HASEGAWA Hitoshi 長谷川均

Researcher Number	40164826
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2018 – 2019: 愛媛大学, 医学系研究科, 教授 2016 – 2017: 愛媛大学, 医学系研究科, 准教授 2015: 愛媛大学, 医学系研究科, 特任教授 2012 – 2015: 愛媛大学, 医学(系)研究科(研究院), 准教授 2007 – 2012: Ehime University, 大学院・医学系研究科, 准教授 … More 2006: Ehime University, Graduate School of Medicine, associate professor, 大学院医学系研究科, 助教授 2005: 愛媛大学, 医学部, 助教授 2002 – 2003: 愛媛大学, 医学部附属病院, 講師 1995 – 2000: 愛媛大学, 医学部・附属病院, 講師 Less
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 / 内科学一般 / Collagenous pathology/Allergology / Basic Section 54020:Connective tissue disease and allergy-related Except Principal Investigator Experimental pathology / Hematology
Keywords	Principal Investigator Chemokines / 制御性T細胞 / 寛容型樹状細胞 / regulatory T cells / lipids / Regulatory T cells / HTLV-I / Transmembrane 4 superfamily / bZIP / Transcription factor … More / CD4^+ T cells / Adult T-cell leukemia / CD151 / MRL / lpr mouse / 自己免疫疾患 / G-protein coupled receptors / chemokines / Th1 cells / Th2 cells / Foxp3 / Peroxisome proliferator-activated receptor / PPAR / 核内受容体リガンド / lysophosphatidylcholine / dendritic cells / protein kinase C / 制御性Ｔ細胞 / CD4^+T cells / Calreficulin / Calreticulin / CD4 T cells / Transmembrane 4 Superfamily / Leucine zipper / leucine zipper / Annexin / Calrefiwlin / tyrosine kinase / Adult T-cell leu kemia / Adult T cell leukemia / HTLV-1 / tyrosine Kinase / Tyrosine kinase / chemokine / chemokine antagonist / collagen diseases / 1pr mouse / Chemokine antagonists / Collagen diseases / ケモカイン / 移植片対宿主病 / 抑制性T細胞 / Graft-versus-host disease … More Except Principal Investigator 炎症 / オステオポンチン / 立体構造 / 競合的阻害 / 膠原病治療モデル / 疾患モデル動物 / 糖脂質 / がん免疫療法 / T細胞レセプター遺伝子 / ケモカイン・ケモカインレセプター / WT1 / Aurora-A kinase / 白血病 / 肺がん / WTI / 遺伝子治療 / 細胞傷害性T細胞 / T細胞レセプター / ケモカイン / ヒト化マウス / がん免疫 / レトロウイルスベクター / 膠原病脂環モデルマウス / 組換え近交系 / 蛋白アナログ / 病理学 / 膠原病モデルマウス / 膠原病疾患モデルマウス Less

寛容型樹状細胞を用いた自己免疫疾患治療の実用化に向けた研究Principal Investigator
- Principal Investigator
  
  長谷川均
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Ehime University
Research for establishment of antigen-specific immunosuppressive therapy in autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  Hasegawa Hitoshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Ehime University
Development of therapeutic strategy by using recombinant-inbred model mouse strains of collagen disease
- Principal Investigator
  
  Miyazaki Tatsuhiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Gifu University
Establishment of the method for efficient induction of human regulatory T cells and tolerogenic dendritic cells and application to therapyPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Hitoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Ehime University
Development of a glomerulonephritis therapeutic modelwith novel protein analogs targeting the polymorphic binding site of osteopontin (Opn)
- Principal Investigator
  
  MIYAZAKI Tatsuhiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Ehime University
Development of cancer immunotherapy using co-transfer of cancer-specific TCR gene and chemokine receptor gene
- Principal Investigator
  
  YASUKAWA Masaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Ehime University
Analysis of the bioactive molecules that enhance the induction and suppressive properties of human regulatory T cells and application to therapyPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Hitoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Ehime University
Development of a therapeutic model for collagen diseases targeting amino acid polymorphism of osteopontin
- Principal Investigator
  
  MIYAZAKI Tatsuhiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Ehime University
Elucidation of the immunoregulation through GPCR expressing in immunocompetent cells and therapy for the autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Hitoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Ehime University
Expression of chemokines and their receptors in GVHD target organs and therapeutic targetPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Hitoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Ehime University
Therapy for collagen diseases by using chemokine antagonistsPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Hitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Ehime University
Genes that influence the development of adult T-cell leukemiaPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Hitoshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Ehime University
Cellular genes induced by HTLV-1 in CD4+ T cellsPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Hitoshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Ehime University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] Mechanisms of tolerance induction by dendritic cells in vivo.2018
- Author(s)
  Hasegawa H, Matsumoto T
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 350-350
- DOI
  10.3389/fimmu.2018.00350
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09551, KAKENHI-PROJECT-17K16208
[Journal Article] Cキナーゼ阻害剤で誘導されたヒト免疫寛容樹状細胞による自己免疫疾患への展開2017
- Author(s)
  松本卓也，長谷川均
- Journal Title
  
  アレルギーの臨床
  
  Volume: 37 Pages: 49-54
- Data Source
  KAKENHI-PROJECT-15K09551
[Journal Article] Human tolerogenic dendritic cells generated with protein kinase C inhibitor are optimal for functional regulatory T cell induction2016
- Author(s)
  Adnan E, Yasukawa M, et al.
- Journal Title
  
  Clin Immunol.
  
  Volume: 173 Pages: 96-108
- DOI
  10.1016/j.clim.2016.09.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04858, KAKENHI-PROJECT-26860752, KAKENHI-PROJECT-15K09551
[Journal Article] Novel Autoantigens Associated with Lupus Nephritis.2015
- Author(s)
  Onishi S, Adnan E, Ishizaki J, Miyazaki T, Tanaka Y, Matsumoto T, Suemori K, Shudou M, Okura T, Takeda H, Sawasaki T, Yasukawa M, Hasegawa H.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 6 Pages: e0126564-e0126564
- DOI
  10.1371/journal.pone.0126564
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460496, KAKENHI-PROJECT-26670467
[Journal Article] 免疫トレランス誘導性樹状細胞の誘導による自己免疫疾患の治療2014
- Author(s)
  長谷川均、末盛浩一郎
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 62 Pages: 469-474
- Data Source
  KAKENHI-PROJECT-24591464
[Journal Article] 樹状細胞のトレランス誘導機能とprotein kinase C2014
- Author(s)
  長谷川均、松本卓也、安川正貴
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 61 Pages: 141-150
- Data Source
  KAKENHI-PROJECT-24591464
[Journal Article] Protein kinase C inhibitor generates stable human tolerogenic dendritic cells.2013
- Author(s)
  Matsumoto T, Yasukawa M, et al.
- Journal Title
  
  J Immunol.
  
  Volume: 191 Issue: 5 Pages: 2247-2257
- DOI
  10.4049/jimmunol.1203053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390245, KAKENHI-PROJECT-24591464
[Journal Article] 生理活性物質によるヒト制御性T細胞および免疫寛容樹状細胞の誘導2013
- Author(s)
  長谷川均
- Journal Title
  
  愛媛医学
  
  Volume: 32 Pages: 91-96
- Data Source
  KAKENHI-PROJECT-24591464
[Journal Article] 免疫トレランスを誘導する樹状細胞を発現させる生理活性物質2013
- Author(s)
  松本卓也、長谷川均、安川正貴
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 59 Pages: 483-490
- NAID
  40019682479
- Data Source
  KAKENHI-PROJECT-24591464
[Journal Article] Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-β production2011
- Author(s)
  Hasegawa H, et al
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 415 Issue: 3 Pages: 526-531
- DOI
  10.1016/j.bbrc.2011.10.119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591282, KAKENHI-PROJECT-23659489
[Journal Article] Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-βproduction2011
- Author(s)
  Hasegawa, H. Yasukawa, M., 他4名
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 415 Pages: 526-531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390294
[Journal Article] Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-βproduction. Biochem2011
- Author(s)
  Hasegawa H, Lei J, Matsumoto T, Onishi S, Suemori K, Yasukawa M
- Journal Title
  
  Biophys. Res. Commun
  
  Volume: 415 Pages: 526-531
- Data Source
  KAKENHI-PROJECT-21591282
[Journal Article] Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-ss production2011
- Author(s)
  Hasegawa H, Yasukawa M, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 415 Pages: 526-531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390294
[Journal Article] Peroxisome proliferator-activated receptor alpha and gamma agonists together with TGF-beta convert human CD4+ CD25-T cells into functional Foxp3+ regulatory T cells2010
- Author(s)
  Lei J., Hasegawa H, Matsumoto T, Yasukawa M
- Journal Title
  
  J. Immunol
  
  Volume: 185 Pages: 7186-7198
- Data Source
  KAKENHI-PROJECT-21591282
[Journal Article] Fractalkine expression and CD16+ monocyte accumulation in glomerular lesions : association with their severity and diversity in lupus models2010
- Author(s)
  Nakatani K, Yoshimoto S, Iwano M, Asai O, Samejima K, Sakan H, Terada M, Hasegawa H, Nose M, Saito Y
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 299
- Data Source
  KAKENHI-PROJECT-21591282
[Journal Article] Peroxisome proliferator-activated receptor alpha and gamma agonists together with TGF-betaconvert human CD4+CD25- T cells into functional Foxp3+ regulatory T cells2010
- Author(s)
  Lei J, Hasegawa H, et al.
- Journal Title
  
  Journal of Immunology
  
  Volume: 185 Pages: 7186-7198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591282
[Journal Article] Human herpesvirus 6 infection impairs Toll-like receptor signaling2010
- Author(s)
  Murakami Y, Tanimoto K, Fujiwara H, An J, Suemori K, Ochi T, Hasegawa H, Yasukawa M
- Journal Title
  
  Virol. J
  
  Volume: 10
- Data Source
  KAKENHI-PROJECT-21591282
[Journal Article] Peroxisome proliferator^-activated receptorαandγagonists together with TGF-βconvert human CD4^+ CD25^-T cells into functional Foxp3^+ regulatory T cells2010
- Author(s)
  Lei, J., Hasegawa, H., Yasukawa, M., 他2名
- Journal Title
  
  J. Immunol
  
  Volume: 185 Pages: 7186-7198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390294
[Journal Article] Fractalkine expression and CD16+ monocyte accumulation in glomerular lesions : Association with their severity and diversity in lupus models2010
- Author(s)
  Nakatani K, Hasegawa H, et al.
- Journal Title
  
  Am.J.Physiol.Renal.Physiol.
  
  Volume: 299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591282
[Journal Article] Human herpesvirus 6 infection impairs Toll-like receptor signaling2010
- Author(s)
  Murakami Y, Hasegawa H, et al.
- Journal Title
  
  Virol.J.
  
  Volume: 7 Pages: 91-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591282
[Journal Article] Chemokine blockade for lupus model mice.2008
- Author(s)
  Hasegawa, H.
- Journal Title
  
  Front Biosci. 99
  
  Pages: 2900-2908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590394
[Journal Article] Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model2008
- Author(s)
  Hasegawa H, Inoue A, Kohno M, Lei J, Miyazaki T, Yoshie O, et.al.
- Journal Title
  
  Gene Ther 15(3)
  
  Pages: 171-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590394
[Journal Article] Chemokine blockade for lupus model mice2008
- Author(s)
  Hasegawa H
- Journal Title
  
  Front. Biosci 13
  
  Pages: 2900-2908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591168
[Journal Article] Chemokine blockade for lupus model mice.2008
- Author(s)
  Hasegawa H
- Journal Title
  
  Front. Biosci. 13
  
  Pages: 2900-2908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591168
[Journal Article] Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model.2008
- Author(s)
  Hasegawa, H, Inoue, A, Miyazaki, T., Yoshie, O., Nose, M., Yasukawa, M., et al.
- Journal Title
  
  Gene Therapy 15
  
  Pages: 171-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590394
[Journal Article] Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model.2008
- Author(s)
  Hasegawa H, et al.
- Journal Title
  
  Gene Therapy 15
  
  Pages: 171-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591168
[Journal Article] Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model2008
- Author(s)
  Hasegawa H, et. al.
- Journal Title
  
  Gene Therapy 15
  
  Pages: 171-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591168
[Journal Article] Chemokine blockade for lupus model mice2008
- Author(s)
  Hasegawa H
- Journal Title
  
  Front Biosci 99
  
  Pages: 2900-2908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590394
[Journal Article] Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model2008
- Author(s)
  Hasegawa H, Inoue A, Kohno M, Lei J, Miyazaki T, Yoshie O, Nose M, Yasukawa M
- Journal Title
  
  Gene Therapy 15
  
  Pages: 171-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591168
[Journal Article] Therapeutic effect of CXCR3-expressing regulatory T cells on liver,lung and intestinal damages in a murine acute GVHD model2007
- Author(s)
  Hasegawa.H., Inoue, A., Kohno, M., Lei, J., Miyazaki, T., Yoshie, O., Nose, M., Yasukawa, M.
- Journal Title
  
  Gene Therapy 15
  
  Pages: 171-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590394
[Journal Article] 急性GVHDマウスモデルにおける標的臓器でのケモカインの発現様式と病態との関連。2007
- Author(s)
  長谷川均他。
- Journal Title
  
  第29回日本造血細胞移植学会抄録
  
  Pages: 174-174
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591045
[Journal Article] ケモカインおよびそのレセプターを分子標的にした自己免疫疾患の治療2007
- Author(s)
  長谷川均
- Journal Title
  
  愛媛医学 26
  
  Pages: 1-7
- Data Source
  KAKENHI-PROJECT-17591045
[Journal Article] ケモカインおよびそのレセプクーを分子標的にした自己免疫疾患の治療2007
- Author(s)
  長谷川均
- Journal Title
  
  愛媛医学 26
  
  Pages: 1-7
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591045
[Journal Article] Expression of chemokines and their receptors in autoimmune diseases and therapeutic targets.2007
- Author(s)
  Hasegawa H.
- Journal Title
  
  Ehime Medical Journal 26
  
  Pages: 1-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591045
[Journal Article] Expression of chemokines in target organs of a murine acute GVHD model.2007
- Author(s)
  Hasegawa H et al.
- Journal Title
  
  Proceedings of the 29^<th> annual meeting of the Japan Society for Hematopoietic Cell Transplantation 174
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591045
[Journal Article] Antagonist of interferon-inducible protein 10/CXCL10 ameliorates the progression of autoimmune sialadenitis in MRL/lpr mice.2006
- Author(s)
  Hasegawa H et al.
- Journal Title
  
  Arthritis ＆ Rheumatism 54
  
  Pages: 1174-1183
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591045
[Journal Article] IK cytokine ameliorates the progression of lupus nephritis in MRL/lpr mice.2006
- Author(s)
  Muraoka M, Hasegawa H et al.
- Journal Title
  
  Arthritis ＆ Rheumatism 54
  
  Pages: 3591-3600
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591045
[Journal Article] Expression of chemokines in GVHD target organs and therapeutic target.2006
- Author(s)
  Hasegawa H et al.
- Journal Title
  
  Proceedings of the Japanese Society for Immunology 36
  
  Pages: 66-66
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591045
[Journal Article] Antagonist of interferon-inducible protein 10/CXCL10 ameliorates the progression of autoimmune sialadenitis in NML/lpr mice2006
- Author(s)
  Hasegawa H et al.
- Journal Title
  
  Arthritis & Rheumatism (In press)
- Data Source
  KAKENHI-PROJECT-17591045
[Journal Article] Expression of chemokines in GVHd target organs and therapeutic target.2006
- Author(s)
  Hasegawa H et al.
- Journal Title
  
  Proceedings of the Japanese Society for Immunology 36
  
  Pages: 66-66
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591045
[Journal Article] ケモカインアンタゴニストによるループス腎炎の抑制2005
- Author(s)
  長谷川均, 井上淳
- Journal Title
  
  臨床免疫 44
  
  Pages: 259-266
- Data Source
  KAKENHI-PROJECT-17591045
[Presentation] Cキナーゼ阻害剤で誘導されたヒト寛容型樹状細胞の特徴と自己免疫疾患からの誘導2018
- Author(s)
  長谷川均、松本卓也、石崎淳、末盛浩一郎
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K09551
[Presentation] Characterization of human tolerogenic dendritic cells generated with protein kinase C inhibitor and induction from patients with autoimmune diseases.2017
- Author(s)
  Hasegawa, H., Matsumoto, T., Adnan, E., Ishizaki, J., Suemori, K., Yasukawa, M.
- Organizer
  2017 ACR/ARHP Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09551
[Presentation] 各種誘導物質で誘導された免疫寛容樹状細胞の抑制機能の比較検討2015
- Author(s)
  長谷川均、Endy Adnan、松本卓也、石崎淳、大西佐知子、末盛浩一郎、安川正貴
- Organizer
  第43回日本臨床免疫学会総会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-15K09551
[Presentation] 自己抗体ループス腎炎の新たな自己抗原の同定と解析2015
- Author(s)
  大西佐知子, 石崎淳, 宮崎龍彦, 山崎仁志, 末盛浩一郎,　松本卓也, 安川正貴, 長谷川均
- Organizer
  日本リウマチ学会総会・学術集集会・国際リウマチシンポジウム
- Place of Presentation
  名古屋市
- Year and Date
  2015-04-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460496
[Presentation] 寛容型樹状細胞の誘導と臨床応用の可能性2014
- Author(s)
  長谷川均
- Organizer
  第42回日本臨床免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2014-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-24591464
[Presentation] Human tolerogenic dendritic cells generated with protein kinase C inhibitor are optimal dor regulatory T cell induction- A comparative study2014
- Author(s)
  Adnan E, Hasegawa H et al
- Organizer
  2014 Annual Scientific Meeting of the American College of Rheumatology
- Place of Presentation
  Boston, USA
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-24591464
[Presentation] Protein kinase C inhibitor generates human tolerogenic dendritic cells that induce Tr1 and Foxp3+ regulatory T cells2012
- Author(s)
  Matsumoto T, Hasegawa H, et al.
- Organizer
  76th Annual Scientific Meeting of the American College of Rheumatology
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-24591464
[Presentation] Analysis of the bioactive molecules that promote the induction of human tolerogenic dendritic cells and application to therapy for Behcet’s disease2012
- Author(s)
  Hasegawa H et al.
- Organizer
  15th International Conference on Behcet’s Disease
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-24591464
[Presentation] Analysis of the bioactive molecules that promote the induction of human tolerogenic dendritic cells and application to therapy for vasculitis2012
- Author(s)
  Hasegawa H, et al
- Organizer
  The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012
- Place of Presentation
  Tokyo
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] Antagonist of CXCL16 ameliorates the progression of vasculitis in arteritis-prone McH5/1pr mice2011
- Author(s)
  Hasegawa H, et al
- Organizer
  19th International Symposium on Molecular Cell Biology of Macrophages
- Place of Presentation
  Osaka
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] ヒト免疫寛容樹状細胞の誘導を促進させる生理活性物質の探索2011
- Author(s)
  松本卓也、長谷川均、金磊、大西佐知子、末盛浩一郎、安川正貴
- Organizer
  第55回日本リウマチ学会総会
- Place of Presentation
  神戸
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] Analysis of the bioactive molecules that promote the induction of human tolerogenic dendritic cells2011
- Author(s)
  Matsumoto T, Hasegawa H, Lei J, Onishi S, Suemori K, Yasukawa M
- Organizer
  75th Annual Scientific Meeting of the American College of Rheumatology
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-11-07
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] Lysophosphatidylcholine enhances suppressive function of human naturally occurring regulatory T cells through TGF-β production2011
- Author(s)
  Hasegawa H, et al
- Organizer
  75th Annual Scientific Meeting of the American College of Rheumatology
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] ヒト制御性T細胞の誘導におけるPPARアゴニストとTSAまたはATRAの併用による相乗効果2011
- Author(s)
  長谷川均、金磊、松本卓也、大西佐知子、末盛浩一郎、安川正貴
- Organizer
  第55回日本リウマチ学会総会
- Place of Presentation
  神戸
- Year and Date
  2011-07-19
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] Antagonist of CXCL16 ameliorates the progression of vasculitis in arteritis-prone McH5/lpr mice2011
- Author(s)
  Hasegawa H, Miyazaki T, Lei J, Matsumoto T, Nose M, Yasukawa M
- Organizer
  19th International Symposium on Molecular Cell Biology of Macrophages
- Place of Presentation
  Osaka, Japan
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] Lysophosphatidylcholine enhances suppressive function of human naturally occurring regulatory T cells through TGF-βproduction2011
- Author(s)
  Hasegawa H, Lei J, Matsumoto T, Onishi S, Suemori K, Yasukawa M
- Organizer
  75th Annual Scientific Meeting of the American College of Rheumatology
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] PPARalphaおよびgammaアゴニストによるヒト制御性T細胞への分化誘導機序2010
- Author(s)
  金嘉、長谷川均, 他
- Organizer
  第54回日本リウマチ学会総会
- Place of Presentation
  神戸
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] PPARαおよびγアゴニストによるヒト制御性T細胞への分化誘導機序2010
- Author(s)
  金磊, 長谷川均, 他
- Organizer
  第54回日本リウマチ学会総会
- Place of Presentation
  神戸ポートピアホテル(神戸)
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] PPARαおよびγアゴニストによるヒト制御性Τ細胞への分化誘導機序2010
- Author(s)
  金磊、長谷川均、松本卓也、河野政志、安川正貴
- Organizer
  第54回日本リウマチ学会総会
- Place of Presentation
  神戸
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] Peroxisome proliferator-activated receptor alpha and gamma agonists together with TGF-beta convert human CD4+CD25- T cells into functional Foxp3+ regulatory T cells2010
- Author(s)
  Hasegawa H, et al.
- Organizer
  74^<th> Annual Scientific Meeting of American College of Rheumatology
- Place of Presentation
  Atlanta, USA
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] CXCL16 antagonist ameliorates the progression of vasculitis in McH5/lpr mice2010
- Author(s)
  Hasegawa H, et al.
- Organizer
  74^<th> Annual Scientific Meeting of American College of Rheumatology
- Place of Presentation
  Atlanta, USA
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] Peroxisome proliferator-activated receptorαandγagonists together with TGF-βconvert human CD4+ CD25-T cells into functional Foxp3+ regulatory T cells2010
- Author(s)
  Hasegawa H, Lei J, Matsumoto T, Yasukawa M
- Organizer
  74^<th> Annual Scientific Meeting of American College of Rheumatology
- Place of Presentation
  Atlanta, USA
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] Peroxisome proliferator-activated receptor α and γ agonists enhance human regulatory T cell function and induction2009
- Author(s)
  長谷川均, et al.
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] ヒト制御性T細胞への分化誘導を促進する生理活性物質の解析2009
- Author(s)
  金磊、長谷川均、河野政志、井上淳、安川正貴
- Organizer
  第53回日本リウマチ学会総会
- Place of Presentation
  東京
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-19591168
[Presentation] Amelioration of lupus nephritis with dendritic cell using a NF-kappaB decoy and histone H3 peptide in NZB/W F1 mice2009
- Author(s)
  長谷川均, et al.
- Organizer
  The 75^<th> Annual Scientific Meeting of the American College of Rheumatolagy
- Place of Presentation
  Philadelphia, U.S.A.
- Year and Date
  2009-10-19
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] PPARαおよびPPARγアゴニストはヒト制御性T細胞への誘導や機能を増強する2009
- Author(s)
  長谷川均、金磊、河野政志、松本卓也、安川正貴
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21591282
[Presentation] 「血管炎研究の最前線」血管炎・腎炎とケモカイン : 治療への応用2008
- Author(s)
  長谷川均
- Organizer
  第54回日本病理学会秋期特別総会
- Place of Presentation
  松山
- Year and Date
  2008-11-20
- Data Source
  KAKENHI-PROJECT-19591168
[Presentation] ヒトCD4陽性Tリンパ球のFoxp3の発現を増強する脂質および核内受容体リガンドの解析2008
- Author(s)
  長谷川均、金磊、河野政志、井上淳、安川正貴
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19591168
[Presentation] ケモカインレセプター発現制御性T細胞を用いた自己免疫疾患およびGVHDの治療2008
- Author(s)
  長谷川均、井上淳、河野政志、能勢眞人、安川正貴
- Organizer
  第52回日本リウマチ学会総会
- Place of Presentation
  札幌
- Year and Date
  2008-04-21
- Data Source
  KAKENHI-PROJECT-19591168
[Presentation] GVHDモデルマウスの肝および腸管傷害に対するCXCR3強制発現制御性T細胞の抑制効果2007
- Author(s)
  井上淳、長谷川均、河野政志、金磊、宮崎龍彦、能勢眞人、安川正貴
- Organizer
  第37回日本免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19591168
[Presentation] Therapeutic effect of CXCR3-expressing regulatory T cells on liver and intestinal damages in a murine acute GVHD model.2007
- Author(s)
  Yamanouchi J, Hasegawa H, Inoue A, Kohno M, Fujiwara H, Hato T, Yasukawa M
- Organizer
  49^<th> American Society of Hematology
- Place of Presentation
  Atlanta, Georgia, USA.
- Year and Date
  2007-12-09
- Data Source
  KAKENHI-PROJECT-19591168
[Presentation] GVHDモデルマウスの肝および腸管傷害に対するCXCR3強制発現制御性T細胞の抑制効果2007
- Author(s)
  井上淳、長谷川均, 他
- Organizer
  日本免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19591168
[Presentation] MRL/lprマウスの臓器傷害に対するCCR2強制発現制御性T細胞の抑制効果2007
- Author(s)
  長谷川均、河野政志、井上淳、金磊、宮崎龍彦、能勢眞人、安川正貴
- Organizer
  第37回日本免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19591168
[Presentation] ループス腎炎小麦胚芽無細胞タンパク質合成技術を利用したループス腎炎の新たな自己抗原の検討
- Author(s)
  大西佐知子, 石崎淳, 松本卓也, 山崎仁志, 末盛浩一郎, 佐田榮司, 安川正貴, 長谷川均, 宮崎龍彦.
- Organizer
  第５８回日本リウマチ学会総会・学術集会・国際リウマチシンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25460496
[Presentation] Cキナーゼ阻害剤を用いた安定性のある免疫寛容樹状細胞の作製と臨床応用
- Author(s)
  松本卓也、長谷川均他。
- Organizer
  第５７回日本リウマチ学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591464
[Presentation] 生理活性物質による安定性のあるヒト制御性T細胞および寛容型樹状細胞の誘導と臨床応用
- Author(s)
  長谷川均
- Organizer
  第４１回日本臨床免疫学会総会
- Place of Presentation
  下関
- Invited
- Data Source
  KAKENHI-PROJECT-24591464

1. NOSE Masato (70030913)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
2. MIYAZAKI Tatsuhiko (80239384)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. INOUE Atsushi (20403826)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. FUJINO Takahiro (40292312)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YASUKAWA Masaki (60127917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. FUJIWARA Hiroshi (20398291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KURATA Mie (80423440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUEMORI Koichiro (80571083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. MASUMOTO Junya (20334914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 河野政志 (00396251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TANAKA Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HASEGAWA Hitoshi 長谷川 均

Research Projects

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寛容型樹状細胞を用いた自己免疫疾患治療の実用化に向けた研究Principal Investigator

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Research for establishment of antigen-specific immunosuppressive therapy in autoimmune diseasesPrincipal Investigator

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Development of therapeutic strategy by using recombinant-inbred model mouse strains of collagen disease

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Establishment of the method for efficient induction of human regulatory T cells and tolerogenic dendritic cells and application to therapyPrincipal Investigator

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Development of a glomerulonephritis therapeutic modelwith novel protein analogs targeting the polymorphic binding site of osteopontin (Opn)

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Development of cancer immunotherapy using co-transfer of cancer-specific TCR gene and chemokine receptor gene

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Analysis of the bioactive molecules that enhance the induction and suppressive properties of human regulatory T cells and application to therapyPrincipal Investigator

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Development of a therapeutic model for collagen diseases targeting amino acid polymorphism of osteopontin

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Elucidation of the immunoregulation through GPCR expressing in immunocompetent cells and therapy for the autoimmune diseasesPrincipal Investigator

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Expression of chemokines and their receptors in GVHD target organs and therapeutic targetPrincipal Investigator

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Therapy for collagen diseases by using chemokine antagonistsPrincipal Investigator

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Genes that influence the development of adult T-cell leukemiaPrincipal Investigator

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Cellular genes induced by HTLV-1 in CD4+ T cellsPrincipal Investigator

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HASEGAWA Hitoshi 長谷川均