ANNAN DORCAS ANNAN DORCAS・AKUBAMUHYIA

Researcher Number	30837240
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2022: 北海道大学, 歯学研究院, 学術研究員
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related Except Principal Investigator Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator tumor / metabolism / angiogenesis / Amino acid transporters / Glutamine metabolism / Tumor angiogenesis / bioenergetics / oxidative stress / sulfasalazine / tumor endothelial cell … More / glutamate / Slc7a11 / Slc7a11/System -xc / Sulfasalazine / Oxidative stress / Tumor amgiogenesis / Glutathione / Glutamate / Glutaminolysis / Tumor endothelial cell … More Except Principal Investigator 腫瘍血管内皮細胞 / 口腔がん / 血管ニッチ / がん幹細胞 Less

Targeting the Cancer Stem Cell in Vascular Niche for Oral Cancer Therapy
- Principal Investigator
  
  Satoh Chiharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Hokkaido University
Elucidation of glutamine metabolism in tumor endothelial cells to develop novel anti-cancer drugsPrincipal Investigator
- Principal Investigator
  
  ANNAN DORCAS
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Hokkaido University

All 2022 2021 2020 2019 Other

All Journal Article Presentation Other

[Journal Article] Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell-specific liposomal siRNA delivery system2022
- Author(s)
  Maishi N, Sakurai Y, Hatakeyama H, Umeyama Y, Nakamura T, Endo R, Alam MT, Li C, Annan DA, Kikuchi H, Morimoto H, Morimoto M, Akiyama K, Ohga N, Hida Y, Harashima H, *Hida K
- Journal Title
  
  Cancer Sci.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K10175
[Journal Article] Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell‐specific liposomal siRNA delivery system2022
- Author(s)
  Maishi Nako、Sakurai Yu、Hatakeyama Hiroto、Umeyama Yui、Nakamura Takashi、Endo Rikito、Alam Mohammad Towfik、Li Cong、Annan Dorcas Akuba‐Muhyia、Kikuchi Hiroshi、Morimoto Hirofumi、Morimoto Masahiro、Akiyama Kosuke、Ohga Noritaka、Hida Yasuhiro、Harashima Hideyoshi、Hida Kyoko
- Journal Title
  
  Cancer Science
  
  Volume: online ahead of print Issue: 5 Pages: 1-1
- DOI
  10.1111/cas.15323
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20195, KAKENHI-PROJECT-21K10107, KAKENHI-PROJECT-20K10175, KAKENHI-PROJECT-21K10036, KAKENHI-PROJECT-19K18549
[Journal Article] Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma2021
- Author(s)
  Yanagiya Misa、Dawood Randa I. H.、Maishi Nako、Hida Yasuhiro、Torii Chisaho、Annan Dorcas A.、Kikuchi Hiroshi、Yanagawa Matsuda Aya、Kitamura Tetsuya、Ohiro Yoichi、Shindoh Masanobu、Tanaka Shinya、Kitagawa Yoshimasa、Hida Kyoko
- Journal Title
  
  Pathology International
  
  Volume: - Issue: 6 Pages: 1-9
- DOI
  10.1111/pin.13094
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18549, KAKENHI-PROJECT-18K09715, KAKENHI-PROJECT-19K19220, KAKENHI-PROJECT-18H02996, KAKENHI-PROJECT-19K10326, KAKENHI-PROJECT-20K09900, KAKENHI-PROJECT-20K10175, KAKENHI-PROJECT-21K10036, KAKENHI-PROJECT-21K10107, KAKENHI-PROJECT-21H04840, KAKENHI-PROJECT-18H02891
[Journal Article] Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy2021
- Author(s)
  Li C, Maishi N, Annan DA, Young MF, Morimoto H, Morimoto M, Nam JM, Hida Y, Hida K
- Journal Title
  
  Breast Cancer Res
  
  Volume: -
- DOI
  10.21203/rs.3.rs-142861/v1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K19220
[Journal Article] Tumor Endothelial Cell-A Biological Tool for Translational Cancer Research2020
- Author(s)
  Annan Dorcas Akuba-Muhyia、Kikuchi Hiroshi、Maishi Nako、Hida Yasuhiro、Hida Kyoko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 9 Pages: 3238-3238
- DOI
  10.3390/ijms21093238
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09900, KAKENHI-PROJECT-19K18549, KAKENHI-PROJECT-18K09715, KAKENHI-PROJECT-19K19220, KAKENHI-PROJECT-18H02996, KAKENHI-PROJECT-18H02891
[Journal Article] がん治療標的としての腫瘍血管内皮細胞の特異性2020
- Author(s)
  間石奈湖, Annan DA, 樋田京子
- Journal Title
  
  炎症と免疫
  
  Volume: 28（5） Pages: 35-40
- Data Source
  KAKENHI-PROJECT-20K10175
[Journal Article] がん治療標的としての腫瘍血管内皮細胞の特異性2020
- Author(s)
  間石奈湖, Annan DA, 樋田京子
- Journal Title
  
  炎症と免疫
  
  Volume: 28 Pages: 35-40
- Data Source
  KAKENHI-PROJECT-19K19220
[Journal Article] Chemotherapy-induced IL-8 upregulates MDR1/ABCB1 in tumor blood vessels and results in unfavorable outcome2020
- Author(s)
  Kikuchi Hiroshi、Maishi Nako、Annan Dorcas A.、Towfik Alam Mohammad、Sato Masumi、Morimoto Masahiro、Takeda Ryo、Ishizuka Keita、Matsumoto Ryuji、Akino Tomoshige、Matsuno Yoshihiro、Hida Yasuhiro、Shinohara Nobu、Hida Kyoko
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 14 Pages: 2996-3008
- DOI
  10.1158/0008-5472.can-19-3791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09900, KAKENHI-PROJECT-19K18549, KAKENHI-PROJECT-18K09715, KAKENHI-PROJECT-19K19220, KAKENHI-PROJECT-18H02996, KAKENHI-PROJECT-18H02891
[Journal Article] Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment2019
- Author(s)
  Dorcas Akuba Muhyia Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Cong Li, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura, Mohammad Towfik Alam, Kazuyuki Minowa, Nobuo Shinohara, Jin-Min Nam, Yasuhiro Hida, Kyoko Hida
- Journal Title
  
  Cell Communication and Signaling
  
  Volume: 17 Issue: 1 Pages: 169-169
- DOI
  10.1186/s12964-019-0478-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09715, KAKENHI-PROJECT-18K09872, KAKENHI-PROJECT-19K10326, KAKENHI-PROJECT-19K18549, KAKENHI-PROJECT-19K19149, KAKENHI-PROJECT-19K19220, KAKENHI-PUBLICLY-18H05092, KAKENHI-PROJECT-17K11116, KAKENHI-PROJECT-17K11660, KAKENHI-PROJECT-17K11823, KAKENHI-PROJECT-18H02996
[Journal Article] Tumor endothelial heterogeneity in cancer progression2019
- Author(s)
  Nako Maishi, Dorcas A. Annan, Hiroshi Kikuchi, Yasuhiro Hida and Kyoko Hida
- Journal Title
  
  Cancers
  
  Volume: 11 Issue: 10 Pages: 1511-1511
- DOI
  10.3390/cancers11101511
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09715, KAKENHI-PROJECT-19K18549, KAKENHI-PROJECT-19K19220, KAKENHI-PROJECT-17K11823, KAKENHI-PROJECT-18H02996
[Journal Article] Development of immortalized human tumor endothelial cells from renal cancer2019
- Author(s)
  Nako Maishi, Hiroshi Kikuchi, Masumi Sato, Hiroko Nagao-Kitamoto, Dorcas A. Annan, Shogo Baba, Takayuki Hojo, Misa Yanagiya, Yusuke Ohba, Genichiro Ishii, Kenkichi Masutomi, Nobuo Shinohara, Yasuhiro Hida, Kyoko Hida
- Journal Title
  
  Int J Mol Sci
  
  Volume: 20 Issue: 18 Pages: 4595-4595
- DOI
  10.3390/ijms20184595
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09715, KAKENHI-PROJECT-19K22506, KAKENHI-PROJECT-19K18549, KAKENHI-PROJECT-19K19149, KAKENHI-PROJECT-19K19220, KAKENHI-PROJECT-19KK0198, KAKENHI-PUBLICLY-18H04850, KAKENHI-PUBLICLY-18H05092, KAKENHI-PUBLICLY-19H05411, KAKENHI-PROJECT-17H04016, KAKENHI-PROJECT-17K11116, KAKENHI-PROJECT-17K11823, KAKENHI-PROJECT-18H02996
[Presentation] Crosstalk of tumor cells and tumor endothelial cells by forming cell clusters promotes tumor metastasis2021
- Author(s)
  間石奈湖，梅山悠伊，菊地央，古御堂純，佐藤峰嘉，武田遼，Dorcas A. Annan, 篠原信雄，樋田泰浩，樋田京子
- Organizer
  第28回日本血管生物医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K10175
[Presentation] Glutamine metabolism facilitates tumor endothelial cell proliferation via redox homeostasis2020
- Author(s)
  Annan DA, Maishi N, Soga T, Hojo T, Hida Y, Hida K
- Organizer
  The 79th Annual Meeting og the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-19K19220
[Presentation] Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment2020
- Author(s)
  Annan DA, Maishi N, Soga T, Dawood RIH, Li C, Kikuchi H, Hojo T, Morimoto M, Kitamura T, Alam MT, Minowa K, Shinohara N, Nam JM, Hida Y and Hida K
- Organizer
  第6回北海道大学部局横断シンポジウム“若手研究者による生命と物質の融合を目指して！
- Data Source
  KAKENHI-PROJECT-19K19220
[Presentation] Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment E-poster2020
- Author(s)
  Annan DA, Maishi N, Soga T, Dawood RIH, Li C, Kikuchi H, Hojo T, Morimoto M, Kitamura T, Alam MT, Minowa K, Shinohara N, Nam JM, Hida Y, Hida K
- Organizer
  The 21st International Vascular Biology Meeting (IVBM 2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K19220
[Presentation] Carbonic anhydrase 2 (CAII) supports tumor endothelial cell survival in lactic acidosis2019
- Author(s)
  Dorcas A. Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Li Cong, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura, Mohammad Towfik Alam, Kazuyuki Minowa, Nobuo Shinohara, Yasuhiro Hida, Kyoko Hida
- Organizer
  28th Meeting of the Japanese Association of Metastasis Research
- Data Source
  KAKENHI-PROJECT-19K19220
[Presentation] Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis2019
- Author(s)
  orcas A. Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Li Cong, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura, Mohammad Towfik Alam, Kazuyuki Minowa, Nobuo Shinohara, Jin-Min Nam, Yasuhiro Hida, Kyoko Hida
- Organizer
  40Th Anniversary International Conference of the Noguchi Memorial Institute for Medical Research
- Data Source
  KAKENHI-PROJECT-19K19220
[Presentation] Carbonic anhydrase 2 (CAII) is essential for tumor endothelial cell proliferation under various metabolic conditions2019
- Author(s)
  Dorcas A. Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Li Cong, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura , Mohammad Towfik Alam , Kazuyuki Minowa, Nobuo Shinohara, Yasuhiro Hida, Kyoko Hida
- Organizer
  The 38th Sapporo International Cancer Symposium
- Data Source
  KAKENHI-PROJECT-19K19220
[Presentation] Carbonic anhydrase 2 (CAII) is essential for tumor endothelial cell proliferation2019
- Author(s)
  Dorcas A. Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Li Cong, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Nobuo Shinohara, Yasuhiro Hida, Kyoko Hida
- Organizer
  108th Annual Meeting of the Japanese Society of Pathology
- Data Source
  KAKENHI-PROJECT-19K19220
[]

1. Satoh Chiharu (50222013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 菊地奈湖 (00632423)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HIDA Kyoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
4. HIDA Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. MAISHI Nako

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
6. 大賀則孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 菊地央

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 櫻井遊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ANNAN DORCAS ANNAN DORCAS・AKUBAMUHYIA

Research Projects

Research Products

Co-Researchers

Targeting the Cancer Stem Cell in Vascular Niche for Oral Cancer Therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of glutamine metabolism in tumor endothelial cells to develop novel anti-cancer drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell-specific liposomal siRNA delivery system2022

Author(s)

Journal Title

Data Source

[Journal Article] Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell‐specific liposomal siRNA delivery system2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor Endothelial Cell-A Biological Tool for Translational Cancer Research2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] がん治療標的としての腫瘍血管内皮細胞の特異性2020

Author(s)

Journal Title

Data Source

[Journal Article] がん治療標的としての腫瘍血管内皮細胞の特異性2020

Author(s)

Journal Title

Data Source

[Journal Article] Chemotherapy-induced IL-8 upregulates MDR1/ABCB1 in tumor blood vessels and results in unfavorable outcome2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor endothelial heterogeneity in cancer progression2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of immortalized human tumor endothelial cells from renal cancer2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Crosstalk of tumor cells and tumor endothelial cells by forming cell clusters promotes tumor metastasis2021

Author(s)

Organizer

Data Source

[Presentation] Glutamine metabolism facilitates tumor endothelial cell proliferation via redox homeostasis2020

Author(s)

Organizer

Data Source

[Presentation] Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment2020

Author(s)

Organizer

Data Source