GOMI Tomoharu 五味知治

Researcher Number	40135033
Other IDs
Affiliation (based on the past Project Information) *help	2005 – 2006: 富山大学, 生命科学先端研究センター, 助教授 2004: 富山医科薬科大学, 実験実習機器センター, 助教授 1991 – 1994: 富山医科薬科大学, 実験実習機器センター, 助教授
Review Section/Research Field	Principal Investigator 物質生物化学 / General medical chemistry / Structural biochemistry
Keywords	Principal Investigator 部位特異的変異導入 / グアニジノ酢酸メチル基転移酵素 / メチル基転移酵素 / AHCYL / 親和性標識 / グリシンメチル基転移酵素 / Sーアデノシルメチオニン / Drug target / Tertiary structure / Site-specific modification … More / Suicide-like reaction / Catalytic mechanism / Adenosvlhomocysteinase / Adenosylhomocysteine / X線解析 / NAD結合 / 薬剤標的 / 立体構造 / 自殺様反応 / 反応機構 / アデノシルホモシステイナーゼ / アデノシルホモシステイン / Amino-terminal acetylation / Positive cooperativity / Site-directed mutagenesis / Affinity labeling / Glycine methyltransferase / Guanidinoacetate methyltransferase / S-Adenosylmethionine / Methyltransferase / アミノ末端アセチル化 / 正の協同性 / S-アデノシルメチオニン / 光親和性標識 / 蛋白質工学 Less

Structure-function relationship of adenosylhomocysteinase as a target for drug designPrincipal Investigator
- Principal Investigator
  
  GOMI Tomoharu
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  University of Toyama
  Toyama Medical and Pharmaceutical University
Comparative studies on structures of S-adenosylmethionine binding sites of mammalian methyltransferasesPrincipal Investigator
- Principal Investigator
  
  GOMI Tomoharu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  TOYAMA MEDICAL AND PHARMA CEUTICAL UNIVERSITY
動物のメチル基転移酵素のアデノシルメチオニン結合領域の構造Principal Investigator
- Principal Investigator
  
  五味知治
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Toyama Medical and Pharmaceutical University
タンパク質工学的手法によるグアニジノ酢酸メチル基転移酵素の構造解析Principal Investigator
- Principal Investigator
  
  五味知治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Toyama Medical and Pharmaceutical University

All 2005 2004

All Journal Article

[Journal Article] Catalytic mechanism of S-adenosylhomocysteine hydrolase:roles of His 54,Asp130,Glu155,Lys185,and Asp1892005
- Author(s)
  Yamada T., Takata Y., Komoto J., Gomi T., Ogawa H., Fujiok aM., and Takusagawa F.
- Journal Title
  
  Int.J.Biochem.Cell Biol. 37(11)
  
  Pages: 2417-2435
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590220
[Journal Article] Catalytic mechanism of S-adenosylhomocysteine hydrolase : roles of His 54, Asp130, Glu155, Lys185, and Asp189.2005
- Author(s)
  Yamada T., Takata Y., Komoto J., Gomi T., Ogawa H., Fujioka M., Takusagawa F.
- Journal Title
  
  Int.J.Biochem.Cell Biol. 37(11)
  
  Pages: 2417-2435
- Data Source
  KAKENHI-PROJECT-16590220
[Journal Article] Catalytic mechanism of S-adenosylhomocysteine hydrolase : roles of His 54, Asp 130, Gl u155, Lys185, and Asp189.2004
- Author(s)
  Yamada T., Takata Y., Komoto J., Gomi T., Ogawa H., Fujioka M., Takusagawa F.
- Journal Title
  
  mt. J. Biochem. Cell Biol. 37(11)
  
  Pages: 2417-2435
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590220

1. FUJIOKA Motoji (30030000)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. OGAWA Hirofumi (30111743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

GOMI Tomoharu 五味 知治

Research Projects

Research Products

Co-Researchers

Structure-function relationship of adenosylhomocysteinase as a target for drug designPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comparative studies on structures of S-adenosylmethionine binding sites of mammalian methyltransferasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

動物のメチル基転移酵素のアデノシルメチオニン結合領域の構造Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

タンパク質工学的手法によるグアニジノ酢酸メチル基転移酵素の構造解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Catalytic mechanism of S-adenosylhomocysteine hydrolase:roles of His 54,Asp130,Glu155,Lys185,and Asp1892005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Catalytic mechanism of S-adenosylhomocysteine hydrolase : roles of His 54, Asp130, Glu155, Lys185, and Asp189.2005

Author(s)

Journal Title

Data Source

[Journal Article] Catalytic mechanism of S-adenosylhomocysteine hydrolase : roles of His 54, Asp 130, Gl u155, Lys185, and Asp189.2004

Author(s)

Journal Title

Description

Data Source

GOMI Tomoharu 五味知治