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KUBO KIHEI  久保 喜平

ORCIDConnect your ORCID iD *help
… Alternative Names

KUBO Kihei  久保 喜平

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Researcher Number 40117619
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2013 – 2015: 大阪府立大学, 生命環境科学研究科(系), 教授
2010: Osaka Prefecture University, 大学院・生命環境科学研究科, 教授
2008 – 2010: Osaka Prefecture University, 生命環境科学研究科, 教授
2005: Osaka Prefecture University, Graduate School of Agriculture and Biological Science, Professor, 大学院・生命環境科学研究科, 教授
2003 – 2004: 大阪府立大学, 農学生命科学研究科, 教授 … More
2002 – 2004: Osaka Prefecture Univ., Graduate School of Agriculture and Biological Science, Professor, 大学院・農学生命科学研究科, 教授
1999 – 2001: Osaka Prefect. Univ., College of Agriculture, Professor, 農学部, 教授
1993 – 1998: 大阪府立大学, 農学部, 助教授
1987 – 1989: 札幌医科大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Risk sciences of radiation/Chemicals / Risk sciences of radiation and chemicals
Except Principal Investigator
Applied veterinary science / 環境影響評価(含放射線生物学) / Biological Sciences / Molecular biology / Risk sciences of radiation/Chemicals / Radiation science
Keywords
Principal Investigator
塩基除去修復 / グリコシラーゼ / 脱塩基部位 / ノックダウン / AP部位 / ARP法 / FARP法 / 細胞周期 / RNAi / DAN polymeraseβ … More / FARP-1 / ARP / ノックアウトMEF / 修復酵素 / 放射線 / 化学物質 / shRNA / 蛍光ARP / snRNA / DSB / MPG / PIKK / RPA2 / タンパク質相互作用 / Pol beta / APEX / タンパク質間相互作用 / p53 / ATM / AP site / DNA損傷 / DNA修復 / マウス胎児線維芽細胞 / HeLa細胞 / ノックダウン細胞 / 修復複合体 / DNA修復制御 / DNA修復 / 活性酸素 / 塩基損傷 / チミングリコール / 哺乳動物 / マウス / グルコシラーゼ / DNA REPAIR / REACTIVE OXYGEN / GLYCOSYLASE / BASE DAMAGE / AP SITES / THYMINE GLYCOL / BASE EXCISION REPAIR / MAMMALIAN … More
Except Principal Investigator
RT-PCR / c-kit / DNA損傷 / DNA damage / チミングリコール / クローニング / DNA repair / DNA修復酵素 / supF遺伝子 / 5-ヒドロキシシトシン / 分裂酵母 / 活性酸素 / オスミウム酸 / 自然突然変異 / 伴侶動物 / 脆弱部位 / プロヒビチン / 肥満細胞腫 / prohibitin / erbB / 脱塩基部位 / ARP / 定量 / DNA修復 / MPG / abasic site / quantitation / Endo III / NTH1 / Fpg / OGG1 / DNAグリコシラーゼ / DNA glycosylase / HPLC / nth欠損株 / Endonuclease VIII / nei遺伝子破壊大腸菌 / 過酸化水素 / nth遺伝子 / nei遺伝子 / 塩基置換変異 / leading鎖合成 / lagging鎖合成 / 8-oxoG / 8-oxo-dGTP / mutT / ミューテーター / 脱ユビキチン / mutT-box / 塩基置換突然変異 / A:T→C:G transversion / 癌遺伝子 / 腫瘍マーカー / ネコゲノムライブラリー / 乳腺腫瘍 / ホモロジー / ネコ乳癌 / c-kit遺伝子 / 癌抑制遺伝子 / 遺伝子マッピング / 染色体脆弱部位 / ネコゲノムDNAライブラリー / RT‐PCR / companion animals / fragile sites / oncogenes / tumor markers / feline genomic library / マーカー染色体 / マッピング / 乳癌 / erb B / 腺癌 / erbB3 / erbB4 / erb B1 / erb B2 / marker chromosome / mapping / mammary tumor / companion animal / アルキル化 / アベイシックサイト / デプリネーション / ビオチン / ウラシル / alkylation / 発癌 / 遺伝病 / Epg / Ogg1 / DAN損傷 / エンドヌクレアーゼ / グリコシラーゼ / cancer / genetic disease / ARP法 / DNAアレイ / 遺伝子 / 発癌物質 / ゲノム / aldehyde reactive probe / DNA array / 塩基除去修復酵素 / クロスリンク / オキザニン / デオキシリボノラクトン / 塩基除去修復 / base excision repair enzymes / crosslink / デアザアデノシン / X線損傷修復 / 潜在的致死損復 / リン酸化 / 多細胞スフェロイド / 骨肉種 / ヌクレオチド プ-ル / 潜在的致死損傷 / アデノシン誘導体 / スフェロイド / 放射線感受性 / HeLa細胞 / 骨肉腫 / Deazaadenosine / Repair of X-ray damages / Potentially lethal damages / Phosphorylation / Multicellular Spheroid / Osteosarcoma / Nucleotide Pool Less
  • Research Projects

    (14 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (21 People)
  •  Regulation of the initiation of base excision repair by the protein-protein interactionsPrincipal Investigator

    • Principal Investigator
      KUBO KIHEI
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      Osaka Prefecture University
  •  Analysis of cell cycle-dependent base excision repair by a novel direct method for detecting the intracellular AP sitesPrincipal Investigator

    • Principal Investigator
      KUBO Kihei
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Osaka Prefecture University
  •  Identification and characterization of base excision repair enzymes involved in the repair of oxidative DNA damage

    • Principal Investigator
      IDE Hiroshi
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  FUNCTION OF NOVEL MAMMALIAN GLYCOSYLASE FOR OXYDATIVE PYRIMIDINEPrincipal Investigator

    • Principal Investigator
      KUBO Kihei
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      OSAKA PREFECTURE UNIVERSITY
  •  活性酸素DNA損傷修復酵素欠損の分子病態

    • Principal Investigator
      山本 和生
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Development of a novel method for gene-specific DNA damage detection

    • Principal Investigator
      IDE Hiroshi
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  活性酸素DNA損傷修復酵素欠損と突然変異

    • Principal Investigator
      山本 和生
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University
  •  活性酸素DNA損傷修復酵素欠損の分子病態

    • Principal Investigator
      山本 和生
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University
  •  DNA repair enzymes for eukaryotic genetic integrity

    • Principal Investigator
      IDE Hiroshi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Molecular biology
    • Research Institution
      Hiroshima University
  •  チミングリコール修復酵素、エンドヌクリエ-スIII、欠損の分子病態

    • Principal Investigator
      山本 和生
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  Development of novel probe molecules for specific detection of abasic sites in DNA

    • Principal Investigator
      IDE Hiroshi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      Hiroshima University
  •  IMPROVED DIAGNOSIS OF TUMORS IN COMPANION ANIMALS USING PCR METHODPrincipal Investigator

    • Principal Investigator
      KUBO Kihei, 高森 康彦
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied veterinary science
    • Research Institution
      OSAKA PREFECTURE UNIVERSITY
  •  Stusy on the significance of the alteration in the expression of tumor related genes in the tumors of companion animals

    • Principal Investigator
      TAKAMORI Yasuhiko
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Applied veterinary science
    • Research Institution
      OSAKA PREFECTURE UNIVERSITY
  •  The Effect of Deazaadenosines on the X-Ray Response of Human Tumor Cell Spheroid

    • Principal Investigator
      MORITA Kazuo
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Sapporo Medical University

All 2015 2014 2013 2010 2004 2003 Other

All Journal Article Presentation Book

  • [Book] Recent Res.Devel.Nucleosides & Nucleotides2003

    • Author(s)
      Ide, H., Kurisu, H., Tanaka, R., Asaeda, A., Kubo, K.
    • Total Pages
      15
    • Data Source
      KAKENHI-PROJECT-15510059
  • [Journal Article] AP endonuclease knockdown enhances methyl methanesulfonate hypersensitivity of DNA polymerase β knockout mouse embryonic fibroblasts2015

    • Author(s)
      Yamamoto, R., Umetsu, M., Yamamoto, M., Matsuyama, S., Takenaka, S., Ide, H., Kubo, K.
    • Journal Title

      Journal of Radiation Research

      Volume: 56 Pages: 462-466

    • DOI

      10.1093/jrr/rru125

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Journal Article] マウス細胞におけるメチル化損傷に対するBER機構について2015

    • Author(s)
      山本亮平、山本瑞希、久保喜平
    • Journal Title

      放射線生物研究

      Volume: 50 Pages: 226-241

    • NAID

      40020691898

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Journal Article] Abundance of BER-related proteins depends on cell proliferation status and the presence of DNA polymerase β2015

    • Author(s)
      Yamamoto, M., Yamamoto, R., Takenaka, S., Matsuyama, S., Kubo, K.
    • Journal Title

      Journal of Radiation Research

      Volume: 56 Pages: 607-614

    • DOI

      10.1093/jrr/rrv010

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Journal Article] Hypersensitivity of mouse NEIL1-knockdown cells to hydrogen peroxide during S phase2014

    • Author(s)
      Ryohei Yamamoto
    • Journal Title

      Journal of Radiation Research

      Volume: in press

    • DOI

      10.1093/jrr/rru021

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22131010, KAKENHI-PROJECT-25340036
  • [Journal Article] Detection of endonuclease III- and 8-oxoguanine glycosylase-sensitive base modifications in γ-irradiate DNA and cells by the aldehyde reactive probe (ARP) assay.2004

    • Author(s)
      Ali, M.M., Kurisu, S., Yoshioka, Y., Terato, H., Oyama, Y., Kubo, K., Ide, H
    • Journal Title

      J.Radiat.Res. 45・2

      Pages: 229-237

    • NAID

      110004041021

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15510059
  • [Journal Article] 塩基除去修復とその相補機構2004

    • Author(s)
      正岡綾, 久保喜平
    • Journal Title

      放射線生物研究 39・4

      Pages: 396-407

    • NAID

      40006576838

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15510059
  • [Journal Article] Detection of endonuclease III- and 8-oxoguanine glycosylase-sensitive base modifications in g-irradiated DNA and cells by aldehyde reactive probe(ARP) assay2004

    • Author(s)
      Ali, M.M., Kurisu, S., Yoshioka, Y., Terato, H., Ohyama, Y, Kubo, K., Ide, H.
    • Journal Title

      J.Radiat.Res. 45(2)

      Pages: 229-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510059
  • [Journal Article] Detection of endonuclease III- and 8-oxoguanine glycosylase-sensitive base modifications in γ-irradiated DNA and cells by the aldehyde reactive probe (ARP) assay.2004

    • Author(s)
      Ali, M.M., Kurisu, S., Yoshioka, Y., Terato, H., Oyama, Y., Kubo, K., Ide, H
    • Journal Title

      J.Radiat.res. 45・2

      Pages: 229-237

    • NAID

      110004041021

    • Data Source
      KAKENHI-PROJECT-15510059
  • [Journal Article] Detection of DNA Damage by the Aldehyde Reactive Probe(ARP) Assay : Principles and its Application2003

    • Author(s)
      Ide, H., Kurisu, S., Tanaka R., Asaeda, A., Kubo, K.
    • Journal Title

      recent Res.Devel.Biochem., Transworld research Network, Kelala, India

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510059
  • [Journal Article] Detection of DNA Damage by the Aldehyde Reactive Probe (ARP) Assay : Principles and its Application2003

    • Author(s)
      Ide, H., Kurisu, S., Tanaka R., Asaeda, A., Kubo, K
    • Journal Title

      Recent Res.Devel.Biochem.Transworld research Network, Kelala, India 1

      Pages: 33-47

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15510059
  • [Presentation] Abundance of BER-related proteins depends on cell proliferation status and the presence of DNA polymerase β2015

    • Author(s)
      Yamamoto, M., Yamamoto, R., Takenaka, S., Matsuyama, S. and Kubo, K.
    • Organizer
      15th international congress of radiation research
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2015-05-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Presentation] メチル化剤がマウスMPGの物理的相互作用に及ぼす影響の検討2015

    • Author(s)
      山本瑞樹、松山聡、久保喜平、山本亮平、竹中重雄
    • Organizer
      日本放射線影響学会ワークショップ
    • Place of Presentation
      富山大学黒田講堂(富山市)
    • Year and Date
      2015-10-26
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Presentation] マウス胎児線維芽細胞におけるDNA polymerase β knockoutとAP endonuclease I knockdownのアルキル化損傷修復への影響2015

    • Author(s)
      中山裕美、山本亮平、松山聡、久保喜平
    • Organizer
      日本放射線影響学会ワークショップ
    • Place of Presentation
      富山大学黒田講堂(富山市)
    • Year and Date
      2015-10-26
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Presentation] マウス胎児線維芽細胞におけるAPE1 knockdownによるアルキル化損傷修復への影響2013

    • Author(s)
      山田 彩容子、梅津 万記大、山本 亮平、松山 聡、久保 喜平
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜市
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Presentation] Neil1ノックダウンマウス細胞の細胞周期による過酸化水素感受性の差2013

    • Author(s)
      山本亮平、大城由香利、下谷竜彦、松山 聡、久保喜平
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      青森市
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Presentation] マウスMPGの単離精製と特性解析2013

    • Author(s)
      橋本 拓磨、永野 綾子、山本 亮平、松山 聡、久保 喜平
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜市
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Presentation] マウス培養細胞からの1価性チミングリコールDNAグリコシラーゼ活性タンパクの分離と分析2010

    • Author(s)
      山本亮平、松山聡、井出博、山本和生、久保喜平
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-21
    • Data Source
      KAKENHI-PROJECT-20510054
  • [Presentation] DNA塩基損傷修復酵素MPGと関連タンパク質の相互作用の検討2010

    • Author(s)
      橋平奈穂子、山本瑞希、山本亮平、竹中重雄、松山聡、久保喜平
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-21
    • Data Source
      KAKENHI-PROJECT-20510054
  • [Presentation] APE1 knockdownヒト子宮頚癌細胞における塩基除去修復動態の検討2010

    • Author(s)
      坪居穏佳、山本瑞希、山本亮平、松山聡、久保喜平
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-20
    • Data Source
      KAKENHI-PROJECT-20510054
  • [Presentation] DNA polymeraseβ knockoutマウス胎児線維芽細胞におけるAP endonuclease knockdownによるメチル化剤感受性の変化

    • Author(s)
      山本亮平、梅津万記大、松山聡、久保喜平
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2014-09-09 – 2014-09-12
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Presentation] Methypurine DNA glycosylaseとその関連タンパク量は細胞の増殖状態およびDNA polymerase βの有無に影響される

    • Author(s)
      山本瑞希、山本亮平、竹中重雄、松山聡、久保喜平
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県・鹿児島市)
    • Year and Date
      2014-10-01 – 2014-10-03
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Presentation] マウスDNA polymerase β knockout細胞におけるFlap endonuclease 1 knockdownのアルキル化損傷修復への影響

    • Author(s)
      鈴木紘史、山本亮平、松山聡、久保喜平
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2014-09-09 – 2014-09-12
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Presentation] 細胞の増殖状態およびDNA polymerase β(Polβ)の存在が他のBER関連タンパク量に与える影響

    • Author(s)
      山本瑞希、山本亮平、竹中重雄、松山聡、久保喜平
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2014-09-09 – 2014-09-12
    • Data Source
      KAKENHI-PROJECT-25340036
  • [Presentation] DNA polymerase β knockoutマウス胎児線維芽細胞におけるAP endonuclease knockdownによるメチル化剤感受性の影響

    • Author(s)
      山本亮平、梅津万記大、山本瑞希、松山聡、久保喜平
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県・鹿児島市)
    • Year and Date
      2014-10-01 – 2014-10-03
    • Data Source
      KAKENHI-PROJECT-25340036
  • 1.  MATUYAMA Satoshi (10254442)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 2.  IDE Hiroshi (30223126)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  TERATO Hiroaki (00243543)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  山本 和生 (20093536)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  OHYAMA Yoshihiko (30169081)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  布柴 達男 (10270802)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  YAMAMOTO Ryouhei (20457998)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 8.  OHASHI Fumihoto (10126013)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  TAKENAKA Shigeo (10280067)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 10.  TAKAMORI Yasuhiko (50090460)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  SASAMOTO Kazumi
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  UI Masahiro (10336810)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MORITA Kazuo (20045347)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  OUCHI Atsusi (70168863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  HAREYAMA Masato (10173098)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  KOIWAI Soichiro (90045336)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  大久保 整 (40106448)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  佐々木 一美
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  MITRA Sankar
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  VAN Houten B
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KOW Yoke W.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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