Susumu Higuchi 樋口進

… Alternative Names

樋口進ヒグチススム

HIGUCHI Susumu 樋口進

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Researcher Number	40156576
Affiliation (Current)	2025: 藤田医科大学, 医学部, その他 2025: 独立行政法人国立病院機構(久里浜医療センター臨床研究部), その他部局等, 名誉院長
Affiliation (based on the past Project Information) *help	2015 – 2017: 独立行政法人国立病院機構(久里浜医療センター臨床研究部), その他部局等, 院長 2014: 独立行政法人国立病院機構(久里浜医療センター臨床研究部), その他部局等, その他 2010: 独立行政法人国立病院機構(久里浜アルコール症センター臨床研究部), 久里浜アルコール症センター, 院長 2010: 藤田保健衛生大学, 医学部, 客員教授
Review Section/Research Field	Except Principal Investigator Applied pharmacology / General internal medicine (including Psychosomatic medicine)
Keywords	Except Principal Investigator voxel-based morphometry / パペッツ回路 / Korsakoff / Wernicke / hippocampus / acetaldehyde / alcoholics / 多型 / 後部帯状回 / 脳血流検査 … More / ウェルニッケコルサコフ症候群 / 海馬 / MRI / ALDH2多型 / アセトアルデヒド脱水素酵素２ / アセトアルデヒド / アルコール依存症 / 施灸の脳科学 / 東洋医学 / 医療・福祉 / 脳神経疾患 / 薬理学 / ゲノム / 薬剤反応性 / 薬物感受性 / 薬物依存 Less

Effect of ALDH2 polymorphism on brain atrophy in alcoholic patients: A matched-pair MRI study by voxel-based morphometric analysis
- Principal Investigator
  
  Matsui Toshifumi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  独立行政法人国立病院機構(久里浜医療センター臨床研究部)
  Kyorin University
Genome-wide association study of sensitivity to narcotics
- Principal Investigator
  
  IKEDA Kazutaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Neuroscientific studies on the effect of moxibustion on chronic diseases
- Principal Investigator
  
  USUDA Nobuteru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Fujita Health University

All 2018 2017 2016 2015 2014 2010 2009 2008

All Journal Article Presentation

[Journal Article] アルコール関連中枢神経障害2018
- Author(s)
  松井敏史、三ツ間小百合、横山顕、松下幸生、樋口進
- Journal Title
  
  Frontiers in Alcoholism
  
  Volume: 6 Pages: 32-40
- Data Source
  KAKENHI-PROJECT-26460632
[Journal Article] Platelet Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men.2017
- Author(s)
  Yokoyama A, Yokoyama T, Mizukami T, Matsui T, Kimura M, Matsushita S, Higuchi S, Maruyama K
- Journal Title
  
  Alcohol Clin Exp Res.
  
  Volume: 41 Issue: 1 Pages: 171-178
- DOI
  10.1111/acer.13283
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460632
[Journal Article] Blood Leukocyte Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men2016
- Author(s)
  Yokoyama A, Brooks PJ, Yokoyama T, Mizukami T, Matsui T, Kimura M, Matsushita S, Higuchi S, Maruyama K
- Journal Title
  
  Alcohol Clin Exp Res
  
  Volume: 40 Issue: 3 Pages: 507-517
- DOI
  10.1111/acer.12983
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460632
[Journal Article] Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes and Alcoholic Ketosis Are Associated with the Serum Uric Acid Level in Japanese Alcoholic Men2016
- Author(s)
  Yokoyama A, Yokoyama T, Mizukami T, Matsui T, Kimura M, Matsushita S, Higuchi S, Maruyama K.
- Journal Title
  
  Alcohol Alcohol
  
  Volume: 51 Issue: 3 Pages: 268-274
- DOI
  10.1093/alcalc/agv123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460632
[Journal Article] アルコール関連の諸問題2016
- Author(s)
  松井敏史, 横山顕, 松下幸生, 神崎恒一, 樋口進, 丸山勝也.
- Journal Title
  
  日本老年医学会雑誌
  
  Volume: 53 Pages: 304-317
- NAID
  40021021491
- Data Source
  KAKENHI-PROJECT-26460632
[Journal Article] Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes Are Strong Determinants of the Serum Triglyceride and Cholesterol Levels of Japanese Alcoholic Men2015
- Author(s)
  Yokoyama A, Yokoyama T, Matsui T, Mizukami T, Kimura M, Matsushita S, Higuchi S, Maruyama K
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 8 Pages: e0133460-e0133460
- DOI
  10.1371/journal.pone.0133460
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460632
[Journal Article] Alcoholic Ketosis: Prevalence, Determinants, and Ketohepatitis in Japanese Alcoholic Men2014
- Author(s)
  Yokoyama A, Yokoyama T, Mizukami T, Matsui T, Shiraishi K, Kimura M, Matsushita S, Higuchi S, Maruyama K
- Journal Title
  
  Alcohol Alcohol
  
  Volume: 49 Issue: 6 Pages: 618-625
- DOI
  10.1093/alcalc/agu048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460632
[Journal Article] Blood ethanol levels of nonabstinent Japanese alcoholic men in the morning after drinking and their ADH1B and ALDH2 genotypes2014
- Author(s)
  Yokoyama A, Yokoyama T, Mizukami T, Matsui T, Kimura M, Matsushita S, Higuchi S, Maruyama K
- Journal Title
  
  Alcohol Alcohol
  
  Volume: 49 Issue: 1 Pages: 31-37
- DOI
  10.1093/alcalc/agt136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460632
[Journal Article] 高齢者における飲酒コントロールと認知症予防2014
- Author(s)
  松井敏史, 神崎恒一, 松下幸生, 樋口進
- Journal Title
  
  認知神経科学
  
  Volume: 16 Pages: 9-17
- NAID
  130006895811
- Data Source
  KAKENHI-PROJECT-26460632
[Journal Article] 生活習慣病と認知機能　予防と治療　アルコール2014
- Author(s)
  松井敏史, 横山顕, 松下幸生, 神崎恒一, 樋口進
- Journal Title
  
  日本臨床
  
  Volume: 72 Pages: 749-756
- Data Source
  KAKENHI-PROJECT-26460632
[Journal Article] Efficacy of disulfiram for the treatment of alcohol dependence assessed with a multicenter randomized controlled trial2014
- Author(s)
  Yoshimura A, Kimura M, Nakayama H, Matsui T, Okudaira F, Akazawa S, Ohkawara M, Cho T, Kono Y, Hashimoto K, Kumagai M, Sahashi Y, Roh S, Higuchi S
- Journal Title
  
  Alcohol Clin Exp Res
  
  Volume: 38 Issue: 2 Pages: 572-578
- DOI
  10.1111/acer.12278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460632
[Journal Article] Macrocytosis, Macrocytic Anemia, and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men2014
- Author(s)
  Yokoyama A, Yokoyama T, Brooks PJ, Mizukami T, Matsui T, Kimura M, Matsushita S, Higuchi S, Maruyama K
- Journal Title
  
  Alcohol Clin Exp Res
  
  Volume: 38 Issue: 5 Pages: 1237-1246
- DOI
  10.1111/acer.12372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460632
[Journal Article] Effect of a comprehensive lifestyle modification program on the bone density of male heavy drinkers.2010
- Author(s)
  Matsui T, Higuchi S, Maruyama K., 他
- Journal Title
  
  Alcohol Clin Exp Res. 34
  
  Pages: 869-875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390200
[Journal Article] Changes in the serum bone metabolism markers of elderly alcoholics during abstinence.2010
- Author(s)
  Matsui T, Yokoyama A, Matsushita S, Mori S, Arai H, Higuchi S, Maruyama K.
- Journal Title
  
  J Am Geriatr Soc. 58
  
  Pages: 984-986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390200
[Journal Article] Assessing multidimensional cognitions of drinking among alcohol-dependent patients : development and validation of a drinking-related cognitions scale (DRCS).2009
- Author(s)
  Sawayama T, Yoneda J, Tanaka K, Shirakawa N, Sawayama E, Higuchi S, Miyaoka H.
- Journal Title
  
  Addict Behav. 34
  
  Pages: 82-85
- NAID
  10021950602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390200
[Journal Article] Decrease in the prevalence of adolescent alcohol use and its possible causes in Japan : periodical nationwide cross-sectional surveys.2009
- Author(s)
  Osaki Y, Tanihata T, Ohida T, Kanda H, Suzuki K, Higuchi S, Kaneita Y, Minowa M, Hayashi K.
- Journal Title
  
  Alcohol Clin Exp Res. 33
  
  Pages: 247-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390200
[Journal Article] Consortium for Alzheimer Disease. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese.2009
- Author(s)
  Takei N, Higuchi S, Kuwano R., 他
- Journal Title
  
  Genomics. 93
  
  Pages: 441-448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390200
[Journal Article] Elevated cerebrospinal fluid tau protein levels in Wernicke's encephalopathy.2008
- Author(s)
  Matsushita S, Miyakawa T, Maesato H, Matsui T, Yokoyama A, Arai H, Higuchi S, Kashima H.
- Journal Title
  
  Alcohol Clin Exp Res. 32
  
  Pages: 1091-1095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390200
[Presentation] ASI(Addiction Severity Index:嗜癖重症度指標)の臨床応用の検討:家族・人間関係をめぐる考察を中心に2010
- Author(s)
  原口彩子,池田和隆,大谷保和,梅野充,合川勇三,樋口進,妹尾栄一
- Organizer
  第13回ニコチン・薬物依存研究フォーラム
- Place of Presentation
  北九州
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-20390162

1. SORA Ichiro (40322713)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. NISHIZAWA Daisuke (80450584)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. IKEDA Kazutaka (60281656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. KASAI Shinya (20399471)

# of Collaborated Projects: 1 results

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5. ARINAMI Tadao (10212648)

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6. FUKUDA Kenichi (80228907)

# of Collaborated Projects: 1 results

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7. UJIKE HIROSHI (90213420)

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8. USUDA Nobuteru (30135123)

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9. SUGIYAMA Satoshi (50340229)

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10. NAGATSU Toshiharu (40064802)

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11. MURAKAMI Kazuo (70110517)

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12. NAKAI Sachiko (30257836)

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13. WATARI Nakazou (40079976)

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14. NAGATSU Ikuko (80084573)

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15. NAKAHARA Daiichirou (80128389)

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16. TAKAHASHI Hisahide (80084606)

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17. HATA Toshimichi (50399044)

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18. HAYASHI Takashi (80399328)

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19. FUKASAWA Motoaki (70387728)

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20. ATSUZAWA Kimie (60387727)

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21. MATSUZAWA Ayami (90273078)

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22. YAMAZAKI Masao (10192395)

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23. NAGAOKA Toshiharu (20021420)

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24. OKAWARA Takeshi (20469034)

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25. SETOU Mitsutoshi (20302664)

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26. OOSUKA Kouzi (40378013)

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27. KANEKO Rina (70367697)

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28. Matsui Toshifumi (50333802)

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# of Collaborated Products: 12 results

Susumu Higuchi 樋口 進

樋口 進 ヒグチ ススム

HIGUCHI Susumu 樋口 進

Research Projects

Research Products

Co-Researchers

Effect of ALDH2 polymorphism on brain atrophy in alcoholic patients: A matched-pair MRI study by voxel-based morphometric analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genome-wide association study of sensitivity to narcotics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neuroscientific studies on the effect of moxibustion on chronic diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] アルコール関連中枢神経障害2018

Author(s)

Journal Title

Data Source

[Journal Article] Platelet Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Blood Leukocyte Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes and Alcoholic Ketosis Are Associated with the Serum Uric Acid Level in Japanese Alcoholic Men2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] アルコール関連の諸問題2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes Are Strong Determinants of the Serum Triglyceride and Cholesterol Levels of Japanese Alcoholic Men2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alcoholic Ketosis: Prevalence, Determinants, and Ketohepatitis in Japanese Alcoholic Men2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Blood ethanol levels of nonabstinent Japanese alcoholic men in the morning after drinking and their ADH1B and ALDH2 genotypes2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 高齢者における飲酒コントロールと認知症予防2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 生活習慣病と認知機能 予防と治療 アルコール2014

Author(s)

Journal Title

Data Source

[Journal Article] Efficacy of disulfiram for the treatment of alcohol dependence assessed with a multicenter randomized controlled trial2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrocytosis, Macrocytic Anemia, and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men2014

Author(s)

Journal Title

Susumu Higuchi 樋口進

樋口進ヒグチススム

HIGUCHI Susumu 樋口進

[Journal Article] 生活習慣病と認知機能　予防と治療　アルコール2014