Kiuchi Masahiro 木内政宏

… Alternative Names

KIUCHI Masahiro 木内政宏

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Researcher Number	30823629
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 助教
Affiliation (based on the past Project Information) *help	2025: 千葉大学, 大学院医学研究院, 助教 2019 – 2023: 千葉大学, 大学院医学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related
Keywords	Principal Investigator H3K27Me3 / 老化誘導性肺線維症 / Cytotoxic CD4陽性T細胞 / SASP / 病原性ヘルパーT細胞 / エピゲノム老化 / Ezh2 / Polycomb複合体 / エピゲノム不安定性 / 加齢性病原性ヘルパーT細胞 … More / ポリコーム / Th1 / ATAC-seq / トライソラックス / Th2 / CXXC1 / H3K4メチル化 / TCR / エピジェネティクス / ヘルパーT細胞 / 免疫 Less

炎症微小環境におけるHLF陽性組織常在性CD4+ T細胞の形成機構の解明Principal Investigator
- Principal Investigator
  
  木内政宏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Chiba University
病原性老化ヘルパーT細胞におけるエピゲノム老化と病態形成機構の解明Principal Investigator
- Principal Investigator
  
  木内政宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Chiba University
The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiationPrincipal Investigator
- Principal Investigator
  
  KIUCHI Masahiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Chiba University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book Patent

[Book] 肺移植の拒絶反応における免疫チェックポイント分子を用いた免疫寛容の誘導に向けての基礎研究2019
- Author(s)
  海寳大輔, 鈴木秀海, 椎名裕樹, 田中教久, 山本高義, 坂入祐一, 和田啓伸, 中島崇裕, 木内政宏, 本橋新一郎, 中山俊憲, 吉野一郎
- Publisher
  (一社)日本移植学会
- Data Source
  KAKENHI-PROJECT-19K16683
[Journal Article] Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease2024
- Author(s)
  Tanaka Shigeru、Yamamoto Takuya、Iwata Arifumi、Kiuchi Masahiro、Kokubo Kota、Iinuma Tomohisa、Sugiyama Takahiro、Hanazawa Toyoyuki、Hirahara Kiyoshi、Ikeda Kei、Nakajima Hiroshi
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 26 Issue: 1 Pages: 55-55
- DOI
  10.1186/s13075-024-03289-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-21K08436, KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-21H02922
[Journal Article] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism2023
- Author(s)
  Kokubo Kota、Hirahara Kiyoshi、Kiuchi Masahiro、Tsuji Kaori、Shimada Yuki、Sonobe Yuri、Shinmi Rie、Hishiya Takahisa、Iwamura Chiaki、Onodera Atsushi、Nakayama Toshinori
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 2
- DOI
  10.1073/pnas.2218345120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-22K15485, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20KK0351, KAKENHI-PROJECT-23K24147, KAKENHI-PROJECT-20K08769
[Journal Article] Single-cell RNA sequencing of peripheral blood mononuclear cells from Kimura disease patient successfully treated with dupilumab2023
- Author(s)
  Suga Kensuke、Kiuchi Masahiro、Kageyama Takahiro、Kokubo Kota、Tanaka Shigeru、Iwata Arifumi、Suzuki Kotaro、Hirahara Kiyoshi、Nakajima Hiroshi
- Journal Title
  
  Allergol. Int.
  
  Volume: 72 Issue: 4 Pages: 610-613
- DOI
  10.1016/j.alit.2023.06.002
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-22K16353, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-23K27607
[Journal Article] Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients2023
- Author(s)
  Tsuji Kaori、Aoki Ami、Onodera Atsushi、Kiuchi Masahiro、Kokubo Kota、Morimoto Yuki、Iinuma Tomohisa、Hanazawa Toyoyuki、Nakayama Toshinori、Hirahara Kiyoshi
- Journal Title
  
  Allergol. Int.
  
  Volume: 72 Issue: 2 Pages: 335-338
- DOI
  10.1016/j.alit.2022.11.009
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20KK0351, KAKENHI-PROJECT-23K24147, KAKENHI-PROJECT-22K15484
[Journal Article] CD69 Imposes Tumor-Specific CD8+ T-cell Fate in Tumor-Draining Lymph Nodes2023
- Author(s)
  Koyama-Nasu Ryo、Kimura Motoko Y.、Kiuchi Masahiro、Aoki Ami、Wang Yangsong、Mita Yukiyoshi、Hasegawa Ichita、Endo Yukihiro、Onodera Atsushi、Hirahara Kiyoshi、Motohashi Shinichiro、Nakayama Toshinori
- Journal Title
  
  Cancer Immunology Research
  
  Volume: 11 Issue: 8 Pages: 1085-1099
- DOI
  10.1158/2326-6066.cir-22-0406
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-23K19462, KAKENHI-PLANNED-22H05189, KAKENHI-PROJECT-23K24147, KAKENHI-PROJECT-23K24441, KAKENHI-PROJECT-19H05650
[Journal Article] Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases2023
- Author(s)
  Onodera Atsushi、Kokubo Kota、Okano Mikiko、Onoue Miki、Kiuchi Masahiro、Iwamura Chiaki、Iinuma Tomohisa、Kimura Motoko Y.、Ebihara Nobuyuki、Hanazawa Toyoyuki、Nakayama Toshinori、Hirahara Kiyoshi
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 247 Pages: 108445-108445
- DOI
  10.1016/j.pharmthera.2023.108445
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-22K09739, KAKENHI-PROJECT-22K15484, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-23K24147, KAKENHI-PROJECT-23K27607, KAKENHI-PROJECT-19H05650
[Journal Article] The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells2023
- Author(s)
  Kumagai Jin、Kiuchi Masahiro、Kokubo Kota、Yagyu Hiroyuki、Nemoto Masahiro、Tsuji Kaori、Nagahata Ken、Sasaki Atsushi、Hishiya Takahisa、Onoue Miki、Shinmi Rie、Sonobe Yuri、Iinuma Tomohisa、Yonekura Syuji、Shinga Jun、Hanazawa Toyoyuki、Koseki Haruhiko、Nakayama Toshinori、Yokote Koutaro、Hirahara Kiyoshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 49 Pages: 2302903120-2302903120
- DOI
  10.1073/pnas.2302903120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-23K15339, KAKENHI-PROJECT-22K15484, KAKENHI-PLANNED-19H05745, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-23K27607, KAKENHI-PROJECT-19H05650
[Journal Article] Nematode ascarosides attenuate mammalian type 2 inflammatory responses2022
- Author(s)
  Shinoda Kenta、Choe Andrea、Hirahara Kiyoshi、Kiuchi Masahiro、Kokubo Kota、Ichikawa Tomomi、Hoki Jason S.、Suzuki Akane S.、Bose Neelanjan、Appleton Judith A.、Aroian Raffi V.、Schroeder Frank C.、Sternberg Paul W.、Nakayama Toshinori
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119(9) Issue: 9
- DOI
  10.1073/pnas.2108686119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754
[Journal Article] Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion2022
- Author(s)
  Iinuma Tomohisa、Kiuchi Masahiro、Hirahara Kiyoshi、Kurita Junya、Kokubo Kota、Yagyu Hiroyuki、Yoneda Riyo、Arai Tomoyuki、Sonobe Yuri、Fukuyo Masaki、Kaneda Atsushi、Yonekura Syuji、Nakayama Toshinori、Okamoto Yoshitaka、Hanazawa Toyoyuki
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 150 Issue: 4 Pages: 850-860.e5
- DOI
  10.1016/j.jaci.2022.06.024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-22K09739, KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-22K15485, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754
[Journal Article] Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis2022
- Author(s)
  Kokubo Kota、Onodera Atsushi、Kiuchi Masahiro、Tsuji Kaori、Hirahara Kiyoshi、Nakayama Toshinori
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 945063-945063
- DOI
  10.3389/fimmu.2022.945063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-22K15485, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20KK0351, KAKENHI-PROJECT-23K24147
[Journal Article] Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis2022
- Author(s)
  Fujimoto Masanori、Yokoyama Masataka、Kiuchi Masahiro、Hosokawa Hiroyuki、Nakayama Akitoshi、Hashimoto Naoko、Sakuma Ikki、Nagano Hidekazu、Yamagata Kazuyuki、Kudo Fujimi、Manabe Ichiro、Lee Eunyoung、Hatano Ryo、Onodera Atsushi、Hirahara Kiyoshi、Yokote Koutaro、Miki Takashi、Nakayama Toshinori、Tanaka Tomoaki
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 1-21
- DOI
  10.1038/s41467-022-33171-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08524, KAKENHI-PROJECT-22K07205, KAKENHI-PROJECT-22K08619, KAKENHI-PROJECT-22K08644, KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-20KK0373, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21H02974, KAKENHI-PROJECT-20K07561, KAKENHI-PROJECT-20K08397, KAKENHI-PROJECT-20K08583, KAKENHI-PROJECT-21K19398, KAKENHI-PROJECT-20KK0351, KAKENHI-PROJECT-23K24062, KAKENHI-PROJECT-23K24147
[Journal Article] Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch2022
- Author(s)
  Okano Mikiko、Hirahara Kiyoshi、Kiuchi Masahiro、Onoue Miki、Iwamura Chiaki、Kokubo Kota、Hishiya Takahisa、Morimoto Yuki、Ikehara Yuzuru、Murakami Akira、Ebihara Nobuyuki、Nakayama Toshinori
- Journal Title
  
  Immunity
  
  Volume: 55 Issue: 12 Pages: 2352-2368.e7
- DOI
  10.1016/j.immuni.2022.09.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-22K15485, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20K08769
[Journal Article] Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity2022
- Author(s)
  Iwamura Chiaki、Hirahara Kiyoshi、Kiuchi Masahiro、Ikehara Sanae、Azuma Kazuhiko、Shimada Tadanaga、Kuriyama Sachiko、Ohki Syota、Yamamoto Emiri、Inaba Yosuke、Shiko Yuki、Aoki Ami、Kokubo Kota、et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 33 Pages: 2203437119-2203437119
- DOI
  10.1073/pnas.2203437119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-22K15485, KAKENHI-PLANNED-22H05189, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03464, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-20K08351, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-23K24337, KAKENHI-PROJECT-20K08769
[Journal Article] CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system2021
- Author(s)
  Nakayama Toshinori、Hirahara Kiyoshi、Kimura Motoko Y、Iwamura Chiaki、Kiuchi Masahiro、Kokubo Kota、Onodera Atsushi、Hashimoto Kahoko、Motohashi Shinichiro
- Journal Title
  
  International Immunology
  
  Volume: 33(12) Issue: 12 Pages: 699-704
- DOI
  10.1093/intimm/dxab053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21537, KAKENHI-PROJECT-19K16683, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03464, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-20K08769, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20KK0351
[Journal Article] マウス同所性肺移植モデルを用いた拒絶反応におけるPD-L1の関連についての検討2021
- Author(s)
  海寳大輔, 鈴木秀海, 松本寛樹, 苅田涼, 平井有紀, 太枝帆高, 西井開, 伊藤祐輝, 小野里優希, 豊田行英, 稲毛輝長, 田中教久, 坂入祐一, 中島崇裕, 木内政宏, 本橋新一郎, 中山俊憲, 吉野一郎
- Journal Title
  
  日本呼吸器外科学会雑誌
  
  Volume: 35(3)
- Data Source
  KAKENHI-PROJECT-19K16683
[Journal Article] Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy.2021
- Author(s)
  Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H
- Journal Title
  
  Mucosal Immunol
  
  Volume: 14 Issue: 3 Pages: 640-651
- DOI
  10.1038/s41385-020-00358-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08782, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19K17818, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-19H03450, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-20H03721, KAKENHI-PROJECT-19K22634, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-21K19083, KAKENHI-PROJECT-21K19495, KAKENHI-PROJECT-18KK0432
[Journal Article] 生化学(分子生物学)2 病原性記憶Th細胞による難治性炎症疾患の病態形成機構2021
- Author(s)
  木内政宏, 平原潔, 中山俊憲
- Journal Title
  
  Annual Review 神経
  
  Volume: 2021
- Data Source
  KAKENHI-PROJECT-19K16683
[Journal Article] Eosinophils: Cells known for over 140 years with broad and new functions2021
- Author(s)
  Aoki Ami、Hirahara Kiyoshi、Kiuchi Masahiro、Nakayama Toshinori
- Journal Title
  
  Allergol. Int.
  
  Volume: 70 Issue: 1 Pages: 3-8
- DOI
  10.1016/j.alit.2020.09.002
- NAID
  130007966778
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-20K17175, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685
[Journal Article] The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation2021
- Author(s)
  Kiuchi Masahiro、Onodera Atsushi、Kokubo Kota、Ichikawa Tomomi、Morimoto Yuki、Kawakami Eiryo、Takayama Naoya、Eto Koji、Koseki Haruhiko、Hirahara Kiyoshi、Nakayama Toshinori
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 218 Issue: 4 Pages: 3-8
- DOI
  10.1084/jem.20201690
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-18K07164, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-21K20754
[Journal Article] The Role of CD4+ Resident Memory T Cells in Local Immunity in the Mucosal Tissue - Protection Versus Pathology -2021
- Author(s)
  Kiyoshi Hirahara、Kota Kokubo、Ami Aoki、Masahiro Kiuchi、Toshinori Nakayama
- Journal Title
  
  Frontiers in Immunology
  
  Volume: - Pages: 616309-616309
- DOI
  10.3389/fimmu.2021.616309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-20K20383, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-21K20754
[Journal Article] Memory-type pathogenic TH2 cells and ILC2s in type 2 allergic inflammation2021
- Author(s)
  Hirahara Kiyoshi、Aoki Ami、Kiuchi Masahiro、Nakayama Toshinori
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: - Issue: 6 Pages: 2063-2066
- DOI
  10.1016/j.jaci.2021.02.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-20K17175, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685
[Journal Article] マウス気管移植モデルを用いた拒絶反応におけるPD-L1の関連についての検討2021
- Author(s)
  海寳大輔, 鈴木秀海, 松本寛樹, 豊田行英, 稲毛輝長, 田中教久, 坂入祐一, 中島崇裕, 木内政宏, 本橋新一郎, 中山俊憲, 吉野一郎
- Journal Title
  
  移植
  
  Volume: 56(1) Pages: 94-94
- Data Source
  KAKENHI-PROJECT-19K16683
[Journal Article] Epigenetic regulation of inflammation by CxxC domain‐containing proteins2021
- Author(s)
  Onodera Atsushi、Kiuchi Masahiro、Kokubo Kota、Nakayama Toshinori
- Journal Title
  
  Immunological Reviews
  
  Volume: 305(1) Issue: 1 Pages: 137-151
- DOI
  10.1111/imr.13056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20KK0351
[Journal Article] AID (Activation-induced cytidine deaminase)2020
- Author(s)
  木内政宏、中山俊憲
- Journal Title
  
  アレルギ－用語解説シリ－ズ
  
  Volume: 69(3) Pages: 222-223
- NAID
  130007845012
- Data Source
  KAKENHI-PROJECT-19K16683
[Journal Article] 繊維化を誘導するCD4+組織常在性記憶T細胞のエピジェネティクス2020
- Author(s)
  平原潔、木内政宏、中山俊憲
- Journal Title
  
  医学のあゆみ
  
  Volume: 275(1) Pages: 133-137
- Data Source
  KAKENHI-PROJECT-19K16683
[Journal Article] CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells2019
- Author(s)
  Ichikawa, T.*, Hirahara, K.*, Kokubo, K.*, Kiuchi, M., Aoki, A., Morimoto, Y., Kumagai, J., Onodera, A., Mato, N., Tumes, D., Goto, Y., Hagiwara, K., Inagaki, Y., Sparwasser, T., Tobe, K., and Nakayama, T.
- Journal Title
  
  Nature Immunology
  
  Volume: 20 Issue: 11 Pages: 1469-1480
- DOI
  10.1038/s41590-019-0494-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07164, KAKENHI-PROJECT-19K22627, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-17H04166, KAKENHI-PROJECT-19H03465, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-17K08876
[Journal Article] The immunopathology of lung fibrosis: amphiregulin-producing pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopontin.2019
- Author(s)
  Hirahara, K, Aoki, A, Morimoto, Y, Kiuchi, M, Okano, M, Nakayama, T
- Journal Title
  
  Semin. Immunopathol.
  
  Volume: 41(3) Issue: 3 Pages: 339-348
- DOI
  10.1007/s00281-019-00735-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-17K08876
[Patent] IL-33関連疾患の予防又は治療剤2019
- Inventor(s)
  中山俊憲, 熊谷仁, 平原潔, 木内政宏
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-057333
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K16683
[Presentation] The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells2023
- Author(s)
  Masahiro Kiuchi, Kota Kokubo, Hiroyuki Yagyu, Masahiro Nemoto, Kaori Tsuji, Takahisa Hishiya, Miki Onoue, Rie Shinmi, Yuri Sonobe, Toshinori Nakayama, Kiyoshi Hirahara
- Organizer
  第52回日本免疫学会学術集会 2024年1月
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15485
[Presentation] Nematode ascarosides attenuate mammalian type 2 inflammatory responses2022
- Author(s)
  Masahiro Kiuchi , Kota Kokubo, Atsushi Onodera, Kiyoshi Hirahara , Toshinori Nakayama
- Organizer
  日本免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15485
[Presentation] The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation2021
- Author(s)
  Masahiro Kiuchi., Atsushi Onodera., Kota Kokubo., Eiryo Kawakami., Haruhiko Koseki., Kiyoshi Hirahara., Toshinori Nakayama.
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16683
[Presentation] Trithorax Cxxc1-directed epigenetic machinery licensing CD4+ T cell differentiation2021
- Author(s)
  Masahiro Kiuchi., Atsushi Onodera., Kota Kokubo., Tomomi Ichikawa., Eiryo Kawakami., Naoya Takayama., Koji Eto., Haruhiko Koseki., Kiyoshi Hirahara., Toshinori Nakayama.
- Organizer
  第85回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16683
[Presentation] Amphiregulin-producing pathogenic memory T helper-2 cells drive airway fibrosis via activation of eosinophils.2019
- Author(s)
  Hirahara, K, Morimoto, Y, Kiuchi, M, Okano, M, Kokubo, K, Nakayama, T
- Organizer
  Tissue Repair and Regeneration (Gordon Research Conference)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16683

1. FUKUYO Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 中山俊憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
3. 小野寺淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 伊沢久未

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 小久保幸太

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
6. 田中知明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 佐久間一基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kiuchi Masahiro 木内 政宏

KIUCHI Masahiro 木内 政宏

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炎症微小環境におけるHLF陽性組織常在性CD4+ T細胞の形成機構の解明Principal Investigator

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病原性老化ヘルパーT細胞におけるエピゲノム老化と病態形成機構の解明Principal Investigator

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The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiationPrincipal Investigator

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[Book] 肺移植の拒絶反応における免疫チェックポイント分子を用いた免疫寛容の誘導に向けての基礎研究2019

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[Journal Article] Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease2024

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[Journal Article] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism2023

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[Journal Article] Single-cell RNA sequencing of peripheral blood mononuclear cells from Kimura disease patient successfully treated with dupilumab2023

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[Journal Article] Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients2023

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[Journal Article] CD69 Imposes Tumor-Specific CD8+ T-cell Fate in Tumor-Draining Lymph Nodes2023

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[Journal Article] Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases2023

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[Journal Article] The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells2023

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[Journal Article] Nematode ascarosides attenuate mammalian type 2 inflammatory responses2022

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[Journal Article] Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion2022

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[Journal Article] Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis2022

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Kiuchi Masahiro 木内政宏

KIUCHI Masahiro 木内政宏