Kawakami Masanobu 川上正のぶ

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KAWAKAMI Masanobu 川上正舒

川上正のぶカワカミマサノブ

川上正督カワカミマサノブ

川上正カワカミマサノブ

川上正舒カワカミマサノブ

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Researcher Number	40161286
External Links
Affiliation (Current)	2025: 自治医科大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help	2013: 自治医科大学, 医学部, 名誉教授(Emeritus Professor) 2012 – 2013: 自治医科大学, 医学部, 名誉教授 2000 – 2011: 自治医科大学, 医学部, 教授 1997 – 1998: Jichi Medical School, Professor Faculty of Medicine, 医学部, 教授 1993 – 1996: 自治医科大学, 医学部, 助教授 … More 1991: 自治医科大学, 医学部, 助教授 1986 – 1988: 国立病院医療センター, 臨床研究部, 室長 1986: 医療セ, その他, その他 Less
Review Section/Research Field	Principal Investigator 内科学一般 / 内分泌・代謝学 / 血管生物学 Except Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine / Eating habits, studies on eating habits / Ophthalmology / Metabolomics / Digestive surgery / 内分泌・代謝学 / 血管生物学 / Human pathology
Keywords	Principal Investigator TNF / サイトカイン / 脂肪細胞 / カケクチン / appetite / cachexia / obesity / 悪疫質 / 食欲 / 悪液質 … More / 肥満 / ホルモン感受性リパーゼ / リポ蛋白リパーゼ / IFN / IL-1 / 細胞分化 / Lipolysis / LPL(Lipoprotein Lipase) / TNF(Tumor Necrosis Factor) / 単球 / マクロファージ / 平滑筋 / 血管内皮細胞 / 接着分子 / LTBP / TGFbeta / 動脈硬化 / ILー1 … More Except Principal Investigator VEGF / TGF-β / 血管内皮細胞 / 動脈硬化 / 糖尿病 / THP-1 / HUVEC / MMP / HGF / 活性酸素 / NO / AGE / 低酸素 / TGF-beta / シグナル伝達 / アポトーシス / 血糖値 / Antioxidant / Cataract / Flavengenol / Ascorbic acid / Tocotrienol / Tocopherol / Astaxanthin / Diabetes / メイラード反応 / セサミン / 過酸化脂質 / 抗酸化剤 / 白内障 / フラバンジェノール / アスコルビン酸 / トコトリエノール / トコフェロール / アスタキサンチン / gene cloning / atherpsclerosis / apoptosis / monocyte / vascular endothelial cells / 遺伝子クローニング / 単球 / STZ rat / SDT rat / Diabetic cataract / Rubeotic glaucoma / Sulfonylurea / Diabetic melites / Diabetic animal model / Diabetic retinopathy / 糖尿病動物モデル / STZラット / SDTラット / 糖尿病白内障 / 血管新生緑内障 / スルホニルウレア / 糖尿病モデル動物 / 糖尿病網膜症 / MITCHONDRIAL ELECTRON TRANSPORT / NO SYNTHASE / NITRIC OXIDE / REACTIVE OXYGEN SPECIES / NADPH OXIDASE / HYPOXIA / K-ATPチャンネル / ATP / HNF-4 / 一酸化窒素 / NADPHオキシダーゼ / 一酸化窒素合成酵素 / ミトコンドリア電子伝達系 / 一酸化炭素 / NADPHオキシターゼ / TGF-β receptor / ER-pP / ER-1 / ER-1細胞 / 癌転移 / TGF-β 受容体 / ER-pP 細胞 / ER-1 細胞 / oxidized LDL / IGF-1 / oxidative stress / hypoxia / アラキドン酸代謝経路 / 細胞内酸化ストレス / 酸化LDL / IGF-I / 酸化ストレス / dissecting aneurysm / coronary atherrome / vascular disease / TGF-beta type II Receptor / TGF-beta type I Receptor / endoglin / latent TGF-beta binding protein / 潜在型TGF-beta1結合タンパク(LTBP) / 腹部大動脈〓 / 解離性大動脈〓 / 潜在型TGF-βI結合タンパク(LTBP) / 解離性大動脈瘤 / 腹部大動脈瘤 / 血管病変 / TGF-βII型受容体 / TGF-βI型受容体 / エンドグリン / 潜在型TGF-β1結合タンパク(LTBP) / SIM法 / GC-MS分析 / 血清メバロン酸 / 安定同位体 / HMG・CoAレダクターゼ / ドリコール / メバロン酸代謝 / マクロファージ / erythropoietin / WHHLMIウサギ / アゴニスト / エリスロポエチン / DNAチップ / ベトナム / ポリフェノール / Nu Voi / ベトナム産 / 胃癌分化度 / LTBP / TGF-β受容体 Less

Molecular mechanisms of suppression of macrophage foam cell formation by an erythropoietin receptor agonist
- Principal Investigator
  
  UEBA HIROTO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Jichi Medical University
Anti-atherosclerotic effects of an erythropoietin receptor agonist
- Principal Investigator
  
  UEBA Hiroto
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Jichi Medical University
糖尿病の予防・抑制におけるベトナム産Nu Voiの基礎および臨床に関する研究
- Principal Investigator
  
  NGUYEN Van Chuyen
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Japan Women's University
Basic and Clinical Studies on Natural Antioxidant Astaxanthin on the Inhibition of Diabetic Complication
- Principal Investigator
  
  NGUYEN Van Chuyen
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Japan Women's University
Analysis of antiapoptotic genes induced in vascular endothelial cells by monocyte adhesion.
- Principal Investigator
  
  UEBA Hiroto
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Jichi Medical School
Mechanism and treatment of diabetic retinopathy
- Principal Investigator
  
  KAKEHASHI Akihiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Jichi Medical School
Regulation of matrix metalloprotcase-9 production induced by monocyte-vascular endothelial cell interaction - role of hepatocyte growth factor and vascular endothelial growth.
- Principal Investigator
  
  UEBA Hiroto
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Omiya Medical Center, Jichi Medical School
THE ELUCIDATION OF THE OXYGEN SENSING AND INTRACELLULAR SIGNALING SYSTEM.
- Principal Investigator
  
  KUROKI Masatoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  JICHI MEDICAL SCHOOL
The study for the mechanism of the development of diabetic retinopathy
- Principal Investigator
  
  KUROKI Masatoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  JICHI MEDICAL SCHOOL
Growth factors and adhesion molecules in the progression of metastasizing capability of cancer cell lines.
- Principal Investigator
  
  KAI Toshihiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Jichi Medical School
Roles of TNF and leptin, the ob gene product, in genetic obesity.Principal Investigator
- Principal Investigator
  
  KAWAKAMI Masanobu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Jichi Medical School, Faculty of Medicine
消化器癌の組織形態におけるTGF-βs, TGF-β受容体および関連タンパクの影響
- Principal Investigator
  
  KAI Toshihiro
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Jichi Medical University
動脈硬化の成因におけるカケクチン/TNFとその関連サイトカインの役割に関する研究Principal Investigator
- Principal Investigator
  
  川上正舒
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Jichi Medical University
TGF-beta and vascular diseases
- Principal Investigator
  
  TAKETAZU Fumitoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Jichi Medical School
動脈硬化巣のサイトカイン産生におけるアセチルLDL受容体の役割に関する研究Principal Investigator
- Principal Investigator
  
  川上正
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Jichi Medical University
カケクチン/TNFによる脂肪細胞の分化抑制および細胞障害作用のメカニズムPrincipal Investigator
- Principal Investigator
  
  川上正舒
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Research Institute, International Medical Center of Japan
安定同位前駆体を用いたメバロン酸代謝物の解析とHMG-COAレダクターゼ活性
- Principal Investigator
  
  大島美恵子
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Research Institute, International Medical Center of Japan
脂肪細胞の機能と分化に及ぼす各種モノカインの影響についてPrincipal Investigator
- Principal Investigator
  
  川上正舒
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Research Institute, International Medical Center of Japan
TNF(癌壊死因子)の正常組織に対する作用Principal Investigator
- Principal Investigator
  
  川上正のぶ
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Research Institute, International Medical Center of Japan

All 2013 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Suppression of coronary atherosclerosis by a helix B surface peptide, a nonerythropoietic tissue- protective compound derived from erythropoietin2013
- Author(s)
  Ueba H, Shiomi M, Brines M, Yamin M, Kobayashi T, Ako J, Momomura S, Cerami A, Kawakami M.
- Journal Title
  
  Mol Med.
  
  Volume: 19(1) Pages: 195-202
- Data Source
  KAKENHI-PROJECT-23591108
[Journal Article] Suppression of coronary atherosclerosis by helix B surface peptide, a nonerythropoietic, tissue-protective compound derived from erythropoietin.2013
- Author(s)
  Ueba H, Shiomi M, Brines M, Yamin M, Kobayashi T, Ako J, Momomura SI, Cerami A, Kawakami M
- Journal Title
  
  Molecular Medicine
  
  Volume: 19 Issue: 1 Pages: 195-202
- DOI
  10.2119/molmed.2013.00037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300157, KAKENHI-PROJECT-23591108
[Journal Article] Reply to Abdelwahid and Smith: The effect on cardiomyocytes of helix B-surface peptide (HBSP), a peptide with cell-protective but not erythropoietic activities of erythropoietin2011
- Author(s)
  Kawakami M, Ueba H, Brines M, Yamin M, Umemoto T, Ako J, Momomura S, and Cerami A
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 108(6) Issue: 6
- DOI
  10.1073/pnas.1012530108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591108
[Journal Article] Reply to Abdel Wahid, Smith : The effect on cardiomyocytes of helix B-surface peptide (HBSP), a peptide with cell-protective but not erythropoietic activities of erythropoietin2011
- Author(s)
  Masanobu Kawakami, Hiroto Ueba
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590887
[Journal Article] Reply to Abdelwahid and Smith : The effect on cardiomyocytes of helix B-surface peptide (HBSP), a peptide with cell-protective but not erythropoietic activities of erythropoietin.2011
- Author(s)
  Masanobu Kawakami, Hiroto Ueba, Michael Brines, Michael Yamin, Tomio Umemoto, Junya Ako, Shin-ichi Momomura, Anthony Cerami
- Journal Title
  
  Proc Natl Acad Sci USA. 108(6)
- Data Source
  KAKENHI-PROJECT-20590887
[Journal Article] Reply to Abdelwahid and Smith : The effect on cardiomyocytes of helix B-surface peptide (HBSP), a peptide with cell-protective but not erythro- poietic activities of erythropoietin2011
- Author(s)
  Masanobu Kawakami, Hiroto Ueba, Michael Brines, Michael Yamin, Tomio Umemoto, Junya Ako, Shin-ichi Momomura, and Anthony Cerami
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 108(6)
- Data Source
  KAKENHI-PROJECT-23591108
[Journal Article] Cardioprotection by a nonerythropoietic, tissue-protective peptide mimicking the 3D structure of erythropoietin.2010
- Author(s)
  Hiroto Ueba, Michael Brines, Michael Yamin, Tomio Umemoto, Junya Ako, Shin-ichi Momomura, Anthony Cerami, Masanobu Kawakami
- Journal Title
  
  Proc Natl Acad Sci USA. 107(32)
  
  Pages: 14357-14362
- Data Source
  KAKENHI-PROJECT-20590887
[Journal Article] C-Reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells : Implications for the destabilization of atherosclerotic plaque.2008
- Author(s)
  Aoi Nabata, Masatoshi Kuroki, Hiroto Ueba, Shigemasa Hashimoto, Tomio Umemoto, Hiroshi Wada, Takanori Yasu, Muneyasu Saito, Shin-ichi Momomura, Masanobu Kawakami
- Journal Title
  
  Atherosclerosis 196(1)
  
  Pages: 129-135
- Data Source
  KAKENHI-PROJECT-20590887
[Journal Article] Effects of Thiazolidinediones on In- Stent Restenosis : A Review of IVUS Studies
- Author(s)
  Yasu T, Ueba H, Katayama T, Kawakami M.
- Journal Title
  
  Intravascular Ultrasound, Yasuhiro Honda (Ed.)
  
  Volume: (ISBN :978-953-307-900-4)(InTech 2012)
- URL
  http://www.intechopen.com/books/intravascular-ultrasound/effects-of-thiazolidinedione-on-in-stent-restenosis-a-review-of-ivus-studies
- Data Source
  KAKENHI-PROJECT-23591108
[Presentation] Suppression of coronary atherosclerosis by a helix B surface peptide, a nonerythropoietic tissue- protective compound derived from erythro- poietin2013
- Author(s)
  Ueba, H., Shiomi, M., Brines, M., Yamin, M., Ako, J., Momomura, S., Cerami, A., Kawakami, M.
- Organizer
  The 77th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama
- Year and Date
  2013-03-15
- Data Source
  KAKENHI-PROJECT-23591108
[Presentation] Suppression of coronary atherosclerosis by a helix B surface peptide, a nonerythropoietic tissue-protective compound derived from erythropoietin2013
- Author(s)
  Ueba, H., Shiomi, M., Brines, M., Yamin, M., Ako, J., Momomura, S., Cerami, A., Kawakami
- Organizer
  The 77th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-23591108
[Presentation] 慢性心不全動物モデルにおける非造血性エリスロポエチン誘導体による心筋保護作用―抗アポトーシス効果による適応2013
- Author(s)
  上羽洋人, Michael Brines, Michael Yamin, Anthony Cerami,梅本富士,阿古潤哉,川上正舒,百村伸一
- Organizer
  第17回日本適応医学会学術集会
- Place of Presentation
  さいたま市
- Year and Date
  2013-06-29
- Data Source
  KAKENHI-PROJECT-23591108
[Presentation] Cardioprotective Properties of Helix B Surface Peptide, a Nonerythropoietic Derivative Mimicking the 3D Structure of Erythropoietin2011
- Author(s)
  Ueba, H., Brines, M., Yamin, M., Umemoto, T., Ako, J., Momomura, S., Cerami, A., Kawakami, M.
- Organizer
  The 75th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23591108
[Presentation] Cardioprotective Prop- erties of Helix B Surface Peptide, a Nonerythropoietic Derivative Mimicking the 3D Structure of Erythropoietin2011
- Author(s)
  Ueba, H., Brines, M., Yamin, M., Umemoto, T., Ako, J., Momomura, S., Cerami, A., Kawakami, M.
- Organizer
  The 75th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama
- Year and Date
  2011-08-03
- Data Source
  KAKENHI-PROJECT-23591108
[Presentation] Cardiomyocyte protection by a nonerythropoietic, tissue-protective peptide derived from erythropoietin.2010
- Author(s)
  Ueba, H, Brines, M, Yamin, M, Umemoto, T, Ako, J, Momomura, S, Cerami, A, Kawakami, M.
- Organizer
  第74回日本循環器学会総会
- Place of Presentation
  京都市
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-20590887
[Presentation] Role of osteopontin and αvβ3 integrin in the regulation of endothelial cell survival by endothelial cell-monocyte interaction.2010
- Author(s)
  Ueba, H, Hashimoto, S, Umemoto, T, Ako, J, Momomura, S, Kawakami, M.
- Organizer
  第42回日本動脈硬化学会総会
- Place of Presentation
  岐阜市
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-20590887
[Presentation] Induction of endothelial cell apoptosis and monocyte matrix metalloproteinase-9 production by C-reactive protein.2009
- Author(s)
  Ueba, H, Nabata, A, Kuroki, M, Hashimoto, S, Umemoto, T, Sugawara, Y, Kubo, N, Momomura, S, Kawakami, M.
- Organizer
  第73回日本循環器学会総会
- Place of Presentation
  大阪市
- Year and Date
  2009-03-21
- Data Source
  KAKENHI-PROJECT-20590887

1. KUROKI Masatoshi (90215096)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. UEBA Hiroto (80316546)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
3. TAKETAZU Fumitoshi (90254937)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. KAI Toshihiro (40260830)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MIYATA Michio (90048976)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NGUYEN Van Chuyen (80175322)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 大島美恵子 (20050487)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SODA Kuniyasu (00221341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HIKINO Hajime (60296126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YASU Takanori (40265278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAKEHASHI Akihiro (30296123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山本従道 (40231675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 高木省治郎 (20158992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 山田茂樹 (80220375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 鈴木恵美子 (80154524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 青塚新一 (80158716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 進藤登

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 石橋俊

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 小川弘子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 塩見雅志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawakami Masanobu 川上 正のぶ

KAWAKAMI Masanobu 川上 正舒

川上 正のぶ カワカミ マサノブ

川上 正督 カワカミ マサノブ

川上 正 カワカミ マサノブ

川上 正舒 カワカミ マサノブ

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Roles of TNF and leptin, the ob gene product, in genetic obesity.Principal Investigator

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動脈硬化の成因におけるカケクチン/TNFとその関連サイトカインの役割に関する研究Principal Investigator

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Kawakami Masanobu 川上正のぶ

KAWAKAMI Masanobu 川上正舒

川上正のぶカワカミマサノブ

川上正督カワカミマサノブ

川上正カワカミマサノブ

川上正舒カワカミマサノブ