• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

TAKAHASHI Keikichi  高橋 慶吉

ORCIDConnect your ORCID iD *help
Researcher Number 40117148
External Links
Affiliation (based on the past Project Information) *help 2009: 国立長寿医療センター研究所, 血管性認知症研究部, 部長
2008: 順天堂大学, 国立長寿医療センター研究所, 部長
2007: 国立長寿医療センター(研究所), 血管性認知症研究部, 部長
2005 – 2006: 国立長寿医療センター, (研究所)・血管性認知症研究部, 部長
2004: National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Department of vascular dementia research, (研究所)・血管性痴呆研究部, 部長 … More
2003: 国立精神・神経センター, 疾病研究第六部, 室長
2002: Dept. Demyelinating Dis. &Aging Chief, 疾病研究第6部, 室長
2001: 国立精神・神経センター, 神経研究所・6部, 室長
2001: 国立精神・神経センター, 神経研究所・疾病6部, 室長
1999 – 2000: National Institute of Neuroscience, NCNP, Department of Demyelinating Disease and Aging, Section Chief, 神経研究所・疾病研究第6部, 室長
1998: National Institute of Neuroscience Division of Demyelinating Disease and Aging,, 神経センター・神経研究所 歙病研究第6部, 室長
1998: 国立精神, 神経センター・神経研究所疾病研究第6部, 室長
1997 – 1998: 国立精神, 神経センター・疾病研究第6部, 室長
1997 – 1998: 国立精神・神経センター, 神経研究所, 室長
1996 – 1997: 国立精神, 神経センター・神経研究所・疾病研究第6部, 室長
1995: 国立精神・神経センター, 神経研究所・第六部, 室長
1993 – 1994: 国立精神・神経センター, 神経研究所, 室長
1988 – 1990: 国立精神, 神経センター・神経研究所・疾病研究第6部, 室長
1989: Natl.Inst.Neurosci., NCNP, Section Chief, 神経研究所・疾病研究第6部, 室長 Less
Review Section/Research Field
Principal Investigator
Neurology / Neurology
Except Principal Investigator
Neurology / Biological Sciences
Keywords
Principal Investigator
CADASIL / Jagged / Vascular dementia / Notch3 / Signal transduction / シグナル伝達 / Calcium channel / Microarray analysis / Vascular smooth muscle cells / 白質脳症 … More / 血管平滑筋 / シグナル受容体 / 血管性痴呆 / calcium channel / マイクロアレイ解析 / 血管平滑筋細胞 / Degeneration of brain artery / Malti-infarct / Notch3 gene / Familial senile dementia / Vascular leukoencephalopathy / Notchシグナル伝達系 / Notch3受容体 / 家族性痴呆症 / 老年期痴呆症 / 脳動脈硬化変性 / 多発性脳梗塞 / Notch3遺伝子 / 家族性老年期痴呆症 / 脳血管性白質脳症 / Insulin-like growth factor II receptor / Insulin-like growth factor / Interleukin-3 / choline acetyltransferase / Neurotrophic factor / Cholinergic neuron / インシュリン様成長因子II / インターロイキン-3 / コリンアセチルトランスフェラーゼ / IGFII受容体 / コリン作動性ニューロン / インシュリン様成長因子 / STM / プレセニリン / S182 / アポリポプロテインE / ベータアミロイド / 病因遺伝子 / 14番染色体 / 家族性アルツハイマー病 … More
Except Principal Investigator
アルツハイマー病 / Alzheimer's disease / MAGE / ミクログリア / アミロイド / 多発性硬化症 / βアミロイド / アルツハイマ-病 / ダウン症 / トリソミ-16マウス / Chimera mouse / Animal model / Down syndrome / Trisomy 16 mouse / コリン作動性ニューロン / キメラ / マウストリソミー16 / 痴呆 / キメラマウス / 動物モデル / neurodegenerative disorder / α-synuclein / 神経変性疾患 / α-シヌクレイン / AB-DIP / adoplin / aging / neprilysin / glypican 1 / apoptosis / β amyloid / Alzheimer / LIM / DRAL / APP / PS2 / PS1 / ラフト / グリピカン / β蛋白 / エービーティップ / アドプリン / 老化 / ネプリライシン / グリピカン1 / アポトーシス / macrophage / microglia / 遺伝子発現 / SAGE / マクロファージ / idiotype network / SSCP / homunculus / CDR3 vaccine / TCR vaccination / TCR vaccine / EAE / autoimmune disease / 抗イディオタイプ・ネットワーク / 抗イディオタイプネットワーク / CDR3領域 / 神経免疫 / TCRワクチン / 老人班 / 老人斑 / amyloid / 免疫 / 十全大補湯 / モノクローナル抗体 / 漢方薬 / ワクチン / エルゴタイプ / 自己免疫病 / T細胞ワクチン / 免疫性神経疾患 / DNA免疫 / 脳移植 / 神経成長因子 / コリン作動性ニュ-ロン Less
  • Research Projects

    (12 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (13 People)
  •  Analysis of immune mechanisms of Alzheimer's disease and development of a novel treatment

    • Principal Investigator
      TABIRA Takeshi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University
      National Institute for Longevity Sciences,NCGG
  •  The role of Notch3 receptor on destruction of the vascular smooth muscle cells in the brain arteries.Principal Investigator

    • Principal Investigator
      TAKAHASHI Keikichi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology
      National Center of Neurology and Psychiatry
  •  A study on the mechanism of α-synuclein deposition: Is a novel α-synuclein interacting protein involved in α-synucleinopathies?

    • Principal Investigator
      ARAKI Wataru
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Institute of Neuroscience, NCNP
  •  Identification of aging-related factors that facilitate Alzheimer's disease

    • Principal Investigator
      TABIRA Takeshi
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      NATIONAL INSTITUTE FOR LONGEVITY SCIENCES
      National Center of Neurology and Psychiatry
  •  ミクログリアに発現しマクロファージに発現しない遺伝子の同定

    • Principal Investigator
      TABIRA Takeshi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      National Institute of Neuroscience, National Center of Neurology and Psychiatry
  •  Development of TCR-CDR3 vaccine for multiple sclerosis

    • Principal Investigator
      YAMAMURA Takashi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      National Istitute of Nueroscience
  •  Genetic study of familial vascular leukoencephalopathyPrincipal Investigator

    • Principal Investigator
      TAKAHASHI Keikichi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  DNA免疫法による免疫性神経疾患の治療・修飾に関する研究

    • Principal Investigator
      YAMAMURA Takashi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  14番染色体家族性アルツハイマー病遺伝子の分離Principal Investigator

    • Principal Investigator
      高橋 慶吉
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Effect of insulin like-growth factor on development and survival of cholinergic neuronsPrincipal Investigator

    • Principal Investigator
      TAKAHASHI Keikichi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  トリソミ-16マウスを用いたアルツハイマ-病発症機序の解析

    • Principal Investigator
      TABIRA Takeshi
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Analysis of pathogenetic mechanism of Alzheimer's disease using trisomy 16 chimera mice

    • Principal Investigator
      NISHIZAWA Masatoyo
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry (NCNP)

All 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation

  • [Journal Article] A family of membrane proteins associated with presenilin expression and gamma-secretase function2008

    • Author(s)
      Araki, W., Takahashi-Sasaki, N., Chui, D. H., Saito, S., Takeda, K., Shirotani, K., Takahashi, K., Murayama, K. S., Kametani, F., Shiraishi, H., Komano, H. & Tabira. T.
    • Journal Title

      FASEB J. 22

      Pages: 819-827

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025056
  • [Journal Article] Novel mutation of the Notch3 gene in a Japanese patient with CADASIL2007

    • Author(s)
      Oki K, Nagata E, Ishiko A, Shimizu A, Tanaka K, Takahashi K, Tabira T, Katayama T, Suzuki N.
    • Journal Title

      Eur. J. Neurol. 14(4)

      Pages: 464-466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025056
  • [Journal Article] CADASIL-causing mutations do not alter Notch3 receptor processing and activation.2006

    • Author(s)
      Low W C, Santa Y, Takahashi K, Tabira T, Kalaria R N
    • Journal Title

      NueroReort 17

      Pages: 945-949

    • Data Source
      KAKENHI-PROJECT-17025056
  • [Journal Article] Notch3 ectodomain is a major component of granular osmiophilic material (GOM) in CADASIL.2006

    • Author(s)
      Ishiko A, Shimizu A, Nagata E, Takahashi K, Tabira T, Suzuki N
    • Journal Title

      Acta Neuropathol 112

      Pages: 333-339

    • Data Source
      KAKENHI-PROJECT-17025056
  • [Journal Article] Notchシグナル異常と血管障害2005

    • Author(s)
      吉崎嘉一, 高橋慶吉
    • Journal Title

      Molecular Medicine 42

      Pages: 783-789

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590920
  • [Journal Article] Functional redundancy of the Notch gene family during mouse embryogenesis : Analysis of Notch gene expression in Notch3-deficient mice.2005

    • Author(s)
      Kitamoto T, Takahashi K, Takimoto H, Tomizuka K, Hayasaka M, Tabira T, Hanaoka K.
    • Journal Title

      Biochem.Biophys.Res.Commun. 331

      Pages: 1154-1162

    • Data Source
      KAKENHI-PROJECT-17025056
  • [Journal Article] Notch signaling and cerebral arteriopathy2005

    • Author(s)
      Kaichi Yoshizaki, Keikichi Takahashi
    • Journal Title

      Molecular Medicine 42

      Pages: 783-789

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590920
  • [Journal Article] Notchシグナル異常と血管障害2005

    • Author(s)
      吉崎嘉一, 高橋慶吉
    • Journal Title

      Molecular Medicine 42(発表予定)

    • Data Source
      KAKENHI-PROJECT-15590920
  • [Journal Article] Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease.2004

    • Author(s)
      Hara H, Monsonego A, Yuasa K, Adachi K, Xiao X, Takeda S, Takahashi K, Weiner HL, Tabira T
    • Journal Title

      J Alzheim Dis 6

      Pages: 483-488

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12210021
  • [Journal Article] Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease.2004

    • Author(s)
      Hara H, Monsonego A, Yuasa K, Adachi K, Xiao X, Takeda S, Takahashi K, Weiner HL, Tabira T.
    • Journal Title

      J Alzheim Dis 6

      Pages: 483-488

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210021
  • [Journal Article] Genetic, clinical and pathological studies of CADASIL in Japan : a partial contribution of Notch3 mutations and implications of smooth muscle cell degeneration for the pathogenesis.2003

    • Author(s)
      Santa Y, Uyama E, Chui DH, Arima M, Kotorii S, Takahashi K, Tabira T
    • Journal Title

      J Neurol Sci 212

      Pages: 79-84

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12210021
  • [Journal Article] Genetic, clinical and pathological studies of CADASIL in Japan : a partial contribution of Notch3 mutations and implications of smooth muscle cell degeneration for the pathogenesis.2003

    • Author(s)
      Santa Y, Uyama E, Chui DH, Arima M, Kotorii S, Takahashi K, Tabira T.
    • Journal Title

      J Neurol Sci 212

      Pages: 79-84

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210021
  • [Presentation] N末端構造に着目した野生型および変異Aβの物性解析2009

    • Author(s)
      武田和也、國本正子、足立香代、渡邊淳、脇田英明、高橋慶吉、田平武
    • Organizer
      第28回日本認知症学会学術集会
    • Place of Presentation
      東北大学百周年記念館、仙台
    • Year and Date
      2009-11-20
    • Data Source
      KAKENHI-PROJECT-17025056
  • 1.  TABIRA Takeshi (80112332)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 10 results
  • 2.  KUNISHITA Tatsuhide (40167383)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  NISHIZAWA Masatoyo (80198457)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  YAMAMURA Takashi (90231670)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  HARA Hideo (00260381)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  ARAKI Wataru (60311429)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  SEKIYAMA Atsuo (30403702)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MATSUMOTO Shinei (40432950)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  SAWADA Makoto (10187297)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  TANAKA Shin (70134624)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  HANAOKA Kazunori (40189577)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  INOUE Haruhisa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KAMEGAI Masahiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi