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SAKANE Tsuyoshi  坂根 剛

ORCIDConnect your ORCID iD *help
Researcher Number 40127519
External Links
Affiliation (based on the past Project Information) *help 1991 – 1999: St. Marianna University School of Medicine, The Medical Department, Professor, 医学部, 教授
1986 – 1990: 島根医科大学, 医学部, 助教授
1986: 島根医大, 医学部, 助教授
Review Section/Research Field
Principal Investigator
内科学一般 / Biological Sciences
Except Principal Investigator
内科学一般
Keywords
Principal Investigator
全身性エリテマトーデス / Systemic lupus erythematosus / パーコール不連続比重遠心法 / systemic lupus erythematosus / receptor editing / 陽性荷電抗DNA抗体 / ループス腎炎 / Polyclonal B cell activation / サイトカイン / natural killer cells … More / oxygen radicals / chemotaxis / neutrophils / B cell activation / autoimmunity / aging / CD3抗体 / B細胞 / T細胞 / リンパ球活性化機序 / NK活性 / 好中球機能 / CD5^+B細胞 / TCRαβ^+CD4^-CD8^-T細胞 / NK細胞 / 活性酸素 / 走化性 / 好中球 / B細胞活性化機序 / 自己免疫 / 老化 / Leu 1^+ B cells / Staphylococcus aureus Cowan I / Percoll discontinuous density gradient centrifugation / Resting B cells / B cell hyperactivity / Staphylococcus aureus Cowan 【I】 / Bリンパ球異常活性 / Bリンパ球活性化機序 / B細胞増殖因子 / Leu1^+細胞 / 黄色ブドウ球菌CowanI株 / 静止期B細胞 / ポリクローナルなB細胞活性化 / B細胞異常活性 / mosaicism / X chromosome / autoreactive T cells / モザイク現象 / X染色体 / 自己反応性T細胞 / polymorphism / genetics / positive charge / A30 gene / lupus nephritis / 自己抗体 / 胚細胞型免疫グロブリン遺伝子 / 抗DNA抗体 / 多型性 / 陽性荷電 / 多形性 / 遺伝子診断 / レセプターエデイテイング / A30遺伝子 / Somatic mutation / Germline immunoglobulin gene / Cationic anti-DNA antibodies / Lupus nephritis / 抗原特異的抗体産生 / 突然変異 / 胚細胞型遺伝子 / Mechanism of anti-DNA antibody production / Nephritogenic anti=DNA antibodies / Polyclonal T cell activation / Cell adhesion molecules / CD4^+ CD45RA^+ T cells / Cells secreting cytokine / T細胞のポリクロ-ナルな活性化 / CD4^+T細胞 / 点突然変異 / 腎障害惹起性抗DNA抗体 / IgG型抗DNA抗体 / 全身性エリテマト-デス / Bリンパ球ポリクロ-ナルな活性化 / 抗DNA抗体産生機序 / 腎障害性抗DNA抗体 / Tリンパ球ポリクロ-ナルな活性化 / 接着分子 / CD4^+CD45RA^+T細胞 / サイトカイン産生細胞 / 全身性エリマト-デス / メタロプロテイネース / 炎症性サイトカイン / 細胞増殖 / 滑膜細胞 / 遺伝子 / 慢性関節リウマチ / Jun-D / 転写因子 / IFN-γ / Txk / チロシンリン酸化蛋白 / Tecファミリー / Th1型細胞 / HIV感染症 … More
Except Principal Investigator
全身性エリテマトーデス / RAG / アポトーシス / MHC class II antigen / Dual immunoregulatory function / Autoreactive T cell clone / グリコシレーション / T3関連抗原 / サプレッサー機能 / ヘルパー機能 / HLAクラス【II】抗原 / 自己認識機構 / 自己リンパ球混合培養反応 / 自己免疫疾患 / MHCクラスII抗原 / 二重免疫調節作用 / 自己反応性T細胞クローン / ANTI DNA ANTIBODY / AUTOANTIBODY / SYSTEMIC LUPUS ERYTHEMATOSUS / APOPTOSIS / RESOMBINATION / RECEPTOR EDITING / recombnation / 抗DNA抗体 / 自己抗体 / recombination / レセプターエディティング / autoreactive lymphocytes / anti-Fas ligand autoantibody / apoptosis / Fas ligand / systemic lupus erythematosus / 抗Fasリンガンド自己抗体 / Fasリガンド / 自己反応性リンパ球 / 抗Fasリガンド自己抗体 / Fasリンガンド / cyclin / cell cycle / transcription factor / proliferation / cytokine / Synovial cells / Rheumatoid arthritis / Vitamin D3 / コラゲナーゼ / 細胞増殖 / ビタミンD_3 / 細胞周期 / 転写因子 / サイトカイン / 増殖 / 慢性関節リウマチ / 滑膜細胞 / 活性化ビタミンD_3 / CD4+ T cells / T lymphocytes / mRNA / Therapy / Interleukin 2 / Systemic lupus erythematosus / Dehydroepiandrosterone / IL-2mRNA / IL-2 / CD4陽性T細胞 / Tリンパ球 / メッセンジャーRNA / 治療 / インターロイキン2 / デヒドロエピアンドロステロン / IgE / IL-12 / Th2型細胞 / Th1型細胞 Less
  • Research Projects

    (14 results)
  • Co-Researchers

    (8 People)
  •  Jun-D遺伝子導入による慢性関節リウマチの治療に関する基礎的研究Principal Investigator

    • Principal Investigator
      坂根 剛
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      St. Marianna University School of Medicine
  •  HIV感染による宿主側免疫機構の破綻とその制御Principal Investigator

    • Principal Investigator
      坂根 剛
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      St. Marianna University School of Medicine
  •  Fas ligands peripheral lymphocytes from patients with systemic lupus erythematosus

    • Principal Investigator
      TAKENO Mitsuhiro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      St.Marianna University School of Medicine
  •  FALURE OF RECOMBINATION ACTIVATING GENE EXPRESSION OF ANATI-DNA AUTOANTIBODY SECRETING B LYMPHOCYTES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

    • Principal Investigator
      SUZUKI Noburu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      ST,MARIANNA UNIVERSITY SCHOOL OF MEDICINE
  •  X-chromosome inactivation mosaicism is implicated in the emergence of autoreactive T cells in patients with systemic lupus erythematosusPrincipal Investigator

    • Principal Investigator
      SAKANE Tusyoshi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      St. Marianna University School of Medicine
  •  Identification of the gene responsible of the development of systemic lupus erythematosusPrincipal Investigator

    • Principal Investigator
      SAKANE Tsuyoshi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      ST.MARIANNA UNIVERSITY SCHOOL OF MEDICINE
  •  Th1型細胞への分化誘導によるアレルギー炎症の制御

    • Principal Investigator
      山下 直美
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      St. Marianna University School of Medicine
  •  Analysis of inhibitory mechanisms of synovial proliferation with vitamin D3

    • Principal Investigator
      HIGAKI Megumu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      St.Marianna Medical University
  •  Molecular biology of anti-DNA autoantibodies with nephritogenic potential in human lupus nephritisPrincipal Investigator

    • Principal Investigator
      SAKANE Tsuyoshi
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      St. Marianna University School of Medicine
  •  Role of dehydroepiandrosterone deficiency for the impaired interleukin 2 production of T cells in human systemic lupus erythematosus

    • Principal Investigator
      SUZUKI Noboru
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      St.Marianna University School of Medicine
  •  Cytokine production pattern of CD4+ T cells and its relation to anti-DNA antibody production in patients with systemic lupus erythematosusPrincipal Investigator

    • Principal Investigator
      SAKANE Tsuyoshi
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      St. Marianna University School of Medicine
      Shimane Medical University
  •  Age-related alteration of immune functions in humans and its relation to autoimmunityPrincipal Investigator

    • Principal Investigator
      SAKANE Tsuyoshi
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      Shimane Medical University
  •  Mechanism of autoantibody production in human systemic lupus erythematosus: analysis of the mechanism using clonal B cell progenies and monoclonal antibodies to the B cell clones.Principal Investigator

    • Principal Investigator
      SAKANE Tsuyoshi
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Shimane Medical University
  •  The abnormality of self-recogition by T cells in autoimmune state

    • Principal Investigator
      KOTANI Hiroyuki
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Shimane Medical University
  • 1.  SUZUKI Noboru (40235982)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 2.  TAKENO Mitsuhiro (50236494)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  NAGAFUCHI Hiroko (80278001)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  KOTANI Hiroyuki (90135905)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  HIGAKI Megumu (70156553)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  山下 直美 (20239974)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  中島 敏治 (70247401)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  UEDA Yuji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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