Tanaka Shigeru 田中繁

Researcher Number	30822051
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 千葉大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator 関節リウマチ / 雌性 / ヘルパーT細胞 / FGFR1 / マクロファージ / セマフォリン Except Principal Investigator 気管支喘息 / Treg / Asthma / 組織常在記憶T細胞 … More / アレルギー性炎症 / 組織修復性制御性T細胞 / スーパーエンハンサー / 気道リモデリング / サイトカイン / リモデリング / epithelial cells / remodeling / 炎症記憶 / アレルギー性気道炎症 / 喘息 / SCD1 / STAT3 / 気道上皮細胞 / c-Maf / Sox4 Less

Mechanisms of allergic airway inflammation by developmental period stress
- Principal Investigator
  
  廣瀬晃一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  International University of Health and Welfare
雌性特有の制御性T細胞の解析による新たな関節リウマチ治療戦略の構築Principal Investigator
- Principal Investigator
  
  田中繁
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Chiba University
Establishment of novel asthma treatment strategies through airway remodeling repair.
- Principal Investigator
  
  Nakajima Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Chiba University
The roles of FGFR1-expressing helper T cells in the pathogenesis of rheumatoid arthritis.Principal Investigator
- Principal Investigator
  
  Tanaka Shigeru
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Chiba University
Role of Treg cells in the development of allergic airway inflammation
- Principal Investigator
  
  Akira Suto
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Chiba University
Role of 'immnue memory' of airway epithelial cells in asthma
- Principal Investigator
  
  Yokota Masaya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Chiba University
:The roles of Semaphorin3G in the pathogenesis of rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  Tanaka Shigeru
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Chiba University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease2024
- Author(s)
  Tanaka Shigeru、Yamamoto Takuya、Iwata Arifumi、Kiuchi Masahiro、Kokubo Kota、Iinuma Tomohisa、Sugiyama Takahiro、Hanazawa Toyoyuki、Hirahara Kiyoshi、Ikeda Kei、Nakajima Hiroshi
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 26 Issue: 1 Pages: 55-55
- DOI
  10.1186/s13075-024-03289-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-21K08436, KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-21H02922
[Journal Article] Eosinophils Contribute to Oral Tolerance via Induction of RORγt-Positive Antigen-Presenting Cells and RORγt-Positive Regulatory T Cells2024
- Author(s)
  Kurihara Shunjiro、Suzuki Kotaro、Yokota Masaya、Ito Takashi、Hayashi Yuki、Kikuchi Ryo、Kageyama Takahiro、Meguro Kazuyuki、Tanaka Shigeru、Iwata Arifumi、Goto Yoshiyuki、Suto Akira、Nakajima Hiroshi
- Journal Title
  
  Biomolecules
  
  Volume: 14 Issue: 1 Pages: 89-89
- DOI
  10.3390/biom14010089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18285, KAKENHI-PROJECT-23KF0133, KAKENHI-PROJECT-23K07738, KAKENHI-PROJECT-21H02922
[Journal Article] Epithelial cell-derived cytokine TSLP modulates metabolic program of regulatory T cells by enhancing fatty acid uptake to suppress the intestinal inflammation2023
- Author(s)
  Kasuya T., Tanaka S., Etori K., Shoda J., Hattori K., Endo Y., Kitajima M., Kageyama T., Iwamoto T., Yokota M., Iwata A., Suto A., Suzuki K., Suzuki H., Ziegler SF., and Nakajima H
- Journal Title
  
  Sci. Rep.
  
  Volume: 13 Issue: 1 Pages: 1653-1653
- DOI
  10.1038/s41598-023-28987-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-20K07460, KAKENHI-PROJECT-20K08797, KAKENHI-PROJECT-21K16297, KAKENHI-PROJECT-23K06590, KAKENHI-PROJECT-23K07738, KAKENHI-PROJECT-22K16353
[Journal Article] IL-21 is required for the maintenance and pathogenesis of murine Vγ4+ IL-17-producing γδT cells2023
- Author(s)
  Ishikawa Junichi、Suto Akira、Abe Kazuya、Hayashi Yuki、Suga Kensuke、Tanaka Shigeru、Kageyama Takahiro、Iwata Arifumi、Suzuki Kazumasa、Suzuki Kotaro、Nakajima Hiroshi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1211620-1211620
- DOI
  10.3389/fimmu.2023.1211620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07738, KAKENHI-PROJECT-22K16353, KAKENHI-PROJECT-21H02922
[Journal Article] A role of Achaete-scute complex homolog 2 in T follicular regulatory cell development2023
- Author(s)
  Iida Kazuma、Suga Kensuke、Suzuki Kotaro、Kurihara Shunjiro、Yabe Yoko、Kageyama Takahiro、Meguro Kazuyuki、Tanaka Shigeru、Iwata Arifumi、Suto Akira、Nakajima Hiroshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 664 Pages: 9-19
- DOI
  10.1016/j.bbrc.2023.04.065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02922
[Journal Article] Immunological features that associate with the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-22022
- Author(s)
  Kageyama Takahiro, Tanaka Shigeru, Etori Keishi, Hattori Koto, Miyachi Kazusa, Kasuya Tadamichi, Iwamoto Taro, Ikeda Kei, Igari Hidetoshi, Yokote Koutaro, Nakajima Hiroshi
- Journal Title
  
  Vaccine
  
  Volume: - Issue: 14 Pages: 2129-2133
- DOI
  10.1016/j.vaccine.2022.02.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16281, KAKENHI-PROJECT-21K16297, KAKENHI-PROJECT-21H02922
[Journal Article] Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium2022
- Author(s)
  Shoda Jumpei、Tanaka Shigeru、Etori Keishi、Hattori Koto、Kasuya Tadamichi、Ikeda Kei、Maezawa Yuko、Suto Akira、Suzuki Kotaro、Nakamura Junichi、Maezawa Yoshiro、Takemoto Minoru、Betsholtz Christer、Yokote Koutaro、Ohtori Seiji、Nakajima Hiroshi
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 24 Issue: 1 Pages: 134-134
- DOI
  10.1186/s13075-022-02817-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-20K08797, KAKENHI-PROJECT-21K16297
[Journal Article] Antibody responses to BNT162b2 mRNA COVID-19 vaccine and their predictors among healthcare workers in a tertiary referral hospital in Japan2021
- Author(s)
  Kageyama Takahiro、Ikeda Kei、Tanaka Shigeru、Taniguchi Toshibumi、Igari Hidetoshi、Onouchi Yoshihiro、Kaneda Atsushi、Matsushita Kazuyuki、Hanaoka Hideki、Nakada Taka-Aki、Ohtori Seiji、Yoshino Ichiro、Matsubara Hisahiro、Nakayama Toshinori、Yokote Koutaro、Nakajima Hiroshi
- Journal Title
  
  Clinical Microbiology and Infection
  
  Volume: 27(12) Issue: 12 Pages: 1861.e1-1861.e5
- DOI
  10.1016/j.cmi.2021.07.042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-19K07520, KAKENHI-PROJECT-21K16297
[Journal Article] Suppressor of cytokine signalling 3 (SOCS3) expressed in podocytes attenuates glomerulonephritis and suppresses autoantibody production in an imiquimod-induced lupus model2021
- Author(s)
  Fukuta M, Suzuki K, Kojima S, Yabe Y, Suzuki K, Iida K, Yamada H, Makino S, Iwata A, Tanaka S, Iwamoto T, Suto A, Nakagomi D, Wakashin H, Maezawa Y, Maezawa Y, Takemoto M, Asanuma K, Nakajima H.
- Journal Title
  
  Lupus Sci Med.
  
  Volume: 8 Issue: 1 Pages: 426-426
- DOI
  10.1136/lupus-2020-000426
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08797, KAKENHI-PROJECT-21K16188, KAKENHI-PROJECT-21K16297
[Journal Article] Inhibition of Interleukin-21 prolongs the survival through the promotion of wound healing after myocardial infarction2021
- Author(s)
  Kubota Akihiko、Suto Akira、Suga Kensuke、Iwata Arifumi、Tanaka Shigeru、Suzuki Kotaro、Kobayashi Yoshio、Nakajima Hiroshi
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 159 Pages: 48-61
- DOI
  10.1016/j.yjmcc.2021.06.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02922
[Journal Article] Associations of ultrasound-based inflammation patterns with peripheral innate lymphoid cell populations, serum cytokines/chemokines, and treatment response to methotrexate in rheumatoid arthritis and spondyloarthritis2021
- Author(s)
  Kato Manami、Ikeda Kei、Sugiyama Takahiro、Tanaka Shigeru、Iida Kazuma、Suga Kensuke、Nishimura Nozomi、Mimura Norihiro、Kasuya Tadamichi、Kumagai Takashi、Furuya Hiroki、Iwamoto Taro、Iwata Arifumi、Furuta Shunsuke、Suto Akira、Suzuki Kotaro、Kawakami Eiryo、Nakajima Hiroshi
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 5 Pages: e0252116-e0252116
- DOI
  10.1371/journal.pone.0252116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16297
[Journal Article] Induction of stable human FOXP3 Tregs by a parasite‐derived TGF‐β mimic2021
- Author(s)
  Cook Laura、Reid Kyle T、H?kkinen Elmeri、Bie Brett、Tanaka Shigeru、Smyth Danielle J、White Madeleine PJ、Wong May Q、Huang Qing、Gillies Jana K、Ziegler Steven F.、Maizels Rick M、Levings Megan K
- Journal Title
  
  Immunology & Cell Biology
  
  Volume: 99 Issue: 8 Pages: 833-847
- DOI
  10.1111/imcb.12475
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16297
[Journal Article] T-bet and STAT6 Coordinately Suppress the Development of IL-9-Mediated Atopic Dermatitis-Like Skin Inflammation in Mice2020
- Author(s)
  Makita S, Takatori H, Matsuki A, Kawashima, Iwata A, Tanaka S, Nakagomi D, Oya Y, Matsumura R, Tamachi T, Suto A, Suzuki K, Hirose K, Nakajima H
- Journal Title
  
  J Invest Dermatol.
  
  Volume: Online ahead of print Issue: 5 Pages: 1274-1285
- DOI
  10.1016/j.jid.2020.08.029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08878, KAKENHI-PROJECT-18H02816, KAKENHI-PROJECT-19K17902, KAKENHI-PROJECT-21H02922, KAKENHI-PROJECT-19K07616, KAKENHI-PROJECT-21K08211, KAKENHI-PROJECT-21K08463
[Journal Article] RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.2020
- Author(s)
  Makita S, Takatori H, Iwata A, Tanaka S, Furuta S, Ikeda K, Suto A, Suzuki K, Ramos SBV, Nakajima H.
- Journal Title
  
  Front Immunol.
  
  Volume: 11 Pages: 1291-1300
- DOI
  10.3389/fimmu.2020.01291
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08797, KAKENHI-PROJECT-18H02816, KAKENHI-PROJECT-19K17902
[Journal Article] Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells2020
- Author(s)
  Suehiro Ken-Ichi、Suto Akira、Suga Kensuke、Furuya Hiroki、Iwata Arifumi、Iwamoto Taro、Tanaka Shigeru、Kageyama Takahiro、Suzuki Kotaro、Hirose Koichi、Lefebvre V?ronique、Nakajima Hiroshi
- Journal Title
  
  Cellular & Molecular Immunology
  
  Volume: 0 Issue: 7 Pages: 0-0
- DOI
  10.1038/s41423-020-0384-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09995, KAKENHI-PROJECT-18H02816, KAKENHI-PROJECT-19K17881, KAKENHI-PROJECT-19K17902, KAKENHI-PROJECT-21K08211
[Journal Article] Imbalance of Ly-6Chi and Ly-6Clo Monocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued by IFN-γ2019
- Author(s)
  Eldredge Laurie C.、Creasy Rane S.、Tanaka Shigeru、Lai Jen-Feng、Ziegler Steven F.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 202 Issue: 9 Pages: 2772-2781
- DOI
  10.4049/jimmunol.1801374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17902
[Presentation] The roles of IL-21 in the development and pathogenesis of IL-17-producing gdT cells.2023
- Author(s)
  Ishikawa J, Suto A, Abe K, Hayashi Y, Suga K, Suzuki K, Kageyama T, Tanaka S, Iwata A, Suzuki K, Nakajima H.
- Organizer
  JSICR/MMCB 2023 Joint Symposium, Wakayama, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02922
[Presentation] A novel methotrexate target Tp63 suppresses Foxp3 expression and exacerbates autoimmune arthritis2023
- Author(s)
  Suga K, Suto A, Tanaka S, Kageyama T, Ishikawa J, Iwata A, Furuta S, Ikeda K, Suzuki K, Nakajima H
- Organizer
  Annual Congress of the European League against Rheumatism. 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02922
[Presentation] Role of IL-21 in the maintenance and pathogenesis of murine Vg4+ IL-17-producing gd T cells.2023
- Author(s)
  Hayashi Y, Ishikawa J, Suto A, Kageyama T, Tanaka S, Iwata A, Suzuki K, Nakajima H
- Organizer
  The 2nd international symposium of clinical immunology (JSCI). Kamakura, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02922
[Presentation] A role of Achaete-scute complex homolog 2 in T follicular regulatory cell development2022
- Author(s)
  Iida K, Suzuki K, Kageyama T, Meguro K, Tanaka S, Iwata A, Suto A, Nakajima H
- Organizer
  The 51st Annual meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21H02922
[Presentation] スーパーエンハンサーによるILC2分化誘導機構の解明2022
- Author(s)
  戸田陽介，古矢裕樹，金井瑞希，影山貴弘，田中　繁，須藤　明，鈴木浩太郎，中島裕史
- Organizer
  第50回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H02922
[Presentation] 関節リウマチ患者におけるFGFR1陽性CD4陽性T細胞の解析2022
- Author(s)
  田中繁
- Organizer
  第9回JCRベーシックリサーチカンファランス
- Data Source
  KAKENHI-PROJECT-21K16297
[Presentation] A role of eosinophils in oral tolerance for food allergy2022
- Author(s)
  Kurihara S, Yokota M, Suzuki K, Kageyama T, Meguro K, Tanaka S, Iwata A, Suto A, Nakajima H
- Organizer
  The 51st Annual meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21H02922
[Presentation] セマフォリン3Gは実験的関節炎を悪化させる2021
- Author(s)
  正田純平　田中繁　餌取慶史　服部古都　粕谷忠道　中村順一　中島裕史
- Organizer
  日本リウマチ学会　ベーシックリサーチカンファランス
- Data Source
  KAKENHI-PROJECT-21K16297

1. 岩田有史 (90436353)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. Akira Suto (50447306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. Yokota Masaya (70721950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Nakajima Hiroshi (00322024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 池田啓 (10456014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 影山貴弘 (40894267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 廣瀬晃一 (90400887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 策愛子 (70966233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUZUKI Kotaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
10. 岩本太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 中山俊憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 木内政宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 遠藤裕介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 後藤義幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 玉地智宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 前澤善朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tanaka Shigeru 田中 繁

Research Projects

Research Products

Co-Researchers

Mechanisms of allergic airway inflammation by developmental period stress

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

雌性特有の制御性T細胞の解析による新たな関節リウマチ治療戦略の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of novel asthma treatment strategies through airway remodeling repair.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The roles of FGFR1-expressing helper T cells in the pathogenesis of rheumatoid arthritis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of Treg cells in the development of allergic airway inflammation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of 'immnue memory' of airway epithelial cells in asthma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

:The roles of Semaphorin3G in the pathogenesis of rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eosinophils Contribute to Oral Tolerance via Induction of RORγt-Positive Antigen-Presenting Cells and RORγt-Positive Regulatory T Cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epithelial cell-derived cytokine TSLP modulates metabolic program of regulatory T cells by enhancing fatty acid uptake to suppress the intestinal inflammation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-21 is required for the maintenance and pathogenesis of murine Vγ4+ IL-17-producing γδT cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A role of Achaete-scute complex homolog 2 in T follicular regulatory cell development2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunological features that associate with the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-22022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium2022

Author(s)

Journal Title

DOI

Tanaka Shigeru 田中繁