Kuwahara Miho 桑原実穂

Researcher Number	30868287
Other IDs
Affiliation (Current)	2025: 岡山大学, 医歯薬学域, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 岡山大学, 医歯薬学域, 助教 2020: 岡山大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 57050:Prosthodontics-related Except Principal Investigator Basic Section 57050:Prosthodontics-related
Keywords	Principal Investigator 関節軟骨 / 細胞老化 / 軟骨細胞 / 軟骨 / CCN3 / 加齢 / 細胞老化関連分泌形質（SASP） / 細胞周期停止因子 / 変形性関節症 / 酸化ストレス … More Except Principal Investigator … More 認知機能 / 咀嚼筋 / マイオカイン / 歯根膜 / 記憶 / 海馬 / 青斑 / ラット / 咬合支持 / 青斑核 / ノルアドレナリン Less

下顎頭軟骨変性を制御する分子メカニズムの解明Principal Investigator
- Principal Investigator
  
  桑原実穂
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Okayama University
Effects of myokines on cognitive decline caused by loss of occlusal support and decline in masticatory function
- Principal Investigator
  
  原哲也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Okayama University
Elucidation of a Novel Mechanism for Controlling Aging of Temporomandibular Joint CartilagePrincipal Investigator
- Principal Investigator
  
  Kuwahara Miho
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Okayama University
Mechanism of hippocampal pyramidal cell degeneration by reduced periodontal ligament stimulation: Neural pathway via the locus coeruleus
- Principal Investigator
  
  Hara Tetsuya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Okayama University
Mechanism of chondrocyte senescence mediated by CCN3Principal Investigator
- Principal Investigator
  
  Kuwahara Miho
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Okayama University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Newly designed flat surface artificial tongue system for speech improvement in glossectomy patients: A preliminary study2022
- Author(s)
  Nagatsuka Hiroaki、Kawakami Shigehisa、Kuwahara Miho、Kubota Chie、Kodama Naoki、Minagi Shogo
- Journal Title
  
  J Prosthodont Res
  
  Volume: 66 Issue: 1 Pages: 87-92
- DOI
  10.2186/jpr.JPR_D_20_00230
- NAID
  130008140808
- ISSN
  1883-1958, 1883-9207
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18601
[Journal Article] Lack of occlusal support did not impact amyloid β deposition in APP knock-in mice2022
- Author(s)
  Murakami Asuka、Hara Tetsuya、Yamada-Kubota Chie、Kuwahara Miho、Ichikawa Tomoka、Minagi Shogo
- Journal Title
  
  J Prosthodont Res
  
  Volume: 66 Issue: 1 Pages: 161-166
- DOI
  10.2186/jpr.JPR_D_20_00205
- NAID
  130008140799
- ISSN
  1883-1958, 1883-9207
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18601, KAKENHI-PROJECT-21K17065
[Journal Article] CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage2020
- Author(s)
  Kuwahara Miho、Kadoya Koichi、Kondo Sei、Fu Shanqi、Miyake Yoshiko、Ogo Ayako、Ono Mitsuaki、Furumatsu Takayuki、Nakata Eiji、Sasaki Takako、Minagi Shogo、Takigawa Masaharu、Kubota Satoshi、Hattori Takako
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 20 Pages: 7556-7556
- DOI
  10.3390/ijms21207556
- NAID
  120006900771
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10150, KAKENHI-PROJECT-20K20611, KAKENHI-PROJECT-19K17399, KAKENHI-PROJECT-20K18601, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-19K22716
[Presentation] 軟骨組織の加齢とともに発現が上昇するCCN3は、その発現上昇と軟骨変性度が年齢、荷重の有無に関わらず相関する2023
- Author(s)
  桑原実穂, 廣瀬一樹, 近藤星, Fu Shanqi, 大野充昭, 古松毅之, 中田英二, 滝川正春, 久保田聡, 服部高子
- Organizer
  生化学会
- Data Source
  KAKENHI-PROJECT-22K17137
[Presentation] 咬合支持の喪失による三叉神経中脳路核と青斑核の変化と認知機能低下のメカニズム2023
- Author(s)
  加藤（市川）知香，原哲也，窪田（山田）知枝，角谷（桑原）実穂，皆木省吾
- Organizer
  日本補綴歯科学会第132回学術大会
- Data Source
  KAKENHI-PROJECT-21K10000
[Presentation] CCN3は関節軟骨の加齢性変性を促進する2021
- Author(s)
  桑原実穂、近藤　星、Fu Shanqi, 大野充昭、古松毅之、中田英二、滝川正春、久保田聡、服部高子
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-20K18601
[Presentation] 軟骨細胞老化促進因子としてのCCN32021
- Author(s)
  桑原実穂、武内聡子、近藤　星、Fu Shanqi, 大野充昭、古松毅之、中田英二、滝川正春、久保田聡、服部高子
- Organizer
  第33回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-20K18601
[Presentation] メトホルミンの軟骨細胞分化に対する作用の解析2020
- Author(s)
  近藤星, 服部高子, 桑原実穂, Fu Shanqi, 森谷徳文, 飯田征二, 滝川正春, 久保田聡
- Organizer
  第41回岡山歯学会
- Data Source
  KAKENHI-PROJECT-20K18601
[Presentation] 腸内細菌の有無が胎児内軟骨成長に与える影響2020
- Author(s)
  内田瑶子、服部高子、福原大樹、Fu Shanqi、近藤　星、桑原実穂、イスラム　モニルル、片岡広太、江國大輔、久保田聡、森田　学
- Organizer
  第33回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-20K18601
[Presentation] non-coding RNAを介したメトホルミンの抗線維化作用の解析2020
- Author(s)
  近藤星、服部高子、桑原実穂、Fu Shanqi、西田崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K18601
[Presentation] 軟骨細胞老化促進因子としてのCCN32020
- Author(s)
  桑原実穂、武内聡子、近藤　星、Fu Shanqi, 大野充昭、古松毅之、中田英二、滝川正春、久保田聡、服部高子
- Organizer
  第33回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-20K18601
[Presentation] Effect of melatonin on rhythmic gene expression in human articular chondrocytes.2020
- Author(s)
  Fu, S., Kuwahara, M., Uchida, Y., Hyashi, D., Shimomura, Y., Takagaki, A., Nishida, T., Nakata, E., Furumatsu, T., Kondo, S., Maruyama, Y., Hattori, A., Kubota, S., Hattori, T.
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K18601
[Presentation] 軟骨組織におけるCCN3の老化促進作用2020
- Author(s)
  桑原実穂、近藤星、Fu Shanqi、大野充昭、古松毅之、中田英二、皆木省吾、滝川正春、久保田聡、服部高子
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K18601
[Presentation] Effect of melatonin on rhythmic gene expression in human articular cartilage.2020
- Author(s)
  Fu, S., Kuwahara, M., Uchida, Y., Kondo, S., Hyashi, D., Shimomura, Y., Takagaki, A., Nishida, T., Maruyama, Y., Ikegami, M., Hattori, A., Kubota, S., Hattori, T.
- Organizer
  第38回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-20K18601

1. Hara Tetsuya (60238160)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 村上明日香 (80885426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 丸尾幸憲 (60314697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 服部高子 (00228488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 角谷宏一 (30991385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 久保田聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuwahara Miho 桑原 実穂

Research Projects

Research Products

Co-Researchers

下顎頭軟骨変性を制御する分子メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of myokines on cognitive decline caused by loss of occlusal support and decline in masticatory function

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of a Novel Mechanism for Controlling Aging of Temporomandibular Joint CartilagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of hippocampal pyramidal cell degeneration by reduced periodontal ligament stimulation: Neural pathway via the locus coeruleus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of chondrocyte senescence mediated by CCN3Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Newly designed flat surface artificial tongue system for speech improvement in glossectomy patients: A preliminary study2022

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Lack of occlusal support did not impact amyloid β deposition in APP knock-in mice2022

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] 軟骨組織の加齢とともに発現が上昇するCCN3は、その発現上昇と軟骨変性度が年齢、 荷重の有無に関わらず相関する2023

Author(s)

Organizer

Data Source

[Presentation] 咬合支持の喪失による三叉神経中脳路核と青斑核の変化と認知機能低下のメカニズム2023

Author(s)

Organizer

Data Source

[Presentation] CCN3は関節軟骨の加齢性変性を促進する2021

Author(s)

Organizer

Data Source

[Presentation] 軟骨細胞老化促進因子としてのCCN32021

Author(s)

Organizer

Data Source

[Presentation] メトホルミンの軟骨細胞分化に対する作用の解析2020

Author(s)

Organizer

Data Source

[Presentation] 腸内細菌の有無が胎児内軟骨成長に与える影響2020

Author(s)

Organizer

Data Source

Kuwahara Miho 桑原実穂

[Presentation] 軟骨組織の加齢とともに発現が上昇するCCN3は、その発現上昇と軟骨変性度が年齢、荷重の有無に関わらず相関する2023