期・総合医療センター(臨床研究支援センター), 脳神経内科, 医長 2022 – 2023: 大阪大学, 大学院医学系研究科, 招へい教員 2018 – 2021: 大阪大学, 医学部附属病院, 医員 2020: 大阪大学, 医学系研究科, 招へい教員 2020: 大阪大学, 医学系研究科, 招聘教員
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 52020:Neurology-related
Keywords	Principal Investigator 反発性軸索ガイダンス因子(RGMa) / 異常蛋白凝集 / 筋萎縮性側索硬化症(ALS) / 細胞骨格 / actin dynamics / NEO1 / RGMa / ALS / 腸管ミトコンドリア / 食事 … More / アストロサイト / 視神経脊髄炎 / 食事療法 / ミトコンドリア / 酸化ストレス / 活性酸素種 / 多発性硬化症 … More Except Principal Investigator 慢性虚血・低酸素 / 慢性低酸素 / 慢性虚血 / 運動ニューロン病 / ミトコンドリアDNA / 代謝 / 血流改善 / 低栄養 / 筋萎縮性側索硬化症 / 神経変性 / 血管拡張 / 低灌流 / 低酸素 / 運動ニューロン疾患 / 運動神経変性 / Leaky gut syndrome / 臨床データベース / 糞便菌叢メタゲノム / Leaky Gut Syndrome / 多発性硬化症 / Leaky Gut Less

細胞骨格動態に着目したプロテイノパチーにおけるバイオマーカーの開発Principal Investigator
- Principal Investigator
  
  清水幹人
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Osaka General Medical Center
細胞骨格動態制御によるALS病態改善の試みPrincipal Investigator
- Principal Investigator
  
  清水幹人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Treatment strategy of amyotrophic lateral sclerosis focusing on controlling spinal blood flow and metabolism
- Principal Investigator
  
  TADA Satoru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Osaka University
Leaky Gut Syndrome and Multiple Sclerosis
- Principal Investigator
  
  Makoto Kinoshita
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Attempt to improve multiple sclerosis progression by the control of intestinal mitochondrial oxidative stressPrincipal Investigator
- Principal Investigator
  
  Shimizu Mikito
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder2023
- Author(s)
  Yamamoto Mamoru、Okuno Tatsusada、Piao Jin-Lan、Shimizu Mikito、Miyamoto Katsuichi、Nukui Takamasa、Kinoshita Makoto、Koda Toru、Dini Haryuni Ratna、Mochizuki Hideki、Sugimoto Tomoyuki、Nakatsuji Yuji
- Journal Title
  
  Journal of Clinical Neuroscience
  
  Volume: 107 Pages: 129-132
- DOI
  10.1016/j.jocn.2022.12.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11165, KAKENHI-PROJECT-22K07539
[Journal Article] RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.2023
- Author(s)
  Shimizu M, Shiraishi N, Tada S, Sasaki T, Beck G, Nagano S, Kinoshita M, Sumi H, Sugimoto T, Ishida Y, Koda T, Ishikura T, Sugiyama Y, Kihara K, Kanakura M, Nakajima T, Takeda S, Takahashi MP, Yamashita T, Okuno T, Mochizuki H.
- Journal Title
  
  Sci Adv
  
  Volume: 9 Issue: 47 Pages: 1-17
- DOI
  10.1126/sciadv.adg3193
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K07539, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-23K21405, KAKENHI-PROJECT-23K27517
[Journal Article] Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis2022
- Author(s)
  Wadayama Tomoya、Shimizu Mikito、Kimura Ikko、Baba Kousuke、Beck Goichi、Nagano Seiichi、Morita Ryo、Nakagawa Hidenori、Shirano Michinori、Goto Tetsushi、Norose Kazumi、Hikosaka Kenji、Murayama Shigeo、Mochizuki Hideki
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 17 Pages: 2661-2666
- DOI
  10.2169/internalmedicine.8564-21
- NAID
  130008158352
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-09-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07839, KAKENHI-PROJECT-19K07520, KAKENHI-PROJECT-20K06910, KAKENHI-PROJECT-20K07461, KAKENHI-PROJECT-22K07538, KAKENHI-PROJECT-22K07539, KAKENHI-PROJECT-22K07550, KAKENHI-PROJECT-19K07988
[Journal Article] Anti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats2021
- Author(s)
  Ishikura Teruyuki、Kinoshita Makoto、Shimizu Mikito、Murata Hisashi、Beppu Shohei、Koda Toru、Tada Satoru、Miyamoto Katsuichi、Kusunoki Susumu、Sugimoto Tomoyuki、Kumanogoh Atsushi、Okuno Tatsusada、Mochizuki Hideki
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 18 Issue: 1 Pages: 1-12
- DOI
  10.1186/s12974-021-02232-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07822, KAKENHI-PROJECT-20K16577
[Journal Article] Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation2020
- Author(s)
  Mikito Shimizu, Tatsusada Okuno, Makoto Kinoshita, Hisae Sumi, Harutoshi Fujimura, Kazuya Yamashita, Tomoyuki Sugimoto, Shuhei Sakakibara, Kaori Sakakibara, Toru Koda, Satoru Tada, Teruyuki Ishikura, Hisashi Murata, Shohei Beppu, Naoyuki Shiraishi, Yasuko Sugiyama, Yuji Nakatsuji, Atsushi Kumanogoh & Hideki Mochizuki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 13274-13274
- DOI
  10.1038/s41598-020-70203-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07822, KAKENHI-PROJECT-20K16577, KAKENHI-PROJECT-18K10743, KAKENHI-PROJECT-18K15451, KAKENHI-PROJECT-18K15452
[Journal Article] Sema4A is implicated in the acceleration of Th17 cell-mediated neuroinflammation in the effector phase2020
- Author(s)
  Koda Toru、Namba Akiko、Kinoshita Makoto、Nakatsuji Yuji、Sugimoto Tomoyuki、Sakakibara Kaori、Tada Satoru、Shimizu Mikito、Yamashita Kazuya、Takata Kazushiro、Ishikura Teruyuki、Murata Syo、Beppu Shohei、Kumanogoh Atsushi、Mochizuki Hideki、Okuno Tatsusada
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 17 Issue: 1 Pages: 1-9
- DOI
  10.1186/s12974-020-01757-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07822, KAKENHI-PROJECT-18K15452, KAKENHI-PROJECT-20K16577, KAKENHI-PROJECT-18K10743
[Journal Article] Single injection of sustained-release prostacyclin analog ONO-1301-MS ameliorates hypoxic toxicity in the murine model of amyotrophic lateral sclerosis.2019
- Author(s)
  Tada S, Okuno T, Shimizu M, Sakai Y, Sumi-Akamaru H, Kinoshita M, Yamashita K, Sanda E, Choong CJ, Namba A, Sasaki T, Koda T, Takata K, Miyagawa S, Sawa Y, Nakatsuji Y, Mochizuki H.
- Journal Title
  
  Sci Rep.
  
  Volume: 27 Issue: 1 Pages: 5252-5252
- DOI
  10.1038/s41598-019-41771-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15452, KAKENHI-PROJECT-18K10743
[Journal Article] Risk of stroke early after implantation of a left ventricular assist device.2019
- Author(s)
  Samura T, Yoshioka D, Toda K, Sakaniwa R, Shimizu M, Miyagawa S, Yoshikawa Y, Hata H, Saito S, Sakata Y, Sawa Y.
- Journal Title
  
  J Thorac Cardiovasc Surg.
  
  Volume: 157 Pages: 259-267
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15452
[Journal Article] Beneficial effects of fingolimod in MS patients with high serum Sema4A levels2018
- Author(s)
  Koda Toru、Namba Akiko、Nakatsuji Yuji、Niino Masaaki、Miyazaki Yusei、Sugimoto Tomoyuki、Kinoshita Makoto、Takata Kazushiro、Yamashita Kazuya、Shimizu Mikito、Fukazawa Toshiyuki、Kumanogoh Atsushi、Mochizuki Hideki、Okuno Tatsusada
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 3 Pages: 1-10
- DOI
  10.1371/journal.pone.0193986
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09339, KAKENHI-PROJECT-18K10743, KAKENHI-PROJECT-18K15452
[Journal Article] Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder2018
- Author(s)
  Yamashita Kazuya、Kinoshita Makoto、Miyamoto Katsuichi、Namba Akiko、Shimizu Mikito、Koda Toru、Sugimoto Tomoyuki、Mori Yuki、Yoshioka Yoshichika、Nakatsuji Yuji、Kumanogoh Atsushi、Kusunoki Susumu、Mochizuki Hideki、Okuno Tatsusada
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 15 Issue: 1 Pages: 125-125
- DOI
  10.1186/s12974-018-1162-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15451, KAKENHI-PROJECT-18K15452, KAKENHI-PROJECT-16H01849, KAKENHI-PROJECT-26282223
[Presentation] RGMa collapses the neuronal actin barrier against extracellular disease-implicated protein and exacerbates ALS pathology2023
- Author(s)
  Mikito Shimizu
- Organizer
  The 66th Annual Meeting of the Japanese Society of Neurochemistry
- Data Source
  KAKENHI-PROJECT-22K07539
[Presentation] The analysis of the monocyte role in NMO with patient-derived AQP4 recombinant antibody2019
- Author(s)
  清水　幹人
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K15452
[Presentation] Identification of innate immunity activation in the pathogenesis of NMO2019
- Author(s)
  清水　幹人
- Organizer
  ECTRIMS 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15452
[Presentation] 患者由来recombinant抗AQP4モノクローナル抗体を持ちいた NMO病態における自然免疫経路の解析2019
- Author(s)
  清水　幹人
- Organizer
  第31回日本神経免疫学会
- Data Source
  KAKENHI-PROJECT-18K15452
[Presentation] Intestinal succinic acid exacerbate experimental autoimmune encephalitis2018
- Author(s)
  Mikito Shimizu, Kazushiro Takata, Makoto Kinoshita, Teruyuki Ishikura, Toru Koda, Tatsusada Okuno, Yuji Nakatsuji, Hideki Mochizuki
- Organizer
  ECTRIMS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15452
[Presentation] Blood flow modulation therapy by prostacyclin agonist ameliorates ALS mice model2018
- Author(s)
  Mikito Shimizu, Satoru Tada, Tatsusada Okuno, Yoshiki Sakai, Hisae Sumi, Makoto Kinoshita, Kazuya Yamashita, Eri Sanda, Choong Chi-Jing, Akiko Hosokawa-Namba, Tsutomu Sasaki, Toru Koda, Kazushiro Takata, Shigeru Miyagawa, Yoshiki Sawa, Yuji Nakatsuji, Hideki Mochizuki
- Organizer
  神経内科学会
- Data Source
  KAKENHI-PROJECT-18K15452
[Presentation] リコンビナント抗AQP4抗体を用いたNMOの病態解析2018
- Author(s)
  清水幹人, 木下允, 甲田亨, 南波明子, 山下和哉, 石倉照之, 中辻裕司, 熊ノ郷淳, 望月秀樹, 奥野龍禎
- Organizer
  神経免疫学会
- Data Source
  KAKENHI-PROJECT-18K15452

1. TADA Satoru (70626530)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 奥野龍禎 (00464248)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. Makoto Kinoshita (10573222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 白石直之 (10882285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 坂口学 (70432474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKATSUJI Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 山本真守

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 甲田亨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 南波明子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 山下和哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 長野清一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Mikito 清水 幹人

Research Projects

Research Products

Co-Researchers

細胞骨格動態に着目したプロテイノパチーにおけるバイオマーカーの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞骨格動態制御によるALS病態改善の試みPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Treatment strategy of amyotrophic lateral sclerosis focusing on controlling spinal blood flow and metabolism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Leaky Gut Syndrome and Multiple Sclerosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Attempt to improve multiple sclerosis progression by the control of intestinal mitochondrial oxidative stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis2022

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Anti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sema4A is implicated in the acceleration of Th17 cell-mediated neuroinflammation in the effector phase2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single injection of sustained-release prostacyclin analog ONO-1301-MS ameliorates hypoxic toxicity in the murine model of amyotrophic lateral sclerosis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Risk of stroke early after implantation of a left ventricular assist device.2019

Author(s)

Journal Title

Data Source

[Journal Article] Beneficial effects of fingolimod in MS patients with high serum Sema4A levels2018

Author(s)

Journal Title

Shimizu Mikito 清水幹人