HOTTA Yoshihiro 堀田芳弘

Researcher Number	40109757
Other IDs
Affiliation (based on the past Project Information) *help	2003 – 2005: Aichi Medical University, Pharmacology, Professor, 医学部, 教授 2002: 愛知医科大学, 医学部, 助教授 1998 – 2000: 愛知医科大学, 医学部, 助教授 1994 – 1996: 愛知医科大学, 医学部, 助教授 1988 – 1989: 愛知医科大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator 応用薬理学・医療系薬学 / Applied pharmacology Except Principal Investigator General pharmacology
Keywords	Principal Investigator ^<31>P-NMR / MPTP / apoptosis / ESR / LVDP / ischemia-reperfused injury / guinea-pig Langendorff hearts / eNOS / Tunel / Na-H exchange inhibitor … More / Myocardial mitochondria / EPR / Fluorometry / Ischemia-reperfusion injury / NO-releasing drug. / eNOS. / ESR. / Fluorometry. / Ischemia-reperfusion injury. / NO放出化合物 / Ischemia-reperfused injury / Tuner / <31>^P-NMR / free radical / Langendorff hearts / guinea-pig / No-releasing drug / NO・ラジカル / NOS / ミトコンドリア / fluorometry / NMR / 左室内圧(LVDP) / 虚血再灌流 / c(e)NOS / NO-releasing drug … More Except Principal Investigator ^<23>Na-NMR / Na^+ / Ca^<2+> / Ca-signal / Ericaceous toxin / Resting Na fluxes / Frequency-force r. / Working heart / Cardiac glycosides / Intracellular Na / β-刺激剤 / アセビ毒 (ATX-III) / Fura-2-Caシグナル / 細胞外Na^+ / 細胞内Na^+ / リドカイン / 頻度収縮力関係 / Na-NMR / 心筋 / 細胞内Na / Caーシグナル / ツツジ科植物毒 / 静止時Na流入 / 頻度ー収縮関係 / 活動心筋 / 強心配糖体 / 細胞内Naイオン / High energy phosphates / Myocardial stretch / K^+ / Proton / Mitochondoria / Heart / NMR / H^+ / 自由エネルギー / 虚血 / 高エネルギー燐酸化合物 / カルシウムイオン / 高エネルギー憐酸化合物 / 心筋伸展 / カリウムイオン / ナトリウムイオン / カルシュームイオン / プロトン / ミトコンドリア / 心臓 / 病態薬理 / 一酸化窒素 / セロトニン / アセビ毒 / 中枢性肺出血モデル Less

Cardiomyocyte apoptosis related with mitochondrial PTP in ischemia-reperfusion injury and the development of new cardiac drug.Principal Investigator
- Principal Investigator
  
  HOTTA Yoshihiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Aichi Medical University
Cardiomyocyte apoptosis induced in ischemia-reperfusion Langendorff preparation and the development of new cardiac drug.Principal Investigator
- Principal Investigator
  
  HOTTA Yoshihiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Aichi Medical University School of Medicine
Maintenance for the positive inotropic effect in ischemic myocardial mitochondria and the development of new cardiac drug.Principal Investigator
- Principal Investigator
  
  HOTTA Yoshihiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Aichi Medical University School of Medicine
中枢性肺出血の病態薬理
- Principal Investigator
  
  TAKEYA Kazumi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Aichi Medical University
Pharmacology in heart mitochondoria
- Principal Investigator
  
  TAKEYA Kazumi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Aichi Medical University
Role of intracellular Na^+ for the inotropic mechanism of working heart
- Principal Investigator
  
  TAKEYA Kazumi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  AICHI MEDICAL UNIVERSITY

All 2006 2005 2004 Other

All Journal Article

[Journal Article] 茶カテキンEGCgのモルモット心臓に対する陽性変力効果:心臓内Ca^<2+>とNO遊離の測定2006
- Author(s)
  Yoshihiro Hotta et al.
- Journal Title
  
  J.Pharmacol, Sci. 100
  
  Pages: 226-226
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Different effects of optical isomers of the 5-HT_<1A> receptor antagonist pyrapyridolol against postischemic guinea-pig myocardial dysfunction and apoptosis through the mitochondrial permeability transition pore.2006
- Author(s)
  Lei Huang, Yoshihiro Hotta, Kunihiro Miyazeki, Naohisa Ishikawa, Yasuyoshi Miki, Yumi Sugimoto, Jun Yamada, Akinobu Nakano, Kimitoshi Nishiwaki, Yasuhiro Shimada.
- Journal Title
  
  Eur J Pharmacol 534
  
  Pages: 165-177
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Protective effects of SAE0400 (SAE), a selective Na^+-Ca^<2+> exchange (NCE) inhibitor on mitochondrial Na^+ or Ca^<2+> uptake in relation to mitochondrial permeability transition pores (MPTP) and ischemia-reperfusion guinea-pig myocardial injury.2005
- Author(s)
  Yoshihiro Hotta et al.
- Journal Title
  
  J.Pharmacol.Sci. 97(Suppl.I)
  
  Pages: 191-191
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Protective effects of SAE0400 (SAE), a selective Na^+-Ca^<2+> exchange (NCE) inhibitor, on mitochondrial Na^+ or Ca^<2+> uptake in relation to mitochondrial permeability transition pores (MPTP) and ischemia-reperfusion guinea-pig myocardial injury.2005
- Author(s)
  Yoshihiro Hotta et al.
- Journal Title
  
  J.Pharmacol.Sci. 97
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Nicorandil inhibits Ca^<++> overload of an isolated porcine myocardial mitochondria through mitochondrial permeability transition pore.2005
- Author(s)
  Yasushi Wakida, Yoshihiro Hotta, Michio Yajima, Naohisa Ishikawa, Motoyuki Fukuda, Takayuki Itoh.
- Journal Title
  
  Therapeutic Res 26
  
  Pages: 1-5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Protective effects of sarpogrelate, a 5-HT_<2A > antagonist, against postischemic myocardial dysfunction in guinea-pig hearts.2005
- Author(s)
  Tatsuya Muto, Yoshihiro Hotta, Kunihiro Miyazeki, Hiroaki Ando, Yumi Sugimoto, Jun Yamada, Yasuyoshi Miki.
- Journal Title
  
  Mol Cell Biochem 272
  
  Pages: 119-132
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Differences in the effects of Na+-H+ exchange inhibitors on cardiac function and apoptosis in guinea-pig ischemia-reperfused hearts.2004
- Author(s)
  Yoshihiro Hotta et al.
- Journal Title
  
  Eur J Pharmacol 503
  
  Pages: 109-122
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Differences in the effects of Na^+-H^+ exchange inhibitors on cardiac function and apoptosis in guinea-pig ischemia-reperfused hearts.2004
- Author(s)
  Hotta Y, Nishimaki H, Takeo T, Itoh G, Yajima M, Otsuka-Murakami H, Ishikawa N, Kawai N, Huang L, Yamada K, Yamamoto S, Matsui K, Ohashi N.
- Journal Title
  
  Eur J Pharmacol 503
  
  Pages: 109-122
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] A role of anti-verotoxin antibody immunoreactive peptide, Virp5, from rat spinal coad.2004
- Author(s)
  ISHIKAWA Naohisa, FENG Gua-Gang, ITO Yoshitake, HOTTA Yoshihiro, WAKIDA Yasushi, MURAKAMI Hidetsugu, YAJIMA Michio, ISHIKAWA Atuko, YOKOCHI Takashi.
- Journal Title
  
  Peptide 251
  
  Pages: 909-1916
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Differences in the effects of Na^+-H^+ exchange inhibitors on cardiac function and apoptosis in guinea-pig ischemia-reperfused hearts.2004
- Author(s)
  Hotta Y et al.
- Journal Title
  
  Eur J Pharmacol 503
  
  Pages: 109-122
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Protective effects of EGCg or GCg, a green tea catechin epimer, against postischemic myocardial dysfunction in guinea pig hearts.
- Author(s)
  Masaya Hirai, Lei Huang, Yoshihiro Hotta, Naohisa Ishikawa, Yasushi Wakida, Yoshitaka Fukuzawa, Akinobu Nakano.
- Journal Title
  
  Life science. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Positive inotropic effect of purified green tea catechin derivative in guinea pig hearts : the measurements of cellular Ca^<2+> and NO release.
- Author(s)
  Yoshihiro Hotta, Lei Huang, Tatsuya Muto, Michio Yajima, Kunihiro Miyazeki, Naohisa Ishikawa, Yoshitaka Fukuzawa, Yasushi Wakida, Hiromi Tushima, Hiroaki Ando, Tunemasa Nonogaki.
- Journal Title
  
  Eur J Phannacol. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Positive inotropic effect of purified green tea catechin derivative in guinea pig hearts : the measurements of cellular Ca^<2+> and NO release.
- Author(s)
  Yoshihiro Hotta, et al.
- Journal Title
  
  Eur J Pharmacol. (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590443

1. TAKEYA Kazumi (30065528)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. MURAKAMI Hidetsugu (80131225)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. YAJIMA Michio (50065596)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. ISHIKAWA Naohisa (80109321)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
5. KAWAI Norio (50095535)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. FUJITA Michiko (10257701)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ANDO Hiroaki (40148317)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. ITO Gen (10022823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 竹尾友宏 (90351105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HOTTA Yoshihiro 堀田 芳弘

Research Projects

Research Products

Co-Researchers

Cardiomyocyte apoptosis related with mitochondrial PTP in ischemia-reperfusion injury and the development of new cardiac drug.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cardiomyocyte apoptosis induced in ischemia-reperfusion Langendorff preparation and the development of new cardiac drug.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Maintenance for the positive inotropic effect in ischemic myocardial mitochondria and the development of new cardiac drug.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

中枢性肺出血の病態薬理

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pharmacology in heart mitochondoria

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of intracellular Na^+ for the inotropic mechanism of working heart

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 茶カテキンEGCgのモルモット心臓に対する陽性変力効果:心臓内Ca^<2+>とNO遊離の測定2006

Author(s)

Journal Title

Data Source

[Journal Article] Different effects of optical isomers of the 5-HT_<1A> receptor antagonist pyrapyridolol against postischemic guinea-pig myocardial dysfunction and apoptosis through the mitochondrial permeability transition pore.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Protective effects of SAE0400 (SAE), a selective Na^+-Ca^<2+> exchange (NCE) inhibitor on mitochondrial Na^+ or Ca^<2+> uptake in relation to mitochondrial permeability transition pores (MPTP) and ischemia-reperfusion guinea-pig myocardial injury.2005

Author(s)

Journal Title

Data Source

[Journal Article] Protective effects of SAE0400 (SAE), a selective Na^+-Ca^<2+> exchange (NCE) inhibitor, on mitochondrial Na^+ or Ca^<2+> uptake in relation to mitochondrial permeability transition pores (MPTP) and ischemia-reperfusion guinea-pig myocardial injury.2005

Author(s)

Journal Title

Data Source

[Journal Article] Nicorandil inhibits Ca^<++> overload of an isolated porcine myocardial mitochondria through mitochondrial permeability transition pore.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Protective effects of sarpogrelate, a 5-HT_<2A > antagonist, against postischemic myocardial dysfunction in guinea-pig hearts.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Differences in the effects of Na+-H+ exchange inhibitors on cardiac function and apoptosis in guinea-pig ischemia-reperfused hearts.2004

Author(s)

Journal Title

Data Source

[Journal Article] Differences in the effects of Na^+-H^+ exchange inhibitors on cardiac function and apoptosis in guinea-pig ischemia-reperfused hearts.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] A role of anti-verotoxin antibody immunoreactive peptide, Virp5, from rat spinal coad.2004

Author(s)

Journal Title

Description

HOTTA Yoshihiro 堀田芳弘