KOMIYAMA Yutaka 小宮山豊

Researcher Number	40140264
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2014 – 2016: 関西医科大学, 医学部, 講師 2009 – 2011: Kansai Medical University, 医学部, 講師 1993 – 2007: 関西医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Laboratory medicine / Laboratory medicine Except Principal Investigator Laboratory medicine / Anesthesiology/Resuscitation studies / Laboratory medicine
Keywords	Principal Investigator 質量分析 / 内因性ジギタリス / cardenolides / bufadienolide / endogenous digitalis-like factor / マリノブフォトキシン / カルデノライド / 腎臓 / ブファディエノライド / 液体クロマトグラフィー … More / lupus anticoagulant / thrombin-antithrombin III / von Willebrand factor / 組織因子 / cardiotonic steroid / esterase / angiotensin / renin / marinobufotoxin / 腎尿細管 / ショック / 組織カリクレイン / コレステロールエステラーゼ / 強心ステロイド / エステラーゼ / アンギオテンシン / レニン / poisoning analysis / kidney / liquid chromatography / mass spectrometry / telocinobufagin / ブファジエノライド / 副腎髄質 / 副腎皮質 / テロシノブフォトキシン / モノクローナル抗体 / ELISA / 血圧 / マリノブファギン / ブファリン / 内因性ジギタリス様物質 / 薬毒物分析 / テロシノブファギン / coagulant assay / circulating anticoagulant / リン脂質 / 出血 / 循環抗凝結素 / 実験動物 / 出血傾向 / 血液検査 / ループスアンチコアグラント / 抗リン脂質抗体 / MS / LC / 凝血学的検査 / 循環抗凝血素 / tissue factor / prothrombin time / re-stenosis / PTCA / 自然発症高血圧ラット / プロトロンビン時間 / プロトロンピン時間 / 再狭窄 / 経皮的冠動脈形成術 / Coronary artery disease / Flow eytometry / Activated platelet / Factor XI / Amyloid beta-protein precursor / Cerebral infarction / Arzheimer's disease / 活性化凝固第XI因子 / アミロイドbeta蛋白前駆体 / アルツハイマ-病 / βアミロイド前駆体蛋白質 / 脳血管障害性痴呆 / 冠動脈疾患 / フローサイトメトリー / 活性化血小板 / 第XI因子 / β-アミロイド前駆体蛋白質 / 脳血管障害 / アルツハイマー病 / 下垂体 / 臨床検査 / 腎障害 / 視床下部 / アルドステロン / DIC / Ca ionophore / LPS / small vesicles / 血管内皮細胞 … More Except Principal Investigator 内因性ジギタリス / ELISA / MS / LC / HPLC / 構造解析 / ENDOGENOUS DIGITALIS / 神経系 / 培養細胞 / ウアバイン / 質量分析 / 高血圧 / mass spectrometry / liquid chromatography / sodium loading / telocinobufagin / marinobufagenin / endogenous digitalis / 液体クロマトグララフィー / 慢性腎不全 / 液体クロマトグラフィー / 食塩負荷 / テロシノブファギン / マリノブファゲニン / poisoning / N-acetyl-p-benzoquinone imine / N-acetylcysteine / acetaminophen / AKBR / 肝ミトコンドリア / LCMS / Nアセチルベンゾキノンイミン / 中毒 / Nアセチルベンゾキンイミン / Nアセチルシステイン / アセトアミノフェン / MASS SPECTROMETRY / PROGESTERONE / NEURONAL TISSUE / ADRENAL MEDULLA / CULTURED CELLS / OUABAIN / プロゲステロン / 副腎髄質 / CELL CULTURE / DIGITALIS BINDING PROTEIN / CENTRAL NERVOUS SYSTEM / BLOOD PRESSURE / SODIUM BALANCE / 細胞培養 / ウアバイン結合タンパク / 電解質代謝 / 内因性ウアバイン / 内因性ジキタリス / 成長因子 / アルドステロン / レニン / テロシノブフォトキシン / マリノブフォトキシン / マリノブファギン / 生理活性物質 / 質量分析イムノアッセイ / 凝固・分子マーカー / ヘリコバクターピロリ / 高感度CRP / 炎症 / 一酸化窒素(NO) / 虚血性心疾患 / 動脈硬化症 / クラミジアニューモニエ Less

Mechanism of production, secretion and hypertension in the endogenous digitalis like factors using mass spectrometry immunoassay
- Principal Investigator
  
  YOSHIKA Masamichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Protective effects of endogenous digitalislike factor on the injury of kidney by aldosteronePrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Yutaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Clinical Chemistry of Newly-found Esterase for Endogenous Digitalis-like FactorPrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Yutaka
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Clinical Chemistry of Newly-found Endogenous Bufalin Isomer in SalivaPrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Yutaka
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Structural analysis of endogenous digitalis and studies on the role of it in electrolytes and blood pressure control. In particular, studies on a novel substance, marinobufagenin with double hydrogen.
- Principal Investigator
  
  TAKAHASHI Hakuo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Research on the movement of antidotes and toxic metabolites in the patients with acetaminophen poisoning
- Principal Investigator
  
  KIRIDOSHI Masaya
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kansai Medical University
Analysis of unknown circulating anticoagulant casesPrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Yutaka
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
冠動脈疾患の危険因子としての抗クラミジアニューモニエ抗体価の臨床的意義に関する研究-内皮細胞由来血管作動性物質と凝固系分子マーカーからの基礎的検討-
- Principal Investigator
  
  TAKAHASHI Hakuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
IDENTIFICATION OF ENDOGENOUS DIGITALIS AND THE ROLE IN WATER-ELETROLYTES BALANCES AND BLOOD PRESSURE REGULATION
- Principal Investigator
  
  TAKAHASHI Hakuo
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Laboratory medicine
- Research Institution
  KANSAI MEDICAL UNIVERSITY
Estimation of re-stenosis after PTCA by laboratory test of coagulation and fibrinolysis.Principal Investigator
- Principal Investigator
  
  KOMIYAMA Yutaka
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
STUDIES ON IDENTIFICATION OF ENDOGENOUS DIGITALISLIKE FACTOR,AND THE ROLE IN WATER-ELECTROLYTES BALANCE AND BLOOD PRESSURE REGULATION
- Principal Investigator
  
  TAKAHASHI Hakuo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  KANSAI MEDICAL UNIVERSITY
傷害血管内皮細胞由来小胞の凝固線溶活性とその内皮細胞傷害マーカーとしての意義Principal Investigator
- Principal Investigator
  
  小宮山豊
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Development of iagnostic tool of Arzheimer's discase with use of platelet factor XI and Amyloid beta-protein precursorPrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Yutaka
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  KANSAI MEDICAL UNIVERSITY

All 2016 2015 2014 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] 2度の非典型溶血性尿毒症症候群の発症を認めた一症例2016
- Author(s)
  吉賀正亨, 小宮山豊, 河崎裕英, 高橋伯夫
- Journal Title
  
  日本検査血液学会雑誌
  
  Volume: 53 Pages: 1738-1740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460662
[Journal Article] 【深く知ろう!血栓止血検査】 PT,APTT　止血異常のスクリーニング検査としてのPT,APTT2016
- Author(s)
  小宮山豊，吉賀正亨
- Journal Title
  
  臨床検査
  
  Volume: 60 Pages: 130-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460662
[Journal Article] フォスファチジルセリン依存性抗プロトロンビン抗体を認めたループスアンチコアグラント・低プロトロンビン血症症候群の1例2016
- Author(s)
  吉賀正亨, 小宮山豊, 吉田美香, 内藤澄悦, 家子正裕, 蔦幸治
- Journal Title
  
  臨床病理
  
  Volume: 64 Pages: 631-635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460662
[Journal Article] データに影響する採血手技2015
- Author(s)
  小宮山豊, 吉賀正亨
- Journal Title
  
  臨床検査
  
  Volume: 59 Pages: 20-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460662
[Journal Article] 今月の特集１　検査室間連携が高める臨床検査の付加価値2014
- Author(s)
  小宮山豊, 吉賀正亨
- Journal Title
  
  臨床検査
  
  Volume: 58 Pages: 460-464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460662
[Journal Article] ラテックス凝集法とEIA法で血小板第4因子-ヘパリン複合体抗体の測定結果に乖離を生じたヘパリン起因性血小板減少症の1例2014
- Author(s)
  吉賀正亨、小宮山豊, 松本宙士, 平井雅美, 寺内理恵, 野村明代, 前羽宏史, 今田崇裕, 大倉ひろ枝, 角坂芳彦, 塩島一朗, 高橋伯夫
- Journal Title
  
  臨床病理
  
  Volume: 62 Pages: 1047-1051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460662
[Journal Article] An ouabain-like factor is secreted from immortalized hypothalamic cells in an aldosterone-dependent manner2011
- Author(s)
  Yoshika M, Komiyama Y, Takahashi H, et al
- Journal Title
  
  Neurochem Int
  
  Volume: 59 Pages: 104-108
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] Ca2+entry mode of Na+/Ca2+exchanger as a new therapeutic target for heart failure with preserved ejection fraction2011
- Author(s)
  Kamimura D, Komiyama Y, Yoshika M, Takahashi H, et al
- Journal Title
  
  Eur Heart J Epub
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] Isolation of marinobufotoxin from the supernatant of cultured PC12 cells2011
- Author(s)
  Yoshika M, Komiyama, Y, et al
- Journal Title
  
  Clin Exp Pharmacol Physiol
  
  Volume: 38 Issue: 5 Pages: 334-7
- DOI
  10.1111/j.1440-1681.2011.05512.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] Isolation of marinobufotoxin from the supernatant of cultured PC12 cells2011
- Author(s)
  Yoshika M, Komiyama Y, Takahashi H, et al
- Journal Title
  
  Clin Exp Pharmacol Physiol
  
  Volume: 38 Pages: 334-337
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] 内因性ジギタリス2011
- Author(s)
  吉賀正亨、小宮山豊、高橋伯夫
- Journal Title
  
  検査と技術
  
  Volume: 39 Pages: 561-564
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] The central mechanism underlying hypertension : a review of the roles of sodium ions, epithelial sodium channels, the renin-angiotensin-aldosterone system, oxidative stress and endogenous digitalis in the brain2011
- Author(s)
  Takahashi H, Komiyama Y、Yoshika M, et al
- Journal Title
  
  Hypertens Res
  
  Volume: 34 Pages: 1147-60
- NAID
  10030276766
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] Ca2+ entry mode of Na+/Ca2+ exchanger as a new therapeutic target for heart failure with preserved ejection fraction2011
- Author(s)
  Kamimura D, Komiyama Y, et al
- Journal Title
  
  Eur Heart J
  
  Volume: (Epub) Issue: 11 Pages: 1-9
- DOI
  10.1093/eurheartj/ehr106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590643, KAKENHI-PLANNED-22136002, KAKENHI-PROJECT-22790250, KAKENHI-PROJECT-22790534, KAKENHI-PROJECT-24590319, KAKENHI-PROJECT-24790567
[Journal Article] An ouabain-like factor is secreted from immortalized hypothalamic cells in an aldosterone-dependent manner2011
- Author(s)
  Yoshika M, Komiyama Y, et al
- Journal Title
  
  Neurochem Int
  
  Volume: 59 Pages: 104-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] 自然発症高血圧ラットにおける内因性ジギタリス様物質、マリノブフォトキシンの動態血圧調節におけるレニン・アンジオテンシン系の関与について2009
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Journal Title
  
  心臓 41
  
  Pages: 401-404
- NAID
  130003376910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] 自然発症高血圧ラットにおける内因性ジギタリス様物質、マリノブフォトキシンの動態血圧調節におけるレニン・アンジオテンシン系の関与について2009
- Author(s)
  吉賀正亨、小宮山豊、高橋伯夫
- Journal Title
  
  心臓
  
  Volume: 41 Pages: 401-404
- NAID
  130003376910
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] The present situation and problem of the analytic instruments of clinical toxicology laboratory in hospital. The experience of three laboratory in west Japan.2009
- Author(s)
  Komiyama Y, Hara K, Takahashi H, Tsuda N, Ishibe T, Maruyama K, Hosaka N, Yahiro M, Hideshima R, Manago J
- Journal Title
  
  Chudoku Kenkyu 22
  
  Pages: 12-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] 西日本3施設における薬毒物分析機器稼働の現状と課題集団中毒に対する危機管理体制2009
- Author(s)
  小宮山豊, 原克子, 高橋伯夫, 津田紀子, 石部琢也, 丸山克之, 穂坂直美, 八尋美保子, 秀島里沙, 眞名子順一
- Journal Title
  
  中毒研究 22
  
  Pages: 12-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] Novel digitalis-like factor, marinobufotoxin, isolated from cultured Y-l cells, and its hypertensive effect in rats.2007
- Author(s)
  Yoshika M, Komiyama Y, Konishi M, Akizawa T, Kobayashi T, Date M, Kobatake S, Masuda M, Masaki H, Takahashi H
- Journal Title
  
  Hypertension 49
  
  Pages: 209-214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] Novel digitalis-like factor, marinobufotoxin, isolated from cultured Y-1 cells, and its hypertensive effect in rats.2007
- Author(s)
  Yoshika M, Komiyama Y, et al.
- Journal Title
  
  Hypertension 49・1
  
  Pages: 209-214
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] Novel digitalis-like factor, marinobufotoxin, isolated from cultured Y-1 cells, and its hypertensive effect in rats.2007
- Author(s)
  Yoshika M, Komiyama Y, Konishi M, Akizawa T, Kobayashi T, Date M, Kobatake S, Masuda M, Masaki H, Takahashi H
- Journal Title
  
  Hypertension 49
  
  Pages: 209-214
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] 【高血圧最新の研究動向】基礎編血圧調節因子循環生理性物質ジギタリス様物質2006
- Author(s)
  高橋伯夫, 小宮山豊
- Journal Title
  
  日本臨床 64・増刊5
  
  Pages: 177-181
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] 特集【体液調節とホルモン】体液調節の基礎 Na利尿ホルモン内因性ジギタリス2006
- Author(s)
  高橋伯夫, 小宮山豊
- Journal Title
  
  ホルモンと臨床 54・5
  
  Pages: 417-423
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure.2005
- Author(s)
  Komiyama, Takashi et al.
- Journal Title
  
  Clinical Biochemistry 38
  
  Pages: 36-45
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] シリーズ最新医学講座-臨床現場における薬毒物検査の実際-エディトリアル2005
- Author(s)
  小宮山豊
- Journal Title
  
  臨床検査 49・3
  
  Pages: 330-332
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure.2005
- Author(s)
  Komiyama Y, Dong XH, Nishimura N, Masaki H, Yoshika M, Masuda M, Takahashi H
- Journal Title
  
  Clin Biochem. 38(1)
  
  Pages: 36-45
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] シリーズ最新医学講座 -臨床現場における薬毒物検査の実際 -第7回「確認分析法(臨床現場におけるGC/MSの活用)」2005
- Author(s)
  原克子, 小宮山豊, 山本透, 高橋伯夫
- Journal Title
  
  臨床検査 49
  
  Pages: 1027-1035
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] "the problem and technique of sampling and sample storage" in Recent advance series of medical technology. : Analysis of poisoning in clinical laboratory2005
- Author(s)
  Manago J, Komiyama Y et al.
- Journal Title
  
  Rinshokensa 49-3
  
  Pages: 333-341
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] シリーズ最新医学講座 -臨床現場における薬毒物検査の実際-「試料採取から保存まて」2005
- Author(s)
  眞名子順一, 小宮山豊他
- Journal Title
  
  臨床検査 49・3
  
  Pages: 333-341
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure.2005
- Author(s)
  Komiyama Y et al.
- Journal Title
  
  Clin Biochem 38・1
  
  Pages: 36-45
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] シリーズ最新医学講座-臨床現場における薬毒物検査の実際-「確認分析法(臨床現場におけるG/MSの活用)」2005
- Author(s)
  原克子, 小宮山豊他
- Journal Title
  
  臨床検査 49・9
  
  Pages: 1027-1035
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] "editorial" in Recent advance series of medical technology. : Analysis of poisoning in clinical laboratory2005
- Author(s)
  Komiyama Y
- Journal Title
  
  Rinshokensa 49-3
  
  Pages: 330-332
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure.2005
- Author(s)
  Komiyama Y, Dong XH, Nishimura N, Masaki H, Yoshika M, Masuda M, Takahashi H
- Journal Title
  
  Clin Biochem 38
  
  Pages: 36-45
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] "The Qualitative and quantitative analysis methods : GC/MS analysis in clinical laboratory" in Recent advance series of medical technology. : Analysis of poisoning in clinical laboratory2005
- Author(s)
  Hara K, Komiyama Y et al.
- Journal Title
  
  Rinshokensa 49・9
  
  Pages: 1027-1035
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] シリーズ最新医学講座 -臨床現場における薬毒物検査の実際-(小宮山豊、屋敷幹雄企画)エディトリアル2005
- Author(s)
  小宮山豊
- Journal Title
  
  臨床検査 49
  
  Pages: 330-332
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] Na+,K+ATPase and cardiovascular disease.2005
- Author(s)
  Komiyama Y et al.
- Journal Title
  
  Rinshokagaku (Japanese Journal of Clinical Chemistry) 64-3-4
  
  Pages: 110-125
- NAID
  130003357222
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] シリーズ最新医学講座 -臨床現場における薬毒物検査の実際 -第1回「試料採取から保存まで」2005
- Author(s)
  眞名子順一, 秀島里紗, 長谷一憲, 穂坂直美, 田中絵梨, 小宮山豊
- Journal Title
  
  臨床検査 49
  
  Pages: 333-341
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure.2005
- Author(s)
  Komiyama Y et al.
- Journal Title
  
  Clin Biochem. 38・1
  
  Pages: 36-45
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] Nanornolar level of ouabain increases intracellular calcium to produce nitric oxide in rat aortic endothelial cells.2004
- Author(s)
  Dong XH, Komiyama Y et al.
- Journal Title
  
  Clin Exp Pharmacol Physiol. 31・5-6
  
  Pages: 276-283
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] The ratio of plasma to Whole-blood serotonin may be a novel marker of atherosclerotic cardiovascular disease.2004
- Author(s)
  Hara K, Hirowatari Y, Yoshika M, Komiyama Y, Tsuka Y, Takahashi H
- Journal Title
  
  J Lab Clin Med (2004)
  
  Pages: 31-37
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] 特集イオンチャンネルと循環器疾患 Na+,K+-ATPaseと循環器疾患2004
- Author(s)
  小宮山豊他
- Journal Title
  
  臨床化学 64・3-4
  
  Pages: 110-125
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] Nanomolar level of ouabain increases intracellular calcium to produce nitric oxide in rat aortic endothelial cells.2004
- Author(s)
  Dong XH, Komiyama Y et al.
- Journal Title
  
  Clin Exp Pharmacol Physiol. 31・5-6
  
  Pages: 276-283
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] 特集イオンチャンネルと循環器疾患Na+,K+-ATPaseと循環器疾患2004
- Author(s)
  小宮山豊, 他
- Journal Title
  
  臨床化学 33
  
  Pages: 119-125
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] Nanomolar level of ouabain increases intracellular calcium to produce nitric oxide in rat aortic endothelial cells.2004
- Author(s)
  Dong XH, komiyama Y, Nishimura N, Masuda M, Takahashi T
- Journal Title
  
  Clin and Exp Pharmacol and Physiol (2004) 31(5-6)
  
  Pages: 276-283
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] An endogenous digitalis-like factor, marinobufotoxin, in spontaneously hypertension rats-involvement of reninangiotensin system in blood pressure regulation-
- Author(s)
  Masamichi Yoshika, Yutaka Komiyama, Hakuo Takahashi
- Journal Title
  
  Shinzo (in printing)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] Ca2+ entry mode of Na+/Ca2+ exchanger as a new therapeutic target for heart failure with preserved ejection fraction
- Author(s)
  Kamimura D, Komiyama Y, et al
- Journal Title
  
  Fur Heart J
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] 自然発症高血圧ラットにおける内因性ジギタリス様物質, マリノブッォトキシンの動態 -血圧調節におけるレニン-アンジオテンシン系の関与について-
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Journal Title
  
  心臓 (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] 自験例を中心としたヘパリン起因性血小板減少症の各種検査の乖離に関する考察2016
- Author(s)
  吉賀正亨、小宮山豊、乾恵美、蔦幸治
- Organizer
  第17回日本検査血液学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-08-06
- Data Source
  KAKENHI-PROJECT-26460662
[Presentation] 内因性ジギタリス様物質マリノブフォトキシンの分泌機構の検討2015
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫, 蔦幸治
- Organizer
  第62回日本臨床検査医学会総会
- Place of Presentation
  長良川国際会議場（岐阜県、岐阜市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26460662
[Presentation] 新規内因性ジギタリスであるtelocinobufotoxinの昇圧作用の検討2011
- Author(s)
  吉賀正亨、高橋伯夫、小宮山豊
- Organizer
  第15回日本心血管内分泌代謝学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター、吹田
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 高血圧発症機序における内因性ジギタリスの臨床検査医学的研究2011
- Author(s)
  吉賀正亨、高橋伯夫、小宮山豊
- Organizer
  第58回日本臨床検査医学会学術集会
- Place of Presentation
  岡山コンベンションセンター、岡山
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 高血圧発症機序における内因性ジギタリスの臨床検査医学的研究2011
- Author(s)
  吉賀正亨、小宮山豊、高橋伯夫
- Organizer
  第58回日本臨床検査医学会学術集会
- Place of Presentation
  岡山・岡山コンベンションセンター
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 新規内因性ジギタリスであるtelocinobufotoxinの昇圧作用の検討2011
- Author(s)
  吉賀正亨、小宮山豊、高橋伯夫
- Organizer
  第15回日本心血管内分泌代謝学会学術集会
- Place of Presentation
  吹田・千里ライフサイエンスセンター
- Year and Date
  2011-11-23
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 副腎細胞を用いたアンジオテンシン2受容体拮抗薬の内因性ジギタリス分泌に関する検討2011
- Author(s)
  吉賀正亨、小宮山豊、高橋伯夫
- Organizer
  第51回日本臨床化学会年次学術集会
- Place of Presentation
  札幌・札幌医科大学
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 副腎細胞を用いたアンジオテンシン2受容体拮抗薬の内因性ジギタリス分泌に関する検討2011
- Author(s)
  吉賀正亨、高橋伯夫、小宮山豊
- Organizer
  第51回日本臨床化学会年次学術集会
- Place of Presentation
  札幌医科大学、札幌
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 高血圧発症機序における新規内因性ジギタリスの臨床検査学的研究2010
- Author(s)
  吉賀正亨、高橋伯夫、小宮山豊
- Organizer
  第57回日本臨床検査医学会学術集会
- Place of Presentation
  京下プラザホテル、東京
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] A mineralocorticoid receptor blocker, eplerenone decreases plasma levels of marinobufagenin-like immunoreactivity in rat2010
- Author(s)
  Yoshika M, Komiyama Y, et al
- Organizer
  International Symposium on Cardiovascular Endocrinology and Metabolism
- Place of Presentation
  奈良県新公会堂、奈良
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 高血圧発症機序における新規内因性ジギタリスの臨床検査学的研究2010
- Author(s)
  吉賀正亨、高橋伯夫、小宮山豊
- Organizer
  第57回日本臨床検査医学会学術集会
- Place of Presentation
  京王プラザホテル、東京
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] A mineralocorticoid receptor blocker, eplerenone decreases plasma levels of marinobufagenin-like immunereactivity in rat2010
- Author(s)
  Yoshika M, Komiyama Y, Takahashi H, et al
- Organizer
  International Symposium on Cardiovascular Endocrinology and Metabolism
- Place of Presentation
  奈良県新公会堂、奈良
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 高速液体クロマトグラフィーを用いた内因性ジギタリス様物質マリノブフォトキシンの分泌機構の検討2009
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第45回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  東京東京ステーションコンファレンス
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 高速液体クロマトグラフィーを用いた内因性ジギタリス様物質マリノブフォトキシンの分泌機構の検討2009
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第45回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  東京ステーションコンファレンス、東京
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 西日本3施設における薬毒物分析機器稼働の現状と課題2008
- Author(s)
  小宮山豊, 原克子, 高橋伯夫, 津田紀子, 丸山克之, 坂田育弘, 穂坂直美, 八尋美保子, 秀島里沙, 眞名子順一
- Organizer
  第30回日本中毒学会シンポジウム
- Place of Presentation
  和歌山
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The effect of endo- genous digitalis, marinobufotoxin and angiotensin in rat adrenal gland2008
- Author(s)
  M Yoshika, Y Komiyama, H Takahashi
- Organizer
  The 31^<st> Japanese congress for hyper- tension
- Place of Presentation
  Sapporo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The present situation and problem of the analytic instruments of clinical toxicology laboratory in hospital. The experience of three laboratory in west Japan.2008
- Author(s)
  Komiyama Y, Hara K, Takahashi H, Tsuda N, Ishibe T, Maruyama K, Hosaka N, Yahiro M, Hideshima R, Manago J
- Organizer
  The 30^<th> Japanese congress for clinical toxicology
- Place of Presentation
  Wakayama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] 副腎髄質における内因性ジギタリス様物質であるマリノブフォトキシンとアンジオテンシンについての検討2008
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The Effect of Endogenous Digital is, Marinobufotoxin, in Sodium Metabolism2008
- Author(s)
  Yoshika, Y Komiyama, H Takahashi
- Organizer
  The 14^<th> International Symposium for SHR rat
- Place of Presentation
  Puraha
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The Effect of Endogenous Digitalis, Marinobufotoxin, in Sodium Metabolism2008
- Author(s)
  M Yoshika, Y Komiyama, H Takahashi
- Organizer
  The 14^<th> International Symposium for SHR rat
- Place of Presentation
  Puraha, Czech Republic
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] 下垂体培養細胞GH3における内因性ジギタリス様物質(マリノブフォトキシン)の分泌動態の検討2007
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第54回日本臨床検査医学会学術集会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The effect of endo- genous digitalis, marinobufotoxin, on the salt-loading rat2007
- Author(s)
  M Yoshika, Y Komiyama, H Takahashi
- Organizer
  The 30^<th> Japanese congress for hyper- tension
- Place of Presentation
  Naha
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] 内因性ジギタリス様物質であるマリノブッォトキシンの食塩負荷したラットおよび培養細胞における検討2007
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第43回高血圧関連疾患モデル学会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The effect of endo- genous digitalis, marinobufotoxin, on therat and cultured cells with salt loading.2007
- Author(s)
  M Yoshika, Y Komiyama, H Takahashi
- Organizer
  The 43rd Japanese conference of hyper- tension and related-model rats
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] 食塩負荷ラットにおける新規内因性ジギタリス様物質であるマリノブフォトキシンの動態2007
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第30回日本高血圧学会総会
- Place of Presentation
  那覇
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The secretion of endo- genous digitalis, marinobufotoxin, in cultured cell, GH3, from hypothalamus2007
- Author(s)
  M Yoshika, Y Komiyama, H Takahashi
- Organizer
  The 54^<th> cogress for Japanese society of laboratory medicine
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543

1. TAKAHASHI Hakuo (80094431)

# of Collaborated Projects: 8 results

# of Collaborated Products: 43 results
2. NOMURA Shosaku (20218358)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. YOSHIKA Masamichi (70434834)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
4. MASUDA Midori (50173753)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KAMIHATA Hiroshi (60233946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KIRIDOSHI Masaya (10330185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKATANI Toshio (70188978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SHINYA Hiroshi (90309229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小坂知也 (10298862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KOBAYASHI Kouji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOMIYAMA Yutaka 小宮山 豊

Research Projects

Research Products

Co-Researchers

Mechanism of production, secretion and hypertension in the endogenous digitalis like factors using mass spectrometry immunoassay

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Protective effects of endogenous digitalislike factor on the injury of kidney by aldosteronePrincipal Investigator

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Clinical Chemistry of Newly-found Esterase for Endogenous Digitalis-like FactorPrincipal Investigator

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Clinical Chemistry of Newly-found Endogenous Bufalin Isomer in SalivaPrincipal Investigator

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Structural analysis of endogenous digitalis and studies on the role of it in electrolytes and blood pressure control. In particular, studies on a novel substance, marinobufagenin with double hydrogen.

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Research on the movement of antidotes and toxic metabolites in the patients with acetaminophen poisoning

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Analysis of unknown circulating anticoagulant casesPrincipal Investigator

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冠動脈疾患の危険因子としての抗クラミジアニューモニエ抗体価の臨床的意義に関する研究-内皮細胞由来血管作動性物質と凝固系分子マーカーからの基礎的検討-

Principal Investigator

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IDENTIFICATION OF ENDOGENOUS DIGITALIS AND THE ROLE IN WATER-ELETROLYTES BALANCES AND BLOOD PRESSURE REGULATION

Principal Investigator

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Estimation of re-stenosis after PTCA by laboratory test of coagulation and fibrinolysis.Principal Investigator

Principal Investigator

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STUDIES ON IDENTIFICATION OF ENDOGENOUS DIGITALISLIKE FACTOR,AND THE ROLE IN WATER-ELECTROLYTES BALANCE AND BLOOD PRESSURE REGULATION

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傷害血管内皮細胞由来小胞の凝固線溶活性とその内皮細胞傷害マーカーとしての意義Principal Investigator

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Development of iagnostic tool of Arzheimer's discase with use of platelet factor XI and Amyloid beta-protein precursorPrincipal Investigator

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KOMIYAMA Yutaka 小宮山豊

[Journal Article] 【深く知ろう!血栓止血検査】 PT,APTT　止血異常のスクリーニング検査としてのPT,APTT2016

[Journal Article] 今月の特集１　検査室間連携が高める臨床検査の付加価値2014