IMANISHI Takeshi 今西武

Researcher Number	40028866
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2007 – 2008: Osaka University, 名誉教授 1998 – 2005: 大阪大学, 薬学研究科, 教授 2003 – 2004: 大阪大学, 大学院・薬学研究科, 教授 1998: 大阪大学, 大学院・薬学研究科, 教授 1993 – 1997: 大阪大学, 薬学部, 教授 1989 – 1990: Osaka Univ., Fac. of Pharm. Sci., Professor, 薬学部, 教授 1988: 大阪大学, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Biological Sciences / Chemical pharmacy / 医薬分子機能学 / Drug development chemistry Except Principal Investigator 血管生物学 / 医薬分子機能学 / Drug development chemistry / Neurology / Biological pharmacy
Keywords	Principal Investigator オリゴヌクレオチド / BNA / 人工核酸 / アンチセンス / ヌクレオシド類縁体 / 遺伝子発現制御 / オリゴヌクレオチド類縁体 / コンホメーション / 遺伝子ネットワーク / アポトーシス … More / 合成 / 糖部立体配座 / アンチジーン / Antisense / 遺伝子導入 / カチオン性リポソーム / DNA / 転写因子 / デコイ核酸法 / アンチセンス法 / 核酸類縁体 / オリゴヌクレオシド / NADH / Quadrone / Pentalenene / Polyquinane / Sesquiterpene / Bond cleavage of cyclopronae ring / Natural product synthesis / 制癌作用 / 立体選択性 / 全合成 / シクロプロパン / クァドロン類縁体 / 抗腫瘍活性 / クァドロン / ペンタレネン / ポリキナン / セスキテルペン / シクロプロパン環の開裂反応 / 天然物合成 / Antigene / Synthesis / Artificial nucleic acid / Oligonucleotide analogue / Nucleoside analogue / Sugar conformation / ホスホロアミダート結合 / 酵素耐性 / Gene transfection / Cationic liposome / Chemiluminescence / unnatural amino acids / Pyridoxal model compounds / Antisence / Oligonucleotides / Nucleoside Analogs / 非天然型アミノ酸 / 化学発光 / 非天然アミノ酸 / ピリドキサールモデル化合物 / Gene Delivery / Cationic Liposome / Conformation / Oligonucleotide / Nucleoside Analog / カテオン性脂質 / リポソーム / カチオン性脂質 / 化学合成 / アンチセンス核酸 / オリゴヌクレオチド誘導体 / 遺伝子医薬品 / ヌクレオシド類緑体 / 遺伝子診断 / 遺伝子検出 / ゲノム創薬 / NF-KB / デコイ法 / 遺伝子治療 / 翻訳阻害 / NF-kB / HCV / RNase H / ICAM-1 / がん治療 / 遺伝子発見制御 / 転写制御 / デコイ核酸 / WT-1 / C-ヌクレオシド / アナンチセンス / 三重鎖核酸 / ヌクレオシド / α-アミノ酸のα-アルキル化 / 不斉四級アミノ酸 / ピリドキサール / 補酵素モデル化合物 / 1,4-ジヒドロピリジン / ケトオキシムの不斉還元 / キラルスルフィニル基 / ビタミンB_6補酵素 / 光学活性スルホキシド / カルシウムイオンチャンネル / 1,4ージヒドロピリジン / 重水素置換 … More Except Principal Investigator スカベンジャー受容体 / GAPDH / HSP90 / HSP70 / 細胞質ドメイン / エンドサイトーシス / Structure-activity relationship / Total synthesis / Protein phosphatase / Leustroducsin / Fostriecin / Stille / Julia反応 / 不斉Diels-Alder反応 / 不斉cis-ジヒドキシル化反応 / 不斉エポキシ化反応 / 収束型合成経路 / リウストロダクシン / 構造活性相関 / 全合成 / プロテインホスファターゼ / ロイストロダクシン / フォストリエシン / Neuropathy / Sweden / Haplotype / trance metals / Environmental factor / Amyloidosis / Transthyretin / Familial amyloidotic polyneuropathy / マイクロアレイ / 遺伝子修復関連遺伝子 / トランスサイレチン(TTR) / single-stranded oligonucleotides (SSOs) / 遺伝子治療 / 家族性アミロイドニューロパチー / ニューロパチー / ニユーロパチー / スウェーデン / ハプロタイプ / 微量元素 / 環境要因 / アミロイドーシス / トランスサイレチン / 家族性アミロイドポリニューロパチー / phosphorylation / aggregation / model molecule / scavenger receptor / macrophage / 核酸分子 / ペプチド分子 / 機能ドメイン / アフィニティカラム / NO産生 / LPS / フコイダン / リン酸化 / アグリゲーション / モデル分子 / マクロファージ / バキュロウイルス / Green Fluorescent Protein / RNAポリメラーゼ / C型肝炎ウイルス / モチーフ配列 / 細胞内輸送 / リガンド / 修飾LDL / コラーゲン / ペプチド / リガンド結合ドメイン / アポリポ蛋白質B100 / ヒスチジン / リガンド解離 / ロイシンジッパー / α-ヘリカルコイルドコイル / ペプチド合成 / アポ蛋白質B100 / リジンクラスター / コラーゲン構造 Less

Development of artificial nucleic acid conjugates as base materials for genome-based drug discovery and DNA-based diagnosticsPrincipal Investigator
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University
遺伝子ネットワーク解明に向けた高機能性人工デコイ核酸の開発Principal Investigator
- Principal Investigator
  
  今西武
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Development of novel protein phosphatase inhibitors based on fostriecin
- Principal Investigator
  
  MIYASHITA Kazuyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University
遺伝子ネットワーク解明に向けた高機能性人工デコイ核酸の開発Principal Investigator
- Principal Investigator
  
  今西武
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製Principal Investigator
- Principal Investigator
  
  今西武
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Gene therapy for familial amybidotic polyneuropathy by urtra-fundaoning artificial nucleic acids
- Principal Investigator
  
  ANDO Yukio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kumamoto University
遺伝子ネットワーク解明に向けた高機能性人工デコイ核酸の開発Principal Investigator
- Principal Investigator
  
  今西武
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製Principal Investigator
- Principal Investigator
  
  今西武
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
遺伝子ネットワーク解明に向けた高機能性人工デコイ核酸の開発Principal Investigator
- Principal Investigator
  
  今西武
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製Principal Investigator
- Principal Investigator
  
  今西武
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製Principal Investigator
- Principal Investigator
  
  今西武
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Study to develop novel genomic drugs by using superfunctional oligonucleotide analoguesPrincipal Investigator
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
超機能性合成オリゴヌクレオチドによる特定遺伝子の転写制御法の開発Principal Investigator
- Principal Investigator
  
  今西武
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
Design and Syntheses of Biologically Functional Molecules Based on the Mechanisms of LifePrincipal Investigator
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
Synthesis and application of functional domain of macrophage scavenger receptor
- Principal Investigator
  
  DOI Takefumi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
C型肝炎ウイルスのRNAポリメラーゼを標的にしたC型肝炎治療薬の開発研究
- Principal Investigator
  
  土井健史
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
Development of highly functional medicines targeting genomic DNA/RNAPrincipal Investigator
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
マクロファージスカベンジャー受容体の細胞内輸送に関与する機能配列の探究
- Principal Investigator
  
  土井健史
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
生物活性を有するアミン類の新しい不斉合成法の開発研究Principal Investigator
- Principal Investigator
  
  今西武
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
スカベンジャー受容体と相互作用するアポリポ蛋白質の解析と動脈硬化抑止への試み
- Principal Investigator
  
  土井健史
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Osaka University
スカベンジャー受容体のリガンド解離機構の研究
- Principal Investigator
  
  土井健史
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Osaka University
スカベンジャー受容体のリガンド結合領域の構造解析
- Principal Investigator
  
  DOI Takefumi
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Osaka University
キラルな補酵素モデル化合物の化学的研究Principal Investigator
- Principal Investigator
  
  今西武
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
Synthetic Studies on Polyquinane SesquiterpenesPrincipal Investigator
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University

All 2009 2008 2007 2004 Other

All Journal Article Presentation

[Journal Article] Synthesis of a Novel trans-3',4'-BNA Monomer Bearing a 4,8-Dioxa-5-azabicyclo-[5.3.0]decane Skeleton2009
- Author(s)
  Tetsuya Kodama, Kensaku Sugaya, Takeshi Baba, Takeshi Imanishi, Satoshi Obika
- Journal Title
  
  Heterocycles 79
  
  Pages: 873-882
- NAID
  40016543114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390030
[Journal Article] Design, Synthesis, and Evaluation of a Novel Bridged Nucleic Acid, 2',5'-BNA ^<ON> with S-type Sugar Conformation Fixed by N-O Linkage2009
- Author(s)
  Tetsuya Kodama, Chieko Matsuo, Hidetsugu Ori, Tetsuya Miyoshi, Satoshi Obika, Kazuyuki Miyashita, Takeshi Imanishi
- Journal Title
  
  Tetrahedron 65
  
  Pages: 2116-2123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390030
[Journal Article] A Bridged Nucleic Acid, 2',4'-BNA^<COC> : Synthesis of Fully Modified Oligonucleotides Bearing Thymine, 5-Methylcytosine, Adenine and Guanine 2',4'-BNA^<COC> Monomers, and RNA-selective Nucleic Acid Recognition2009
- Author(s)
  Yasunori Mitsuoka, Tetsuya Kodama, Ryo Ohnishi, Yoshiyuki Hari, Takeshi Imanishi and Satoshi Obika
- Journal Title
  
  Nucleic Acids Res 37
  
  Pages: 1225-1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390030
[Journal Article] Synthesis and properties of 3'-amino-2',4'-BNA, a bridged nucleic acid with a N3'-P5' phosphoramidate linkage. Bioorg2008
- Author(s)
  Satoshi Obika, S.M.Abdur Rahman, Bingbing Song, Mayumi Onoda, Makoto Koizumi, Koji Morita, Takeshi Imanishi
- Journal Title
  
  Med. Chem 16
  
  Pages: 9230-9237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390030
[Journal Article] Design, synthesis and properties of 2',4'-BNA ^<NC> : A bridged nucleic acid analogue2008
- Author(s)
  S. M. Abdur. Rahman, Sayori. Seki, Satoshi. Obika, Haruhisa Yoshikawa, Kazuyuki Miyashita, Takeshi Imanishi
- Journal Title
  
  J. Am. Chem. Soc. 130
  
  Pages: 4886-4896
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390030
[Journal Article] 2',4'-BNA derivatives bearing an unnatural nucleobase: Synthesis and application to triplex-forming oligonucleotides2004
- Author(s)
  H.Inohara, S.Obika, T.Imanishi
- Journal Title
  
  Nucleic Acids Symposium Series 48
  
  Pages: 165-166
- Data Source
  KAKENHI-PROJECT-16011235
[Journal Article] A novel and efficient method for inside selective esterification of terminal vic-diols2004
- Author(s)
  M.Ikejiri, K.Miyashita, T.Tsunemi, T.Imanishi
- Journal Title
  
  Tetrahedron Lett. 45(6)
  
  Pages: 1243-1246
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590083
[Journal Article] サイトカイン誘導天然物Leustroducsin Bの全合成研究2004
- Author(s)
  宮下和之, 常深智之, 池尻昌宏, 今西武
- Journal Title
  
  第30回反応と合成の進歩シンポジウム講演要旨集
  
  Pages: 254-255
- Data Source
  KAKENHI-PROJECT-16590083
[Journal Article] Synthetic study on leustroducsin B having a cytokine induction activity2004
- Author(s)
  K.Miyashita, T.Tsunemi, M.Ikejiri, T.Imanishi
- Journal Title
  
  30th Symposium on Progress in Organic Reactions and Syntheses-Application in the Life Sciences-
  
  Pages: 254-255
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590083
[Journal Article] A novel and efficient method for inside selective esterification of terminal vic-diols2004
- Author(s)
  M.Ikejiri, K.Miyashita, T.Tsunemi T.Imanishi
- Journal Title
  
  Tetrahedron Lett. 45・6
  
  Pages: 1243-1246
- Data Source
  KAKENHI-PROJECT-16590083
[Journal Article] Synthesis and properties of a novel bridged nucleic acid analogue bearing a P3'->N5' phosphoramidate linkage, 5'-amino-3',5'-BNA2004
- Author(s)
  M.Sekiguchi, S.Obika, R.Somjing, T.Imanishi
- Journal Title
  
  Nucleic Acids Symposium Series 48
  
  Pages: 7-8
- Data Source
  KAKENHI-PROJECT-16011235
[Journal Article] Synergistic stabilization of triplex by combination of comb-type cationic copolymer and 2',4'-BNA2004
- Author(s)
  T.Katayama, A.Maruyama, S.Obika, T.Imanishi, H.Torigoe
- Journal Title
  
  Nucleic Acids Symposium Series 48
  
  Pages: 165-166
- Data Source
  KAKENHI-PROJECT-16011235
[Journal Article] Synthesis and conformation of a novel bridged nucleic acid having a trans-fused 3,5,8-trioxabicyclo[5.3.0]decane structure2004
- Author(s)
  S.Obika, T.Osaki, M.Sekiguchi, R.Somjing, Y.Harada, T.Imanishi
- Journal Title
  
  Tetrahedron Letters 45,24
  
  Pages: 4801-4804
- Data Source
  KAKENHI-PROJECT-16011235
[Journal Article] Adjustment of the γ dihedral angle of an oligonucleotide P3'->N5' phosphoramidate enhances its binding affinity towards complementary
- Author(s)
  S.Obika, M.Sekiguchi, R.Somjing, T.Imanishi
- Journal Title
  
  Angew.Chem., Int.Ed.Engl. (in press)
- Data Source
  KAKENHI-PROJECT-16011235
[Presentation] 架橋型人工核酸BNA修飾によるsiRNAの高機能化2008
- Author(s)
  佐藤寛之、津田直人、生川径祐、今西武、小比賀聡
- Organizer
  第81回日本生化学会大会・第31回日本分子生物学会年会合同大会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-19390030
[Presentation] 2,2'一ビスベンズイミダゾール骨格を有した新規蛍光分子の開発とオリゴヌクレオチドラベル化に関する研究2008
- Author(s)
  松山憲司、渡部徹也、兒玉哲也、小比賀聡、宮下和之、今西武
- Organizer
  第三回バイオ関連化学合同シンポジウム2008
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-19390030
[Presentation] 3,4一エポキシピペリジン構造を有する新規DNAアルキル分子の合成と活性評価2008
- Author(s)
  河田裕治、山口卓男、宮下和之、小比賀聡、今西武
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19390030
[Presentation] カルバマート骨格を有する新規架橋型人工核酸の合成とその評価2008
- Author(s)
  西田勝、見玉」互也、馬場武、小比賀聡、今西武
- Organizer
  第34回反応と合成の進歩シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19390030
[Presentation] Synthesis andproperties of a 2'-deoxy analogue of trans-3',4'-BNA having an S-type sugar conformation2007
- Author(s)
  兒玉哲也、松尾智恵子、小里英嗣、小比賀聡、宮下和之、今西武
- Organizer
  5th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-19390030
[Presentation] Studies toward the total synthesis of azinomycin A, a potent antitumor antibiotic2007
- Author(s)
  山口卓男、河田裕治、宮下和之、今西武
- Organizer
  The 21st International Congress for Heterocyclic Chemistry
- Place of Presentation
  Sydney
- Data Source
  KAKENHI-PROJECT-19390030

1. DOI Takefumi (00211409)

# of Collaborated Projects: 13 results

# of Collaborated Products: 0 results
2. OBIKA Satoshi (80243252)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. MIYASHITA Kazuyuki (10166168)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. KODAMA Tetsuya (00432443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. ANDO Yukio (20253742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAMURA Masaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

IMANISHI Takeshi 今西 武

Research Projects

Research Products

Co-Researchers

Development of artificial nucleic acid conjugates as base materials for genome-based drug discovery and DNA-based diagnosticsPrincipal Investigator

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遺伝子ネットワーク解明に向けた高機能性人工デコイ核酸の開発Principal Investigator

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遺伝子ネットワーク解明に向けた高機能性人工デコイ核酸の開発Principal Investigator

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がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製Principal Investigator

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遺伝子ネットワーク解明に向けた高機能性人工デコイ核酸の開発Principal Investigator

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がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製Principal Investigator

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遺伝子ネットワーク解明に向けた高機能性人工デコイ核酸の開発Principal Investigator

Principal Investigator

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Review Section

Research Institution

がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製Principal Investigator

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がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製Principal Investigator

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Study to develop novel genomic drugs by using superfunctional oligonucleotide analoguesPrincipal Investigator

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超機能性合成オリゴヌクレオチドによる特定遺伝子の転写制御法の開発Principal Investigator

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IMANISHI Takeshi 今西武