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YAGIHASHI Soroku  八木橋 操六

… Alternative Names

八木橋 繰六  ヤギハシ ソウロク

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Researcher Number 40111231
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-4255-774X
External Links
Affiliation (Current) 2025: 弘前大学, 医学研究科, 特任教授
Affiliation (based on the past Project Information) *help 2019 – 2023: 東邦大学, 医学部, 教授(寄付講座)
2018: 公益財団法人額田医学生物学研究所, 総合研究室, 所長
2016 – 2018: 公益財団法人額田医学生物学研究所, その他部局等, その他
2016 – 2017: 弘前大学, 医学研究科, 特任教授
2014 – 2015: 弘前大学, 医学(系)研究科(研究院), その他 … More
2014: 弘前大学, 医学部, 特任教授
2012 – 2013: 弘前大学, 医学(系)研究科(研究院), 教授
2010: 弘前大学, 医学系医学科, 教授
2007 – 2010: Hirosaki University, 大学院・医学研究科, 教授
1998 – 2006: 弘前大学, 医学部, 教授
1995 – 1996: 弘前大学, 医学部, 教授
1993: Hirosaki Univ SCH of MED, Professor, 医学部, 教授
1988 – 1992: 弘前大学, 医学部, 講師 Less
Review Section/Research Field
Principal Investigator
Experimental pathology / Basic Section 54040:Metabolism and endocrinology-related / 内分泌・代謝学 / Metabolomics / Human pathology / Experimental pathology / Human pathology
Except Principal Investigator
Neurology / Human pathology / Metabolomics / Medical systems / 広領域
Keywords
Principal Investigator
糖尿病 / ポリオール代謝 / Neuropathy / 末梢神経障害 / 2型糖尿病 / アルドース還元酵素 / 合併症 / AGE / インスリン抵抗性 / グリケーション … More / 病理変化 / 膵島神経 / 膵島血管 / RAGE / Aldose reductase / Polyol pathway / 血管障害 / 細小血管障害 / トランスジェニックマウス / 形態計測 / 病理 / 膵ランゲルハンス島 / アミロイド / β細胞 / 酸化ストレス / アポトーシス / 細胞傷害 / AGE(後期糖化生成物) / 膵島アミロイド / 微小血管 / 自律神経 / 膵島病理 / 細胞・組織 / 内科 / トランスレーショナルリサーチ / 発生・分化 / ソマトスタチン / グルカゴンン / インスリン / 糖尿病治療 / 細胞変換(化生) / 治療 / 分化転換 / α細胞 / ホルモン陰性内分泌細胞 / 内分泌細胞分化 / 膵島 / Diabetic complications / Target therapy / Glycation / ニューロパチー / 細胞傷害機構 / 遺伝子改変動物 / 標的治療 / Microangiopathy / Advanced glycation end-products / Complications / Tissue injury / Diabetes mellit / 活性酸素 / 細胞障害 / Inhibitor / Nephropathy / Transgenic Mice / Complication / Polyol Pathway / Aldose Reductase / Diabetes / 阻害剤 / 腎症 / Axonal degeneration / Neurofilament / Nerve grouwth factor / Morphometry / Regeneration / Diabetes mellitus / 軸索変性 / ニューロフィラメント / 神経成長因子受容体 / 再生神経 / アルドース還元酵素抑制剤 / 細胞骨格 / 軸索退縮 / 組織計測 / 糖尿病ラット / 糖尿病性神経障害 / サイトカイン / ランゲルハンス島 / 炎症 / マクロファージ / 新規治療法 / 急性腎不全 / 全身性炎症反応症候群(SIRS) / 虚血・再灌流 / アルドース還元酵素阻害薬 / 神経変性 / 免疫組織化学 / アルツハイマー病 / 老化 / 組織分布 / ニュ-ロフィラメント / 軸索萎縮 / ニュ-ロパチ- … More
Except Principal Investigator
糖尿病 / PCR / PGK / HUMARA / 骨髄異形成症候群 / マイクロダイセクション / 末梢神経障害 / 末梢神経 / 高血圧 / 生物・生体工学 / 量子ビーム / 神経科学 / 医用超音波システム / 病理 / 神経内科 / Klotho マウス / 小径神経線維 / 加齢 / Klotho マウス / サルコペニア / 加齢現象 / diabetic neuropathy / aldose reductase inhibitor / protein kinase C / aldose reductase / knockout mice / transgenic mice / polyol pathway / ノックアウトマウス / トランスジェニックマウス / アルドース還元酵素 / ポリオール代謝 / 神経障害 / 合併症 / IMMUNOHISTOCHEMISTRY / ACUTE LEUKEMIA / TUMOR SUPPRESSOR GENE / DNA METHYLATION / MYELODYSPLASTIC SYNDROMES / 免疫組織化学 / 免疫組織学 / 急性白血病 / 腫瘍抑制遺伝子 / DNAメチル化 / X-CHROMOSOME / CLONALITY / MYELODYSPLASTIC SYNDROME / MICRODISSECTION / X染色体 / クロナリティー / Biological membranes / Surface-sublimation by condensed-light beam / Deep-etching replica / Freeze-fracturing replica / Clean-vacuum evaporater / 光照射エッチング / 網膜 / ディ-プ・エッチング法 / 真空蒸着装置 / 生体膜 / 集束光による表面昇華 / ディ-プ・エッチング・レプリカ法 / 凍結レプリカ法 / クリ-ン真空蒸着装置 / 細小血管症 / 神経伝導速度 / 糖尿病合併症 / 高血圧臓器障害 / SHR / 末梢神経病理 / 細小血管障害 / 高血圧自然発症ラット / 再灌流傷害 / 未梢神経 / HGF治療 / 遺伝子治療 / 再潅流傷害 / 虚血 / HGF遺伝子治療 / マクロファージ / 虚血・再灌流傷害 / 糖尿病性末梢神経障害 / 虚血性末梢神経障害 / 病理学 / スフィンゴ脂質 / 生理活性 / 生体分子 / 細胞・組織 Less
  • Research Projects

    (21 results)
  • Research Products

    (199 results)
  • Co-Researchers

    (35 People)
  •  Islet neurovascular network in type 2 diabetes and its modification by diabetes treatmentfication by diabetes treatmentPrincipal Investigator

    • Principal Investigator
      八木橋 操六
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Toho University
  •  Altered neurovascular network in type 2 diabetes and its repairPrincipal Investigator

    • Principal Investigator
      Yagihashi Soroku
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Toho University
  •  Development of photoacoustic imaging system for prevention of lower limb amputation induced by diabetic polyneuropathy

    • Principal Investigator
      ISHIHARA Miya
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical systems
    • Research Institution
      National Defense Medical College
  •  Analysis of islet remodeling in type 2 diabetes and exploratory regulation of endocrine cell transdifferentiation (metaplasia)Principal Investigator

    • Principal Investigator
      Yagihashi Soroku
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      The Nukada Institute for Medical & Biological Research
  •  Nerve ageing and sarcopenia

    • Principal Investigator
      Nukada Hitoshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      The Nukada Institute for Medical & Biological Research
  •  Hypertensive neuropathy: underlying mechanisms

    • Principal Investigator
      NUKADA Hitoshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      The Nukada Institute for Medical and Biological Reseach
  •  Analysis of islet amyloid in Japanese type 2 diabetic patients and exploration of new treatment for diabetesPrincipal Investigator

    • Principal Investigator
      YAGIHASHI Soroku
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Human pathology
    • Research Institution
      Hirosaki University
  •  Ischemic neuropathy : pathogenesis and treatment

    • Principal Investigator
      NUKADA Hitoshi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      The Nukada Institute for Medical and Biological Reseach
  •  Experimental therapy for diabetic complication targeting endothelium activating factor, sphingosine-1-phosphate

    • Principal Investigator
      WADA Ryuichi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Hirosaki University
  •  全身性炎症反応症候群(SIRS)におけるポリオール代謝の役割と新規治寮法の開発Principal Investigator

    • Principal Investigator
      八木橋 操六
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Hirosaki University
  •  Diabetic complications in mice transgenic and knockout for human aldose reductase.

    • Principal Investigator
      WADA Ryuichi, 山岸 晋一朗
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Hirosaki University
  •  Exploration of pathogenesis of diabetic complications using transgenic mice and attempts of gene therapyPrincipal Investigator

    • Principal Investigator
      YAGIHASHI Soroku
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hirosaki University
  •  THE ROLE OF DNA METHYLATION ON LEUKEMIC TRANSFORMATION IN MYELODYSPLASTIC SYNDROMES

    • Principal Investigator
      KUROTAKI Hidekachi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Hirosaki University
  •  CLONAL ANALYSIS FOR MYELODYSPLASTIC SYNDROME BY MICRODISSECTION

    • Principal Investigator
      KUROTAKI Hidekachi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Hirosaki University
  •  後期糖化生成物およびその受容体の生体内分布と組織病変とのかかわりについてPrincipal Investigator

    • Principal Investigator
      八木橋 操六
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Human pathology
    • Research Institution
      Hirosaki University
  •  Hyperglycemic tissue injury: Pathogenesis of diabetic complications and its preventionPrincipal Investigator

    • Principal Investigator
      YAGIHASHI Soroku
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hirosaki University
  •  Fundamental studies on the pathogenesis of diabetic complications using transgenic mice expressing human aldose reductasePrincipal Investigator

    • Principal Investigator
      YAGIHASHI Soroku
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hirosaki University
  •  Studies on the pathogenesis and treatment of diabetic neuropahy ; mechanisms of impaired regeneration of peripheral nerve and tiral for its inhibitionPrincipal Investigator

    • Principal Investigator
      YAGIHASHI Soroku
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Hirosaki University
  •  Improvement and application of high-vacuum evaporater with condensed-light beam heater for deep-etching replication of TEM specimen

    • Principal Investigator
      TONOSAKI Akira
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      広領域
    • Research Institution
      Yamagata University
  •  糖尿病性神経障害の成因に関する研究-細胞骨格異常とその遺伝子についてPrincipal Investigator

    • Principal Investigator
      八木橋 操六
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Hirosaki University
  •  糖尿病性神経障害の成因に関する研究--細胞骨格及び膜異常の検討Principal Investigator

    • Principal Investigator
      八木橋 操六
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Institution
      Hirosaki University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book Patent

  • [Book] Diabetic Neuropathy (Pathologic basis for diabetic neuropathy in humans)2022

    • Author(s)
      Yagihashi S (ed by Tavakoli M)
    • Total Pages
      380
    • Publisher
      Elsevier
    • ISBN
      9780128206690
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Book] 糖尿病神経障害.感覚運動神経障害.糖尿病最新の治療2013-2015(岩本安彦、羽田勝計、門脇孝編)2013

    • Author(s)
      八木橋操六(分担執筆)
    • Publisher
      南江堂、東京
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Book] 糖尿病性神経障害. 病気と薬.パーフェクトBook、薬局増刊号(横田千津子、池田宇一、大越教夫編)、2012

    • Author(s)
      杉本一博、八木橋操六
    • Publisher
      南山堂、東京
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Book] 神経障害の疫学.ヴィジュアル糖尿病臨床のすべて.糖尿病予防と治療のエビデンス、荒木栄一、植木浩二郎編2012

    • Author(s)
      八木橋操六(分担執筆)
    • Publisher
      中山書店、東京、
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Book] 糖尿病性神経障害の発症機序.糖尿病学イラストレイテッド.春日雅人編2012

    • Author(s)
      八木橋操六
    • Publisher
      洋土社、東京
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Book] 糖尿病神経障害(多発神経障害と単神経障害)の病態について教えてください.循環器医から寄せられる「糖尿病と血管合併症」に関する100の質問、小室一成、山岸昌一編、2012

    • Author(s)
      八木橋操六
    • Publisher
      メディカルレビュー社、東京
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Book] 糖尿病学。基礎と臨床。(門脇孝、石橋俊、佐倉宏、戸部一之、野田光彦編)2007

    • Author(s)
      八木橋操六(分担執筆)
    • Publisher
      西村書店(東京)
    • Data Source
      KAKENHI-PROJECT-18659106
  • [Book] 臨床医のための糖尿病病理2004

    • Author(s)
      八木橋 操六
    • Total Pages
      241
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Bi-glandular and persistent enterovirus infection and distinct changes of the pancreas in slowly progressive type 1 diabetes mellitus2023

    • Author(s)
      Fukui Tomoyasu、Kobayashi Tetsuro、Jimbo Erika、Aida Kaoru、Shimada Akira、Oikawa Yoichi、Mori Yasumichi、Fujii Takeshi、Koyama Rikako、Kobayashi Kazuhiko、Takeshita Akira、Yagihashi Soroku
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 6977-6977

    • DOI

      10.1038/s41598-023-33011-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-21K08541, KAKENHI-PROJECT-22K08682, KAKENHI-PROJECT-22K08678, KAKENHI-PROJECT-21K08534
  • [Journal Article] Contribution of animal models to diabetes research: Its history, significance, and translation to humans.2023

    • Author(s)
      Soroku Yagihashi
    • Journal Title

      J Diabetes Investig

      Volume: 14 Issue: 9 Pages: 1015-1037

    • DOI

      10.1111/jdi.14034

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08682, KAKENHI-PROJECT-19K09036
  • [Journal Article] Gut as a source of new beta-cells and Segi's cap2023

    • Author(s)
      Yagihashi S.
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 14 Pages: 838-840

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Journal Article] Gut as a source of new β‐cells and Segi's cap2023

    • Author(s)
      Yagihashi Soroku
    • Journal Title

      Journal of Diabetes Investigation

      Volume: May Issue: 7 Pages: 838-840

    • DOI

      10.1111/jdi.14025

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-22K08682
  • [Journal Article] Immunohistochemical detection of enteroviruses in pancreatic tissues of patients with type 1 diabetes using a polyclonal antibody against 2A protease of Coxsackievirus. J Diabetes Invest2022

    • Author(s)
      Jimbo E, Kobayashi T, Takeshita A, Mine K, Nagafuchi S, Fukui T, Yagihashi S,
    • Journal Title

      J Diabetes Invest

      Volume: 13 Issue: 3 Pages: 435-442

    • DOI

      10.1111/jdi.13700

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-21K08541
  • [Journal Article] RAGE activation in macrophages and development of experimental diabetic polyneuropathy2022

    • Author(s)
      Osonoi Sho、Mizukami Hiroki、Takeuchi Yuki、Sugawa Hikari、Ogasawara Saori、Takaku Shizuka、Sasaki Takanori、Kudoh Kazuhiro、Ito Koichi、Sango Kazunori、Nagai Ryoji、Yamamoto Yasuhiko、Daimon Makoto、Yamamoto Hiroshi、Yagihashi Soroku
    • Journal Title

      JCI Insight

      Volume: 7 Issue: 23

    • DOI

      10.1172/jci.insight.160555

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-20K07027, KAKENHI-PROJECT-22K08682, KAKENHI-PROJECT-21H02695, KAKENHI-PROJECT-20K07773
  • [Journal Article] Diabetes in humans activates pancreatic stellate cells via RAGE in pancreatic ductal adenocarcinoma.2022

    • Author(s)
      Uchida C, Mizukami H, Hara Y, Saito T, Umetsu S, Igawa A, Osonoi S, Kudoh K, Yamamoto H, Yagihashi S, Hakamada K
    • Journal Title

      Int J Mol Sci

      Volume: 22 Issue: 21 Pages: 11716-11716

    • DOI

      10.3390/ijms222111716

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-21K08546, KAKENHI-PROJECT-21K08746, KAKENHI-PROJECT-21H02695
  • [Journal Article] The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population2022

    • Author(s)
      Takeuchi Yuki、Mizukami Hiroki、Kudoh Kazuhiro、Osonoi Sho、Sasaki Takanori、Kushibiki Hanae、Ogasawara Saori、Hara Yutaro、Igawa Akiko、Pan Xuekai、Yamada Takahiro、Yamazaki Keisuke、Mikami Tatsuya、Daimon Makoto、Yagihashi Soroku、Hakamada Kenichi、Nakaji Shigeyuki
    • Journal Title

      Neurobiology of Disease

      Volume: 173 Pages: 105839-105839

    • DOI

      10.1016/j.nbd.2022.105839

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-21K08546, KAKENHI-PROJECT-22K08682
  • [Journal Article] Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice2021

    • Author(s)
      Takhashi K, Mizukami H, Osonoi S, Ogasawara S, Hara Y, Kudoh K, Takeuchi Y, Sasaki T, Daimon M, Yagihashi S
    • Journal Title

      Neurobiol Dis

      Volume: 155 Pages: 105392-105392

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Journal Article] Islet microangiopathy and augmented be-ta cell loss in Japanese non-obese type 2 diabetes patients who died of acute myocardial infarction2021

    • Author(s)
      Takahashi K, Mizukami H, Sho Osonoi, Takeuchi Y, Kudoh K, Sasaki T, Daimon M, Yagihashi S
    • Journal Title

      J Diabetes Investigation

      Volume: 12 Issue: 12 Pages: 2149-2161

    • DOI

      10.1111/jdi.13601

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-21K08546
  • [Journal Article] Beneficial effects of combination therapy of canagliflozin and teneligliptin on diabetic polyneuropathy and beta-cell volume density in spontaneously type 2 diabeteic Goto-Kakizaki rats.2020

    • Author(s)
      Guo D, Mizukami H, Osonoi S, Takahashi K, Ogasawara S, Kudo K, Sasaki T, Yagihashi S
    • Journal Title

      Metabolism

      Volume: 107 Pages: 154232-154232

    • DOI

      10.1016/j.metabol.2020.154232

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Journal Article] What can we learn from the islet of Joslin Medalists?2020

    • Author(s)
      Yagihashi S
    • Journal Title

      J Diabetes Invest

      Volume: 11 Issue: 5 Pages: 1117-1119

    • DOI

      10.1111/jdi.13283

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Journal Article] Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.2020

    • Author(s)
      Umetsu S, Mizukami H, Saito T, Uchida C, Igawa A, Kudo K, Itabashi C, Osonoi S, Danyang G, Sasaki T, Yagihashi S, Hakamada K.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 1156-1156

    • DOI

      10.1038/s41598-020-57883-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10587, KAKENHI-PROJECT-18K16220, KAKENHI-PROJECT-19K09036
  • [Journal Article] Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway.2020

    • Author(s)
      Mizukami H, Osonoi S, Takaku S, Yamagishi SI, Ogasawara S, Sango K, Chung S, Yagihashi S
    • Journal Title

      Brain Commun

      Volume: 2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Journal Article] Cutaneous microangiopathy in patients with type2 diabetes: Impaired vascular endothelial growth factor expression and its correlation with neuropathy, retinopathy and nephropathy2019

    • Author(s)
      Sugimoto Kazuhiro、Murakami Hiroshi、Deguchi Takahisa、Arimura Aiko、Daimon Makoto、Suzuki Susumu、Shimbo Takuro、Yagihashi Soroku
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 10 Issue: 5 Pages: 13020-13020

    • DOI

      10.1111/jdi.13020

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K01643, KAKENHI-PROJECT-16K09771, KAKENHI-PROJECT-19K09036
  • [Journal Article] Unique inflammatory changes in exocrine and endocrine pancreas in enterovirus-induced fulminant Type 1 diabetes2019

    • Author(s)
      Takita M, Jimbo E, Fukui T, AIda K, Shimada A, Oikawa Y, Yagihashi S, Miura J, Babazono T, Kobayashi T
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 104 Pages: 4282-4294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Journal Article] Crucial role of Reg I from acinar-like cell cluster touching with islets (ATLANTIS) on mitogenesis of beta cells in EMC virus-induced diabetic mice2018

    • Author(s)
      Aida Kaoru、Kobayashi Tetsuro、Takeshita Akira、Jimbo Erika、Nishida Yoriko、Yagihashi Soroku、Hosoi Mitsuko、Fukui Tomoyasu、Sugawara Akira、Takasawa Shin
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 2 Pages: 963-969

    • DOI

      10.1016/j.bbrc.2018.06.103

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09895, KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-16K09771
  • [Journal Article] Distinct Inflammatory Changes of the Pancreas of Slowly Progressive Insulin-dependent (Type 1) Diabetes2018

    • Author(s)
      Aida Kaoru、Fukui Tomoyasu、Jimbo Erika、Yagihashi Soroku、Shimada Akira、Oikawa Yoichi、Mori Yasumichi、Fujii Takeshi、Nishida Yoriko、Koyama Rikako、Kobayashi Tetsuro
    • Journal Title

      Pancreas

      Volume: 47 Issue: 9 Pages: 1101-1109

    • DOI

      10.1097/mpa.0000000000001144

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Journal Article] Diabetic Neuropathy: New Insights to Early Diagnosis and Treatments2018

    • Author(s)
      Yorek Mark、Malik Rayaz A.、Calcutt Nigel A.、Vinik Aaron、Yagihashi Soroku
    • Journal Title

      Journal of Diabetes Research

      Volume: 2018 Pages: 1-3

    • DOI

      10.1155/2018/5378439

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Journal Article] A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism.2018

    • Author(s)
      Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara S, Mizukami H, Yagihashi S, Chung SK, Sango K.
    • Journal Title

      J Neurochem

      Volume: 144 Issue: 6 Pages: 710-722

    • DOI

      10.1111/jnc.14277

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09771, KAKENHI-PROJECT-18K06507, KAKENHI-PROJECT-15K06763, KAKENHI-PROJECT-16K07048
  • [Journal Article] Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation.2017

    • Author(s)
      Saito T, Mizukami H, Umetsu S, Uchida C, Inaba W, Abe M, Takahashi K, Kudo K, Itabashi C, Yagihashi S, Hakamada K.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 18056-18067

    • DOI

      10.1038/s41598-017-18438-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09771, KAKENHI-PROJECT-16K10587
  • [Journal Article] Diabetes and pancreas size, does it matter?2017

    • Author(s)
      Yagihashi S
    • Journal Title

      J Diabetes Investig

      Volume: 8 Issue: 4 Pages: 413-415

    • DOI

      10.1111/jdi.12590

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Journal Article] Impaired axonal regeneration in diabetes. Perspective on the underlying mechanism from in vivo and in vitro experimental studies.2017

    • Author(s)
      Sango K, Mizukami H, Horie H, Yagihashi S.
    • Journal Title

      Frontiers in Endocrinology

      Volume: 8 Pages: 12-12

    • DOI

      10.3389/fendo.2017.00012

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07048, KAKENHI-PROJECT-16K09771
  • [Journal Article] Pancreas Atrophy and Islet Amyloid Deposition in patients with elderly-onset type 2 diabetes.2017

    • Author(s)
      Xin A, Mizukami H, Inaba W, Yoshida T, Takeuchi YK, Yagihashi S
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: 102 Issue: 9 Pages: 3162-3171

    • DOI

      10.1210/jc.2016-3735

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Journal Article] Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa.2017

    • Author(s)
      Funamizu Y, Nishijima H, Ueno T, Ueno S, Mizukami H, Yagihashi S, Tomiyama M.
    • Journal Title

      Neurosci Res.

      Volume: 121 Pages: 49-53

    • DOI

      10.1016/j.neures.2017.03.010

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09771, KAKENHI-PROJECT-15H04889, KAKENHI-PROJECT-15K10503
  • [Journal Article] Four-year sequential nerve conduction changes since first visit in Japanese patients with early type 2 diabetes.2017

    • Author(s)
      Kobori M, Yagihashi S, Shiina N, Shiozawa N, Haginoya A, Ojima M, Douguchi S, Tamasawa A, Saitou M, Baba M, Osonoi T.
    • Journal Title

      J Diabetes Investig

      Volume: 8 Issue: 3 Pages: 369-376

    • DOI

      10.1111/jdi.12583

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Journal Article] Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implications2016

    • Author(s)
      Yagihashi S, Inaba W, Mizukami H
    • Journal Title

      J Diabetes Investig

      Volume: 7 Issue: 2 Pages: 155-165

    • DOI

      10.1111/jdi.12424

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Journal Article] Pancreatic ductal hyperplasia/dysplasia with obstructive chronic pancreatitis: an association with reduced pancreatic weight in type 1 diabetes.2016

    • Author(s)
      Kobayashi T, Aida K, Fukui T, Jimbo E, Shimada A, Mori Y, Fujii T, Yagihashi S.
    • Journal Title

      Diabetologia

      Volume: 59 Issue: 4 Pages: 865-867

    • DOI

      10.1007/s00125-016-3867-x

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09406, KAKENHI-PROJECT-16K09771
  • [Journal Article] Glucotoxic Mechanisms and Related Therapeutic Approaches2016

    • Author(s)
      Yagihashi S
    • Journal Title

      Int Rev Neurobiolo

      Volume: 127 Pages: 121-149

    • DOI

      10.1016/bs.irn.2016.03.006

    • ISBN
      9780128039151
    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09367, KAKENHI-PROJECT-16K09771
  • [Journal Article] Neuropathy in the spontaneously hypertensive rat: An electrophysiological and histological study2016

    • Author(s)
      Nukada H, Baba M, Ogasawara S, McMorran D, Yagihashi S
    • Journal Title

      Muscle Nerve

      Volume: - Issue: 4 Pages: 756-762

    • DOI

      10.1002/mus.25098

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09367, KAKENHI-PROJECT-16K09771
  • [Journal Article] The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: Effects on peripheral sensory nerve function, structure and molecular changes2016

    • Author(s)
      Tsuboi K, Mizukami H, Inaba W, Baba M, Yagihashi S
    • Journal Title

      Diabetologia

      Volume: 59 Issue: 4 Pages: 865-867

    • DOI

      10.1111/jnc.13439

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Journal Article] Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implicationas2016

    • Author(s)
      Yagihashi S, Inaba W, Mizukami H
    • Journal Title

      J Diabetes Investig

      Volume: 7 Pages: 155-165

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Journal Article] mRNA expression of delta-HER2 and its clinicopathological correlation in HER2-overexpressing breast cancer.2016

    • Author(s)
      Wada R, Yagihashi S, Naito Z
    • Journal Title

      Mol Med Rep

      Volume: 14 Pages: 5104-5110

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Journal Article] 糖尿病性神経障害とは~その病理学的観点から~2015

    • Author(s)
      八木橋操六
    • Journal Title

      Diabetes Frontier

      Volume: 26 Pages: 440-447

    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Journal Article] Neurological Symptoms of Sarcoidosis-induced Small Fiber Neuropathy Effectively Relieved with High-dose Steroid Pulse Therapy2015

    • Author(s)
      Saito H, Yamaguchi T, Adachi Y, Yamashita T, Wakai Y, Saito K, Shinohara Suzuki K, Yagihashi S, Terada J, Tatsumi K. Y,
    • Journal Title

      Intern Med

      Volume: 54 Pages: 1282-1296

    • NAID

      130005069786

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Journal Article] Clinical Utility of Skin Biopsy in Differentiating between Parkinson's Disease and Multiple System Atrophy2015

    • Author(s)
      Haga R, Sugimoto K, Nishijima H, Miki Y, Suzuki C, Wakabayashi K, Baba M, Yagihashi S, Tomiyama M
    • Journal Title

      Parkinsons Dis.

      Volume: 2015 Pages: 167038-167038

    • DOI

      10.1155/2015/167038

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Journal Article] Advances in pathology of diab europathy--a tribute to Paul Langerhans.2015

    • Author(s)
      Yagihashi S
    • Journal Title

      Pathol Int

      Volume: 65 Pages: 157-169

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Journal Article] 日本人の細小血管障害の特徴,新時代の臨床糖尿病学(下巻)2015

    • Author(s)
      八木橋操六
    • Journal Title

      日本臨床(増刊号2)

      Volume: 74 Pages: 15-21

    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Journal Article] Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline ofβ-cell mass in Japanese type 2 diabetic patients2014

    • Author(s)
      Mizukami H, Takahashi K, Inaba W, Tsuboi K, Osonoi S, Yoshida T, Yagihashi S
    • Journal Title

      Diabetes Care 2014 Apr 4

      Volume: [Epub ahead of print](PMID:24705612)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab).2014

    • Author(s)
      Biessels GJ, Bril V, Calcutt NA, Cameron NE, Cotter MA, Dobrowsky R, Fernyhough P, Malik RA, Obrosova IG, Pop-Busui R, Russell JW, Sima AA, Stevens MJ, Schmidt RE, Tesfaye S, Vinik AI, Wright DE, Yagihashi S, Yorek MA, Ziegler D, Zochodne DW
    • Journal Title

      J Peripher Nerv Syst

      Volume: 19 Pages: 77-87

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament.2014

    • Author(s)
      Harada Y, Furukawa K, Asari T, Chin S, Ono A, Tanaka T, Mizukami H, Murakami M, Yagihashi S, Motomura S, Ishibashi Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 443 Pages: 1014-1020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of β-cell mass in Japanese type 2 diabetic patients2014

    • Author(s)
      Mizukami H, Takahashi K, Inaba W, Tsuboi K, Osonoi S, Yoshida T, Yagihashi S.
    • Journal Title

      Diabetes Care

      Volume: 37

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese2014

    • Author(s)
      Mizukami H, Takahashi K, Inaba W, Osonoi S, Kamata K, Tsuboi K, Yagihashi S
    • Journal Title

      J Diabetes Invest

      Volume: 5 Issue: 1 Pages: 38-47

    • DOI

      10.1111/jdi.12118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591292, KAKENHI-PROJECT-24659158
  • [Journal Article] Characterization of pancreatic islets in two selectively bred mouse lines with different susceptibilities to high-fat diet-induced glucose intolerance.2014

    • Author(s)
      Nagao M, Asai A, Inaba W, Kawahara M, Shuto Y, Kobayashi S, Sanoyama D, Sugihara H, Yagihashi S, Oikawa S
    • Journal Title

      PLoS One

      Volume: 9 Issue: 1 Pages: e84725-e84725

    • DOI

      10.1371/journal.pone.0084725

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158, KAKENHI-PROJECT-25860300
  • [Journal Article] Impaired nerve fiber re- generation in axotomized peripheral nerves in streptozotocin-diabetic rats.2014

    • Author(s)
      Nishida N, Yamagishi S, Mizukami H, Yagihashi S
    • Journal Title

      J Diabetes Invest

      Volume: 4 Pages: 533-539

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] Characterization of pancreatic islets in two selectively bred mouse lines with different susceptibilities to high-fat diet-induced glucose intolerance2014

    • Author(s)
      Nagao M, Asai A, Inaba W, Kawahara M, Shuto Y, Kobayashi S, Sanoyama D, Sugihara H, Yagihashi S, Oikawa S
    • Journal Title

      PLoS One

      Volume: 9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Exendin-4 improves β-cell function in autophagy-deficient β-cell2013

    • Author(s)
      Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y, Yagihashi S, Fujitani Y, Watada H
    • Journal Title

      Endocrinology

      Volume: 154 Pages: 4512-4524

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats2013

    • Author(s)
      Mizukami H, Inaba W, Takahashi K, Kamata K, Tsuboi K, Yagihashi S
    • Journal Title

      Pancreas

      Volume: 42 Issue: 5 Pages: 786-794

    • DOI

      10.1097/mpa.0b013e318287c9b5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments.2013

    • Author(s)
      Chin S, Furukawa K, Ono A, Asari T, Harada Y, Wada K, Tanaka T, Inaba W, Mizukami H, Motomura S, Yagihashi S, Ishibashi Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 436 Pages: 698-704

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] Exendin-4 improves β-cell function in autophagy-deficient β-cells.2013

    • Author(s)
      Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y, Yagihashi S, Fujitani Y, Watada H.
    • Journal Title

      Endocrinology

      Volume: 154 Pages: 4512-4524

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] The impact of low-dose insulin on peripheral nerve insulin receptor signaling in streptozotocin-induced diabetic rats.2013

    • Author(s)
      Sugimoto K, Baba M, Suzuki S, Yagihashi S.
    • Journal Title

      PLoS One

      Volume: 8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] Disseminated infection and pulmonary embolization of Cunninghamella bertholletiae complicated with hemophagocytic lymphohistiocytosis.2013

    • Author(s)
      Hirayama Y, Yajima N, Kaimori M, Akagi T, Kubo K, Saito D, Hizawa Y, Wada R, Yagihashi S.
    • Journal Title

      Intern Med

      Volume: 52 Pages: 2275-2279

    • NAID

      130003392582

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] 糖尿病性神経障害の成因研究の進歩2013

    • Author(s)
      八木橋操六、水上 浩哉
    • Journal Title

      医学のあゆみ

      Volume: 44 Pages: 139-145

    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] The impact of low-dose insulin on peripheral nerve insulin receptor signaling in streptozotocin-induced diabetic rats2013

    • Author(s)
      Sugimoto K, Baba M, Suzuki S, Yagihashi S.
    • Journal Title

      PLoS One

      Volume: 8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Primary gastric synovial sarcoma: molecular diagnosis and prediction of prognosis.2013

    • Author(s)
      Kamata K, Wada R, Yajima N, Sawada M, Wakasa H, Yagihashi S.
    • Journal Title

      Clin J Gastroenterol

      Volume: 6 Pages: 303-308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats.2013

    • Author(s)
      Mizukami H, Inaba W, Takahashi K, Kamata K, Tsuboi K, Yagihashi S.
    • Journal Title

      Pancreas

      Volume: 42 Pages: 786-794

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] Exendin-4 improves β-cell function in autophagy-deficient β-cells.2013

    • Author(s)
      Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku
    • Journal Title

      Endocrinology

      Volume: 154 Issue: 12 Pages: 4512-24

    • DOI

      10.1210/en.2013-1578

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390244, KAKENHI-PROJECT-24659158, KAKENHI-PROJECT-25460276, KAKENHI-PROJECT-25860757
  • [Journal Article] 糖尿病性多発神経障害の成因を考える : 病理と生化学の関連 (特集 糖尿病性神経障害臨床のピットフォール : 糖尿病および関連領域専門医それぞれの立場から) 。2013

    • Author(s)
      水上 浩哉 , 八木橋操六
    • Journal Title

      糖尿病

      Volume: 5 Pages: 6-13

    • NAID

      40019808899

    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] The impact of low-dose insulin on peripheral nerve insulin receptor signaling in streptozotocin-induced diabetic rats2013

    • Author(s)
      Sugimoto K, Baba M, Suzuki S, Yagihashi S
    • Journal Title

      PLoS One

      Volume: 8 Issue: 8 Pages: e74247-e74247

    • DOI

      10.1371/journal.pone.0074247

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Whipple disease diagnosed with PCR using formalin-fixed paraffin-embedded specimens of the intestinal mucosa.2013

    • Author(s)
      Yajima N, Wada R, Kimura S, Matsuzaki Y, Chiba D, Ebina Y, Ohkusu K, Yagihashi S.
    • Journal Title

      Intern Med

      Volume: 52 Pages: 219-222

    • NAID

      130003365854

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] Imaging of insulin factory: Is it just imagination or approaching reality?2012

    • Author(s)
      Soroku Yagihashi
    • Journal Title

      J Diabetes Invest

      Volume: 3(5) Pages: 429-431

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats2012

    • Author(s)
      Inaba W, Mizukami H, Kamata K, Takahashi K, Tsuboi K, Yagihashi S
    • Journal Title

      Eur J Pharmacol

      Volume: 691 Issue: 1-3 Pages: 297-306

    • DOI

      10.1016/j.ejphar.2012.07.030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Augmented reduction of islet beta-cell mas in Goto-Kakizaki rats fed high fat diet and its suppression by pitavastatin treatment2012

    • Author(s)
      Mizukami H, Inaba W, Takahashi K, Inoue K, Sawanobori K, Yagihashi S
    • Journal Title

      J Diabetes Invest

      Volume: 3 Issue: 3 Pages: 235-244

    • DOI

      10.1111/j.2040-1124.2011.00173.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat2012

    • Author(s)
      Takahashi K, Mizukami H, Kamata K, Inaba W, Kato N, Hibi C, Yagihashi S
    • Journal Title

      PloS One

      Volume: 7 Issue: 1 Pages: e30134-e30134

    • DOI

      10.1371/journal.pone.0030134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Imaging of insulin factory: Is it just imagination or approaching reality?2012

    • Author(s)
      Yagihashi S.
    • Journal Title

      J Diabetes Invest

      Volume: 3 Issue: 5 Pages: 429-31

    • DOI

      10.1111/j.2040-1124.2012.00236.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Clinical staging od type 2 diabetes: The time has come.2012

    • Author(s)
      Soroku Yagihashi
    • Journal Title

      J Diabetes Invest

      Volume: 3(1)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Clinical staging of type 2 diabetes: The time has come2012

    • Author(s)
      Yagihashi S.
    • Journal Title

      J Diabetes Invest

      Volume: 3 Issue: 1 Pages: 1-2

    • DOI

      10.1111/j.2040-1124.2011.00192.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Journal Article] Increased susceptibility to ischemia and macrophage activation in STZ-diabetic rat nerve2012

    • Author(s)
      Nukada H, McMorran PD, Baba M, Ogasawara S, Yagihashi S
    • Journal Title

      Brain Res

      Volume: 1373 Pages: 172-182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Journal Article] Increased susceptibility to ischemia and macrophage activation in STZ-diabetic rat nerve.2011

    • Author(s)
      Nukada H, McMorran PD, Baba M, Ogasawara S, Yagihashi S
    • Journal Title

      Brain Res

      Volume: 1373 Pages: 172-182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591037
  • [Journal Article] Increased susceptibility to ischemia and macrophage activation in STZ-diabetic rat nerve.2011

    • Author(s)
      Nukada H, McMorran PD, Baba M, Ogasawara S, Yagihashi S
    • Journal Title

      Brain Res 1373

      Pages: 172-82

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591037
  • [Journal Article] The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice.2010

    • Author(s)
      Yagihashi S, Mizukami H, Ogasawara S, Yamagishi S, Nukada H, Kato N, Hibi C, Chung S, Chung S
    • Journal Title

      J Pathol 220

      Pages: 530-41

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591037
  • [Journal Article] The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice.2010

    • Author(s)
      Yagihashi S, Mizukami H, Ogasawara S, Yamagishi S, Nukada H, Kato N, Hibi C, Chung S, Chung S.
    • Journal Title

      J Pathol

      Volume: 220 Pages: 530-541

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591037
  • [Journal Article] 簡易診断基準をベースにした糖尿病多発神経障害の臨床病期分類作成の試みと前向き疫学調査初年度における実態2009

    • Author(s)
      八木橋操六、安田斉、佐藤譲、馬場正之、額田均, ら
    • Journal Title

      末梢神経 20

      Pages: 159-61

    • NAID

      10027267911

    • Data Source
      KAKENHI-PROJECT-20591037
  • [Journal Article] 高血圧と末梢神経障害:高血圧自然発症ラット末梢神経の虚血の対する脆弱性2009

    • Author(s)
      額田均、馬場正之、小笠原早織、八木橋操六
    • Journal Title

      末梢神経 20

      Pages: 172-3

    • Data Source
      KAKENHI-PROJECT-20591037
  • [Journal Article] 簡易診断基準をベースにした糖尿病多発神経障害の臨床病期分類作成の試みと前向き疫学調査初年度における実態2009

    • Author(s)
      八木橋操六、安田斉、佐藤譲, ら
    • Journal Title

      末梢神経 20

      Pages: 159-161

    • NAID

      10027267911

    • Data Source
      KAKENHI-PROJECT-20591037
  • [Journal Article] Correction of protein kinase C activity and macrophage migration in peripheral nerve by pioglitazone, peroxisome proliferator activate-gamma-ligand, in insulin-deficient diabetic rats2008

    • Author(s)
      Yamagishi SI, Ogasawara S, Mizukami H, Yajima N, Wada RI, Sugawara A, Yagihashi S.
    • Journal Title

      J Neurochem 104

      Pages: 491-499

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659106
  • [Journal Article] Correction of protein kinase C activity and macrophage migration in peripheral nerve by pioglitazone, peroxisome proliferator activated-gamma-ligand in insulin-deficient diabetic rats2008

    • Author(s)
      Yamagishi S, Ogasawara S, Mizukami H, Yajima N, Wada R, Sugawara A, Yagihashi S
    • Journal Title

      J Neurochem 104

      Pages: 491-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591030
  • [Journal Article] 糖尿病神経障害の成因と治療その新たな展開は. 炎症論からみた糖尿病性神経障害 : 新しい治療の方向を目指して2008

    • Author(s)
      八木橋操六
    • Journal Title

      糖尿病 51S1

    • Data Source
      KAKENHI-PROJECT-19591030
  • [Journal Article] Implication of proinflammatory reactions in pathogenesis of microvascul ar complications in diabetes2007

    • Author(s)
      Yagihashi S, Yamagishi SI, Wada R.
    • Journal Title

      Hirosaki Med J 59

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659106
  • [Journal Article] Prolonged ischemic conduction failure after reperfusion in diabetic nerve.2007

    • Author(s)
      Baba M, Nukada H, McMorran D, Takahashi K, Wada R, Yagihashi S
    • Journal Title

      Muscle Nerve 33・3

      Pages: 350-355

    • Data Source
      KAKENHI-PROJECT-18659106
  • [Journal Article] 基礎講座糖尿病モデル動物I神経障害2007

    • Author(s)
      和田龍一、八木橋操六
    • Journal Title

      Diabetes Frontier 18

      Pages: 391-398

    • Data Source
      KAKENHI-PROJECT-19591030
  • [Journal Article] ポリオール代謝ルネサンス. ポリオール代謝の新しい展開と臨床応用に向けて2007

    • Author(s)
      八木橋操六
    • Journal Title

      糖尿病合併症 21

      Pages: 25-32

    • Data Source
      KAKENHI-PROJECT-18659106
  • [Journal Article] Prolonged ischemic conduction failure after reperfusion in diabetic nerve.2006

    • Author(s)
      Baba M, Nukdada H, McMorran D, Takahashi K, Wada R, Yagihashi S.
    • Journal Title

      Muscle Nerve 33・3

      Pages: 350-355

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] 2型糖尿病の膵病理2006

    • Author(s)
      八木橋操六, 和田龍一, 水上浩哉, 矢嶋信久
    • Journal Title

      病理と臨床 24・7

      Pages: 698-706

    • Data Source
      KAKENHI-PROJECT-18659106
  • [Journal Article] Prolonged ischemic conduction failure after reperfusion in diabetic nerve.2006

    • Author(s)
      Baba M, Nukada H, McMorran D, Takahashi K, Wada R, Yagihashi S
    • Journal Title

      Muscle Nerve 33

      Pages: 350-355

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Three-year inhibition of aldose reductase on development of symptomatic neuropathy in diabetic patients.2006

    • Author(s)
      Baba M, Kimura K, Suda T, Yagihashi S
    • Journal Title

      J Peripher Nerv Syst 11・2

      Pages: 176-178

    • Data Source
      KAKENHI-PROJECT-18659106
  • [Journal Article] Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic beta-cells.2006

    • Author(s)
      Kudo T, Wu J, Ogawa Y, Suga S, Hasegawa N, Suda T, Mizukami H, Yagihashi S, Wakui M
    • Journal Title

      J Pharmacol Exp Ther 318・3

      Pages: 1203-1210

    • Data Source
      KAKENHI-PROJECT-18659106
  • [Journal Article] Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage.2006

    • Author(s)
      Ho EC, Lam KS, Chen YS, Yip JC, Arvindakshan M, Yamagishi S, Yagihashi S, Oates PJ, Ellery CA, Chung SS, Chung SK
    • Journal Title

      Diabetes 55・7

      Pages: 1946-1953

    • Data Source
      KAKENHI-PROJECT-18659106
  • [Journal Article] 糖尿病性神経障害の病態生理2006

    • Author(s)
      八木橋操六
    • Journal Title

      Current Therapy 24・6

      Pages: 956-961

    • Data Source
      KAKENHI-PROJECT-18659106
  • [Journal Article] Role of advanced glycation endproducts and their receptors in development of diabetic neuropathy.2005

    • Author(s)
      Wada R, Yagihashi S
    • Journal Title

      Ann NY Acad Sci 1043

      Pages: 598-604

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Prolonged ischemic conduction failure after reperfusion in diabetic nerve.2005

    • Author(s)
      Baba M, Yagihashi S, et al.
    • Journal Title

      Muscle Nerve 33(3)

      Pages: 350-355

    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Role of advanced glycation endproducts and their receptors in development of diabetic neuropathy.2005

    • Author(s)
      Wada R, Yagihashi S.
    • Journal Title

      Ann NY Acad Sci 1043

      Pages: 598-604

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment.2005

    • Author(s)
      Toki T, Yagihashi S, et al.
    • Journal Title

      Blood 105(8)

      Pages: 3100-3108

    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Role of advanced glycation end products and their receptors in development of diabetic neuropathy.2005

    • Author(s)
      Wada R, Yagihashi S.
    • Journal Title

      Ann N Y Acad Sci 1043

      Pages: 598-604

    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice.2004

    • Author(s)
      Uehara K, Yamagishi S, Chin S, Yagihashi S.
    • Journal Title

      Diabetes 53・12

      Pages: 3239-3247

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Effects of polyol pathway hyperactivity on protein kinase C activity, n ociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice.2004

    • Author(s)
      Uehara K, Yamagishi S, Otsuki S, Chin S, Yagihashi S.
    • Journal Title

      Diabetes 53(12)

      Pages: 3239-47

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590861
  • [Journal Article] Peripheral nerve endoneurial microangiopathy and necrosis in rats with insulinoma.2004

    • Author(s)
      Sugimoto K, Shoji M, Yasujima M, Suda T, Yagihashi S.
    • Journal Title

      Acta Neuropathol 108・6(Berl)

      Pages: 503-514

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice.2004

    • Author(s)
      Uehara K, Yamagishi S, Otsuki S, Chin S, Yagihashi S
    • Journal Title

      Diabetes 53

      Pages: 3239-3247

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Peripheral nerve endoneurial microangiopathy and necrosis in rats with insulinoma.2004

    • Author(s)
      Sugimoto K, Shoji M, Yasujima M, Suda T, Yagihashi S
    • Journal Title

      Acta Neuropathol (Berl) 108

      Pages: 503-514

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Reduced cell replication and induction of apoptosis by advanced glycation end products in rat Schwann cells.2004

    • Author(s)
      Sekido H, Suzuki T, Jomori T, Takeuchi M, Yabe-Nishimura C, Yagihashi S.
    • Journal Title

      Biochem Biophys Res Commun 320・1

      Pages: 214-248

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice.2004

    • Author(s)
      Uehara K, Yamagishi S, Otsuki S, Chin S, Yagihashi S.
    • Journal Title

      Diabetes 53(12)

      Pages: 3239-3247

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590861
  • [Journal Article] Reduced cell replication and induction of apoptosis by advanced glycation end products in rat Schwann cells.2004

    • Author(s)
      Sekido H, Suzuki T, Jomori T, Takeuchi M, Yabe-Nishimura C, Yagihashi S
    • Journal Title

      Biochem Biophys Res Commun 320

      Pages: 214-248

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Differential influence of increased polyol pathway on protein kinase C expressions between endoneurial and epineurial tissues in diabetic mice.2003

    • Author(s)
      Yamagishi S, Uehara K, Otsuki S, Yagihashi S:
    • Journal Title

      J Neurochem 87

      Pages: 497-507

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Journal Article] Differential influence of increased polyol pathway on protein kinase C expressions between endoneurial and epineurial tissues in diabetic mice.2003

    • Author(s)
      Yamagishi S, Uehara K, Otsuki S, Yagihashi S.
    • Journal Title

      J Neurochem 87・2

      Pages: 497-507

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370073
  • [Patent] 急性腎不全の予防または治療剤2006

    • Inventor(s)
      八木橋 操六, 小笠原 早織, 日比 千尋
    • Industrial Property Rights Holder
      弘前大学, 三和化学
    • Industrial Property Number
      2005-362579
    • Filing Date
      2006-12-15
    • Data Source
      KAKENHI-PROJECT-18659106
  • [Presentation] Implication of cyclin D2 in beta cell proliferation of human perinatal islet2021

    • Author(s)
      Osonoi S, Sasaki T, Kudo K, Yagihashi S, Mizukami H
    • Organizer
      80th American Diabetes Association meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Presentation] Activated xanthine oxidase in serum is a potent therapeutic target for experimental diabetic polyneuropathy2021

    • Author(s)
      Ichinohe H, Mizukami H, Osonoi S, Takahashi K, Ogasawara S, Yagihashi S
    • Organizer
      80th American Diabetes Association meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Presentation] Type 2 diabetes is a prognostic factor of non-B nonC hepatocellular carcinoma with increasing DPYSL3 promoter hypermethylation2021

    • Author(s)
      Mizukami H, Umetsu S, Uchida C, Igawa A, Kudoh K, Osonoi S, Sasaki T, Yagihashi S
    • Organizer
      80th American Diabetes Association meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Presentation] ヒト2型糖尿病におけるM1マクロファージ浸潤と末梢神経病理学的変化2019

    • Author(s)
      山田咲季子,遅野井祥,高橋和久,工藤和洋,板橋智映子,八木橋操六,水上浩哉
    • Organizer
      第62回日本糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 急性心筋梗塞合併2型糖尿病は膵島病理学的所見により亜分類される2019

    • Author(s)
      水上浩哉、高橋和久、遅野井祥、郭丹陽、工藤和洋、板橋智映子、八木橋操六
    • Organizer
      第108回日本病理学会
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Presentation] Performance validation of improved photoacoustic/ultrasound superposed imaging system for evaluation of diabetic neuropathy2019

    • Author(s)
      Miya Ishihara, Kaku Irisawa,Dai Murakoshi,Takeshi Hirasawa,Shinpei Okawa,Ryuichi Azuma ,Takeshi Osonoi,Hitoshi Nukada,Soroku Yagihashi
    • Organizer
      SPIE Photonics West Biomedical Optics, BiOS 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H02113
  • [Presentation] 新しい2型糖尿病亜分類の膵島病理学的所見に基づく検証2019

    • Author(s)
      水上浩哉,高橋和久,遅野井祥,工藤和洋,板橋智映子,八木橋操六
    • Organizer
      第62回日本糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 糖尿病性神経障害におけるM1マクロファージ浸潤は逆行性軸索輸送を減弱させる2019

    • Author(s)
      遲野井祥,水上浩哉,進藤陸生,高橋和久,小笠原早織,三五一憲,山本靖彦,山本博,八木橋操六
    • Organizer
      第62回日本糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 正常高値HbA1cは小径神経障害の危険因子である2019

    • Author(s)
      板橋智映子,小笠原早織,高橋和久,遅野井祥,工藤和洋,内田知顕,梅津誠子,井川明子,八木橋操六,水上浩哉
    • Organizer
      第62回日本糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 膵島アミロイド沈着と低酸素関連分子の発現について2019

    • Author(s)
      新井仁,遅野井祥,高橋和久,工藤和洋,板橋智映子,八木橋操六,水上浩哉
    • Organizer
      第62回日本糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 緩徐進行1型糖尿病(SPIDDM)における膵内外分泌腺異常2019

    • Author(s)
      神保江莉加,滝田美夏子,福井智康,会田薫,島田朗,及川洋一,八木橋操六,小林哲郎
    • Organizer
      第62回日本糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 劇症1型糖尿病における膵病理の特徴2019

    • Author(s)
      滝田美夏子,神保江莉加,福井智康,会田薫,及川洋一,島田朗,八木橋操六,小林哲郎
    • Organizer
      第62回日本糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 胎生期から学童期の膵島内分泌細胞は各細胞独自の容積、増殖能を示す2019

    • Author(s)
      一戸寛、遅野井祥、郭丹陽、工藤和洋、水上浩哉、八木橋操六
    • Organizer
      第108回日本病理学会
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Presentation] キサンチンオキシダーゼ阻害は糖尿病性神経障害DRGを改善する2019

    • Author(s)
      高橋和久,遅野井祥,小笠原早織,八木橋操六,水上浩哉
    • Organizer
      第62回日本糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 新しい2型糖尿病亜分類の膵島病理学的所見に基づく検討2019

    • Author(s)
      水上浩哉、高橋和久、遅野井祥、工藤和洋、板橋智映子、八木橋操六
    • Organizer
      第62回日本糖尿病学会
    • Data Source
      KAKENHI-PROJECT-19K09036
  • [Presentation] 緩徐進行1型糖尿病(SPIDDM)における膵内外分泌腺異常2018

    • Author(s)
      神保江莉加,増田治美,福井智康,会田薫,八木橋操六, 島田朗,小林哲郎
    • Organizer
      第61回日本糖尿病学会学術集会総会
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 小児膵島は成人と異なる機序で維持される2018

    • Author(s)
      一戸寛,遅野井祥,成瀬亜純,木村ひより,高橋和久,阿部信,稲葉渉,水上浩哉,八木橋操六
    • Organizer
      第61回日本糖尿病学会学術集会総会
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 緩徐進行1 型糖尿病と急性発症1 型糖尿病膵の同異点2018

    • Author(s)
      福井智康,八木橋操六,小林哲郎
    • Organizer
      第61回日本糖尿病学会学術集会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 光音響イメージングの糖尿病多発神経障害の診断 病態評価への応用の試み2018

    • Author(s)
      八木橋操六, 石原 美弥
    • Organizer
      第61 回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-17H02113
  • [Presentation] 2型糖尿病と膵導管癌CDKN2A/P16プロモーターメチル化の関連2018

    • Author(s)
      阿部信,斎藤傑,内田知顕,梅津誠子,板橋智映子, 工藤和洋,八木橋操六,水上浩哉
    • Organizer
      第61回日本糖尿病学会学術集会総会
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] Clinical application of photoacoustic imaging to the evaluation of diabetic polyneuropathy2018

    • Author(s)
      Soroku Yagihashi,Miya Ishihara,Ryotaro Hotta,Ryuichi Azuma,Hitoshi Nukada,Hiroki Mizukami,Kaku Irisawa,Dai Murakoshi,Nana Shiozawa,Satako Douguchi,Miyoko Saitou,Atsuko Tamasawa,Takeshi Osonoi
    • Organizer
      ADA2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H02113
  • [Presentation] 2型糖尿病モデルdb/dbマウスにおけるキサンチン酸化還元酵素阻害薬による膵島病理学的変化への影響2018

    • Author(s)
      吉田健一郎,高橋和久,遅野井祥,小笠原早織,八木橋操六,水上浩哉
    • Organizer
      第61回日本糖尿病学会学術集会総会
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 高血圧性末梢神経障害に対する糖尿病の影響:高血圧自然発症ラット(SHR)での検討2017

    • Author(s)
      堀田亮太郎、額田 均、八木橋操六、馬場正之
    • Organizer
      第40回日本高血圧学会
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Presentation] Adjuvant effects of diabetes on hypertensive neuropathy in spontaneously hypertensive rats.2017

    • Author(s)
      Nukada H, Hotta R, Baba M, Ogasawara S, Yagihashi S.
    • Organizer
      NeuroDiab 2017、 the European Association for the Study of Diabetes (EASD)
    • Place of Presentation
      Coimbra, Portugal
    • Year and Date
      2017-09-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Presentation] Adjuvant effects of diabetes on hypertensive neuropathy in spontaneously hypertensive rats.2017

    • Author(s)
      Nukada H, Hotta R, Baba M, Ogasawara S, Yagihashi S.
    • Organizer
      The 9th Scientific Meeting of the Asian Association for the Study of Diabetes
    • Place of Presentation
      名古屋
    • Year and Date
      2017-05-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Presentation] Adjuvant effects of diabetes on hypertensive neuropathy in spontaneously hypertensive rats.2017

    • Author(s)
      Nukada H, Hotta R, Baba M, Ogasawara S, Yagihashi S
    • Organizer
      NeuroDiab 2017, the European Association for the Study of Diabetes (EASD)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Presentation] Adjuvant effects of diabetes on hypertensive neuropathy in spontaneously hypertensive rats.2017

    • Author(s)
      Nukada H, Hotta R, Baba M, Ogasawara S, Yagihashi S
    • Organizer
      The 9th Scientific Meeting of the Asian Association for the Study of Diabetes, Nagoya
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Presentation] 高血圧性末梢神経障害に対する糖尿病の影響:高血圧自然発症ラット(SHR)での検討2017

    • Author(s)
      堀田亮太郎、額田 均、八木橋操六、馬場正之
    • Organizer
      平成29年度糖尿病性神経障害を考える会
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Presentation] Islet alterations in patients with type 2 diabetes complicated with macroangiopathic diseases2016

    • Author(s)
      Takahashi K, Hiroki Mizukami, Tetsuyuki Tateda, Soroku Yagihashi
    • Organizer
      American Diabetes Association 76th meeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-06-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 緩徐進行1型糖尿病(SPIDDM)の病理学的検討2016

    • Author(s)
      神保絵梨佳、小林哲郎、福井智朗、八木橋操六
    • Organizer
      第59回日本糖尿病学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2016-05-16
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 大血管障害を有する2型糖尿病者膵島の病理学的検討2016

    • Author(s)
      高橋和久、水上浩哉、八木橋操六
    • Organizer
      第59回日本糖尿病学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2016-05-16
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 糖尿病性神経障害Update(教育講演)2016

    • Author(s)
      八木橋操六
    • Organizer
      第27回日本末梢神経学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-08-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 中高齢期の自然発症2型糖尿病GKラットの膵島変化に対するDPP-IV阻害薬効果2016

    • Author(s)
      稲葉渉、水上浩哉、小笠原早織、八木橋操六
    • Organizer
      第59回日本糖尿病学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2016-05-16
    • Data Source
      KAKENHI-PROJECT-16K09771
  • [Presentation] 高血圧自然発症ラット(SHR)末梢神経障害に対する降圧剤の効果2015

    • Author(s)
      堀田亮太郎、額田 均、八木橋操六
    • Organizer
      第38回日本高血圧学会
    • Place of Presentation
      愛媛
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Presentation] Progressive decline of compound muscle action potentials in motor nerve conduction studies in Japanese type 2 diabetic patients - four years follow-up study2015

    • Author(s)
      Kobori M, Yagihashi S, Shiina N, ShiozawaN, Haginoya A, Ojima M, Douguchi S, Tamasawa A, Saito M, Osonoi T
    • Organizer
      第25回欧州糖尿病学会末梢神経障害学会
    • Place of Presentation
      Elsinore, Denmark
    • Year and Date
      2015-09-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Presentation] The effects of angiotensin II receptor blocker (ARB) on neuropathy in spontaneopusly hypertensive rats2015

    • Author(s)
      Hotta R, Nukada H, Yagihashi S
    • Organizer
      第25回欧州糖尿病学会末梢神経障害学会
    • Place of Presentation
      Elsinore, Denmark
    • Year and Date
      2015-09-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Presentation] 高血圧自然発症ラット(SHR)末梢神経障害に対する降圧剤の効果2015

    • Author(s)
      堀田亮太郎、額田 均、八木橋操六
    • Organizer
      第26回日本末梢神経学会
    • Place of Presentation
      松本
    • Year and Date
      2015-09-17
    • Data Source
      KAKENHI-PROJECT-15K09367
  • [Presentation] 糖尿病性神経障害の成因と病態2014

    • Author(s)
      八木橋操六
    • Organizer
      日本糖尿病学会総会
    • Place of Presentation
      大阪市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Islet amyloid with macrophage migration correlates with augmented beta-cell deficits in type 2 diabetic patients2014

    • Author(s)
      Kamata K, Mizukami H, Inaba W, Takahashi K, Yagihashi S
    • Organizer
      American Diabetes Association Annual Meeting
    • Place of Presentation
      San Franscisco, USA
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] 日本人2型糖尿病の膵島アミロイド沈着と炎症反応2014

    • Author(s)
      鎌田耕輔、水上浩哉、稲葉渉、高橋一徳、八木橋操六
    • Organizer
      日本糖尿病学会総会
    • Place of Presentation
      大阪市
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] 糖尿病性末梢神経障害に対する高血圧の影響:高血圧自然発症ラット(SHR)での検討2014

    • Author(s)
      額田 均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第55回日本神経学会
    • Place of Presentation
      博多
    • Year and Date
      2014-05-21
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Presentation] インクレチン関連薬使用糖尿病者の膵病理2014

    • Author(s)
      八木橋操六、水上浩哉、稲葉渉、坪井堅太郎
    • Organizer
      日本糖尿病学会総会
    • Place of Presentation
      大阪市
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] 糖尿病性神経障害の成因の新たな展開2014

    • Author(s)
      水上浩哉、八木橋操六
    • Organizer
      日本糖尿病学会総会
    • Place of Presentation
      大阪市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] 膵炎・膵臓がんの非臨床及び臨床評価(シンポジウム)2014

    • Author(s)
      八木橋操六
    • Organizer
      日本毒性学会学術集会
    • Place of Presentation
      神戸市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] 糖尿病性末梢神経障害に対する高血圧の影響:高血圧自然発症ラット(SHR)での検討2014

    • Author(s)
      額田 均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第57回日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Presentation] Hypertensive neuropathy in spontaneously hypertensive rat2014

    • Author(s)
      Nukada H, Baba M, McMorran D, Yagihashi S
    • Organizer
      32nd World Congress of Internal Medicine
    • Place of Presentation
      韓国・ソウル
    • Year and Date
      2014-10-24
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Presentation] Amelioration of neuropathic changes with correction of nerve insulin resistance in diabetic Goto-Kakizaki rats treated with DPP-IV inhibitor vildagliptin2013

    • Author(s)
      Tsuboi K, Mizukami H, Inaba W, Kamata K, Ogasawara S, Yagihashi S
    • Organizer
      49th Annual meeting of European Association of Study of Diabetes
    • Place of Presentation
      Barcelona, Spain
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] 網羅的メタボローム解析による新規糖尿病性神経障害発症機序の探索2013

    • Author(s)
      水上浩哉、坪井堅太郎、三五一憲、鎌田耕輔、稲葉渉、八木橋操六
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Metabolomic analysis of glycolytic pathway responsible for diabetic neuropathy beyond polyol pathway hyperactivity2013

    • Author(s)
      Mizukami H, Tsuboi K, Sango K, Chung SK, Yagihashi S
    • Organizer
      73rd Annual Meeting of American Diabetes Association
    • Place of Presentation
      Chicago, USA
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Slow and minimal decline of beta cell mass associated with aging in non-diabetic Japanese and lack of compensatory islet hyperplasia in obesity2013

    • Author(s)
      Mizukami H, Takahashi K, Inaba W, Kamata K, Uehara O, Tsuboi K, Yagihashi S
    • Organizer
      49th Annual meeting of European Association of Study of Diabetes
    • Place of Presentation
      Barcelona, Spain
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] ヒト2型糖尿病膵β細胞容積減少と酸化ストレス、ERストレス、オートファジーとの関連について2013

    • Author(s)
      吉田太郎、水上浩哉、稲葉渉、鎌田耕輔、坪井堅太郎、八木橋操六
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Involvement of DNA damage, ER-stress and autophagy deficits in the β cell loss in Japanese type 2 diabetic patients2013

    • Author(s)
      Iwashita M, Mizukami H, naba W, Osonoi S, Kamata K, Tsuboi K, Yagihashi S
    • Organizer
      56th Annual Meeting of Japan Diabetes Society
    • Place of Presentation
      Kumamoto
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Progress and perspective of diabetic neuropathy care. New approach to the pathogenesis of diabetic polyneuropathy2013

    • Author(s)
      Mizukami H, Yagihashi S
    • Organizer
      56th Annual Meeting of Japan Diabetic Society
    • Place of Presentation
      Kumamoto
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] 糖尿病病理学の進歩2013

    • Author(s)
      八木橋操六
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Involvement of DNA damage, ER-stress and autophagy deficits in the b cell loss in Japanese type 2 diabetic patients2013

    • Author(s)
      Osonoi S, Mizukami H, Inaba W, Kamata K, Tsuboi K, Yagihashi S
    • Organizer
      73rd Annual Meeting of American Diabetes Association
    • Place of Presentation
      Chicago, USA
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Hexosamine pathway in the pathogenesis of diabetic neuropathy. Effects of glucosamine on the cultured Schwann cells2012

    • Author(s)
      Mizukami H, Tsuboi K, Kamata K, Takahashi K, Yagihashi S,
    • Organizer
      22nd Annual Meeting of European Study Group of Diabetic Neuropathy
    • Place of Presentation
      Dresden,Germany
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] 糖尿病性神経障害研究の進歩2012

    • Author(s)
      八木橋操六
    • Organizer
      第27回日本糖尿病合併症学会
    • Place of Presentation
      福岡市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Pathogenesis of diabetic neuropathy. Sugar or beyond sugar?2012

    • Author(s)
      Yagihashi S
    • Organizer
      9th International Diabetes Federation Asian and West Pacific Region Congress
    • Place of Presentation
      京都市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Preservation of islet beta cell mass with improvement of cell proliferation signals in GK rats treated with DPP-IV inhibitor.2012

    • Author(s)
      Kamata K, Mizukami H, Inaba W, Takahashi K, Yagihashi S
    • Organizer
      72nd Scientific sessions of American Diabetes Association
    • Place of Presentation
      Philadelphia,USA
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Slow and progressive age-related decline of beta cell mass and proliferation activity of beta cells in non-diabetic Japanese subjects2012

    • Author(s)
      Mizukami H,Takahashi K, Inaba W, Kamata K, Tsuboi K, Yagihashi S
    • Organizer
      72nd Scientific Meeting if American Diabetes Assocation
    • Place of Presentation
      Philadelphia, USA
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Amelioration of neuropathic changes with correction of nerve insulin resistance in diabetic Goto-Kakizaki rats treated with DPP-IV inhibitor, vildagliptin2012

    • Author(s)
      Tsuboi K, Mizukami H, Inaba W, KamataK, Ogasawara S, Yagihashi S
    • Organizer
      28th Annual Meeting of Neurodiab sutyd group
    • Place of Presentation
      Dresden, Germany
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] 加齢、肥満によるヒト膵島容量変化の検討2012

    • Author(s)
      水上浩哉、高橋一徳、稲葉渉、鎌田耕輔、小笠原早織、八木橋操六
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      於京王プラザホテル
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] 網羅的メタボローム解析による糖尿病性神経障害の新しい発症機序の探索2012

    • Author(s)
      水上浩哉、坪井堅太郎、 三五一憲、鎌田耕輔、稲葉渉、八木橋操六
    • Organizer
      第56回日本糖尿病学会年次集会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Progressive age-related decline of beta cell mass and proliferation activity of beta cells in non-diabetic Japanese subjects2012

    • Author(s)
      Mizukami H, Takahashi K, Inaba W, Kamata K, Tsuboi K, Yagihashi S
    • Organizer
      72nd Scientific sessions of American Diabetes Association
    • Place of Presentation
      Philadelphia,USA
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] Is the skin biopsy useful to determine the severity of polyneuropathy in Japanese type 2 diabetic subjects?2012

    • Author(s)
      Yagihashi S, Murakami H, Sugimoto K, Uehara O, Tamasawa N, Murakami C, Baba M
    • Organizer
      22nd Annual Meeting of European Study Group of Diabetic Neuropathy
    • Place of Presentation
      Dresden,Germany
    • Data Source
      KAKENHI-PROJECT-24659158
  • [Presentation] 糖尿病ラット末梢神経の虚血・再潅流傷害に対する形態学的脆弱性とマクロファージ活性化2010

    • Author(s)
      額田均、馬場正之、小笠原早織、Denise McMorran、八木橋操六
    • Organizer
      第21回日本末梢神経学会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-20591037
  • [Presentation] Ischaemic susceptibility in hypertensive nerve2009

    • Author(s)
      額田均, 馬場正之, 小笠原早織, McMorran PD, 八木橋操六
    • Organizer
      2009 Peripheral Society Meeting
    • Place of Presentation
      ドイツ、ウルツバーグ
    • Data Source
      KAKENHI-PROJECT-20591037
  • [Presentation] 虚血・再灌流、炎症論からみた神経障害、「シンポジウム:糖尿病血管合併症の成因解明へのアプローチ」2009

    • Author(s)
      額田均、八木橋操六、馬場正之
    • Organizer
      第23回日本糖尿病・肥満動物学会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-20591037
  • [Presentation] 高血圧と虚血性末梢神経障害:高血圧ラットでの検討2009

    • Author(s)
      額田均、馬場正之、Denise McMorran、八木橋操六
    • Organizer
      第52回日本糖尿病学会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-20591037
  • [Presentation] 虚血・再灌流、炎症からみた末梢神経障害2009

    • Author(s)
      額田均、八木橋操六、馬場正之
    • Organizer
      第23回日本糖尿病・肥満動物学会、シンポジウム「糖尿病合併症の成因解明へのアプローチ」
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-20591037
  • [Presentation] Ischaemic susceptibility in hypertensive nerve.2009

    • Author(s)
      Nukada H, Baba M, Ogasawara S, McMorran PD, Yagihashi S
    • Organizer
      2009 Peripheral Society Meeting
    • Place of Presentation
      Germany, Wurzberg
    • Data Source
      KAKENHI-PROJECT-20591037
  • [Presentation] 高血圧と末梢神経障害:高血圧自然発症ラット末梢神経の虚血に対する脆弱性2009

    • Author(s)
      額田均、馬場正之、小笠原早織、Denise McMorran、八木橋操六
    • Organizer
      第20回日本末梢神経学会
    • Place of Presentation
      大宮
    • Data Source
      KAKENHI-PROJECT-20591037
  • [Presentation] Hypertension and neuropathy : ischaemic susceptibility in SHR nerves2009

    • Author(s)
      額田均, 馬場正之, 小笠原早織, McMorran PD, 八木橋操六
    • Organizer
      ISDN/NEURODIAB Meeting, IDF Satellite Symposium
    • Place of Presentation
      カナダ、トロント
    • Data Source
      KAKENHI-PROJECT-20591037
  • [Presentation] Hypertension and neuropathy : ischaemic susceptibility in SHR nerves, ISDN/NEURODIAB Meeting2009

    • Author(s)
      Nukada H, Baba M, Ogasawara S, McMorran PD, Yagihashi S
    • Organizer
      IDF Satellite Symposium
    • Place of Presentation
      Canada, Toronto
    • Data Source
      KAKENHI-PROJECT-20591037
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    • Author(s)
      額田均、馬場正之、Denise McMorran、八木橋操六
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-20591037
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    • Author(s)
      Yagihashi S, Yamagishi SI, Ogasawara S, Sugawara A, Chung S
    • Organizer
      17 Neurodiab Meeting(Congress of European Soceity of Diabetic Neuropathy Study Group)
    • Place of Presentation
      オランダ、ユトレヒト市
    • Year and Date
      2007-09-14
    • Data Source
      KAKENHI-PROJECT-18659106
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    • Author(s)
      額田 均、 馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第36回日本高血圧学会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Presentation] 高血圧性末梢神経障害における細小血管症

    • Author(s)
      額田 均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第54回日本神経学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Presentation] Microangiopathy in hypertensive neuropathy

    • Author(s)
      Nukada H, Baba M, Ogasawara S, McMorran D, Mizukami H, Yagihashi S
    • Organizer
      2012 NEURODIAB Meeting
    • Place of Presentation
      ドレスデン、ドイツ
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Presentation] 高血圧性末梢神経障害での細小血管症

    • Author(s)
      額田 均、 馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第54回日本神経学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Presentation] 高血圧性末梢神経障害:SHRでの検討

    • Author(s)
      額田 均、馬場正之、小笠原早織、Denise McMorran、八木橋操六
    • Organizer
      第53回日本神経学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591307
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    • Author(s)
      額田 均、馬場正之、小笠原早織、Denise McMorran、八木橋操六
    • Organizer
      第55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24591307
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    • Author(s)
      額田 均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Presentation] 高血圧性末梢神経障害での細小血管症

    • Author(s)
      額田 均、 馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24591307
  • [Presentation] 糖尿病性神経障害の新しい展開

    • Author(s)
      八木橋操六
    • Organizer
      第56回日本糖尿病学会学術集会シンポジウム
    • Place of Presentation
      熊本
    • Invited
    • Data Source
      KAKENHI-PROJECT-24591307
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    • Author(s)
      八木橋操六
    • Organizer
      第101回日本病理学会学術集会
    • Place of Presentation
      札幌
    • Invited
    • Data Source
      KAKENHI-PROJECT-24591307
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