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Koyama Takafumi  小山 隆文

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小山 隆文  コヤマ タカフミ

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Researcher Number 30828538
Affiliation (Current) 2025: 国立研究開発法人国立がん研究センター, 中央病院, 医長
Affiliation (based on the past Project Information) *help 2022 – 2023: 国立研究開発法人国立がん研究センター, 中央病院, 医長
2020 – 2021: 国立研究開発法人国立がん研究センター, 中央病院, 医員
Review Section/Research Field
Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 58:Society medicine, nursing, and related fields
Keywords
Principal Investigator
耐性機序 / TP53 / モデル化 / バイオマーカー / MDM2 / PDX / HPD / 野生型TP53 / MDM2増幅
Except Principal Investigator
抗体医薬による輸注反応(IRR) … More / 抗体薬物複合体 / サイトカインプロファイル / 新規抗体医薬 / サイトカイン / IRR / がん新薬早期開発 / 患者-医師間コミュニケーション / ソーシャルサポート / 不安 / うつ / 心理的影響 / がん遺伝子検査パネル Less
  • Research Projects

    (3 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (10 People)
  •  進行癌に対する次世代抗体薬投与時サイトカインプロファイル緊急網羅的解析モデル探索

    • Principal Investigator
      清水 俊雄
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Wakayama Medical University
  •  Fundamental research on biomarkers and Immunological response for solid tumors harboring MDM2 amplificationPrincipal Investigator

    • Principal Investigator
      小山 隆文
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      National Cancer Center Japan
  •  Psychosocial Impact of Cancer Gene Panel Test

    • Principal Investigator
      Uchitomi Yosuke
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 58:Society medicine, nursing, and related fields
    • Research Institution
      National Cancer Center Japan

All 2024 2023 2022

All Journal Article Presentation

  • [Journal Article] The impact of rare cancer and early-line treatments on the benefit of comprehensive genome profiling-based precision oncology2024

    • Author(s)
      Kubo T.、Sunami K.、Koyama T. et.al
    • Journal Title

      ESMO Open

      Volume: 9 Issue: 4 Pages: 102981-102981

    • DOI

      10.1016/j.esmoop.2024.102981

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15614
  • [Journal Article] A Learning Program for Treatment Recommendations by Molecular Tumor Boards and Artificial Intelligence2024

    • Author(s)
      Sunami Kuniko、Naito Yoichi、Koyama Takafumi et.al
    • Journal Title

      JAMA Oncology

      Volume: 10 Issue: 1 Pages: 95-95

    • DOI

      10.1001/jamaoncol.2023.5120

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15614, KAKENHI-PROJECT-21H02795
  • [Journal Article] Travel Time and Distance and Participation in Precision Oncology Trials at the National Cancer Center Hospital2023

    • Author(s)
      Uehara Yuji、Koyama Takafumi、Katsuya Yuki、Sato Jun、Sudo Kazuki、Kondo Shunsuke、Yoshida Tatsuya、Shoji Hirokazu、Shimoi Tatsunori、Yonemori Kan、Yamamoto Noboru
    • Journal Title

      JAMA Network Open

      Volume: 6 Issue: 9 Pages: e2333188-e2333188

    • DOI

      10.1001/jamanetworkopen.2023.33188

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15614
  • [Journal Article] Clinical Activity and Exploratory Resistance Mechanism of Milademetan, an MDM2 Inhibitor, in Intimal Sarcoma with <i>MDM2</i> Amplification: An Open-Label Phase Ib/II Study2023

    • Author(s)
      Koyama Takafumi、Shimizu Toshio、Kojima Yuki、Sudo Kazuki、Okuma Hitomi Sumiyoshi、Shimoi Tatsunori、Ichikawa Hitoshi、Kohsaka Shinji、Sadachi Ryo、Hirakawa Akihiro、Yoshida Akihiko、Ando Reiko Makihara、Ueno Toshihide、Yanagaki Mitsuru、Matsui Naoko、Nakamura Kenichi、Yamamoto Noboru、Yonemori Kan
    • Journal Title

      Cancer Discovery

      Volume: 13 Issue: 8 Pages: 1814-1825

    • DOI

      10.1158/2159-8290.cd-23-0419

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15614, KAKENHI-PROJECT-20K11703, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-21H03062
  • [Journal Article] Utility of molecular subtypes and genetic alterations for evaluating clinical outcomes in 1029 patients with endometrial cancer2023

    • Author(s)
      Asami Y, Kobayshi Kato M, Shiraishi K, Yoshida H
    • Journal Title

      Br J Cancer

      Volume: 128 Issue: 8 Pages: 1582-1591

    • DOI

      10.1038/s41416-023-02203-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K16891, KAKENHI-PROJECT-19K16572, KAKENHI-PROJECT-22K15614
  • [Journal Article] First-in-human study of ONO-4578, an antagonist of prostaglandin E2 receptor 4, alone and with nivolumab in solid tumors2022

    • Author(s)
      Iwasa Satoru、Koyama Takafumi、Nishino Makoto、Kondo Shunsuke、Sudo Kazuki、Yonemori Kan、Yoshida Tatsuya、Tamura Kenji、Shimizu Toshio、Fujiwara Yutaka、Kitano Shigehisa、Shimomura Akihiko、Sato Jun、Yokoyama Fumiharu、Iida Hiroyuki、Kondo Maki、Yamamoto Noboru
    • Journal Title

      Cancer Science

      Volume: 114 Issue: 1 Pages: 211-220

    • DOI

      10.1111/cas.15574

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K15614
  • [Journal Article] Dose Escalation Data from the Phase 1 Study of the Liposomal Formulation of Eribulin (E7389-LF) in Japanese Patients with Advanced Solid Tumors2022

    • Author(s)
      Sato Jun、Shimizu Toshio、Koyama Takafumi、Iwasa Satoru、Shimomura Akihiko、Kondo Shunsuke、Kitano Shigehisa、Yonemori Kan、Fujiwara Yutaka、Tamura Kenji、Suzuki Takuya、Takase Takao、Nagai Reiko、Yamaguchi Kohei、Semba Taro、Zhao Zi-Ming、Ren Min、Yamamoto Noboru
    • Journal Title

      Clinical Cancer Research

      Volume: 28 Issue: 9 Pages: 1783-1791

    • DOI

      10.1158/1078-0432.ccr-21-3518

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K15614
  • [Journal Article] Clinical utility of comprehensive genomic profiling tests for advanced or metastatic solid tumor in clinical practice2022

    • Author(s)
      Ida Hanae、Koyama Takafumi、Mizuno Takaaki、Sunami Kuniko、Kubo Takashi、Sudo Kazuki、Tao Kayoko、Hirata Makoto、Yonemori Kan、Kato Ken、Okusaka Takuji、Ohe Yuichiro、Matsui Yoshiyuki、Yamazaki Naoya、Ogawa Chitose、Kawai Akira、Narita Yoshitaka、Esaki Minoru、Yamamoto Noboru
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 12 Pages: 4300-4310

    • DOI

      10.1111/cas.15586

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15614, KAKENHI-PROJECT-23K24468
  • [Journal Article] Practical consideration for successful sequential tumor biopsies in first-in-human trials2022

    • Author(s)
      Koyama Takafumi、Shimizu Toshio、Sato Jun、Katsuya Yuki、Iwasa Satoru、Kondo Shunsuke、Yoshida Tatsuya、Sudo Kazuki、Nishino Makoto、Takiguchi Yuichi、Yonemori Kan、Yamamoto Noboru
    • Journal Title

      Investigational New Drugs

      Volume: 40 Issue: 4 Pages: 841-849

    • DOI

      10.1007/s10637-022-01236-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K15614
  • [Journal Article] Phase I/IIa Trial of BMS-986148, an Anti-mesothelin Antibody?drug Conjugate, Alone or in Combination with Nivolumab in Patients with Advanced Solid Tumors2022

    • Author(s)
      Rottey Sylvie、Clarke Jeffrey、Aung Kyaw、Machiels Jean-Pascal、Markman Ben、Heinhuis Kimberley M.、Millward Michael、Lolkema Martijn、Patel Sandip Pravin、de Souza Paul、Duca Matteo、Curigliano Giuseppe、Santoro Armando、Koyama Takafumi、Brown Michelle、Vezina Heather、He Chunsheng、Chu Quincy Siu-Chung
    • Journal Title

      Clinical Cancer Research

      Volume: 28 Issue: 1 Pages: 95-105

    • DOI

      10.1158/1078-0432.ccr-21-1181

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15614
  • [Presentation] MDM2 Amplified Tumor.2023

    • Author(s)
      Takafumi Koyama
    • Organizer
      21st Annual Meeting of the Japan Society of Medical Oncology
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K15614
  • [Presentation] Exploratory novel biomarker and resistance mechanism of milademetan, an MDM2 inhibitor, in MDM2 amplified intimal sarcoma from an open-label phase 1b/2 trial (NCCH1806/MK004) .2023

    • Author(s)
      Takafumi Koyama
    • Organizer
      Annual Meeting of the Amrican Society of Medical Oncology 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K15614
  • [Presentation] Clinical Utility of Comprehensive Genomic Profiling Tests for Advanced or Metastatic Solid Tumor under the Japanese National Health Insurance System2022

    • Author(s)
      Takafumi Koyama
    • Organizer
      第20回日本臨床腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K15614
  • 1.  Uchitomi Yosuke (60243565)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  白井 由紀 (30587382)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  藤森 麻衣子 (40450572)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  清水 俊雄 (30411599)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  吉田 達哉 (10729338)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  勝屋 友幾 (40752704)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  渡邊 慶介 (60847466)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  山本 昇 (80501874)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  洪 泰浩 (80426519)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  加藤 真弓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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