Miyashita Satoshi 宮下聡

Researcher Number	30828900
Other IDs	https://orcid.org/0000-0003-3421-2477
Affiliation (Current)	2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所病態生化学研究部, 室長
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所病態生化学研究部, 室長 2021 – 2022: 新潟大学, 脳研究所, 助教 2020: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所病態生化学研究部, リサーチフェロー
Review Section/Research Field	Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related
Keywords	Principal Investigator UBCs / 小脳 / Unipolar brush cells / 顆粒細胞 / 高次機能 / snRNA-seq / 空間トランスクリプトーム / development / Unipolar brush cell / 発生 … More / single cell RNA / unipolar brush cells / single cell RNAseq / 神経発生 Less

Exploring the role of unipolar brush cells in motor and cognitive function of the cerebellum.Principal Investigator
- Principal Investigator
  
  宮下聡
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  National Center of Neurology and Psychiatry
The role of Unipolar brush cells in the cerebellar functionsPrincipal Investigator
- Principal Investigator
  
  Miyashita Satoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Niigata University
  National Center of Neurology and Psychiatry

All 2025 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] The microcephaly-associated transcriptional regulator AUTS2 cooperates with Polycomb complex PRC2 to produce upper-layer neurons in mice2025
- Author(s)
  Shimaoka Kazumi、Hori Kei、Miyashita Satoshi、Inoue Yukiko U、Tabe Nao K N、Sakamoto Asami、Hasegawa Ikuko、Nishitani Kayo、Yamashiro Kunihiko、Egusa Saki F、Tatsumoto Shoji、Go Yasuhiro、Abe Manabu、Sakimura Kenji、Inoue Takayoshi、Imamura Takuya、Hoshino Mikio
- Journal Title
  
  The EMBO Journal
  
  Volume: 44 Issue: 5 Pages: 1354-1378
- DOI
  10.1038/s44318-024-00343-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-21H05238, KAKENHI-PLANNED-21H05245, KAKENHI-PROJECT-23K23796, KAKENHI-PROJECT-23K23973, KAKENHI-PROJECT-23K23993, KAKENHI-PROJECT-23K05612, KAKENHI-PROJECT-24K21918, KAKENHI-PROJECT-22K15134, KAKENHI-PROJECT-23K14295
[Journal Article] Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation2024
- Author(s)
  Dewa Ken-ichi、Arimura Nariko、Kakegawa Wataru et al.
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 458-458
- DOI
  10.1038/s41467-023-44579-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19364, KAKENHI-PROJECT-23K14203, KAKENHI-PROJECT-23K14295, KAKENHI-PROJECT-22KJ0316, KAKENHI-PROJECT-22K21353, KAKENHI-PROJECT-20K06881, KAKENHI-PROJECT-22K06784, KAKENHI-PROJECT-23K05612, KAKENHI-PROJECT-21K06416, KAKENHI-PROJECT-21K06788, KAKENHI-PROJECT-21K20853, KAKENHI-PROJECT-20H03420, KAKENHI-PLANNED-20H05902, KAKENHI-ORGANIZER-21H05238, KAKENHI-PLANNED-21H05245, KAKENHI-PROJECT-23K23973, KAKENHI-PROJECT-23K23993, KAKENHI-PROJECT-20H05628, KAKENHI-PROJECT-24K01943
[Journal Article] Kinesin-like motor protein KIF23 maintains neural stem?and progenitor cell pools in the developing cortex2024
- Author(s)
  Naher Sharmin、Iemura Kenji、Miyashita Satoshi、Hoshino Mikio、Tanaka Kozo、Niwa Shinsuke、Tsai Jin-Wu、Kikkawa Takako、Osumi Noriko
- Journal Title
  
  The EMBO Journal
  
  Volume: 44 Issue: 2 Pages: 331-355
- DOI
  10.1038/s44318-024-00327-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23877, KAKENHI-PROJECT-23K23993, KAKENHI-PROJECT-23K27165, KAKENHI-PROJECT-24K02203, KAKENHI-PROJECT-23K06297, KAKENHI-PROJECT-23K14295
[Journal Article] CRISPR/CasRx suppresses KRAS-induced brain arteriovenous malformation developed in postnatal brain endothelial cells in mice.2024
- Author(s)
  Saito S, Nakamura Y, Miyashita S, Sato T, Hoshina K, Okada M, Hasegawa H, Oishi M, Fujii Y, Korbelin J, Kubota Y, Tainaka K, Natsumeda M, Ueno M.
- Journal Title
  
  JCI Insight
  
  Volume: 9 Issue: 22
- DOI
  10.1172/jci.insight.179729
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-23H04222, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K24198, KAKENHI-PROJECT-20K17921, KAKENHI-PROJECT-24K02129, KAKENHI-PROJECT-21K07290, KAKENHI-PROJECT-23K14295
[Journal Article] Transcriptional features of low‐grade neuroepithelial tumors with the <scp>BRAF V600E</scp> mutation associated with epileptogenicity2024
- Author(s)
  Iijima Keiya、Komatsu Kanako、Miyashita Satoshi、Suyama Kyoka、Murayama Kumiko、Hashizume Koichi、Tabe Nao K.、Miyata Hajime、Iwasaki Masaki、Taya Shinichiro、Hoshino Mikio
- Journal Title
  
  Genes to Cells
  
  Volume: 29 Issue: 3 Pages: 192-206
- DOI
  10.1111/gtc.13096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14295, KAKENHI-PROJECT-22K09273
[Journal Article] Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord2023
- Author(s)
  Nakamura Yuka、Kurabe Miyuki、Matsumoto Mami、Sato Tokiharu、Miyashita Satoshi、Hoshina Kana、Kamiya Yoshinori、Tainaka Kazuki、Matsuzawa Hitoshi、Ohno Nobuhiko、Ueno Masaki
- Journal Title
  
  eLife
  
  Volume: 12 Pages: 1-31
- DOI
  10.7554/elife.83108
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08943, KAKENHI-PROJECT-22K15202, KAKENHI-PLANNED-21H05241, KAKENHI-PUBLICLY-21H05683, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H02590, KAKENHI-PROJECT-20K21460, KAKENHI-PROJECT-20K15919, KAKENHI-ORGANIZER-21H05238, KAKENHI-PROJECT-23K24198, KAKENHI-PROJECT-21K07290
[Journal Article] Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.2023
- Author(s)
  Tran DM, Yoshioka N, Bizen N, Mori-Ochiai Y, Yano M, Yanai S, Hasegawa J, Miyashita S, Hoshino M, Sasaki J, Sasaki T, Takebayashi H
- Journal Title
  
  Dis Model Mech
  
  Volume: 16 Issue: 7 Pages: 192-206
- DOI
  10.1242/dmm.050169
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15912, KAKENHI-PROJECT-23K14295, KAKENHI-PROJECT-23K06300, KAKENHI-PROJECT-23K06317, KAKENHI-PROJECT-22K19287, KAKENHI-PROJECT-19H03543, KAKENHI-PROJECT-21H02652, KAKENHI-PUBLICLY-22H05589, KAKENHI-PROJECT-20H00485, KAKENHI-PROJECT-21H02680, KAKENHI-PROJECT-23K23993, KAKENHI-PROJECT-23K27319
[Journal Article] Epigenetic upregulation of Schlafen11 renders WNT- and SHH-activated medulloblastomas sensitive to cisplatin2022
- Author(s)
  Nakata Satoshi、Murai Junko、Okada Masayasu,,,,,Tateishi Kensuke、Yamashita Shinji、Eberhart Charles G、Natsumeda Manabu
- Journal Title
  
  Neuro-Oncology
  
  Volume: 25 Issue: 5 Pages: 899-912
- DOI
  10.1093/neuonc/noac243
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09210, KAKENHI-PROJECT-22K16679, KAKENHI-PROJECT-21KK0156, KAKENHI-PROJECT-20K15919, KAKENHI-PROJECT-23K24297, KAKENHI-PROJECT-22K20953, KAKENHI-PROJECT-21H03042
[Journal Article] Transit Amplifying Progenitors in the Cerebellum: Similarities to and Differences from Transit Amplifying Cells in Other Brain Regions and between Species2022
- Author(s)
  Miyashita Satoshi、Hoshino Mikio
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 4 Pages: 726-726
- DOI
  10.3390/cells11040726
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-INTERNATIONAL-16K21734, KAKENHI-PROJECT-20K15919, KAKENHI-PROJECT-18H02538
[Journal Article] Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient <i>mdx</i> mice2021
- Author(s)
  Nogami Ken'ichiro、Maruyama Yusuke、Sakai-Takemura Fusako、Motohashi Norio、Elhussieny Ahmed、Imamura Michihiro、Miyashita Satoshi、Ogawa Megumu、Noguchi Satoru、Tamura Yuki、Kira Jun-ichi、Aoki Yoshitsugu、Takeda Shin'ichi、Miyagoe-Suzuki Yuko
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 30 Issue: 11 Pages: 1006-1019
- DOI
  10.1093/hmg/ddab100
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02067, KAKENHI-PROJECT-21K11615, KAKENHI-PROJECT-20K15919, KAKENHI-PROJECT-19K07519
[Journal Article] Notch Signaling between Cerebellar Granule Cell Progenitors2021
- Author(s)
  Adachi Toma、Miyashita Satoshi、Yamashita Mariko、Shimoda Mana、Okonechnikov Konstantin、Chavez Lukas、Kool Marcel、Pfister Stefan M.、Inoue Takafumi、Kawauchi Daisuke、Hoshino Mikio
- Journal Title
  
  eneuro
  
  Volume: 8 Issue: 3 Pages: 0468-20
- DOI
  10.1523/eneuro.0468-20.2021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18J20309, KAKENHI-INTERNATIONAL-16K21734, KAKENHI-PROJECT-20K15919, KAKENHI-PROJECT-18H02538
[Journal Article] Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1.2021
- Author(s)
  Satoshi Miyashita, Tomoo Owa, Yusuke Seto, Mariko Yamashita, Shogo Aida, Masaki Sone, Kentaro Ichijo, Tomoki Nishioka, Kozo Kaibuchi, Yoshiya Kawaguchi, Shinichiro Taya, Mikio Hoshino
- Journal Title
  
  EMBO J.
  
  Volume: 40 Issue: 14 Pages: 2230-2247
- DOI
  10.15252/embj.2020105712
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06881, KAKENHI-PROJECT-20K15919, KAKENHI-PROJECT-20K06886
[Journal Article] The role of SCFSkp2 and SCFβ-TrCP1/2 in the cerebellar granule cell precursors2020
- Author(s)
  Yamashita M, Owa T, Shiraishi R, Adachi T, Ichijo K, Taya S, Miyashita S, Hoshino M
- Journal Title
  
  Genes Cells
  
  Volume: (12) Issue: 12 Pages: 796-810
- DOI
  10.1111/gtc.12813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06886, KAKENHI-PROJECT-20K15919, KAKENHI-ORGANIZER-16H06524, KAKENHI-PROJECT-19H03536, KAKENHI-PROJECT-18J20309, KAKENHI-PROJECT-17K07126, KAKENHI-PLANNED-16H06528
[Journal Article] AUTS2 regulation of synapses for proper synaptic inputs and social communication.2020
- Author(s)
  Hori Kei、Yamashiro Kunihiko、Nagai Taku、... Yamada Mitsuhiko、Yamada Kiyofumi、Hoshino Mikio
- Journal Title
  
  iScience
  
  Volume: ー Issue: 6 Pages: 101183-101183
- DOI
  10.1016/j.isci.2020.101183
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18J10102, KAKENHI-PROJECT-20K06881, KAKENHI-PROJECT-20K07082, KAKENHI-PROJECT-20K15919, KAKENHI-INTERNATIONAL-16K21734, KAKENHI-ORGANIZER-16H06524, KAKENHI-PLANNED-16H06531, KAKENHI-PUBLICLY-19H04912, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-19H03313, KAKENHI-PROJECT-19H03536, KAKENHI-PROJECT-18K13371, KAKENHI-PLANNED-16H06528, KAKENHI-PROJECT-18H02538
[Journal Article] DSCAM regulates delamination of neurons in the developing midbrain2020
- Author(s)
  Arimura Nariko、Okada Mako、Taya Shinichiro、Dewa Ken-ichi、Tsuzuki Akiko、Uetake Hirotomo、Miyashita Satoshi、Hashizume Koichi、Shimaoka Kazumi、Egusa Saki、Nishioka Tomoki、Yanagawa Yuchio、Yamakawa Kazuhiro、Inoue Yukiko U.、Inoue Takayoshi、Kaibuchi Kozo、Hoshino Mikio
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 36 Pages: 1693-1693
- DOI
  10.1126/sciadv.aba1693
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07071, KAKENHI-PROJECT-20K06467, KAKENHI-PROJECT-20K06886, KAKENHI-PROJECT-20K15919, KAKENHI-INTERNATIONAL-16K21734, KAKENHI-ORGANIZER-16H06524, KAKENHI-PROJECT-19H03536, KAKENHI-PROJECT-17K07126, KAKENHI-PLANNED-16H06528, KAKENHI-PROJECT-18H02538
[Presentation] Transcriptional features of low grade neuroepithelial tumors associated with epileptogenicity2024
- Author(s)
  Satoshi Miyashita, Mikio Hoshino
- Organizer
  Society for Neuroscience 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14295
[Presentation] 手術脳検体を用いた一細胞核トランスクリプトーム解析によるmTORオパチーてんかんの細胞分子病態の探索2024
- Author(s)
  宮下聡、飯島圭哉、田部直央、高尾昌樹、田谷真一郎、岩崎真樹、星野幹雄
- Organizer
  Neuro2024
- Data Source
  KAKENHI-PROJECT-23K14295
[Presentation] Transit amplification of cerebellar granule cell in human and mouse cerebellum.2022
- Author(s)
  宮下　聡
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20K15919
[Presentation] A novel developmental pattern of cerebellar granule cells revealed by big data-driven approach2021
- Author(s)
  Satoshi Miyashita
- Organizer
  Korea-Japan Joynt Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15919
[Presentation] ビッグデータが切り開く小脳顆粒細胞の新しい発生様式とその分子基盤2021
- Author(s)
  宮下　聡
- Organizer
  CBIR若手インスパイアシンポジウム
- Data Source
  KAKENHI-PROJECT-20K15919

1. UENO Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. TATEISHI Kensuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. GO Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. NARIKO Arimura

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 倉部美起

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# of Collaborated Products: 1 results
6. 掛川渉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 田中耕三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 田谷真一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 吉岡望

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 青木吉嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 星野幹雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 曽根雅紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyashita Satoshi 宮下 聡

Research Projects

Research Products

Co-Researchers

Exploring the role of unipolar brush cells in motor and cognitive function of the cerebellum.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of Unipolar brush cells in the cerebellar functionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The microcephaly-associated transcriptional regulator AUTS2 cooperates with Polycomb complex PRC2 to produce upper-layer neurons in mice2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kinesin-like motor protein KIF23 maintains neural stem?and progenitor cell pools in the developing cortex2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPR/CasRx suppresses KRAS-induced brain arteriovenous malformation developed in postnatal brain endothelial cells in mice.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptional features of low‐grade neuroepithelial tumors with the <scp>BRAF V600E</scp> mutation associated with epileptogenicity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic upregulation of Schlafen11 renders WNT- and SHH-activated medulloblastomas sensitive to cisplatin2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transit Amplifying Progenitors in the Cerebellum: Similarities to and Differences from Transit Amplifying Cells in Other Brain Regions and between Species2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient <i>mdx</i> mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Notch Signaling between Cerebellar Granule Cell Progenitors2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of SCFSkp2 and SCFβ-TrCP1/2 in the cerebellar granule cell precursors2020

Author(s)

Journal Title

DOI

Miyashita Satoshi 宮下聡