Hibino Sana 日比野沙奈

Researcher Number	30836424
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2025: 東京大学, 先端科学技術研究センター, 特任研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京大学, 先端科学技術研究センター, 特任研究員 2019 – 2021: 東京大学, 先端科学技術研究センター, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator 腫瘍免疫 / T細胞 / ポリアミン / オンコメタボライト / メタボライト / スペルミジン / 免疫チェックポイント阻害剤 / 疲弊T細胞 / oncometabolite / DAMPs / がん免疫 / 腫瘍微小環境 / 抗腫瘍免疫応答

熱ショックタンパク質を発現する腫瘍内疲弊T細胞集団の意義の解明Principal Investigator
- Principal Investigator
  
  日比野沙奈
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo
Metabolite secretome of dying cancer cells contributes to T cell dysfunctionPrincipal Investigator
- Principal Investigator
  
  Hibino Sana
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo
Metabolite secretome of necrotic tumor cells contributes to T cell dysfunction in cancerPrincipal Investigator
- Principal Investigator
  
  Hibino Sana
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo

All 2023 2021 2020

All Journal Article Presentation

[Journal Article] Tumor cell-derived spermidine is an oncometabolite that suppress TCR clustering for intratumoral CD8+ T cell activation2023
- Author(s)
  Sana Hibino, Shotaro Eto, Sho Hangai, Keiko Endo, Sanae Ashitani, Maki Sugaya, Tsuyoshi Osawa, Tomoyoshi Soga, Tadatsugu Taniguchi, and Hideyuki Yanai
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: －
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15499
[Journal Article] Inflammation-induced tumorigenesis and metastasis2021
- Author(s)
  Sana Hibino, Tetsuro Kawazoe, Hidenori Kasahara, Shinji Itoh, Takatsugu Ishimoto, Mamiko Sakata-Yanagimoto, and Koji Taniguchi
- Journal Title
  
  Int J Mol Sci.
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16736
[Journal Article] HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis2021
- Author(s)
  Senda N, Yanai H, Hibino S, Li L, Mizushima Y, Miyagaki T, Saeki M, Kishi Y, Hangai S, Nishio J, Sugaya M, Taniguchi T, Sato S
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 118 Issue: 1
- DOI
  10.1073/pnas.2022343118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08683, KAKENHI-PUBLICLY-19H05253, KAKENHI-PROJECT-20H00504, KAKENHI-PROJECT-19J00887, KAKENHI-PROJECT-18K07167, KAKENHI-PROJECT-18K14622, KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-19K16736, KAKENHI-PROJECT-16H06279, KAKENHI-PUBLICLY-20H05383, KAKENHI-PUBLICLY-21H00242, KAKENHI-PROJECT-20H03179
[Journal Article] Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells2021
- Author(s)
  Hangai Sho、Kawamura Takeshi、Kimura Yoshitaka、Chang Ching-Yun、Hibino Sana、Yamamoto Daisuke、Nakai Yousuke、Tateishi Ryosuke、Oshima Masanobu、Oshima Hiroko、Kodama Tatsuhiko、Moriya Kyoji、Koike Kazuhiko、Yanai Hideyuki、Taniguchi Tadatsugu
- Journal Title
  
  Nature Immunology
  
  Volume: 22 Issue: 8 Pages: 947-957
- DOI
  10.1038/s41590-021-00967-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00504, KAKENHI-PROJECT-19H03498, KAKENHI-PROJECT-21K15465, KAKENHI-PROJECT-21K15499, KAKENHI-PROJECT-19J00887
[Presentation] Metabolite secretome of necrotic tumor cells contributes to T cell dysfunction in cancer2021
- Author(s)
  日比野沙奈、柳井秀元
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15499
[Presentation] ネクローシス癌細胞から放出されるオンコメタボライトが、T細胞機能の制御におけるチェックポイントとして機能する2020
- Author(s)
  日比野沙奈、柳井秀元
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16736
[Presentation] ネクローシス癌細胞が放出する低分子代謝物による、抗腫瘍T細胞免疫応答の制御メカニズムの解明2020
- Author(s)
  日比野　沙奈、柳井秀元
- Organizer
  第一回日本癌学会若手の会
- Data Source
  KAKENHI-PROJECT-19K16736
[Presentation] ネクローシス癌細胞が放出するオンコメタボライトによる、抗腫瘍T細胞免疫応答の制御メカニズムの解明2020
- Author(s)
  日比野沙奈、柳井秀元
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K16736

1. MIYAGAKI Tomomitsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. YANAI Hideyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 谷口維紹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 半谷匠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hibino Sana 日比野 沙奈

Research Projects

Research Products

Co-Researchers

熱ショックタンパク質を発現する腫瘍内疲弊T細胞集団の意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Metabolite secretome of dying cancer cells contributes to T cell dysfunctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Metabolite secretome of necrotic tumor cells contributes to T cell dysfunction in cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Tumor cell-derived spermidine is an oncometabolite that suppress TCR clustering for intratumoral CD8+ T cell activation2023

Author(s)

Journal Title

Data Source

[Journal Article] Inflammation-induced tumorigenesis and metastasis2021

Author(s)

Journal Title

Data Source

[Journal Article] HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Metabolite secretome of necrotic tumor cells contributes to T cell dysfunction in cancer2021

Author(s)

Organizer

Data Source

[Presentation] ネクローシス癌細胞から放出されるオンコメタボライトが、T細胞機能の制御におけるチェックポイントとして機能する2020

Author(s)

Organizer

Data Source

[Presentation] ネクローシス癌細胞が放出する低分子代謝物による、抗腫瘍T細胞免疫応答の制御メカニズムの解明2020

Author(s)

Organizer

Data Source

[Presentation] ネクローシス癌細胞が放出するオンコメタボライトによる、抗腫瘍T細胞免疫応答の制御メカニズムの解明2020

Author(s)

Organizer

Data Source

Hibino Sana 日比野沙奈