SEMBA Takashi 千場隆

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Semba Takashi 千場隆

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Researcher Number	30897682
Other IDs
Affiliation (Current)	2025: 公益財団法人がん研究会, がん研究所発がん研究部, 研究員 2025: 熊本大学, 大学院生命科学研究部(医), 客員講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 公益財団法人がん研究会, がん研究所発がん研究部, 研究員 2021 – 2024: 熊本大学, 国際先端医学研究機構, 客員講師
Review Section/Research Field	Principal Investigator Basic Section 55040:Respiratory surgery-related Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 55010:General surgery and pediatric surgery-related
Keywords	Principal Investigator 細胞間相互作用 / CAFs / シングルセルマルチオミクス / 腫瘍微小環境 / C-JUN N-terminal Kinase / 腫瘍関連線維芽細胞 / 非小細胞肺癌 / 遺伝子改変マウス / LY6D / 癌幹細胞 / 肺癌 … More Except Principal Investigator … More 非小細胞肺癌 / 線維化 / 胃癌 / 遠隔臓器連関 / 血小板 / PDGF / CAFs / 腫瘍間質 / Ly6d / LY6D / 好中球 / 肺癌 Less

Development of novel antibody drugs for non-small cell lung cancer based on surface molecular screening
- Principal Investigator
  
  鈴木実
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kumamoto University
JNKシグナル制御による免疫抑制的腫瘍微小環境の克服Principal Investigator
- Principal Investigator
  
  千場隆
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Japanese Foundation for Cancer Research
遠隔臓器コミュニケーションによるスキルス胃癌線維化メカニズムの解明
- Principal Investigator
  
  安田忠仁
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Japanese Foundation for Cancer Research
非小細胞肺癌における腫瘍関連好中球浸潤の分子メカニズムとその臨床的意義の解明
- Principal Investigator
  
  池田公英
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kumamoto University
Investigation of the functions and the roles of LY6D as a novel cancer stem-cell marker of non-small cell lung cancerPrincipal Investigator
- Principal Investigator
  
  Semba Takashi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kumamoto University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment2024
- Author(s)
  Yonemura A、Semba T、Zhang J、Fan Y、Yasuda-Yoshihara N、Wang H、Uchihara T、Yasuda T、Nishimura A、Fu L、Hu X、Wei F、Kitamura F、Akiyama T、Yamashita K、Eto K、Iwagami S、Iwatsuki M、Miyamoto Y、Matsusaki K、Yamasaki J、Nagano O、Saya H、Song S、Tan P、Baba H、Ajani Jaffer A.、Ishimoto T
- Journal Title
  
  Cell Reports
  
  Volume: 43 Issue: 1 Pages: 113613-113613
- DOI
  10.1016/j.celrep.2023.113613
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14572, KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-23K08113, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23H00410, KAKENHI-PROJECT-23K27689
[Journal Article] RAC1-mediated integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination2024
- Author(s)
  Zhang Jun、Fu Lingfeng、Wang Huaitao、Yonemura Atsuko、Semba Takashi、Yasuda-Yoshihara Noriko、Nishimura Akiho、Tajiri Takuya、Tong Yilin、Yasuda Tadahito、Uchihara Tomoyuki、Yamazaki Masaya、Okamoto Yuya、Yamasaki Juntaro、Nagano Osamu、Baba Hideo、Ishimoto Takatsugu
- Journal Title
  
  Cancer Letters
  
  Volume: 591 Pages: 216901-216901
- DOI
  10.1016/j.canlet.2024.216901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14572, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27689
[Journal Article] Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer2023
- Author(s)
  Kitamura F、Semba T、Yasuda-Yoshihara N、Yamada K、Nishimura A、Yamasaki J、Nagano O、Yasuda T、Yonemura A、Tong Y、Wang H、Akiyama T、Matsumura K、Uemura N、Itoyama R、Bu L、Fu L、Hu X、Wei F、Mima K、Imai K、Hayashi H、Yamashita Y、Miyamoto Y、Baba H、Ishimoto T
- Journal Title
  
  JCI Insight
  
  Volume: 8 Issue: 20
- DOI
  10.1172/jci.insight.163022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14572, KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-22K08756, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-22K16537, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463, KAKENHI-PROJECT-23K27689
[Journal Article] A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts2023
- Author(s)
  Wei F , Uchihara T , Yonemura A , Yasuda-Yoshihara N , Yasuda T , Semba T , Fukuda M , Akiyama T , Kitamura F , Kariya R , Yamasaki J , Aihara K , Yamashita K , Nagano O , Okada S , Baba H , Ishimoto T
- Journal Title
  
  The FEBS Journal
  
  Volume: - Issue: 10 Pages: 2604-2615
- DOI
  10.1111/febs.16712
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-20K08961, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-23K06745, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463
[Journal Article] Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion2023
- Author(s)
  Hu X、Yasuda T、Yasuda-Yosihara N、Yonemura A、Umemoto T、Nakachi Y、Yamashita K、Semba T、Arima K、Uchihara T、Nishimura A、Bu L、Fu Li、Wei F、Zhang J、Tong Y、Wang H、Iwamoto K、Fukuda T、Nakagawa H、Taniguchi K、Miyamoto Y、Baba H、Ishimoto T
- Journal Title
  
  JHEP Reports
  
  Volume: 5 Issue: 12 Pages: 100892-100892
- DOI
  10.1016/j.jhepr.2023.100892
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21K08686, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-20H03758, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K27463, KAKENHI-PROJECT-23K27669
[Journal Article] IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment2023
- Author(s)
  Zhang Jun、Fu Lingfeng、Yasuda-Yoshihara Noriko、Yonemura Atsuko、Wei Feng、Bu Luke、Hu Xichen、Akiyama Takahiko、Kitamura Fumimasa、Yasuda Tadahito、Semba Takashi、Uchihara Tomoyuki、Itoyama Rumi、Yamashita Kohei、Eto Kojiro、Iwagami Shiro、Yashiro Masakazu、Komohara Yoshihiro、Baba Hideo、Ishimoto Takatsugu
- Journal Title
  
  Gastric Cancer
  
  Volume: 26 Issue: 2 Pages: 187-202
- DOI
  10.1007/s10120-022-01352-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463
[Journal Article] Identification of the JNK-Active Triple-Negative Breast Cancer Cluster Associated With an Immunosuppressive Tumor Microenvironment2022
- Author(s)
  Semba, T., Wang, X., Xie, X., Cohen, E. N., Reuben, J. M., Dalby, K. N., Long, J. P., Phi, L. T. H., Tripathy, D., Ueno, N. T.
- Journal Title
  
  JNCI: Journal of the National Cancer Institute
  
  Volume: 114 Issue: 1 Pages: 97-108
- DOI
  10.1093/jnci/djab128
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16515
[Journal Article] Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors.2022
- Author(s)
  T. Akiyama, T. Yasuda, T. Uchihara, N. Yasuda-Yoshihara, BJY. Tan, A. Yonemura, T. Semba, J. Yamasaki, Y. Komohara, K. Ohnishi, F. Wei, L. Fu, J. Zhang, F. Kitamura, K. Yamashita, K. Eto, S. Iwagami, H. Tsukamoto, T. Umemoto, M. Masuda, O. Nagano, Y. Satou, H. Saya, P. Tan, H. Baba, T. Ishimoto
- Journal Title
  
  Cancer Res.
  
  Volume: 83 Issue: 5 Pages: 753-770
- DOI
  10.1158/0008-5472.can-22-1890
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07370, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-20K07690, KAKENHI-PROJECT-21K19416, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463
[Presentation] 新規高度多重免疫染色技術を用いた胃癌における癌関連線維芽細胞の空間的一細胞解析2023
- Author(s)
  千場隆、王懐涛、米村敦子、トン依霖、石本崇胤
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27689
[Presentation] シングルセルRNA-seq解析による胃癌間質細胞の多様性に関する検討2023
- Author(s)
  千場隆、米村敦子、山崎昌哉、石本崇胤
- Organizer
  NGS EXPO 2023
- Data Source
  KAKENHI-PROJECT-23K27689

1. 石本崇胤 (00594889)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. 池田公英 (20448525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 鈴木実 (80312940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 黒滝大翼 (10568455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 安田忠仁 (00867947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 山崎淳太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. 大西紘二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SEMBA Takashi 千場 隆

Semba Takashi 千場 隆

Research Projects

Research Products

Co-Researchers

Development of novel antibody drugs for non-small cell lung cancer based on surface molecular screening

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

JNKシグナル制御による免疫抑制的腫瘍微小環境の克服Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

遠隔臓器コミュニケーションによるスキルス胃癌線維化メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

非小細胞肺癌における腫瘍関連好中球浸潤の分子メカニズムとその臨床的意義の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the functions and the roles of LY6D as a novel cancer stem-cell marker of non-small cell lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RAC1-mediated integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of the JNK-Active Triple-Negative Breast Cancer Cluster Associated With an Immunosuppressive Tumor Microenvironment2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors.2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] 新規高度多重免疫染色技術を用いた胃癌における癌関連線維芽細胞の空間的一細胞解析2023

Author(s)

Organizer

Data Source

[Presentation] シングルセルRNA-seq解析による胃癌間質細胞の多様性に関する検討2023

SEMBA Takashi 千場隆

Semba Takashi 千場隆