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KAWANO Michio  河野 道生

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Researcher Number 40161343
Other IDs
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Affiliation (based on the past Project Information) *help 2010: Yamaguchi University, 医学(系)研究科(研究院), 教授
2008 – 2010: 山口大学, 大学院・医学系研究科, 教授
2006: Yamaguchi University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授
2005: 山口大学, 大学院・医学系研究科, 教授
2001 – 2004: Yamaguchi University, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 … More
1997 – 2000: 山口大学, 医学部, 教授
1996: University Hospital, HIROSHIMA UNIVERSITY Assistant Professor, 医学部附属病院, 講師
1992 – 1996: Hiroshima University Hospital, Assistant Professor, 医学部・附属病院, 講師
1994: 広島大学, 医学部附属病院, 講師
1992: Hiroshima University Hospital, Assistant Professor, 医学部附属病院, 講師
1991: 広島大学, 医学部. 附属病院, 助手
1991: 広島大学, 医学部附属病院, 助手
1990: Medical Hospital, Hiroshima Univ., Research Associate., 医学部・附属病院, 助手
1989: 広島大学, 医学部附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Hematology / Biological Sciences / Hematology
Except Principal Investigator
Hematology / Hematology / Humanities and Social Sciences
Keywords
Principal Investigator
骨髄腫 / 骨髄腫細胞 / IL-6 / CD45 / CD19 / 未熟型骨髄腫細胞 / 形質細胞分化 / MPC-1 / Pax-5 / Myeloma … More / 良性M蛋白血症 / Galectin-1 / CD45RA / lipid rafts / 脂質ラフト / immature myeloma cells / myeloma / STAT3 / STAT1 / SCIDマウス / 前駆細胞 / 骨髄ストローマ細胞 / 接着分子 / Myeloma cells / Autocrine growth / 表面抗原解析 / M蛋白血症 / signal transduction / CD45R0 / myeloma cells / CD-45 / シグナル伝達 / CD45RO / CD45 isoform / 細胞膜分子動態 / ラフト / フォスファターゼ / CD45アイソフォーム / differentiation inducing therapy / SCID mice / interleukin 6 / myeloma cell differentiation / MAPK / Lyn / 分化誘導療法 / 骨髄腫細胞分化 / SCID mouse / Myeloma cell / Transcription factor / Gene transfer / Methylation / 転写因子 / 遺伝子導入 / メチル化 / Asdhesion molecule / Plasma cell / Cell differentiation / Interleukin 6 / Tumor precursor / Immature myeloma cells / ソーティング / インターロイキン6 / アポトーシス / 形質細胞 / 細胞分化 / インターロイキン 6 / 腫瘍前駆細胞 / 未熟骨髄腫細胞 / Cell sorter / Monoclonal antibody / Precursor cells / Stromal cells / Integrin / Adhesion molecules / モノクロ-ナル抗体 / 骨髄ストロ-マ細胞 / セルソーター / モノクローナル抗体 / インテグリン / Nuclear factor / Transcriptional factor / Gene activation / Interleukin-6 / NF-IL-6 / Nuclear binding protein / Transcriptional Regulation / Interleukin 6 gene / Multiple Myeloma / オ-トクリン増殖 / 核内蛋白 / 転写調節因子 / 遺伝子発現 / ILー6 / 細胞系統逸脱 / SOX4 / CD56 / PPAR / NF-kB / DHEA / 遺伝子プロファイリング / MGUS / 未熟型形質細胞 / 未熟形質細胞 … More
Except Principal Investigator
IL-6 / CD45 / CD19 / 骨髄腫 / 2 / ERK1 / STAT3 / Lyn / FGFR3 / cell proliferation / myeloma / 細胞増殖 / PI 3-kinase / IL-6Rα / Akt / PLC / MAPK / 骨髄腫細胞 / Pax-5 / NF-IL6 / 多発性骨髄腫 / signal-transducing molecules / IL-6誘導遺伝子 / マイクロアレイ / 質量分析 / PI3-kinase / 刺激伝達分子 / raft / cell survival / IGF-I receptor / IL-G / サブトラクション / IGF-I / ラフト / 細胞生存 / IL-6受容体α / IGF-I受容体 / src family kinase / multiple myeloma / アポトーシス / STAT / src / Caイオン / src型PTK / SCID mice / signal transduction / SCIDマウス / 刺激伝達 / oncogenesis / plasma call / Myeloma / transcriptional regulation / Myeloma cell / 発癌機構 / 形質細胞 / 転写調節 / Transcriptional Factor / Growth Factor / Autocrine / Interleukin-6 / Multiple Myeloma / ゲル・シフト・アッセイ / RTーPCR / NFーIL6 / オ-トクライン / インタ-ロイキン6(ILー6) / 転写調節因子 / 増殖因子 / オートクライン / インターロイキン6 / CD54 / NF-kB / PPAR / 研修会 / 授業 / 遺伝子 / 中等教育 / 組換えDNA実験 Less
  • Research Projects

    (20 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (15 People)
  •  骨髄腫細胞株におけるCD56発現機構の解析Principal Investigator

    • Principal Investigator
      河野 道生
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Yamaguchi University
  •  The elucidation of mechanism of action of PPAR to suppress constitutive NF-kB activity on human myeloma cells

    • Principal Investigator
      OOTSUYAMA Kenichirou
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Yamaguchi University
  •  Analysis of the IL-6-mediated intracellular signaling molecules in myeloma cell growth

    • Principal Investigator
      ISHIKAWA Hideaki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Yamaguchi University
  •  The mechanism of translocation of CD45R0 to lipid rafts in IL-6-induced proliferation of human myeloma cellsPrincipal Investigator

    • Principal Investigator
      KAWANO Michio, 津山 尚宏
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Yamaguchi University
  •  前癌病変BMGから骨髄腫への進展に関わるホルモンDHEAの動態とその機能解析Principal Investigator

    • Principal Investigator
      河野 道生
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Yamaguchi University
  •  高等学校における組換えDNA実習を通した遺伝子教育に関する研究

    • Principal Investigator
      田中 伸和
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Humanities and Social Sciences
    • Research Institution
      Hiroshima University
  •  前癌病変良性M蛋白血症から骨髄腫への進展に関する分子疫学的研究Principal Investigator

    • Principal Investigator
      河野 道生
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Yamaguchi University
  •  Regulatory mechanism of membrane coreceptors in the proliferation of human myeloma cellsPrincipal Investigator

    • Principal Investigator
      KAWANO Michio
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Yamaguchi University
  •  Analysis of the signal transduction molecules and genes that regulate the proliferation of myeloma cells

    • Principal Investigator
      ISHIKAWA Hideki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Yamaguchi University
  •  骨髄腫の前癌病変BMGから骨髄腫への進展に関する研究Principal Investigator

    • Principal Investigator
      河野 道生
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Yamaguchi University
  •  骨髄腫を含めたM蛋白血症の進展と未熟形質細胞の動態との関連Principal Investigator

    • Principal Investigator
      河野 道生
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Yamaguchi University
  •  Functional analysis of the molecules modulating the proliferative signals of human myeloma cells by IL-6

    • Principal Investigator
      ISHIKAWA Hideaki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Yamaguchi University
  •  Differentiation induction of human myeloma cellsPrincipal Investigator

    • Principal Investigator
      KAWANO Michio M
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Yamaguchi University
  •  Involvement of CD19 molecules in proliferation of human immature myeloma cells by interleukin-6

    • Principal Investigator
      ISHIKAWA Hideaki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Yamaguchi University
  •  Oncogenesis of Human Myeloma and Altered Expression of Pax-5 genePrincipal Investigator

    • Principal Investigator
      KAWANO Michio
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Yamaguchi University
  •  ALTERED EXPRESSION OF TRANSCRIPTION FACTOR FOR CD19 GENE IN HUMAN MYELOMA CELLS

    • Principal Investigator
      TANAKA Hideo
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  STUDY ON THE IDENTIFICATION OF MYELOMA PRECURSOR CELLS AND THEIR INDUCTION OF DIFFERENTIATIONPrincipal Investigator

    • Principal Investigator
      KAWANO Michio
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      HIROSIMA UNIVERSITY
  •  Growth Regulation of Human Myeloma cells: Regulatory Mechanism in the bone marrow microenvironment.Principal Investigator

    • Principal Investigator
      KAWANO Michio
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  The transcriptional factor involved in the constitutive expression of interleukin-6 in multiple myeloma

    • Principal Investigator
      TANABE Osamu
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Mechanism of IL-6 Gene Activation in Myeloma CellsPrincipal Investigator

    • Principal Investigator
      KAWANO Michio
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Hiroshima University

All 2010 2009 2008 2006 2004 2003 2002

All Journal Article Presentation Book

  • [Book] 三輪血液病学2006

    • Author(s)
      河野道生
    • Total Pages
      2070
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591000
  • [Book] 多発性骨髄腫 Up-to-date2006

    • Author(s)
      河野道生
    • Total Pages
      191
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591000
  • [Book] 多発性骨髄腫 Up-to-date2006

    • Author(s)
      河野道生
    • Total Pages
      191
    • Publisher
      メデイカルレビュー社
    • Data Source
      KAKENHI-PROJECT-17591000
  • [Book] 内科学(多発性骨髄腫とその類縁疾患)2003

    • Author(s)
      河野道生
    • Total Pages
      6
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370305
  • [Journal Article] CD56 expression in human myeloma cells derived from the neurogenic gene expression : possible role of the SRY-HMG box gene, SOX4.2010

    • Author(s)
      Iqbal MS, Otsuyama K, Shamsasenjan K, Asaoku H, Kawano MM.
    • Journal Title

      Int J Hematol. 91(2)

      Pages: 267-75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Journal Article] Constitutively lower expressions of CD54 on primary myeloma cells and their different localizations in bone marrow.2009

    • Author(s)
      Iqbal MS, Otsuyama K, Shamsasenjan K, Mahmoud MS, Gondo T, Kawano MM.
    • Journal Title

      Eur J Haematol. 83(4)

      Pages: 302-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Journal Article] IL-6-induced activation of MYC is responsible for the down-regulation of CD33 expression in CD33+ myeloma cells.2009

    • Author(s)
      Shamsasenjan K, Otsuyama K, Abroun S, Iqbal MS, Mahmoud MS, Asaoku H, Kawano MM.
    • Journal Title

      Int J Hematol. 89(3)

      Pages: 310-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Journal Article] Growth mechanism of myeloma cells2004

    • Author(s)
      Kawano MM.
    • Journal Title

      Hematology Frontier 14

      Pages: 1499-1504

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370305
  • [Journal Article] 多発性骨髄腫と類縁疾患 1.骨髄腫細胞の増殖機構2004

    • Author(s)
      河野道生
    • Journal Title

      血液フロンティア 14・10

      Pages: 1499-1504

    • Data Source
      KAKENHI-PROJECT-14370305
  • [Journal Article] 多発性骨髄腫と類縁疾患 1.骨髄腫細胞の増殖機構2004

    • Author(s)
      河野道生
    • Journal Title

      血液フロンテイア 14

      Pages: 1499-1504

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370305
  • [Journal Article] 多発性骨髄腫の病態と分子標的療法 増殖機序2004

    • Author(s)
      河野道生
    • Journal Title

      血液・腫瘍科 48・3

      Pages: 243-249

    • Data Source
      KAKENHI-PROJECT-14370305
  • [Journal Article] Multiple myeloma and related diseases2003

    • Author(s)
      Kawano MM.
    • Journal Title

      Internal Medicne (Bunkoudou, Tokyo)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370305
  • [Journal Article] Multiple Myeloma in 100^<th> anniversary2002

    • Author(s)
      Kawano MM.
    • Journal Title

      The Journal of the Japanese Society of Internal Medicine 91

      Pages: 2106-2113

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370305
  • [Journal Article] 内科-100年のあゆみ(血液)III.主要疾患の歴史 8.多発性骨髄腫2002

    • Author(s)
      河野道生
    • Journal Title

      日本内科学会雑誌 91

      Pages: 2106-2113

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370305
  • [Journal Article] Recent Progress in Multiple Myeloma2002

    • Author(s)
      Kawano MM.
    • Journal Title

      Excerpta Medica 18

      Pages: 4-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370305
  • [Journal Article] 多発性骨髄腫-最近の進歩2002

    • Author(s)
      河野道生
    • Journal Title

      Excerpta Medica 18

      Pages: 4-9

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370305
  • [Presentation] Perivascular localization of myeloma cells with lower expression of CD54.2009

    • Author(s)
      Kawano M, Otsuyama K, Iqbal MS, Gondo T
    • Organizer
      The 71st Annual meeting of the Japanese Society of Hematology
    • Place of Presentation
      Kyoto 京都京都国際会議場
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Presentation] 骨髄腫細胞のCD56発現におけるSOX遺伝子群の関わりについて2009

    • Author(s)
      Iqbal MS, Shamsasenjan K, 大津山賢一郎、河野道生
    • Organizer
      第48回日本血液学会中国四国地方会
    • Place of Presentation
      松山.文化ホール
    • Year and Date
      2009-03-07
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Presentation] Up-regulation of SOX4 but not down-regulation of SOX1 in CD56 expression of human myeloma cells.2009

    • Author(s)
      Iqbal MS, Otsuyama K, Shamsasenjan K, Kawano M
    • Organizer
      The 71st Annual meeting of the Japanese Society of Hematology
    • Place of Presentation
      Kyoto 京都京都国際会議場
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Presentation] Up-regulation of SOX4 but not down-regulation of SOX1 in CD56 expression of humanmyeloma cell lines2009

    • Author(s)
      河野道生
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都府京都市国立京都国際会館
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-21591207
  • [Presentation] Decreased expression levels of CD54 associated with decreased activity of CXCL12 in primary myeloma cells.2008

    • Author(s)
      Kawano M, Iqbal MS, Otsuyama K, Shamsasenjan K, Amin J, Islam A, Abroun S.
    • Organizer
      The 50th Annual Meeting of American Society of Hematology
    • Place of Presentation
      San Francisco, CA, U.S.A. MOSCON CENTER
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Presentation] 骨髄腫細胞株におけるNF-kB活性の高低とストレス刺激抵抗性について2008

    • Author(s)
      Islam A, Amin J, Shamsasenjan K, Iqbal MS, 大津山賢一郎、河野道生
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都 京都国際会議場
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Presentation] Symposium "Multiple Myeloma, Constitutive NF-kB activation in myeloma cells ; its underlying mechanism and functional significance"2008

    • Author(s)
      大津山賢一郎, 河野道生
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都 京都国際会議場
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Presentation] 骨髄腫細胞株の恒常的NF-kB活性の非古典的経路に関わる分子NIKについて2008

    • Author(s)
      大津山賢一郎、Amin J, Shamsasenjan K, Iqbal MS, Islam A, 河野道生
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都 京都国際会議場
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Presentation] IL-6依存性および非依存性骨髄腫細胞株における恒常的NF-kB活性とNF-kB標的遺伝子発現の比較2008

    • Author(s)
      Amin J, 大津山賢一郎、Shamsasenjan K, Iqbal MS, Islam A, 河野道生
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都 京都国際会議場
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Presentation] Molecular mechanism of CD56 expression in human myeloma cells2008

    • Author(s)
      Iqbal MS, Otsuyama K, Shamsasenjan K, Kawano M.
    • Organizer
      The 50th Annual Meeting of American Society of Hematology
    • Place of Presentation
      San Francisco, CA, U.S.A. MOSCON CENTER
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Presentation] 単クローン性形質細胞におけるNF-kB標的遺伝子CD54発現の多様性2008

    • Author(s)
      河野道生、Islam A, Amin J, Shamsasenjan K, Iqbal MS, 大津山賢一郎
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都 京都国際会議場
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Presentation] MYC responsible for down-regulation of CD33 expression in myeloma cells2008

    • Author(s)
      Shamsasenjan K, Otsuvama K, Iqbal MS, Mahmoud MS, Kawano M.
    • Organizer
      The 50th Annual Meeting of American Society of Hematology
    • Place of Presentation
      San Francisco, CA, U.S.A. MOSCON CENTER
    • Data Source
      KAKENHI-PROJECT-20591129
  • [Presentation] 骨髄腫細胞のCD56発現は神経系遺伝子発現による2008

    • Author(s)
      Iqbal MS, Shamsasenjan K, Amin J, Islam A, 大津山賢一郎、河野道生
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都 京都国際会議場
    • Data Source
      KAKENHI-PROJECT-20591129
  • 1.  ISHIKAWA Hideaki (40294623)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 0 results
  • 2.  TSUYAMA Naohiro (10335747)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 3.  KURAMOTO Atsushi (50034070)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  OBATA Masanori (80158831)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  石田 禎夫 (20305220)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  TANABE Osamu (70221398)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  OOTSUYAMA Kenichirou (10432741)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 8.  FUJIMURA King (80034114)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  TANAKA Hideo (50243613)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  FUJII Ryuichi (30264401)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  MIZUKAMI Yoichi (80274158)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  田中 伸和 (50263744)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  白石 友紀 (10033268)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  松田 英幸 (50032595)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  平井 和光 (20093940)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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