KUBO KIHEI 久保喜平

… Alternative Names

KUBO Kihei 久保喜平

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Researcher Number	40117619
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2013 – 2015: 大阪府立大学, 生命環境科学研究科(系), 教授 2010: Osaka Prefecture University, 大学院・生命環境科学研究科, 教授 2008 – 2010: Osaka Prefecture University, 生命環境科学研究科, 教授 2005: Osaka Prefecture University, Graduate School of Agriculture and Biological Science, Professor, 大学院・生命環境科学研究科, 教授 2003 – 2004: 大阪府立大学, 農学生命科学研究科, 教授 … More 2002 – 2004: Osaka Prefecture Univ., Graduate School of Agriculture and Biological Science, Professor, 大学院・農学生命科学研究科, 教授 1999 – 2001: Osaka Prefect. Univ., College of Agriculture, Professor, 農学部, 教授 1993 – 1998: 大阪府立大学, 農学部, 助教授 1987 – 1989: 札幌医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Risk sciences of radiation/Chemicals / Risk sciences of radiation and chemicals Except Principal Investigator 環境影響評価(含放射線生物学) / Applied veterinary science / Radiation science / Risk sciences of radiation/Chemicals / Molecular biology / Biological Sciences
Keywords	Principal Investigator 脱塩基部位 / グリコシラーゼ / 塩基除去修復 / ノックダウン / MAMMALIAN / BASE EXCISION REPAIR / THYMINE GLYCOL / AP SITES / BASE DAMAGE / GLYCOSYLASE … More / REACTIVE OXYGEN / DNA REPAIR / グルコシラーゼ / マウス / 哺乳動物 / チミングリコール / 塩基損傷 / 活性酸素 / DNA修復 / DNA修復制御 / 修復複合体 / ノックダウン細胞 / ＨｅＬａ細胞 / マウス胎児線維芽細胞 / ＤＮＡ修復 / DNA損傷 / AP site / ATM / ｐ53 / タンパク質間相互作用 / APEX / Pol beta / タンパク質相互作用 / RPA2 / PIKK / MPG / DSB / snRNA / 蛍光ARP / shRNA / 化学物質 / 放射線 / 修復酵素 / ノックアウトMEF / ARP / FARP-1 / DAN polymeraseβ / RNAi / 細胞周期 / FARP法 / ARP法 / AP部位 … More Except Principal Investigator DNA damage / DNA損傷 / c-kit / RT-PCR / DNA修復酵素 / DNA repair / クローニング / チミングリコール / HPLC / DNA glycosylase / DNAグリコシラーゼ / OGG1 / Fpg / NTH1 / Endo III / quantitation / abasic site / MPG / DNA修復 / 定量 / ARP / 脱塩基部位 / erbB / prohibitin / 肥満細胞腫 / プロヒビチン / 脆弱部位 / 伴侶動物 / 自然突然変異 / オスミウム酸 / 活性酸素 / 分裂酵母 / 5-ヒドロキシシトシン / supF遺伝子 / Nucleotide Pool / Osteosarcoma / Multicellular Spheroid / Phosphorylation / Potentially lethal damages / Repair of X-ray damages / Deazaadenosine / 骨肉腫 / HeLa細胞 / 放射線感受性 / スフェロイド / アデノシン誘導体 / 潜在的致死損傷 / ヌクレオチドプ-ル / 骨肉種 / 多細胞スフェロイド / リン酸化 / 潜在的致死損復 / X線損傷修復 / デアザアデノシン / crosslink / base excision repair enzymes / 塩基除去修復 / デオキシリボノラクトン / オキザニン / クロスリンク / 塩基除去修復酵素 / DNA array / aldehyde reactive probe / ゲノム / 発癌物質 / 遺伝子 / DNAアレイ / ARP法 / genetic disease / cancer / グリコシラーゼ / エンドヌクレアーゼ / DAN損傷 / Ogg1 / Epg / 遺伝病 / 発癌 / alkylation / ウラシル / ビオチン / デプリネーション / アベイシックサイト / アルキル化 / companion animal / mammary tumor / mapping / marker chromosome / erb B2 / erb B1 / erbB4 / erbB3 / 腺癌 / erb B / 乳癌 / マッピング / マーカー染色体 / feline genomic library / tumor markers / oncogenes / fragile sites / companion animals / RT‐PCR / ネコゲノムDNAライブラリー / 染色体脆弱部位 / 遺伝子マッピング / 癌抑制遺伝子 / c-kit遺伝子 / ネコ乳癌 / ホモロジー / 乳腺腫瘍 / ネコゲノムライブラリー / 腫瘍マーカー / 癌遺伝子 / A:T→C:G transversion / 塩基置換突然変異 / mutT-box / 脱ユビキチン / ミューテーター / mutT / 8-oxo-dGTP / 8-oxoG / lagging鎖合成 / leading鎖合成 / 塩基置換変異 / nei遺伝子 / nth遺伝子 / 過酸化水素 / nei遺伝子破壊大腸菌 / Endonuclease VIII / nth欠損株 Less

Regulation of the initiation of base excision repair by the protein-protein interactionsPrincipal Investigator
- Principal Investigator
  
  KUBO KIHEI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Osaka Prefecture University
Analysis of cell cycle-dependent base excision repair by a novel direct method for detecting the intracellular AP sitesPrincipal Investigator
- Principal Investigator
  
  KUBO Kihei
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Osaka Prefecture University
Identification and characterization of base excision repair enzymes involved in the repair of oxidative DNA damage
- Principal Investigator
  
  IDE Hiroshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  HIROSHIMA UNIVERSITY
FUNCTION OF NOVEL MAMMALIAN GLYCOSYLASE FOR OXYDATIVE PYRIMIDINEPrincipal Investigator
- Principal Investigator
  
  KUBO Kihei
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  OSAKA PREFECTURE UNIVERSITY
活性酸素DNA損傷修復酵素欠損の分子病態
- Principal Investigator
  
  山本和生
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Development of a novel method for gene-specific DNA damage detection
- Principal Investigator
  
  IDE Hiroshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  HIROSHIMA UNIVERSITY
活性酸素DNA損傷修復酵素欠損と突然変異
- Principal Investigator
  
  山本和生
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
活性酸素DNA損傷修復酵素欠損の分子病態
- Principal Investigator
  
  山本和生
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
DNA repair enzymes for eukaryotic genetic integrity
- Principal Investigator
  
  IDE Hiroshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Molecular biology
- Research Institution
  Hiroshima University
チミングリコール修復酵素、エンドヌクリエ-スIII、欠損の分子病態
- Principal Investigator
  
  山本和生
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Development of novel probe molecules for specific detection of abasic sites in DNA
- Principal Investigator
  
  IDE Hiroshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Hiroshima University
IMPROVED DIAGNOSIS OF TUMORS IN COMPANION ANIMALS USING PCR METHODPrincipal Investigator
- Principal Investigator
  
  KUBO Kihei, 高森康彦
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  OSAKA PREFECTURE UNIVERSITY
Stusy on the significance of the alteration in the expression of tumor related genes in the tumors of companion animals
- Principal Investigator
  
  TAKAMORI Yasuhiko
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  OSAKA PREFECTURE UNIVERSITY
The Effect of Deazaadenosines on the X-Ray Response of Human Tumor Cell Spheroid
- Principal Investigator
  
  MORITA Kazuo
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Sapporo Medical University

All 2015 2014 2013 2010 2004 2003 Other

All Journal Article Presentation Book

[Book] Recent Res.Devel.Nucleosides & Nucleotides2003
- Author(s)
  Ide, H., Kurisu, H., Tanaka, R., Asaeda, A., Kubo, K.
- Total Pages
  15
- Data Source
  KAKENHI-PROJECT-15510059
[Journal Article] AP endonuclease knockdown enhances methyl methanesulfonate hypersensitivity of DNA polymerase β knockout mouse embryonic fibroblast2015
- Author(s)
  Yamamoto, R., Umetsu, M., Yamamoto, M., Matsuyama, S., Takenaka, S., Ide, H., Kubo, K.
- Journal Title
  
  Jounal of Radiation Research
  
  Volume: 56 Issue: 3 Pages: 462-466
- DOI
  10.1093/jrr/rru125
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25340036
[Journal Article] マウス細胞におけるメチル化損傷に対するBER機構について2015
- Author(s)
  山本亮平、山本瑞希、久保喜平
- Journal Title
  
  放射線生物研究
  
  Volume: 50 Pages: 226-241
- NAID
  40020691898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25340036
[Journal Article] Abundance of BER-related proteins depends on the cellular proliferation status and presence of DNA polymerase β2015
- Author(s)
  Yamamoto, M., Yamamoto, R., Takenaka, S., Matsuyama, S., Kubo, K.
- Journal Title
  
  Jounal of Radiation Research
  
  Volume: 56 Issue: 4 Pages: 707-712
- DOI
  10.1093/jrr/rrv010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25340036
[Journal Article] Hypersensitivity of mouse NEIL1-knockdown cells to hydrogen peroxide during S phase2014
- Author(s)
  Ryohei Yamamoto
- Journal Title
  
  Journal of Radiation Research
  
  Volume: in press Issue: 4 Pages: 707-712
- DOI
  10.1093/jrr/rru021
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131010, KAKENHI-PROJECT-25340036
[Journal Article] Detection of endonuclease III- and 8-oxoguanine glycosylase-sensitive base modifications in γ-irradiate DNA and cells by the aldehyde reactive probe (ARP) assay.2004
- Author(s)
  Ali, M.M., Kurisu, S., Yoshioka, Y., Terato, H., Oyama, Y., Kubo, K., Ide, H
- Journal Title
  
  J.Radiat.Res. 45・2
  
  Pages: 229-237
- NAID
  110004041021
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510059
[Journal Article] 塩基除去修復とその相補機構2004
- Author(s)
  正岡綾, 久保喜平
- Journal Title
  
  放射線生物研究 39・4
  
  Pages: 396-407
- NAID
  40006576838
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510059
[Journal Article] Detection of endonuclease III- and 8-oxoguanine glycosylase-sensitive base modifications in g-irradiated DNA and cells by aldehyde reactive probe(ARP) assay2004
- Author(s)
  Ali, M.M., Kurisu, S., Yoshioka, Y., Terato, H., Ohyama, Y, Kubo, K., Ide, H.
- Journal Title
  
  J.Radiat.Res. 45(2)
  
  Pages: 229-237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510059
[Journal Article] Detection of endonuclease III- and 8-oxoguanine glycosylase-sensitive base modifications in γ-irradiated DNA and cells by the aldehyde reactive probe (ARP) assay.2004
- Author(s)
  Ali, M.M., Kurisu, S., Yoshioka, Y., Terato, H., Oyama, Y., Kubo, K., Ide, H
- Journal Title
  
  J.Radiat.res. 45・2
  
  Pages: 229-237
- NAID
  110004041021
- Data Source
  KAKENHI-PROJECT-15510059
[Journal Article] Detection of DNA Damage by the Aldehyde Reactive Probe(ARP) Assay : Principles and its Application2003
- Author(s)
  Ide, H., Kurisu, S., Tanaka R., Asaeda, A., Kubo, K.
- Journal Title
  
  recent Res.Devel.Biochem., Transworld research Network, Kelala, India
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510059
[Journal Article] Detection of DNA Damage by the Aldehyde Reactive Probe (ARP) Assay : Principles and its Application2003
- Author(s)
  Ide, H., Kurisu, S., Tanaka R., Asaeda, A., Kubo, K
- Journal Title
  
  Recent Res.Devel.Biochem.Transworld research Network, Kelala, India 1
  
  Pages: 33-47
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510059
[Presentation] Abundance of BER-related proteins depends on cell proliferation status and the presence of DNA polymerase β2015
- Author(s)
  Yamamoto, M., Yamamoto, R., Takenaka, S., Matsuyama, S. and Kubo, K.
- Organizer
  15th international congress of radiation research
- Place of Presentation
  国立京都国際会館（京都市左京区）
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340036
[Presentation] メチル化剤がマウスMPGの物理的相互作用に及ぼす影響の検討2015
- Author(s)
  山本瑞樹、松山聡、久保喜平、山本亮平、竹中重雄
- Organizer
  日本放射線影響学会ワークショップ
- Place of Presentation
  富山大学黒田講堂（富山市）
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-25340036
[Presentation] マウス胎児線維芽細胞におけるDNA polymerase β knockoutとAP endonuclease I knockdownのアルキル化損傷修復への影響2015
- Author(s)
  中山裕美、山本亮平、松山聡、久保喜平
- Organizer
  日本放射線影響学会ワークショップ
- Place of Presentation
  富山大学黒田講堂（富山市）
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-25340036
[Presentation] マウス胎児線維芽細胞におけるAPE1 knockdownによるアルキル化損傷修復への影響2013
- Author(s)
  山田　彩容子、梅津　万記大、山本　亮平、松山　聡、久保　喜平
- Organizer
  第156回日本獣医学会学術集会
- Place of Presentation
  岐阜市
- Data Source
  KAKENHI-PROJECT-25340036
[Presentation] Neil1ノックダウンマウス細胞の細胞周期による過酸化水素感受性の差2013
- Author(s)
  山本亮平、大城由香利、下谷竜彦、松山　聡、久保喜平
- Organizer
  日本放射線影響学会第56回大会
- Place of Presentation
  青森市
- Data Source
  KAKENHI-PROJECT-25340036
[Presentation] マウスMPGの単離精製と特性解析2013
- Author(s)
  橋本　拓磨、永野　綾子、山本　亮平、松山　聡、久保　喜平
- Organizer
  第156回日本獣医学会学術集会
- Place of Presentation
  岐阜市
- Data Source
  KAKENHI-PROJECT-25340036
[Presentation] マウス培養細胞からの1価性チミングリコールDNAグリコシラーゼ活性タンパクの分離と分析2010
- Author(s)
  山本亮平、松山聡、井出博、山本和生、久保喜平
- Organizer
  日本放射線影響学会第53回大会
- Place of Presentation
  京都
- Year and Date
  2010-10-21
- Data Source
  KAKENHI-PROJECT-20510054
[Presentation] DNA塩基損傷修復酵素MPGと関連タンパク質の相互作用の検討2010
- Author(s)
  橋平奈穂子、山本瑞希、山本亮平、竹中重雄、松山聡、久保喜平
- Organizer
  日本放射線影響学会第53回大会
- Place of Presentation
  京都
- Year and Date
  2010-10-21
- Data Source
  KAKENHI-PROJECT-20510054
[Presentation] APE1 knockdownヒト子宮頚癌細胞における塩基除去修復動態の検討2010
- Author(s)
  坪居穏佳、山本瑞希、山本亮平、松山聡、久保喜平
- Organizer
  日本放射線影響学会第53回大会
- Place of Presentation
  京都
- Year and Date
  2010-10-20
- Data Source
  KAKENHI-PROJECT-20510054
[Presentation] DNA polymeraseβ knockoutマウス胎児線維芽細胞におけるAP endonuclease knockdownによるメチル化剤感受性の変化
- Author(s)
  山本亮平、梅津万記大、松山聡、久保喜平
- Organizer
  第157回日本獣医学会学術集会
- Place of Presentation
  北海道大学（北海道・札幌市）
- Year and Date
  2014-09-09 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-25340036
[Presentation] Methypurine DNA glycosylaseとその関連タンパク量は細胞の増殖状態およびDNA polymerase βの有無に影響される
- Author(s)
  山本瑞希、山本亮平、竹中重雄、松山聡、久保喜平
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  かごしま県民交流センター（鹿児島県・鹿児島市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-25340036
[Presentation] マウスDNA polymerase β knockout細胞におけるFlap endonuclease 1 knockdownのアルキル化損傷修復への影響
- Author(s)
  鈴木紘史、山本亮平、松山聡、久保喜平
- Organizer
  第157回日本獣医学会学術集会
- Place of Presentation
  北海道大学（北海道・札幌市）
- Year and Date
  2014-09-09 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-25340036
[Presentation] 細胞の増殖状態およびDNA polymerase β（Polβ）の存在が他のBER関連タンパク量に与える影響
- Author(s)
  山本瑞希、山本亮平、竹中重雄、松山聡、久保喜平
- Organizer
  第157回日本獣医学会学術集会
- Place of Presentation
  北海道大学（北海道・札幌市）
- Year and Date
  2014-09-09 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-25340036
[Presentation] DNA polymerase β knockoutマウス胎児線維芽細胞におけるAP endonuclease knockdownによるメチル化剤感受性の影響
- Author(s)
  山本亮平、梅津万記大、山本瑞希、松山聡、久保喜平
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  かごしま県民交流センター（鹿児島県・鹿児島市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-25340036

1. MATUYAMA Satoshi (10254442)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. IDE Hiroshi (30223126)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. TERATO Hiroaki (00243543)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. 山本和生 (20093536)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. OHYAMA Yoshihiko (30169081)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 布柴達男 (10270802)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. YAMAMOTO Ryouhei (20457998)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
8. OHASHI Fumihoto (10126013)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TAKENAKA Shigeo (10280067)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
10. TAKAMORI Yasuhiko (50090460)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. SASAMOTO Kazumi

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. UI Masahiro (10336810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MORITA Kazuo (20045347)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. OUCHI Atsusi (70168863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HAREYAMA Masato (10173098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KOIWAI Soichiro (90045336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 大久保整 (40106448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 佐々木一美

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MITRA Sankar

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. VAN Houten B

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KOW Yoke W.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUBO KIHEI 久保 喜平

KUBO Kihei 久保 喜平

Research Projects

Research Products

Co-Researchers

Regulation of the initiation of base excision repair by the protein-protein interactionsPrincipal Investigator

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Analysis of cell cycle-dependent base excision repair by a novel direct method for detecting the intracellular AP sitesPrincipal Investigator

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FUNCTION OF NOVEL MAMMALIAN GLYCOSYLASE FOR OXYDATIVE PYRIMIDINEPrincipal Investigator

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IMPROVED DIAGNOSIS OF TUMORS IN COMPANION ANIMALS USING PCR METHODPrincipal Investigator

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[Book] Recent Res.Devel.Nucleosides & Nucleotides2003

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KUBO KIHEI 久保喜平

KUBO Kihei 久保喜平