YAMASHITA Shugo 山下修吾

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Yamsahita Shugo 山下修吾

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Researcher Number	30845730
Other IDs
Affiliation (Current)	2025: 同志社女子大学, 薬学部, 特任助教
Affiliation (based on the past Project Information) *help	2025: 同志社女子大学, 薬学部, 特任助教 2019 – 2023: 同志社女子大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / 0801:Pharmaceutical sciences and related fields
Keywords	Principal Investigator 高分子ミセル / 体内動態制御 / 薬物動態学 / 薬学 / プロテオミクス / モデル＆シミュレーション / 数理モデル / 生体模倣システム / 生理学的薬物速度論 (PBPK) / タンパク質コロナ … More / 疎水性イオン対 / PK/PD / コンパートメントモデル / 腫瘍組織内動態 / デンドロン / ポリアミノ酸 / ドラッグデリバリーシステム / ポリペプチド / FGF23 / CKD-MBD / 熱応答性 / ポリペプチドミセル / DDS Less

生体模倣システムを基盤とした高分子ミセル体内動態予測を可能とする数理モデルの構築Principal Investigator
- Principal Investigator
  
  山下修吾
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Doshisha Women's College of Liberal Arts
Impact of inner core composition to and hard protein corona formed on polymeric micellesPrincipal Investigator
- Principal Investigator
  
  山下修吾
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Doshisha Women's College of Liberal Arts
Establishment of a Pharmacokinetics-Pharmacodynamics modeling evaluation system to enable function vs. efficacy analysis of anticancer drug delivery systemsPrincipal Investigator
- Principal Investigator
  
  Yamashita Shugo
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Doshisha Women's College of Liberal Arts
Development of bone-targeting, thermal-sensitive micelles for treatment of CKD-MBDPrincipal Investigator
- Principal Investigator
  
  Yamsahita Shugo
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Doshisha Women's College of Liberal Arts

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Variations in the inner core affect the pharmacokinetics of indomethacin-encapsulated polymeric micelles2024
- Author(s)
  Yamashita Shugo、Azuma Karen、Tanaka Yuka、Kimura Shunsuke、Kiriyama Akiko
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 654 Pages: 123933-123933
- DOI
  10.1016/j.ijpharm.2024.123933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14423
[Journal Article] Evaluation of anticancer effect of micelle-encapsulated doxorubicin using gamma-distributed delay model2024
- Author(s)
  Yamashita Shugo、Kume Aomi、Tsujimoto Nao、Nozaki Saya、Kimura Shunsuke、Kiriyama Akiko
- Journal Title
  
  Journal of Drug Delivery Science and Technology
  
  Volume: 91 Pages: 105244-105244
- DOI
  10.1016/j.jddst.2023.105244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14423
[Journal Article] Pharmacokinetic/Pharmacodynamic Models of an Alzheimer’s Drug, Donepezil, in Rats2022
- Author(s)
  Kiriyama Akiko、Kimura Shunsuke、Yamashita Shugo
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 51 Issue: 3 Pages: 329-337
- DOI
  10.1124/dmd.122.001061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06697, KAKENHI-PROJECT-21K15324
[Journal Article] Phosphorylated Serine-Modified Polyamidoamine Dendrimer as an Osteoid Surface-Targeting Drug Carrier2022
- Author(s)
  Yamashita Shugo、Katsumi Hidemasa、Sakane Toshiyasu、Yamamoto Akira
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 19 Issue: 7 Pages: 2573-2582
- DOI
  10.1021/acs.molpharmaceut.2c00271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15324
[Journal Article] アミノ酸修飾を利用したターゲティング型ドラッグデリバリーシステムの開発2021
- Author(s)
  勝見英正、山下修吾、森下将輝、山本　昌
- Journal Title
  
  粉体工学
  
  Volume: 58 Pages: 376-383
- NAID
  130008069671
- Data Source
  KAKENHI-PROJECT-21K15324
[Journal Article] Dendrimer-based micelles with highly potent targeting to sites of active bone turnover for the treatment of bone metastasis2020
- Author(s)
  Shugo Yamashita、Hidemasa Katsumi、Erika Shimizu、Yuto Nakao、Ayane Yoshioka、Minako Fukui、Hiroyuki Kimura、Toshiyasu Sakane、Akira Yamamoto
- Journal Title
  
  European Journal of Pharmaceutics and Biopharmaceutics
  
  Volume: 157 Pages: 85-96
- DOI
  10.1016/j.ejpb.2020.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H04473, KAKENHI-PROJECT-19K23812
[Presentation] マウスにおけるダカルバジンの体内動態の基礎的検討2024
- Author(s)
  後口実希、今西梓、喜里山暁子、木村峻輔、山下修吾
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K14423
[Presentation] 新たなホウ素中性子捕捉療法を目指したPEG-polyBPAの開発－PEG分子量が及ぼす体内動態への影響－2024
- Author(s)
  東出明香里、山下修吾、坂田翠、木村峻輔、根木滋、喜里山暁子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K14423
[Presentation] ドネペジルとシロスタゾールの併用がドネペジルの組織移行性に及ぼす影響について2024
- Author(s)
  比連崎良美、岡本星里奈、山下修吾、木村峻輔、喜里山暁子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K14423
[Presentation] ホウ素中性子捕捉療法能を兼ね備えた薬物輸送担体PEG-polyBPAの開発－体内動態に及ぼすBPA重合度の影響－2024
- Author(s)
  坂田翠、山下修吾、東出明香里、木村峻輔、根木滋、喜里山暁子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K14423
[Presentation] An approach using a gamma-distributed delay model for predictive pharmacokinetic-pharmacodynamic modeling after administration of doxorubicin-encapsulated polymeric micelles2023
- Author(s)
  Shugo Yamashita, Shunsuke Kimura, Akiko Kiriyama
- Organizer
  25th North American International Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14423
[Presentation] 内核組成の異なるインドメタシン封入高分子ミセル表面に形成されるタンパク質コロナの変化2023
- Author(s)
  山下修吾、東かれん、田中優花、木村峻輔、喜里山暁子
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K15324
[Presentation] 単離腫瘍灌流モデルを用いたコンパートメントモデル解析による放出制御型高分子ミセルの機能評価2023
- Author(s)
  山下修吾、木村峻輔、喜里山暁子
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14423
[Presentation] 単離腫瘍灌流法を用いたコンパートメントモデル解析によるターゲティング型高分子ミセルの機能評価2023
- Author(s)
  山下修吾、木村峻輔、喜里山暁子
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-23K14423
[Presentation] アルツハイマー型認知症治療薬・ドネペジルのラットにおけるPK/PD解析2023
- Author(s)
  喜里山暁子、桝谷祐香梨、松尾真奈、比連崎好美、山下修吾、木村峻輔
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K15324
[Presentation] Evaluation of active-targeting polymeric micelle function by gamma distributed delay compartmental analysis using a tissue-isolated tumor perfusion system2023
- Author(s)
  Shugo Yamashita, Shunsuke Kimura, Akiko Kiriyama
- Organizer
  2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14423
[Presentation] PEG-ペプチド高分子ミセルの体内動態に及ぼす疎水性イオン対パターンの影響2022
- Author(s)
  山下修吾、東かれん、田中優花、木村峻輔、喜里山暁子
- Organizer
  日本薬学会第142年会 (オンライン)
- Data Source
  KAKENHI-PROJECT-21K15324
[Presentation] インドメタシン封入高分子ミセルの体内動態に及ぼす疎水性イオンペアリングパターンの影響2022
- Author(s)
  田中優花、山下修吾、東かれん、木村峻輔、喜里山暁子
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-21K15324
[Presentation] 溶解度に依存しない新規膜透過メカニズムを応用した粉末吸入製剤の可能性2022
- Author(s)
  木村峻輔、山下修吾、喜里山暁子
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-21K15324
[Presentation] 慢性腎臓病に伴う-骨ミネラル代謝異常治療を目的とした温熱感受性骨ターゲティング型ミセルの開発2021
- Author(s)
  山下修吾、勝見英正、木村峻輔、喜里山暁子
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-21K15324
[Presentation] 新規膜透過機構を基盤とするシプロフロキサシン粉末吸入製剤の開発2021
- Author(s)
  木村峻輔、犬伏紗和子、山下修吾、喜里山暁子
- Organizer
  第37回日本DDS学会学術集会 (千葉)
- Data Source
  KAKENHI-PROJECT-21K15324
[Presentation] CKD-MBD 治療を目的とするアスパラギン酸-フェニルアラニンコポリペプチドミセルの開発2021
- Author(s)
  山下修吾, 勝見英正, 木村峻輔, 喜里山暁子
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19K23812

1. KIMURA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 喜里山暁子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 勝見英正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 山本晶

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMASHITA Shugo 山下 修吾

Yamsahita Shugo 山下 修吾

Research Projects

Research Products

Co-Researchers

生体模倣システムを基盤とした高分子ミセル体内動態予測を可能とする数理モデルの構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impact of inner core composition to and hard protein corona formed on polymeric micellesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a Pharmacokinetics-Pharmacodynamics modeling evaluation system to enable function vs. efficacy analysis of anticancer drug delivery systemsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of bone-targeting, thermal-sensitive micelles for treatment of CKD-MBDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Variations in the inner core affect the pharmacokinetics of indomethacin-encapsulated polymeric micelles2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of anticancer effect of micelle-encapsulated doxorubicin using gamma-distributed delay model2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pharmacokinetic/Pharmacodynamic Models of an Alzheimer’s Drug, Donepezil, in Rats2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylated Serine-Modified Polyamidoamine Dendrimer as an Osteoid Surface-Targeting Drug Carrier2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] アミノ酸修飾を利用したターゲティング型ドラッグデリバリーシステムの開発2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Dendrimer-based micelles with highly potent targeting to sites of active bone turnover for the treatment of bone metastasis2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] マウスにおけるダカルバジンの体内動態の基礎的検討2024

Author(s)

Organizer

Data Source

[Presentation] 新たなホウ素中性子捕捉療法を目指したPEG-polyBPAの開発－PEG分子量が及ぼす体内動態への影響－2024

Author(s)

Organizer

Data Source

[Presentation] ドネペジルとシロスタゾールの併用がドネペジルの組織移行性に及ぼす影響について2024

Author(s)

Organizer

Data Source

[Presentation] ホウ素中性子捕捉療法能を兼ね備えた薬物輸送担体PEG-polyBPAの開発－体内動態に及ぼすBPA重合度の影響－2024

Author(s)

Organizer

Data Source

[Presentation] An approach using a gamma-distributed delay model for predictive pharmacokinetic-pharmacodynamic modeling after administration of doxorubicin-encapsulated polymeric micelles2023

Author(s)

Organizer

Data Source

[Presentation] 内核組成の異なるインドメタシン封入高分子ミセル表面に形成されるタンパク質コロナの変化2023

YAMASHITA Shugo 山下修吾

Yamsahita Shugo 山下修吾