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Ochiai Toyoko  落合 豊子

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OCHIAI Toyoko  落合 豊子

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Researcher Number 40133425
Other IDs
Affiliation (Current) 2025: 一般社団法人プラズマ化学生物学研究所, 研究部, 研究員
2025: 日本大学, 医学部, 研究医員
Affiliation (based on the past Project Information) *help 2020: 一般社団法人プラズマ化学生物学研究所, 研究部, 研究員
2015 – 2019: 日本大学, 医学部, 教授
2010 – 2013: 日本大学, 医学部, 教授
2007 – 2008: Nihon University, 医学部, 教授
Review Section/Research Field
Principal Investigator
Dermatology / Basic Section 53050:Dermatology-related
Except Principal Investigator
Dermatology
Keywords
Principal Investigator
アポトーシス / ミトコンドリア / メラノーマ / 低温大気圧プラズマ / マスト細胞 / アスピリン / NOx / プラズマ照射培地 / 低温大気圧プラズマ照射剤 / 細胞死 … More / 低温大気圧プラズマ照射液 / 非アポトーシス型細胞死 / 亜硝酸イオン / プラズマ活性化輸液 / プラズマ照射液 / 一酸化窒素 / ネクロトーシス / オートファジー / プラズマ照射輸液剤 / 骨肉腫 / TRAIL / Drp-1 / ミトコンドリアダイナミクス / 抗がん作用 / AGP / 酸化ストレス / 活性酸素 / 腫瘍選択性 / Cav1.2LTCCs / Ca^<2+>チャネル / siRNA / CRACチャネル / L型カルシウムチャンネル / α1c (Cav1.2) / L 型カルシウムチャンネル / Capacitative Ca Entry機構 / L-type Ca^<2+> channels / ロイコトリエン / カルシウム … More
Except Principal Investigator
ROS / 活性酸素 / ミトコンドリア / アポトーシス / メラノーマ / TRAIL / ミトコンドリアダイナミクス / 抗がん作用 / がん / アポト-シス / 細胞膜脱分極 / カルシウム / 酸化ストレス / 腫瘍選択性 / endoplasmic reticulum / KATP / melanoma / ATP感受性カリウムチャネル Less
  • Research Projects

    (6 results)
  • Research Products

    (40 results)
  • Co-Researchers

    (5 People)
  •  Melanoma treatment by plasma-activated infusion and NOx donorsPrincipal Investigator

    • Principal Investigator
      Ochiai Toyoko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Plasma ChemiBio Laboratory
      Nihon University
  •  Therapeutic study on melanoma-killing activity of plasma-stimulated mediumPrincipal Investigator

    • Principal Investigator
      OCHIAI Toyoko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Nihon University
  •  Melanoma treatment by targeting the mitochondrial dynamics

    • Principal Investigator
      SUZUKI Yoshihiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Nihon University
  •  Melanoma therapy by TRAIL and KATP channel inhibitors

    • Principal Investigator
      SUZUKI Yoshihiro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Nihon University
  •  analysis of the mechanism for aspirin modulation of IgE-dependent mast cell activationPrincipal Investigator

    • Principal Investigator
      OCHIAI Toyoko
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Nihon University
  •  Aspirin enhances antigen-induced leukotriene synthesis in mast cells via dihydropyridine-sensitive calcium entry: implication for aspirin intolerancePrincipal Investigator

    • Principal Investigator
      OCHIAI Toyoko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Nihon University

All 2020 2019 2018 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006

All Journal Article Presentation Patent

  • [Journal Article] Aspirin Induces Mitochondrial Ca 2+ Remodeling in Tumor Cells via ROS-Depolarization-Voltage-Gated Ca 2+ Entry2020

    • Author(s)
      Fujikawa Itsuho, Ando Takashi, Suzuki-Karasaki Manami, Suzuki-Karasaki Miki, Ochiai Toyoko, Suzuki-Karasaki Y.oshihiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 13 Pages: 4771-4771

    • DOI

      10.3390/ijms21134771

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08279, KAKENHI-PROJECT-18K09121
  • [Journal Article] The Mitochondrial Ca2+ Overload via Voltage-Gated Ca2+ Entry Contributes to an Anti-Melanoma Effect of Diallyl Trisulfide.2020

    • Author(s)
      Chinatsu Nakagawa, Manami Suzuki-Karasaki , Miki Suzuki-Karasaki, Toyoko Ochiai, Yoshihiro Suzuki-Karasaki .
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 2 Pages: 491-506

    • DOI

      10.3390/ijms21020491

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08279, KAKENHI-PROJECT-18K09121
  • [Journal Article] Autophagy inhibitors regulate TRAIL sensitivity in human malignant cells by targeting the mitochondrial network and calcium dynamics.2019

    • Author(s)
      Onoe-Takahashi A, Suzuki-Karasaki M, Suzuki-Karasaki M, Ochiai T, Suzuki-Karasaki Y.
    • Journal Title

      International Journal of Oncology

      Volume: 54 Pages: 1734-1746

    • DOI

      10.3892/ijo.2019.4760

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08279, KAKENHI-PROJECT-18K09121
  • [Journal Article] Cold PSM, but not TRAIL, triggers autophagic cell death: A therapeutic advantage of PSM over TRAIL2018

    • Author(s)
      Tomohisa Ito,1 Takashi Ando,2 Miki Suzuki-Karasaki,1,3 Tomohiko Tokunaga,4 Yukihiro Yoshida,1 Toyoko Ochiai,5 Yasuaki Tokuhashi,1 and Yoshihiro Suzuki-Karasaki3,6
    • Journal Title

      Int J Oncol

      Volume: 53 Pages: 503-514

    • DOI

      10.3892/ijo.2018.4413

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10988, KAKENHI-PROJECT-18K08279, KAKENHI-PROJECT-18K09121, KAKENHI-PROJECT-16K10851
  • [Journal Article] Cold plasma-stimulated medium (PSM), but not TRAIL, trigger autophagic cell death: a therapeutic advantage of PSM over TRAIL.2018

    • Author(s)
      Ito T, Ando T, Suzuki-Karasaki M, Tokunaga T, Yoshida Y, Ochiai T, Tokuhashi Y Suzuki-Karasaki Y.
    • Journal Title

      Int J Oncol

      Volume: 印刷中

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09792
  • [Journal Article] Plasma-stimulated medium kills TRAIL-resistant human malignant cells by promoting caspase-independent cell death via membrane potential and calcium dynamics modulation.2018

    • Author(s)
      Tokunaga, Ando T, Suzuki-Karasaki M, Ito T, Onoe-Takahashi A, Ochai T, Soma M, Suzuki-Karasaki Y.
    • Journal Title

      Int J Oncol

      Volume: 52(3) Pages: 697-708

    • DOI

      10.3892/ijo.2018.4251

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06883, KAKENHI-PROJECT-15K09750, KAKENHI-PROJECT-15K09792, KAKENHI-PROJECT-16K10851
  • [Journal Article] Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells :role of plasma membrane depolarization2015

    • Author(s)
      Yoshihiro Suzuki-Karasaki , Toyoko Ochiai et al.
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 21572-21588

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09792
  • [Journal Article] Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization2015

    • Author(s)
      Yoshihiro Suzuki-Karasaki, Kyoko Fujiwara, Kosuke Saito, Miki-Suzuki-Karasaki, Toyoko Ochiai, Masayoshi Soma
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 21572-21588

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09750
  • [Journal Article] Crosstalk between mitochondrial ROS and depolarization in the potentiation of TRAIL-induced apoptosis in human tumor cells.2014

    • Author(s)
      Suzuki-Karasaki M, Ochiai T, Suzuki-Karasaki Y
    • Journal Title

      International Journal of Oncology

      Volume: 44 Issue: 2 Pages: 616-628

    • DOI

      10.3892/ijo.2013.2215

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591631
  • [Journal Article] Depolarization controls TRAIL sensitization and selective killing of cancer cells : crosstalk with ROS2014

    • Author(s)
      Suzuki-Karasaki Y, Suzuki-Karasaki M, Uchida M, Ochiai T
    • Journal Title

      Frontiers Oncol

      Volume: 4(Article 128) Pages: 1-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591631
  • [Journal Article] Hydrogen peroxide induces cell death in human TRAIL-resistant melanoma through intracellular superoxide generation.2013

    • Author(s)
      Tochigi M, Inoue T, Suzuki-Karasaki M, Ochiai T, Ra C, Suzuki-Karasaki Y.
    • Journal Title

      International Journal of Oncology

      Volume: 42 Issue: 3 Pages: 863-872

    • DOI

      10.3892/ijo.2013.1769

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591631
  • [Journal Article] Hydrogen peroxide induces cell death in human TRAIL-resistant melanoma through intracellular superoxide generation2013

    • Author(s)
      Tochigi M, Inoue T, Suzuki-Karasaki M, Ochiai T, Ra C, Suzuki-Karasaki Y
    • Journal Title

      Int J Oncol

      Volume: 42 Pages: 863-872

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591631
  • [Journal Article] Crosstalk between mitochondrial ROS and depolarization in the potentiation of TRAIL-induced apoptosis in human tumor cells2013

    • Author(s)
      Suzuki-Karasaki M, Ochiai T. Suzuki-Karasaki Y
    • Journal Title

      Int J Oncol

      Volume: 44 Pages: 616-628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591631
  • [Journal Article] Diallyl trisulfide sensitizes human melanoma cells to TRAIL-induced cell death by promoting endoplasmic reticulum-mediated apoptosis2013

    • Author(s)
      Murai M, Inoue T, Suzuki-Karasaki M, Ochiai T, Ra C, Nishida S, Suzuki-Karasaki Y
    • Journal Title

      Int J Oncol.

      Volume: 41(6) Issue: 6 Pages: 2029-2037

    • DOI

      10.3892/ijo.2012.1656

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591631
  • [Journal Article] Diallyl trisulfide sensitizes human melanoma cells to TRAIL-induced cell death by promoting endoplasmic reticulum-mediated apoptosis2012

    • Author(s)
      Murai M, Inoue T, Suzuki-Karasaki M, Ochiai T, Ra C, Nishida S, Suzuki-Karasaki Y
    • Journal Title

      Int J Oncol

      Volume: 41 Pages: 2029-37

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591631
  • [Journal Article] Depolarization potentiates TRAIL-induced apoptosis in human melanoma cells: Role for ATP-sensitive K+ channels and endoplasmic reticulum stress.2012

    • Author(s)
      Suzuki Y, Inoue T, Murai M, Suzuki-Karasaki M, Ochiai T, Ra C.
    • Journal Title

      Int J Oncol.

      Volume: 41(2) Issue: 2 Pages: 465-475

    • DOI

      10.3892/ijo.2012.1483

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591631
  • [Journal Article] Depolarization potentiates TRAIL- induced apoptosis in human melanoma cells : Role for ATP-sensitive K^+ channels and endoplasmic reticulum stress2012

    • Author(s)
      Suzuki Y, Inoue T, Murai M, Suzuki-Karasaki M, Ochiai T, Ra C
    • Journal Title

      Int J Oncol

      Volume: 41 Pages: 465-75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591631
  • [Journal Article] Aspirin and salicylates modulate IgE-mediated leukotriene secretion in mast cells through a dihydropyridine receptor-mediated Ca2+ finflux2009

    • Author(s)
      K Togo, Y Suzuki, T Yoshimaru, T Inoue, T Terui, T Ochiai, C Ra
    • Journal Title

      Clinical Immunology 131

      Pages: 145-156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591330
  • [Journal Article] Aspirin and salicylates modulate IgE-mediated leukotriene secretion in mast cells through a dihydropyridine receptor-mediated Ca^<2+> influx2009

    • Author(s)
      Togo K, Suzuki y, Ochiai, T, RaC, et al.
    • Journal Title

      Clinical Immunology (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591330
  • [Journal Article] アスピリンによるマスト細胞ロイコトリエン生成充進の機序2008

    • Author(s)
      東郷香奈、鈴木良弘、落合豊子、羅智靖
    • Journal Title

      臨床免疫 アレルギー科 49

      Pages: 633-637

    • Data Source
      KAKENHI-PROJECT-19591330
  • [Journal Article] アスピリンによるマスト細胞ロイコトリエン生成亢進の機序2008

    • Author(s)
      東郷香奈, 鈴木良弘, 落合豊子, ほか
    • Journal Title

      臨床免疫・アレルギー科 49(6)

      Pages: 633-637

    • Data Source
      KAKENHI-PROJECT-19591330
  • [Patent] 抗癌剤の製造方法、抗癌剤および医薬2018

    • Inventor(s)
      鈴木良弘、鈴木美喜、落合豊子
    • Industrial Property Rights Holder
      鈴木良弘、鈴木美喜、落合豊子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2020
    • Data Source
      KAKENHI-PROJECT-18K08279
  • [Presentation] The role of mitochondrial toxicity in tumor-selective toxicity2019

    • Author(s)
      Yoshihiro Suzuki-Karasaki, Manami Suzuki-Karasaki, Miki Suzuki-Karasaki, Toyoko Ochiai.
    • Organizer
      23rd International Symposium on Molecular Medicine. 30 March 2019, Bangkok, Thailand.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08279
  • [Presentation] Air plasma-activated medium induces an iron-dependent cell death in human malignant tumor cells.2019

    • Author(s)
      Manami Suzuki-Karasaki, Takashi Ando, Miki Suzuki-Karasaki, Toyoko Ochiai, Yoshihiro Suzuki-Karasaki.
    • Organizer
      24th World Congress on Advances in Oncology & 24th International Symposium on Molecular Medicine. Sparta, Greece
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08279
  • [Presentation] Cold atmospheric plasma irradiated liquid:a novel tumor-selective anticancer liquid advantageous over PAM.2019

    • Author(s)
      Manami Suzuki-Karasaki, Takashi Ando, Miki Suzuki-Karasaki, Toyoko Ochiai, Yoshihiro Suzuki-Karasaki.
    • Organizer
      23rd International Symposium on Molecular Medicine 30 March 2019, Bangkok,Thailand.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08279
  • [Presentation] Cold atmospheric plasma irradiated liquid:a novel tumor-selective anticancer liquid advantageous over PAM.2019

    • Author(s)
      Suzuki-Karasaki M, Ando T, Suzuki-Karasaki M, Ochiai T, Suzuki-Karasaki Y.
    • Organizer
      23rd International Symposium on Molecular Medicine. 30 March 2019, Bangkok, Thailand.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08279
  • [Presentation] Critical regulatory role of reactive oxygen/nitrogen species (RONS) in the antitumor activity of cold plasma-stimulated transfusion (PLAST).2018

    • Author(s)
      Suzuki-Karasaki M, Suzuki-Karasaki M, Miyahara H, Ochiai T, Suzuki-Karasaki Y.
    • Organizer
      23rd World Congress on Advances in Oncology. 20 September 2018, Athens, Greece.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08279
  • [Presentation] Plasma-stimulated medium (PSM)のアポト-シス抵抗性悪性腫瘍に対する抗腫瘍作用メカニズム 第33回日本皮膚悪性腫瘍学会学術大会2017

    • Author(s)
      徳永智彦、小野江明日香、相馬正義、落合豊子、鈴木良弘
    • Organizer
      第33回日本皮膚悪性腫瘍学会学術大会
    • Data Source
      KAKENHI-PROJECT-15K09750
  • [Presentation] Plasma-stimulated medium (PSM)のアポト-シス抵抗性悪性腫瘍に対する抗腫瘍作用メカニズム2017

    • Author(s)
      徳永智彦、小野江明日香、相馬正義、落合豊子、鈴木良弘
    • Organizer
      第33回日本皮膚悪性腫瘍学会学術大会
    • Data Source
      KAKENHI-PROJECT-15K09792
  • [Presentation] アスピリンによるL型カルシウムチャネル(LTCC)を介したマスト細胞の活性化2011

    • Author(s)
      村井真由美、落合豊子, 他
    • Organizer
      第15回ラテックスアレルギー研究会 ラテックスアレルギー/OASフォーラム2010
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-22591232
  • [Presentation] アスピリンによるL型カルシウムチャネル(LTCC)を介したマスト細胞の活性化2010

    • Author(s)
      村井真由美、落合豊子他
    • Organizer
      第15回ラテックスアレルギー研究会ラテックスアレルギー/OASフォーラム
    • Place of Presentation
      横浜
    • Year and Date
      2010-07-11
    • Data Source
      KAKENHI-PROJECT-22591232
  • [Presentation] Aspirin regulates Ca2+ influx in mast cells by modulating mitochondrial Ca2+ and reactive oxygen species signals2010

    • Author(s)
      Mayumi Murai, Yoshihiro Suzuki Toshio Inoue, Miki Suzuki-Karasaki, Toyoko Ochiai, Chisei Ra
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-22
    • Data Source
      KAKENHI-PROJECT-22591232
  • [Presentation] Chisei Ra Aspirin regulates Ca2+ influc in mast cells by modulating mitochondrial Ca2+ and reactive oxygen species signals.2010

    • Author(s)
      Mayumi Murai, Yoshihiro Suzuki Toshio Inoue, Miki Suzuki-Karasaki, Toyoko Ochiai
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-22
    • Data Source
      KAKENHI-PROJECT-22591232
  • [Presentation] Aspirin regulates leukotriene synthesis in mast cells via dihydropyridine-sensitive calcium entry2008

    • Author(s)
      東郷香奈 落合豊子 鈴木良弘, 他
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      京都市(国際会議場)
    • Data Source
      KAKENHI-PROJECT-19591330
  • [Presentation] Aspirin regulates leukotriene synthesis in mast cells via dihydropyridine-sensitive calcium entry2008

    • Author(s)
      Kana Togo, Yoshihiro Suzuki, Tetsuro Yoshimaru, Toshio Inoue, Tadashi Terui, Chisei Ra, Toyoko Ochiai
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-19591330
  • [Presentation] アスピリンによるミトコンドリアを介したマスト細胞活性化調節2007

    • Author(s)
      東郷香奈 落合豊子 鈴木良弘, 他
    • Organizer
      第57回日本アレルギー学会秋季学術大会
    • Place of Presentation
      横浜市(パンフィコ横浜)
    • Year and Date
      2007-11-02
    • Data Source
      KAKENHI-PROJECT-19591330
  • [Presentation] Aspirin regulates leukotriene C4 synthesis in mast cells through modulating a non-capacitative calcium entry2007

    • Author(s)
      Kana Togo-Kitamura, Yoshihiro Suzuki, Tetsuro Yoshimaru, Toshio Inoue, Chisei Ra,Tadashi Terui, Toyoko Ochiai
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19591330
  • [Presentation] アスピリンの免疫調節作用に対する新たな視点:ミトコンドリア機能制御2007

    • Author(s)
      東郷香奈、鈴木良弘、吉丸哲郎, 井上寿男、照井正、落合豊子、羅智靖
    • Organizer
      日本研究皮膚科学会第32回年次学術大会・総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19591330
  • [Presentation] アスピリンによるミトコンドリアを介したマスト細胞活性化調節2007

    • Author(s)
      東郷香奈、鈴木良弘、吉丸哲郎, 井上寿男、照井正、落合豊子、羅智靖
    • Organizer
      第57回日本アレルギー学会秋季学術大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19591330
  • [Presentation] アスピリンのマスト細胞機能への影響2006

    • Author(s)
      北村香奈、鈴木良弘、吉丸哲郎、井上寿男、照井正、落合豊子、羅 智靖
    • Organizer
      第56回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19591330
  • 1.  SUZUKI Yoshihiro (80206549)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 37 results
  • 2.  RA Chisei (60230851)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 10 results
  • 3.  安藤 隆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  吉田 行弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  相馬 正義
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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