HAYASHI Toshimitsu 林利光

Researcher Number	40092796
Other IDs
Affiliation (based on the past Project Information) *help	2006: 富山大学, 教授 2006: University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Professor, 医学薬学研究部, 教授 2006: 富山大学, 大学院医学薬学研究部, 教授 2005: 富山大学, 薬学部, 教授 2004: 富山医科薬科大学, 薬学部, 教授 … More 2000 – 2001: 富山医科薬科大学, 薬学部, 教授 1998 – 1999: Toyama Medical and Pharmaceutical University, Faculty of Pharmaceutical Sciences, 薬学部, 助教授 1994 – 1997: 富山医科薬科大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Chemical pharmacy / Living organism molecular science Except Principal Investigator Bioorganic chemistry / Applied pharmacology / 応用薬理学・医療系薬学 / 医薬分子機能学 / Chemical pharmacy
Keywords	Principal Investigator Scoparia dulcis / organ culture / scopadulciol / scopadulcic acid B / diterpene / tissue culture / 器官培養 / スコパドルシオール / スコパドルシ酸B / ジテルペン … More / 組織培養 / copalyl diphosphate synthase / カルモジュリン / シャスモン酸メチル / プロテオーム解析 / ジャスモン酸メチル … More Except Principal Investigator 単純ヘルペスウイルス / chalcone synthase / herpes simplex virus / Psilotum nodum / ガンシクロビル / アシクロビル / 遺伝子治療 / polyketide / 交差反応 / stilbene synthase / ポリケタイド / カルコン合成酵素 / 放線菌 / interleukin-6 / interleukin-2 / vSrc / cSrc / tyrosine kinase / 抗生物質 / 単純ヘルペスウィルス / インターロイキン6 / インターロイキン2 / antiviral assay / monoclonal antibody / glycoproteins / human coronavirus / 作用標的 / ウイルス活性 / 糖蛋白質 / ヒトコロナウイルス / 抗ウイルス活性試験 / モノクローナル抗体 / 糖蛋白 / コロナウイルス / liposome vector / scepadulciol / ponicidin / ganciclovir / acyclovir / thymidine kinase / cancer gene therapy / bystander効果 / ポンシジン / チミジンキチーゼ / リポソームベクター / スコパドルシオール / ポニシジン / チミジンキナーゼ / 癌遺伝子治療 / point mutation / cross reaction / マツバラン / STS / CHS / 点突然変異 / スチルベン合成酵素 / Synergistic effect / Ganciclovir / Acyclovir / TK-expressing cell lines / Thymidine Kinase (TK) / Herpes simplex virus / Antiviral activity / Gene therapy / TK発現細胞株 / 相乗効果 / TK発現癌細胞株 / チミジンキナーゼ(TK) / 単純ヘルペス・ウイルス / 抗ウイルス作用 / carotenoid / antibiotic / triterpene / diterpene / Candida boidinii / pNOTeI / メチロトフ酵母 / CHS superfamily / 非メバロン酸経路 / シグナルペプチド / スチルベン合成酵素(STS) / カルコン合成酵素(CHS) / カロチノイド / トリテルペン / ジテルペン / かび / 放射菌 / チロシンカイネース / シグナル伝達 / バイオアッセイ / スクリーニング / チロシンキナーゼ / 昆虫抗菌性成分 Less

高等植物における環状ジテルペンの生合成制御機構のポストゲノム手法による解析Principal Investigator
- Principal Investigator
  
  林利光
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  University of Toyama
Evaluation of anti-human coronavirus agents
- Principal Investigator
  
  HAYASHI Kyoko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  University of Toyama
  Toyama Medical and Pharmaceutical University
Enhancement of anticancer effects by HSV-TK potentiators and evaluation of navel liposome vectors in MSV-TK/prodding gene therapy
- Principal Investigator
  
  HAYASHI Kyoko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Study on the Alteration of Catalytic Activities by the Change of Three Dimensional Structure of Enzyme Proteins
- Principal Investigator
  
  SANKAWA Ushio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Toyama Medical & Pharmaceutical University
Genetic Engineering for Bio-active Natural Produtcs
- Principal Investigator
  
  SANKAWA Ushio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Toyama Medical & Pharmaceutical University
Research on the potentiators of HSV-specific thymidine kinase for the purpose of their application to gene therapy and antiviral therapy
- Principal Investigator
  
  HAYASHI Kyoko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Toyama Medical and Pharmaceutical University
Study on The Establishment of Bioassay Systems for The Screening to Find Lead Compound for Drug Development
- Principal Investigator
  
  SANKAWA Ushio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Practical Studies on Drug Development with The Leads Biological Natural Products
- Principal Investigator
  
  SANKAWA Ushio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
ESTABLISHMENT OF EFFICIENT METHOD FOR PRODUCTION OF SCOPADULCIC ACID B BY USING TISSUE CULTURE SYSTEMPrincipal Investigator
- Principal Investigator
  
  HAYASHI Toshimitsu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

All 2006 2005

All Journal Article

[Journal Article] Involvement of 2-C-methyl-D-erythritol-4-phosphate pathway in biosynthesis of aphidicolin-like tetracyclic diterpene of Scoparia dulcis.2006
- Author(s)
  Nkembo K.M., Lee J.-B., Nakagiri T., Hayashi T.
- Journal Title
  
  Biol. Pharm. Bull. 54
  
  Pages: 758-760
- NAID
  110004836373
- Data Source
  KAKENHI-PROJECT-17651121
[Journal Article] Stimulation of calcium signal transduction results in enhancement of production of scopadulcic acid B by methyl jasmonate in the cultured tissues of Scoparia dulcis2005
- Author(s)
  Nkembo K.M., Kurosaki F., Lee J.-B., Hayashi T.
- Journal Title
  
  Plant Biotechnol. 22
  
  Pages: 333-337
- NAID
  10028054205
- Data Source
  KAKENHI-PROJECT-17651121
[Journal Article] Selective enhancement of scopadulcic acid B production in the cultured tissues of Scoparia dulcis by methyl jasmonate2005
- Author(s)
  Nkembo K.M., Lee J.-B., Hayashi T.
- Journal Title
  
  Chem.Pharm.Bull. 53
  
  Pages: 780-782
- NAID
  110003665662
- Data Source
  KAKENHI-PROJECT-17651121
[Journal Article] cDNA cloning, functional expression and characterization of ent-copalyl diphosphate synthase from Scoparia dulcis L.2005
- Author(s)
  Nakagiri T., Lee J.-B., Hayashi T.
- Journal Title
  
  Plant Sci. 169
  
  Pages: 760-767
- Data Source
  KAKENHI-PROJECT-17651121

1. IWANAMI Naoko (90283077)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. SANKAWA Ushio (60012613)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. SHIBUYA Masaaki (50170923)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. HAYASHI Kyoko (60110623)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. LEE Jung-bum (40332655)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. SHIMIZU Mineo (00019118)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 黒崎文也 (70143865)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. MAITANI Yoshie (10231581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 佐藤俊次

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SATO Tsoshitsugu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MACRE Bradle

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FLOSS Heimg

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. FLOSS Heinz

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HAYASHI Toshimitsu 林 利光

Research Projects

Research Products

Co-Researchers

高等植物における環状ジテルペンの生合成制御機構のポストゲノム手法による解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of anti-human coronavirus agents

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Enhancement of anticancer effects by HSV-TK potentiators and evaluation of navel liposome vectors in MSV-TK/prodding gene therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the Alteration of Catalytic Activities by the Change of Three Dimensional Structure of Enzyme Proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic Engineering for Bio-active Natural Produtcs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on the potentiators of HSV-specific thymidine kinase for the purpose of their application to gene therapy and antiviral therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on The Establishment of Bioassay Systems for The Screening to Find Lead Compound for Drug Development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Practical Studies on Drug Development with The Leads Biological Natural Products

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ESTABLISHMENT OF EFFICIENT METHOD FOR PRODUCTION OF SCOPADULCIC ACID B BY USING TISSUE CULTURE SYSTEMPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Involvement of 2-C-methyl-D-erythritol-4-phosphate pathway in biosynthesis of aphidicolin-like tetracyclic diterpene of Scoparia dulcis.2006

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Stimulation of calcium signal transduction results in enhancement of production of scopadulcic acid B by methyl jasmonate in the cultured tissues of Scoparia dulcis2005

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Selective enhancement of scopadulcic acid B production in the cultured tissues of Scoparia dulcis by methyl jasmonate2005

Author(s)

Journal Title

NAID

Data Source

[Journal Article] cDNA cloning, functional expression and characterization of ent-copalyl diphosphate synthase from Scoparia dulcis L.2005

Author(s)

Journal Title

Data Source

HAYASHI Toshimitsu 林利光