Hirabayashi Shigeki 平林茂樹

Researcher Number	30910947
Other IDs
Affiliation (Current)	2025: 九州大学, 医学研究院, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 九州大学, 医学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator トランスクリプトーム / ゲノム編集 / 遺伝性血液腫瘍 / CRISPRスクリーニング / 血液腫瘍 / がん

遺伝性血液腫瘍の変異が病態に及ぼす本質的な意義の解明Principal Investigator
- Principal Investigator
  
  平林茂樹
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyushu University
Search for Novel Cancer Therapeutic Targets Based on Large-Scale Genomics and Functional ScreeningPrincipal Investigator
- Principal Investigator
  
  Hirabayashi Shigeki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyushu University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Central role of the mTORC1 pathway in glucocorticoid activity against B-ALL cells2024
- Author(s)
  Imanaga H, Semba Y, Sasaki K, Setoguchi K, Maniriho H, Yamauchi T, Terasaki T, Hirabayashi S, Nakao F, Nogami J, Izraeli S, Akashi K, Maeda T
- Journal Title
  
  Blood Neoplasia
  
  Volume: -
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16323
[Journal Article] HTLV-1 bZIP factor impairs DNA mismatch repair system2023
- Author(s)
  Sakurada-Aono Maki、Sakamoto Takashi、Kobayashi Masayuki、Takiuchi Yoko、Iwai Fumie、Tada Kohei、Sasanuma Hiroyuki、Hirabayashi Shigeki、Murakawa Yasuhiro、Shirakawa Kotaro、Sakamoto Chihiro、Shindo Keisuke、Yasunaga Jun-ichirou、Matsuoka Masao、Pommier Yves、Takeda Shunichi、Takaori-Kondo Akifumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 657 Pages: 43-49
- DOI
  10.1016/j.bbrc.2023.03.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16323, KAKENHI-PROJECT-19H03689, KAKENHI-PROJECT-20H03514, KAKENHI-PROJECT-22KF0209, KAKENHI-PROJECT-23K24365
[Journal Article] Impact of MRD on clinical outcomes of unrelated hematopoietic stem cell transplantation in patients with Ph+ ALL: A retrospective nationwide study2023
- Author(s)
  Hirabayashi S, Kondo T, Nishiwaki S, Mizuta S, Doki N, Fukuda T, Uchida N, Ozawa Y, Kanda Y, Imanaka R, Takahashi S, Ishikawa J, Yano S, Nakamae H, Eto T, Kimura T, Tanaka J, Ichinohe T, Atsuta Y, Kako S.
- Journal Title
  
  American Journal of Hematology
  
  Volume: 98 Issue: 10 Pages: 1606-1618
- DOI
  10.1002/ajh.27041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16323
[Journal Article] Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance2023
- Author(s)
  Nakao Fumihiko、Setoguchi Kiyoko、Semba Yuichiro、Yamauchi Takuji、Nogami Jumpei、Sasaki Kensuke、Imanaga Hiroshi、Terasaki Tatsuya、Miyazaki Manaka、Hirabayashi Shigeki、Miyawaki Kohta、Kikushige Yoshikane、Masuda Takeshi、Akashi Koichi、Maeda Takahiro
- Journal Title
  
  Leukemia
  
  Volume: - Issue: 5 Pages: 1028-1038
- DOI
  10.1038/s41375-023-01879-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16323, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-23K07816, KAKENHI-PROJECT-20H05699, KAKENHI-PROJECT-21H04827
[Journal Article] Advantages of peripheral blood stem cells from unrelated donors versus bone marrow transplants in outcomes of adult acute myeloid leukemia patients2022
- Author(s)
  Jo Tomoyasu、Arai Yasuyuki、Kondo Tadakazu、Mizuno Shohei、Hirabayashi Shigeki et al.
- Journal Title
  
  Cytotherapy
  
  Volume: 24 Issue: 10 Pages: 1013-1025
- DOI
  10.1016/j.jcyt.2022.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16323
[Journal Article] Effect of Multiple HLA Locus Mismatches on Outcomes after Single Cord Blood Transplantation.2022
- Author(s)
  Kanda J, Hirabayashi S, Yokoyama H, Kawase T, Tanaka H, Uchida N, Taniguchi S, Takahashi S, Onizuka M, Tanaka M, Sugio Y, Eto T, Kanda Y, Kimura T, Ichinohe T, Atsuta Y, Morishima S.
- Journal Title
  
  Transplant Cell Ther.
  
  Volume: 28 Issue: 7 Pages: 398-398
- DOI
  10.1016/j.jtct.2022.05.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08737, KAKENHI-PROJECT-22K08488, KAKENHI-PROJECT-22K16323, KAKENHI-PROJECT-17K09934
[Journal Article] Comparing cord blood transplantation and matched related donor transplantation in non-remission acute myeloid leukemia2022
- Author(s)
  Shimomura Y, Takahashi S., et al.
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 4 Pages: 1132-1138
- DOI
  10.1038/s41375-021-01474-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08858, KAKENHI-PROJECT-21K15579, KAKENHI-PROJECT-22K16323
[Presentation] Identification of Novel Transcripts and Potential Therapeutic Targets for Acute Leukemia2023
- Author(s)
  Wada F, Kato S, Bhagat S, Hirabayashi S, Son R, Oguchi A, Takeuchi K, Sekito S, Hirai T, Zhang Z, Horisawa Y, Iwasaki M, Takeda J, Kanda J, Sakamoto T, Shirakawa K, Takaori-Kondo A, Murakawa Y
- Organizer
  65th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16323
[Presentation] Genome-Wide CRISPR/Cas9 Screens Identify DDX19A/DDX19B As a Critical Regulator of Intrinsic Apoptosis By Regulating MCL1 mRNA Cellular Localization2023
- Author(s)
  Terasaki T, Semba Y, Sasaki K, Miyata K, Yamauchi T, Imanaga H, Nakao F, Hirabayashi S, Nogami J, Akahane K, Inukai T, Akashi K, and Maeda T
- Organizer
  65th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16323
[Presentation] GATOR1 complex is a critical regulator of glucocorticoid sensitivity in B-ALL cells2022
- Author(s)
  今永博、仙波雄一郎、佐々木謙介、宮田喜代子、山内拓司、寺崎達也、中尾文彦、平林茂樹、野上順平、赤司浩一、前田高宏
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16323
[Presentation] A Genome-Wide CRISPR-Cas9 Screen Reveals GATOR1 Complex Is a Critical Regulator of Glucocorticoid Sensitivity in B-Cell Precursor Acute Lymphoblastic Leukemia2022
- Author(s)
  Hiroshi Imanaga, Yuichiro Semba, Kensuke Sasaki, Kiyoko Miyata, Takuji Yamauchi, Tatsuya Terasaki, Fumihiko Nakao, Shigeki Hirabayashi et al.
- Organizer
  64th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16323
[Presentation] CRISPRスクリーンによりB-ALLにおけるグルココルチコイド感受性の制御因子としてGATOR1complexを同定2022
- Author(s)
  今永博、平林茂樹、赤司浩一、前田高宏
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K16323
[Presentation] Mitochondrial E3 ligase complex regulates venetoclax sensitivity via modulating BAX equilibrium2022
- Author(s)
  中尾文彦、仙波雄一郎、宮田喜代子、山内拓司、野上順平、今永博、寺崎達也、宮崎眞佳、平林茂樹、増田豪、赤司浩一、前田高宏
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16323

1. 森島聡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 高橋聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirabayashi Shigeki 平林 茂樹

Research Projects

Research Products

Co-Researchers

遺伝性血液腫瘍の変異が病態に及ぼす本質的な意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for Novel Cancer Therapeutic Targets Based on Large-Scale Genomics and Functional ScreeningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Central role of the mTORC1 pathway in glucocorticoid activity against B-ALL cells2024

Author(s)

Journal Title

Data Source

[Journal Article] HTLV-1 bZIP factor impairs DNA mismatch repair system2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of MRD on clinical outcomes of unrelated hematopoietic stem cell transplantation in patients with Ph+ ALL: A retrospective nationwide study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Advantages of peripheral blood stem cells from unrelated donors versus bone marrow transplants in outcomes of adult acute myeloid leukemia patients2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of Multiple HLA Locus Mismatches on Outcomes after Single Cord Blood Transplantation.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparing cord blood transplantation and matched related donor transplantation in non-remission acute myeloid leukemia2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] Identification of Novel Transcripts and Potential Therapeutic Targets for Acute Leukemia2023

Author(s)

Organizer

Data Source

[Presentation] Genome-Wide CRISPR/Cas9 Screens Identify DDX19A/DDX19B As a Critical Regulator of Intrinsic Apoptosis By Regulating MCL1 mRNA Cellular Localization2023

Author(s)

Organizer

Data Source

[Presentation] GATOR1 complex is a critical regulator of glucocorticoid sensitivity in B-ALL cells2022

Author(s)

Organizer

Data Source

[Presentation] A Genome-Wide CRISPR-Cas9 Screen Reveals GATOR1 Complex Is a Critical Regulator of Glucocorticoid Sensitivity in B-Cell Precursor Acute Lymphoblastic Leukemia2022

Author(s)

Organizer

Data Source

[Presentation] CRISPRスクリーンによりB-ALLにおけるグルココルチコイド感受性の制御因子としてGATOR1complexを同定2022

Author(s)

Organizer

Data Source

[Presentation] Mitochondrial E3 ligase complex regulates venetoclax sensitivity via modulating BAX equilibrium2022

Author(s)

Organizer

Data Source

Hirabayashi Shigeki 平林茂樹