OHKUBO Tsuyako 大久保つや子

Researcher Number	40099065
Other IDs
Affiliation (based on the past Project Information) *help	2010 – 2011: 福岡歯科大学, 歯学部, 准教授 2008 – 2009: 福岡歯科大学, 歯学部, 講師 1991 – 1993: 福岡歯科大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Functional basic dentistry / General physiology Except Principal Investigator Functional basic dentistry / General physiology
Keywords	Principal Investigator 細胞増殖 / Proliferation / Fibroblast / Guaiacol / Eugenol / Substance P / 歯髄線維芽細胞 / サブスタンス P / フエノール系薬剤 / 増殖 … More / 線維芽細胞 / グアヤコール / ユ-ジノール / サブスタンスP / メチレーション / 癌増殖 / p53 / 癌抑制遺伝子 / アポトーシス / Cav3.1(CACNA1G) / T型カルシウムチャネル / 腫瘍 / 癌 / 細胞死 / 電位依存性カルシウムチャネル … More Except Principal Investigator Nuerogenic inflammation / Capsaicin / Substance P release / Guaiacol / Eugenol / Phenolic compounds / 歯髄炎 / カプサイシン鎮痛 / グアヤコ-ル鎮痛 / ユ-ジノ-ル鎮痛 / 歯髄とサブスタンスP / フェノ-ル性歯髄鎮痛薬 / ユージノール / 神経原性炎症 / カプサイシン / サブスタンスP遊離 / グアヤコール / ユ-ジノール / フエノール性歯髄鎮痛薬 / 細胞・組織 / 平滑筋 / 循環器・高血圧 / 細胞組織 / 薬理学 / 生理学 / ProTX-I / α1G / α1H / キメラチャネル / カルシウムチャネル / クモ毒 / T型Caチャネル / 発現 / 電流 / シグナル伝達 / Caチャネル / イオンチャネル Less

Functional modification of T-type Ca2+channel gene by methylation and its role in tumor cellsPrincipal Investigator
- Principal Investigator
  
  OHKUBO Tsuyako
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Fukuoka Dental College
Physiological Significance of the T-type Ca channels in smooth muscle cells.
- Principal Investigator
  
  KITAMURA Kenji
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Fukuoka Dental College
Effects of substance P and phenolic compounds on proliferation of pulpal fibroblasts.Principal Investigator
- Principal Investigator
  
  OHKUBO Tsuyako
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Fukuoka Dental College
Mechanism of analgesic action of some phenolic compounds used for dental practice.
- Principal Investigator
  
  TAKAHASHI Hiroshi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Fukuoka Dental College

All 2012 2011 2010 2009 2008 2006 Other

All Journal Article Presentation

[Journal Article] T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in anti-proliferation and apoptosis in MCF-7 human breast cancer cells2012
- Author(s)
  Ohkubo T, Yamazaki J.
- Journal Title
  
  International Journal of Oncology
  
  Volume: 41(1) Pages: 267-275
- DOI
  10.3892/ijo.2012.1422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590247
[Journal Article] Tarantula Toxin ProTx-I Differentiates Between Human T-type Voltage-Gated Ca2+ Channels Cav3.1 and Cav3.22010
- Author(s)
  Ohkubo T, Yamazaki J, Kitamura K.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 112 Issue: 4 Pages: 452-458
- DOI
  10.1254/jphs.09356FP
- NAID
  130000253386
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590247
[Journal Article] Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca^<2+> channels Ca_v3.1 and Ca_v3.22010
- Author(s)
  T.Ohkubo, et al.
- Journal Title
  
  Journal of Pharmacolog-ical Science
  
  Volume: 112 Pages: 452-458
- NAID
  10027909166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590247
[Journal Article] Molecular and immunohistochemical studies in expression of voltage-dependent Ca channels in dorsal root gangria from storeptozotocin-induced diabetic mice.2006
- Author(s)
  Umeda M., Ohkubo T., Ono J., Fukuizumi T., Kitamura K.
- Journal Title
  
  Life Science 79
  
  Pages: 1995-2000
- Data Source
  KAKENHI-PROJECT-18590213
[Journal Article] Molecular and immunohistochemical studies in expression of voltage-dependent Ca channels in dorsal root gangria from storeptozotocin-induced diabetic mice2006
- Author(s)
  Umeda M., Ohkubo T., Ono J., Fukuizumi T., Kitamura K.
- Journal Title
  
  Life Science 79
  
  Pages: 1995-2000
- Data Source
  KAKENHI-PROJECT-18590213
[Journal Article] Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca^<2+> channels Cav3.1 and Cav3.2.
- Author(s)
  Ohkubo, T., Kitamura K.
- Journal Title
  
  (submitted.)
  
  Pages: 0-0
- NAID
  130000253386
- Data Source
  KAKENHI-PROJECT-18590213
[Presentation] Cav3.1カルシウムチャネルを介したアポトーシス機序2012
- Author(s)
  大久保つや子, 他2名
- Organizer
  日本薬理学会第85回年会
- Place of Presentation
  京都
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-21590247
[Presentation] T型カルシウムチャネルCav3.1のMCF-7細胞増殖抑制の機序2011
- Author(s)
  大久保つや子, 他1名
- Organizer
  日本薬理学会第84回年会
- Place of Presentation
  東京
- Year and Date
  2011-03-23
- Data Source
  KAKENHI-PROJECT-21590247
[Presentation] T型カルシウムチャネルCav3.1のMCF-7細胞増殖抑制の機序2011
- Author(s)
  大久保つや子
- Organizer
  日本薬理学会第84回年会
- Place of Presentation
  横浜市
- Year and Date
  2011-03-23
- Data Source
  KAKENHI-PROJECT-21590247
[Presentation] MCF-7乳癌由来細胞においてT型Ca2+チャネルCav3.1はアポトーシス促進に関与する2011
- Author(s)
  大久保つや子, 他2名
- Organizer
  日本薬理学会第64回西南部会
- Place of Presentation
  福岡
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-21590247
[Presentation] 型カルシウムチャネルによるヒト乳ガン由来MCF-7細胞増殖の制御2010
- Author(s)
  大久保つや子, 他2名
- Organizer
  日本薬理学会第83回年会
- Place of Presentation
  東京
- Year and Date
  2010-03-18
- Data Source
  KAKENHI-PROJECT-21590247
[Presentation] T型カルシウムチャネルによるヒト乳ガン由来MCF-7細胞増殖の制御2010
- Author(s)
  大久保つや子
- Organizer
  日本薬理学会第83回年会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2010-03-18
- Data Source
  KAKENHI-PROJECT-21590247
[Presentation] Tarantula toxin ProTx-I differentiates between voltage-gated T-type Ca2+ channels hCav3.1 and hCav3.2.2009
- Author(s)
  T. Ohkubo, K. Kitamura
- Organizer
  36th International Congress of Physiological Sciences
- Place of Presentation
  Kyoto, japan
- Data Source
  KAKENHI-PROJECT-18590213
[Presentation] Tarantula toxin ProTx-1 differentiates between voltage-gated T-type Ca^<2+> channels hCav3.1 and hCav3.2.2009
- Author(s)
  Ohkubo T., Kitamura K.
- Organizer
  36th International Congress of Physiological Sciences
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-18590213
[Presentation] ヒト乳ガン由来MCF-7細胞の増殖制御におけるT型Ca2+チャネルの関与2009
- Author(s)
  大久保つや子, 他2名
- Organizer
  日本薬理学会第62回西南部会
- Place of Presentation
  松山
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21590247
[Presentation] ヒト乳ガン由来MCF-7細胞の増殖制御におけるT型Ca2+チャネルの関与2009
- Author(s)
  大久保つや子
- Organizer
  日本薬理学会第62回西南部会
- Place of Presentation
  愛媛県松山市
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-21590247
[Presentation] The ProTx-1 receptor site of T-type Ca^<2+> channels.2008
- Author(s)
  Ohkubo T.
- Organizer
  日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2008-03-18
- Data Source
  KAKENHI-PROJECT-18590213

1. SHIBATA Manabu (40099049)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KITAMURA Kenji (30112345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. TAKAHASHI Hiroshi (00084260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHKUBO Tsuyako 大久保 つや子

Research Projects

Research Products

Co-Researchers

Functional modification of T-type Ca2+channel gene by methylation and its role in tumor cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Physiological Significance of the T-type Ca channels in smooth muscle cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of substance P and phenolic compounds on proliferation of pulpal fibroblasts.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of analgesic action of some phenolic compounds used for dental practice.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in anti-proliferation and apoptosis in MCF-7 human breast cancer cells2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tarantula Toxin ProTx-I Differentiates Between Human T-type Voltage-Gated Ca2+ Channels Cav3.1 and Cav3.22010

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca^<2+> channels Ca_v3.1 and Ca_v3.22010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Molecular and immunohistochemical studies in expression of voltage-dependent Ca channels in dorsal root gangria from storeptozotocin-induced diabetic mice.2006

Author(s)

Journal Title

Data Source

[Journal Article] Molecular and immunohistochemical studies in expression of voltage-dependent Ca channels in dorsal root gangria from storeptozotocin-induced diabetic mice2006

Author(s)

Journal Title

Data Source

[Journal Article] Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca^<2+> channels Cav3.1 and Cav3.2.

Author(s)

Journal Title

NAID

Data Source

[Presentation] Cav3.1カルシウムチャネルを介したアポトーシス機序2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] T型カルシウムチャネルCav3.1のMCF-7細胞増殖抑制の機序2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] T型カルシウムチャネルCav3.1のMCF-7細胞増殖抑制の機序2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] MCF-7乳癌由来細胞においてT型Ca2+チャネルCav3.1はアポトーシス促進に関与する2011

Author(s)

Organizer

OHKUBO Tsuyako 大久保つや子