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SEMBA Takashi  千場 隆

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Semba Takashi  千場 隆

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Researcher Number 30897682
Other IDs
Affiliation (Current) 2025: 公益財団法人がん研究会, がん研究所 発がん研究部, 研究員
2025: 熊本大学, 大学院生命科学研究部(医), 客員講師
Affiliation (based on the past Project Information) *help 2023 – 2024: 公益財団法人がん研究会, がん研究所 発がん研究部, 研究員
2021 – 2024: 熊本大学, 国際先端医学研究機構, 客員講師
Review Section/Research Field
Principal Investigator
Basic Section 55040:Respiratory surgery-related
Except Principal Investigator
Basic Section 55040:Respiratory surgery-related / Basic Section 55010:General surgery and pediatric surgery-related
Keywords
Principal Investigator
細胞間相互作用 / CAFs / シングルセルマルチオミクス / 腫瘍微小環境 / C-JUN N-terminal Kinase / 腫瘍関連線維芽細胞 / 非小細胞肺癌 / 遺伝子改変マウス / LY6D / 癌幹細胞 / 肺癌 … More
Except Principal Investigator
… More 非小細胞肺癌 / 線維化 / 胃癌 / 遠隔臓器連関 / 血小板 / PDGF / CAFs / 腫瘍間質 / Ly6d / LY6D / 好中球 / 肺癌 Less
  • Research Projects

    (5 results)
  • Research Products

    (10 results)
  • Co-Researchers

    (7 People)
  •  Development of novel antibody drugs for non-small cell lung cancer based on surface molecular screening

    • Principal Investigator
      鈴木 実
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Kumamoto University
  •  JNKシグナル制御による免疫抑制的腫瘍微小環境の克服Principal Investigator

    • Principal Investigator
      千場 隆
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Japanese Foundation for Cancer Research
  •  遠隔臓器コミュニケーションによるスキルス胃癌線維化メカニズムの解明

    • Principal Investigator
      安田 忠仁
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Japanese Foundation for Cancer Research
  •  非小細胞肺癌における腫瘍関連好中球浸潤の分子メカニズムとその臨床的意義の解明

    • Principal Investigator
      池田 公英
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Kumamoto University
  •  Investigation of the functions and the roles of LY6D as a novel cancer stem-cell marker of non-small cell lung cancerPrincipal Investigator

    • Principal Investigator
      Semba Takashi
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Kumamoto University

All 2024 2023 2022

All Journal Article Presentation

  • [Journal Article] Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment2024

    • Author(s)
      Yonemura A、Semba T、Zhang J、Fan Y、Yasuda-Yoshihara N、Wang H、Uchihara T、Yasuda T、Nishimura A、Fu L、Hu X、Wei F、Kitamura F、Akiyama T、Yamashita K、Eto K、Iwagami S、Iwatsuki M、Miyamoto Y、Matsusaki K、Yamasaki J、Nagano O、Saya H、Song S、Tan P、Baba H、Ajani Jaffer A.、Ishimoto T
    • Journal Title

      Cell Reports

      Volume: 43 Issue: 1 Pages: 113613-113613

    • DOI

      10.1016/j.celrep.2023.113613

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K14572, KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-23K08113, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23H00410, KAKENHI-PROJECT-23K27689
  • [Journal Article] RAC1-mediated integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination2024

    • Author(s)
      Zhang Jun、Fu Lingfeng、Wang Huaitao、Yonemura Atsuko、Semba Takashi、Yasuda-Yoshihara Noriko、Nishimura Akiho、Tajiri Takuya、Tong Yilin、Yasuda Tadahito、Uchihara Tomoyuki、Yamazaki Masaya、Okamoto Yuya、Yamasaki Juntaro、Nagano Osamu、Baba Hideo、Ishimoto Takatsugu
    • Journal Title

      Cancer Letters

      Volume: 591 Pages: 216901-216901

    • DOI

      10.1016/j.canlet.2024.216901

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K14572, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27689
  • [Journal Article] Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer2023

    • Author(s)
      Kitamura F、Semba T、Yasuda-Yoshihara N、Yamada K、Nishimura A、Yamasaki J、Nagano O、Yasuda T、Yonemura A、Tong Y、Wang H、Akiyama T、Matsumura K、Uemura N、Itoyama R、Bu L、Fu L、Hu X、Wei F、Mima K、Imai K、Hayashi H、Yamashita Y、Miyamoto Y、Baba H、Ishimoto T
    • Journal Title

      JCI Insight

      Volume: 8 Issue: 20

    • DOI

      10.1172/jci.insight.163022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14572, KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-22K08756, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-22K16537, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463, KAKENHI-PROJECT-23K27689
  • [Journal Article] A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts2023

    • Author(s)
      Wei F , Uchihara T , Yonemura A , Yasuda-Yoshihara N , Yasuda T , Semba T , Fukuda M , Akiyama T , Kitamura F , Kariya R , Yamasaki J , Aihara K , Yamashita K , Nagano O , Okada S , Baba H , Ishimoto T
    • Journal Title

      The FEBS Journal

      Volume: - Issue: 10 Pages: 2604-2615

    • DOI

      10.1111/febs.16712

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-20K08961, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-23K06745, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463
  • [Journal Article] Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion2023

    • Author(s)
      Hu X、Yasuda T、Yasuda-Yosihara N、Yonemura A、Umemoto T、Nakachi Y、Yamashita K、Semba T、Arima K、Uchihara T、Nishimura A、Bu L、Fu Li、Wei F、Zhang J、Tong Y、Wang H、Iwamoto K、Fukuda T、Nakagawa H、Taniguchi K、Miyamoto Y、Baba H、Ishimoto T
    • Journal Title

      JHEP Reports

      Volume: 5 Issue: 12 Pages: 100892-100892

    • DOI

      10.1016/j.jhepr.2023.100892

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21K08686, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-20H03758, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K27463, KAKENHI-PROJECT-23K27669
  • [Journal Article] IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment2023

    • Author(s)
      Zhang Jun、Fu Lingfeng、Yasuda-Yoshihara Noriko、Yonemura Atsuko、Wei Feng、Bu Luke、Hu Xichen、Akiyama Takahiko、Kitamura Fumimasa、Yasuda Tadahito、Semba Takashi、Uchihara Tomoyuki、Itoyama Rumi、Yamashita Kohei、Eto Kojiro、Iwagami Shiro、Yashiro Masakazu、Komohara Yoshihiro、Baba Hideo、Ishimoto Takatsugu
    • Journal Title

      Gastric Cancer

      Volume: 26 Issue: 2 Pages: 187-202

    • DOI

      10.1007/s10120-022-01352-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463
  • [Journal Article] Identification of the JNK-Active Triple-Negative Breast Cancer Cluster Associated With an Immunosuppressive Tumor Microenvironment2022

    • Author(s)
      Semba, T., Wang, X., Xie, X., Cohen, E. N., Reuben, J. M., Dalby, K. N., Long, J. P., Phi, L. T. H., Tripathy, D., Ueno, N. T.
    • Journal Title

      JNCI: Journal of the National Cancer Institute

      Volume: 114 Issue: 1 Pages: 97-108

    • DOI

      10.1093/jnci/djab128

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16515
  • [Journal Article] Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors.2022

    • Author(s)
      T. Akiyama, T. Yasuda, T. Uchihara, N. Yasuda-Yoshihara, BJY. Tan, A. Yonemura, T. Semba, J. Yamasaki, Y. Komohara, K. Ohnishi, F. Wei, L. Fu, J. Zhang, F. Kitamura, K. Yamashita, K. Eto, S. Iwagami, H. Tsukamoto, T. Umemoto, M. Masuda, O. Nagano, Y. Satou, H. Saya, P. Tan, H. Baba, T. Ishimoto
    • Journal Title

      Cancer Res.

      Volume: 83 Issue: 5 Pages: 753-770

    • DOI

      10.1158/0008-5472.can-22-1890

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07370, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-20K07690, KAKENHI-PROJECT-21K19416, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463
  • [Presentation] 新規高度多重免疫染色技術を用いた胃癌における癌関連線維芽細胞の空間的一細胞解析2023

    • Author(s)
      千場隆、王懐涛、米村敦子、トン依霖、石本崇胤
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K27689
  • [Presentation] シングルセルRNA-seq解析による胃癌間質細胞の多様性に関する検討2023

    • Author(s)
      千場隆、米村敦子、山崎昌哉、石本崇胤
    • Organizer
      NGS EXPO 2023
    • Data Source
      KAKENHI-PROJECT-23K27689
  • 1.  石本 崇胤 (00594889)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 2.  池田 公英 (20448525)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  鈴木 実 (80312940)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  黒滝 大翼 (10568455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  安田 忠仁 (00867947)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  山崎 淳太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 7.  大西 紘二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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