Kunimasa Kei 國政啓

Researcher Number	30838892
Other IDs
Affiliation (Current)	2025: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 呼吸器内科副部長
Affiliation (based on the past Project Information) *help	2022 – 2023: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 呼吸器内科副部長 2019 – 2021: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 呼吸器内科医長
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator SWI/SNF / 肺癌 / オルガノイド / SMARCA4 / ドライバー遺伝子変異 / 肺がん / ゲノムバイオマーカー / 次世代シーケンサー / ドライバー変異 / 腫瘍内不均一性 / EGFR / PD-L1

Elucidation of carcinogenesis mechanism and development of novel therapy using SMARCA4-deficient thoracic undifferentiated tumor organoidsPrincipal Investigator
- Principal Investigator
  
  國政啓
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Osaka International Cancer Institute
Genetic dissection of intratumor heterogeneity in lung cancer harboring driver mutations based on tumor PD-L1 expressionPrincipal Investigator
- Principal Investigator
  
  Kunimasa Kei
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Osaka International Cancer Institute

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report2022
- Author(s)
  Kunimasa Kei、Hirotsu Yosuke、Amemiya Kenji、Nakamura Harumi、Nishino Kazumi、Honma Keiichiro、Okami Jiro、Omata Masao、Kumagai Toru
- Journal Title
  
  JTO Clinical and Research Reports
  
  Volume: 3 Issue: 5 Pages: 100305-100305
- DOI
  10.1016/j.jtocrr.2022.100305
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03668, KAKENHI-PROJECT-19H01076, KAKENHI-PROJECT-19K17694
[Journal Article] Comparison of sampling methods for next generation sequencing for patients with lung cancer2022
- Author(s)
  Kunimasa Kei、Matsumoto Shingo、Nishino Kazumi、Honma Keiichiro、Maeda Noboru、Kuhara Hanako、Tamiya Motohiro、Inoue Takako、Kawamura Takahisa、Kimura Toru、Maniwa Tomohiro、Okami Jiro、Goto Koichi、Kumagai Toru
- Journal Title
  
  Cancer Medicine
  
  Volume: - Issue: 14 Pages: 2744-2754
- DOI
  10.1002/cam4.4632
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01076, KAKENHI-PROJECT-19K17694
[Journal Article] Late recurrence of lung adenocarcinoma harboring EGFR exon 20 insertion (A763_Y764insFQEA) mutation successfully treated with osimertinib2021
- Author(s)
  Kunimasa Kei、Nishino Kazumi、Kukita Yoji、Matsumoto Shingo、Kawachi Hayato、Kawamura Takahisa、Inoue Takako、Tamiya Motohiro、Honma Keiichiro、Sugimoto Naotoshi、Yamasaki Tomoyuki、Imamura Fumio、Goto Koichi、Kumagai Toru
- Journal Title
  
  Cancer Genetics
  
  Volume: 256-257 Pages: 57-61
- DOI
  10.1016/j.cancergen.2021.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17694
[Journal Article] Atezolizumab with bevacizumab, paclitaxel and carboplatin was effective for patients with SMARCA4-deficient thoracic sarcoma2021
- Author(s)
  Kawachi Hayato、Kunimasa Kei、Kukita Yoji、Nakamura Harumi、Honma Keiichiro、Kawamura Takahisa、Inoue Takako、Tamiya Motohiro、Kuhara Hanako、Nishino Kazumi、Mizote Yu、Akazawa Takashi、Tahara Hideaki、Kumagai Toru
- Journal Title
  
  Immunotherapy
  
  Volume: 13 Issue: 10 Pages: 799-806
- DOI
  10.2217/imt-2020-0311
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17694, KAKENHI-PROJECT-20K07045
[Journal Article] STK11 loss drives rapid progression in a breast cancer patient resulting in pulmonary tumor thrombotic microangiopathy2021
- Author(s)
  Fujisawa Fumie、Kunimasa Kei、Kano-Fujiwara Rieko、Sato Yoshiharu、Kusama Hiroki、Nishio Minako、Matsui Saki、Yoshinami Tetsuhiro、Kittaka Nobuyoshi、Nakamura Harumi、Nagata Shigenori、Honma Keiichiro、Yagi Toshinari、Nakayama Takahiro、Tamaki Yasuhiro、Imamura Fumio
- Journal Title
  
  Breast Cancer
  
  Volume: 28 Issue: 3 Pages: 765-771
- DOI
  10.1007/s12282-020-01200-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17694
[Journal Article] EML4-ALK fusion variant.3 and co-occurrent PIK3CA E542K mutation exhibiting primary resistance to three generations of ALK inhibitors2021
- Author(s)
  Kunimasa Kei、Hirotsu Yosuke、Kukita Yoji、Ueda Yumi、Sato Yoshiharu、Kimura Madoka、Otsuka Tomoyuki、Hamamoto Yuichiro、Tamiya Motohiro、Inoue Takako、Kawamura Takahisa、Nishino Kazumi、Amemiya Kenji、Goto Taichiro、Mochizuki Hitoshi、Honma Keiichiro、Omata Masao、Kumagai Toru
- Journal Title
  
  Cancer Genetics
  
  Volume: 256-257 Pages: 131-135
- DOI
  10.1016/j.cancergen.2021.05.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03668, KAKENHI-PROJECT-19K17694
[Journal Article] Conversion Surgery for Advanced Thoracic SMARCA4-Deficient Undifferentiated Tumor With Atezolizumab in Combination With Bevacizumab, Paclitaxel, and Carboplatin Treatment: A Case Report2021
- Author(s)
  Kunimasa Kei、Okami Jiro、Takenaka Satoshi、Honma Keiichiro、Kukita Yoji、Nagata Shigenori、Kawamura Takahisa、Inoue Takako、Tamiya Motohiro、Kuhara Hanako、Nishino Kazumi、Tahara Hideaki、Kumagai Toru
- Journal Title
  
  JTO Clinical and Research Reports
  
  Volume: 2 Issue: 11 Pages: 100235-100235
- DOI
  10.1016/j.jtocrr.2021.100235
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01076, KAKENHI-PROJECT-19K17694
[Journal Article] Multiregional sequence revealed SMARCA4 R1192C mutant clones acquired EGFR C797S mutation in the metastatic site of an EGFR-mutated NSCLC patient2020
- Author(s)
  Kunimasa Kei、Hirotsu Yosuke、Miyashita Yoshihiro、Goto Taichiro、Amemiya Kenji、Mochizuki Hitoshi、Samamoto Ikuko、Ohki Takamasa、Oyama Toshio、Honma Keiichiro、Imamura Fumio、Nishino Kazumi、Kumagai Toru、Omata Masao
- Journal Title
  
  Lung Cancer
  
  Volume: 148 Pages: 28-32
- DOI
  10.1016/j.lungcan.2020.07.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17694
[Journal Article] Genome analysis of peeling archival cytology samples detects driver mutations in lung cancer2020
- Author(s)
  Kunimasa Kei、Hirotsu Yosuke、Amemiya Kenji、Nagakubo Yuki、Goto Taichiro、Miyashita Yoshihiro, et al.
- Journal Title
  
  Cancer Medicine
  
  Volume: 00 Issue: 13 Pages: 1-11
- DOI
  10.1002/cam4.3089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17694
[Journal Article] Rapid progressive lung cancers harbouring multiple clonal driver mutations with big bang evolution model2020
- Author(s)
  Kunimasa Kei、Hirotsu Yosuke、Nakamura Harumi、Tamiya Motohiro、Iijima Yuki、Ishida Hiroto、Hamamoto Yuichiro、Maniwa Tomohiro、Kimura Toru、Nishino Kazumi、Goto Taichiro、Amemiya Kenji、Mochizuki Hitoshi、Oyama Toshio、Nakatsuka Shin-ichi、Kumagai Toru、Okami Jiro、Higashiyama Masahiko、Imamura Fumio、Omata Masao
- Journal Title
  
  Cancer Genetics
  
  Volume: 241 Pages: 51-56
- DOI
  10.1016/j.cancergen.2019.12.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17694, KAKENHI-PROJECT-19H01076
[Journal Article] Improvement strategies for successful next-generation sequencing analysis of lung cancer2020
- Author(s)
  Kunimasa Kei、Matsumoto Shingo、Nishino Kazumi、Nakamura Harumi、Kuhara Hanako、Tamiya Motohiro、Inoue Takako、Kawamura Takahisa、Kawachi Hayato、Kuno Kika、Kimura Toru、Maniwa Tomohiro、Okami Jiro、Nakatsuka Shin-ichi、Goto Koichi、Kumagai Toru
- Journal Title
  
  Future Oncology
  
  Volume: 16(22) Issue: 22 Pages: 1597-1606
- DOI
  10.2217/fon-2020-0332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17694, KAKENHI-PROJECT-19H01076
[Presentation] ABCP複合療法を6コース施行後に完全切除に成功した進行期SMARCA4-Deficient Undifferentiated Tumorの一例2021
- Author(s)
  國政啓
- Organizer
  第62回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17694
[Presentation] EGFR-A763_Y764insFGEA変異を有する晩期再発症例にOsimertinibが著効した一例2021
- Author(s)
  國政啓
- Organizer
  第113回日本肺癌学会関西支部学術集会
- Data Source
  KAKENHI-PROJECT-19K17694
[Presentation] Oncogenic mutation count as a prognostic predictor of 1st Pembrolizumab for PD-L1-positive NSCLC2021
- Author(s)
  國政啓
- Organizer
  第62回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17694
[Presentation] 抗PD-1抗体治療が著効したSubclonal EGFR mutationを有する肺腺癌症例2020
- Author(s)
  國政啓
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17694
[Presentation] 肺癌における保存細胞診検体と腫瘍組織検体の次世代シーケンサー解析結果一致率の検討2020
- Author(s)
  國政啓
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K17694
[Presentation] EGFR C797S, SMARCA4 R1192Cクローンがafatinib耐性転移巣を形成した一症例2020
- Author(s)
  國政啓
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17694
[Presentation] LC-SCRUM Japanでの次世代シーケンサーによる遺伝子解析成功率向上を目指した取り組み2020
- Author(s)
  國政啓
- Organizer
  第43回日本呼吸器内視鏡学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17694
[Presentation] 肺癌診療におけるゲノム解析と免疫療法2020
- Author(s)
  國政啓
- Organizer
  第82回日本臨床外科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17694
[Presentation] Multiregion sequenceによりSMARCA4変異クローンが転移先でEGFRC797S耐性変異を獲得したEGFR遺伝子変異症例2020
- Author(s)
  國政啓
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K17694
[Presentation] Rapid progressive multiple clonal driver lung adenocarcinomaの一例2019
- Author(s)
  國政啓
- Organizer
  第60回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17694

1. 弘津陽介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 岡見次郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kunimasa Kei 國政 啓

Research Projects

Research Products

Co-Researchers

Elucidation of carcinogenesis mechanism and development of novel therapy using SMARCA4-deficient thoracic undifferentiated tumor organoidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genetic dissection of intratumor heterogeneity in lung cancer harboring driver mutations based on tumor PD-L1 expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of sampling methods for next generation sequencing for patients with lung cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Late recurrence of lung adenocarcinoma harboring EGFR exon 20 insertion (A763_Y764insFQEA) mutation successfully treated with osimertinib2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Atezolizumab with bevacizumab, paclitaxel and carboplatin was effective for patients with SMARCA4-deficient thoracic sarcoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] STK11 loss drives rapid progression in a breast cancer patient resulting in pulmonary tumor thrombotic microangiopathy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EML4-ALK fusion variant.3 and co-occurrent PIK3CA E542K mutation exhibiting primary resistance to three generations of ALK inhibitors2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conversion Surgery for Advanced Thoracic SMARCA4-Deficient Undifferentiated Tumor With Atezolizumab in Combination With Bevacizumab, Paclitaxel, and Carboplatin Treatment: A Case Report2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiregional sequence revealed SMARCA4 R1192C mutant clones acquired EGFR C797S mutation in the metastatic site of an EGFR-mutated NSCLC patient2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome analysis of peeling archival cytology samples detects driver mutations in lung cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid progressive lung cancers harbouring multiple clonal driver mutations with big bang evolution model2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Improvement strategies for successful next-generation sequencing analysis of lung cancer2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] ABCP複合療法を6コース施行後に完全切除に成功した進行期SMARCA4-Deficient Undifferentiated Tumorの一例2021

Author(s)

Organizer

Data Source

[Presentation] EGFR-A763_Y764insFGEA変異を有する晩期再発症例にOsimertinibが著効した一例2021

Author(s)

Organizer

Data Source

[Presentation] Oncogenic mutation count as a prognostic predictor of 1st Pembrolizumab for PD-L1-positive NSCLC2021

Kunimasa Kei 國政啓