Yamaguchi Junji 山口隼司

Researcher Number	30875282
Other IDs	https://orcid.org/0009-0002-9199-9931
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 順天堂大学, 大学院医学研究科, 助教 2020: 順天堂大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 46020:Anatomy and histopathology of nervous system-related / 0802:Biomedical structure and function and related fields
Keywords	Principal Investigator リソソーム / Atg7 / p62 / オートファジー / カテプシンD / 電子顕微鏡 / NBR1 / 神経性セロイドリポフスチン症

リソソーム蓄積症の疾患誘導に関わるリソソーム膜損傷と細胞障害機序の解明Principal Investigator
- Principal Investigator
  
  山口隼司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University
Investigation of the role of autophagy in Neuronal Ceroid LipofuscinosesPrincipal Investigator
- Principal Investigator
  
  Junji Yamaguchi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Juntendo University
Investigation of the new role of autophagy in the loss of lysosomal proteasePrincipal Investigator
- Principal Investigator
  
  Yamaguchi Junji
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0802:Biomedical structure and function and related fields
- Research Institution
  Juntendo University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Recent advances in in-resin correlative light and electron microscopy of Epon-embedded cells2023
- Author(s)
  Tanida Isei, Yamaguchi Junji, Suzuki Chigure, Kakuta Soichiro, Uchiyama Yasuo
- Journal Title
  
  Microscopy
  
  Volume: 72 Issue: 5 Pages: 383-387
- DOI
  10.1093/jmicro/dfad028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07376, KAKENHI-PROJECT-21K15198, KAKENHI-PUBLICLY-22H04652
[Journal Article] Application of immuno- and affinity labeling with fluorescent dyes to in-resin CLEM of Epon-embedded cells2023
- Author(s)
  Tanida Isei, Yamaguchi Junji, Suzuki Chigure, Kakuta Soichiro, Uchiyama Yasuo
- Journal Title
  
  Heliyon
  
  Volume: 9 Issue: 6 Pages: e17394-e17394
- DOI
  10.1016/j.heliyon.2023.e17394
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07376, KAKENHI-PROJECT-21K15198, KAKENHI-PUBLICLY-22H04652
[Journal Article] TUNEL‐positive structures in activated microglia and SQSTM1/p62‐positive structures in activated astrocytes in the neurodegenerative brain of a CLN10 mouse model2023
- Author(s)
  Mitsui Shun, Yamaguchi Junji, Suzuki Chigure, Uchiyama Yasuo, Tanida Isei
- Journal Title
  
  Glia
  
  Volume: 71 Issue: 12 Pages: 2753-2769
- DOI
  10.1002/glia.24449
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07376, KAKENHI-PROJECT-21K15198, KAKENHI-PUBLICLY-22H04652
[Journal Article] In-resin CLEM of Epon-embedded cells using proximity labeling2022
- Author(s)
  Sanada Takahito、Yamaguchi Junji、Furuta Yoko、Kakuta Soichiro、Tanida Isei、Uchiyama Yasuo
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 11130-11130
- DOI
  10.1038/s41598-022-15438-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15198, KAKENHI-PUBLICLY-22H04652
[Journal Article] Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins2022
- Author(s)
  Suzuki Chigure、Yamaguchi Junji、Sanada Takahito、Oliva Trejo Juan Alejandro、Kakuta Souichirou、Shibata Masahiro、Tanida Isei、Uchiyama Yasuo
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 11662-11615
- DOI
  10.1038/s41598-022-15805-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07376, KAKENHI-PROJECT-21K15198, KAKENHI-PUBLICLY-22H04652
[Journal Article] <scp>GPHR</scp> ‐mediated acidification of the Golgi lumen is essential for cholesterol biosynthesis in the brain2022
- Author(s)
  Sou Yu‐shin、Yamaguchi Junji、Kameda Hiroshi、Masuda Keisuke、Maeda Yusuke、Uchiyama Yasuo、Koike Masato
- Journal Title
  
  FEBS Letters
  
  Volume: 596 Issue: 22 Pages: 2873-2888
- DOI
  10.1002/1873-3468.14491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15198, KAKENHI-PROJECT-20K07743
[Journal Article] Membranous Structures Directly Come in Contact With p62/SQSTM1 Bodies2021
- Author(s)
  Tanida Isei、Haruta Tomohiro、Suga Mitsuo、Takei Shunsuke、Takebe Akira、Furuta Yoko、Yamaguchi Junji、Oliva Trejo Juan Alejandro、Kakuta Soichiro、Uchiyama Yasuo
- Journal Title
  
  Journal of Histochemistry & Cytochemistry
  
  Volume: 69 Issue: 6 Pages: 407-414
- DOI
  10.1369/00221554211011423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22744, KAKENHI-PUBLICLY-20H05342, KAKENHI-PROJECT-21K15198
[Journal Article] Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice2021
- Author(s)
  Sato Shigeto、Noda Sachiko、Torii Satoru、Amo Taku、Ikeda Aya、Funayama Manabu、Yamaguchi Junji、Fukuda Takahiro、Kondo Hiromi、Tada Norihiro、Arakawa Satoko、Watanabe Masahiko、Uchiyama Yasuo、Shimizu Shigeomi、Hattori Nobutaka
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 30 Issue: 6 Pages: 443-453
- DOI
  10.1093/hmg/ddab057
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07878, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17K09769, KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-20K22744, KAKENHI-PLANNED-17H06414, KAKENHI-PUBLICLY-20H05314, KAKENHI-PROJECT-18K05691, KAKENHI-PROJECT-20K07353, KAKENHI-PROJECT-21K15198, KAKENHI-PROJECT-20H00467
[Journal Article] Three-Dimensional Architecture of Glomerular Endothelial Cells Revealed by FIB-SEM Tomography2021
- Author(s)
  Kawasaki Yuto、Hosoyamada Yasue、Miyaki Takayuki、Yamaguchi Junji、Kakuta Soichiro、Sakai Tatsuo、Ichimura Koichiro
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 9 Pages: 653472-653472
- DOI
  10.3389/fcell.2021.653472
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K00276, KAKENHI-PROJECT-20K22744, KAKENHI-PROJECT-21K15198
[Journal Article] Two-color in-resin CLEM of Epon-embedded cells using osmium resistant green and red fluorescent proteins2020
- Author(s)
  Tanida Isei、Furuta Yoko、Yamaguchi Junji、Kakuta Soichiro、Oliva Trejo Juan Alejandro、Uchiyama Yasuo
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 21871-21871
- DOI
  10.1038/s41598-020-78879-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22744, KAKENHI-PUBLICLY-20H05342
[Presentation] カテプシンD欠損マウス神経細胞内に蓄積する異常リソソームを標的とした選択的オートファジーの解析2023
- Author(s)
  山口隼司
- Organizer
  第128回　日本解剖学会
- Data Source
  KAKENHI-PROJECT-21K15198
[Presentation] 中枢神経系特異的CTSD / Atg7両欠損マウスを用いた神経細胞内不良リソソームの品質管理機構の解明2022
- Author(s)
  山口　隼司、鈴木ちぐれ、角田宗一郎、眞田貴人、三井駿、谷田以誠、内山安男
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-20K22744
[Presentation] 中枢神経系特異的CTSD / Atg7両欠損マウスを用いた神経細胞内不良リソソームの品質管理機構の解明2022
- Author(s)
  山口　隼司
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-21K15198

1. FUNAYAMA Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. AMO Taku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. SUZUKI Chigure

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
4. 坂井建雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Junji 山口 隼司

Research Projects

Research Products

Co-Researchers

リソソーム蓄積症の疾患誘導に関わるリソソーム膜損傷と細胞障害機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the role of autophagy in Neuronal Ceroid LipofuscinosesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the new role of autophagy in the loss of lysosomal proteasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Recent advances in in-resin correlative light and electron microscopy of Epon-embedded cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Application of immuno- and affinity labeling with fluorescent dyes to in-resin CLEM of Epon-embedded cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TUNEL‐positive structures in activated microglia and SQSTM1/p62‐positive structures in activated astrocytes in the neurodegenerative brain of a CLN10 mouse model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In-resin CLEM of Epon-embedded cells using proximity labeling2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <scp>GPHR</scp> ‐mediated acidification of the Golgi lumen is essential for cholesterol biosynthesis in the brain2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Membranous Structures Directly Come in Contact With p62/SQSTM1 Bodies2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three-Dimensional Architecture of Glomerular Endothelial Cells Revealed by FIB-SEM Tomography2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two-color in-resin CLEM of Epon-embedded cells using osmium resistant green and red fluorescent proteins2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] カテプシンD欠損マウス神経細胞内に蓄積する異常リソソームを標的とした選択的オートファ ジーの解析2023

Author(s)

Organizer

Data Source

[Presentation] 中枢神経系特異的CTSD / Atg7両欠損マウスを用いた神経細胞内不良リソソームの品質管理機構の解明2022

Author(s)

Organizer

Data Source

Yamaguchi Junji 山口隼司

[Presentation] カテプシンD欠損マウス神経細胞内に蓄積する異常リソソームを標的とした選択的オートファジーの解析2023