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KIHARA Fumiko  根岸 文子

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… Alternative Names

根岸 文子  ネギシ フミコ

NEGISHI Fu  木原 文子

木原 文子  キハラ フミコ

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Researcher Number 40177902
Other IDs
Affiliation (Current) 2025: 帝京大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2023: 帝京大学, 薬学部, 准教授
2006: Department of Pharmacology, Teikyo University, Lecturer, 薬学部・臨床薬学, 講師
2005: Hirosaki University, Department of Cell Genetics, Sasaki Institute, Research Fellow, 細胞遺伝部, 研究員
2004 – 2005: Sasaki institute, Cell Genrtics, Researcher, 細胞遺伝部, 主任研究員
2004: 財団法人 佐々木研究所, 細胞遺伝部, 主任研究員 … More
2004: 財団法人 佐々木研究所, 細胞遺伝部, 研究員
2002 – 2003: 財団法人佐々木研究所, 細胞遺伝部, 研究員
2000 – 2001: (財)佐々木研究所, 細胞遺伝部, 研究員
1999: 財団法人 佐々木研究所, 細胞遺伝部, 研究員
1999: Department of Cell Genetics, Sasaki Institute, Research Associate, 細胞遺伝部, 研究員
1998: 佐々木研究所, 細胞遺伝部, 研究員
1996 – 1997: (財)佐々木研究所, 細胞遺伝部, 研究員
1996: (財), 佐々木研究所, 研究員
1995: 財団法人佐々木研究所, 細胞遺伝部, 研究員
1989: 東京大学, 医科学研究所, 教務職員 Less
Review Section/Research Field
Principal Investigator
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Hematology / Experimental pathology / Developmental biology
Except Principal Investigator
Hematology / Hematology / Experimental pathology / Biological pharmacy
Keywords
Principal Investigator
PU.1 / 分化 / 脂肪分解制御 / ぺリリピン1 / NEU1シアリダーゼ / 脂肪分解 / ZANA / シアリダーゼ阻害活性阻害剤 / 肝細胞の脂肪滴形成・退縮 / C9-BA-DANA … More / DANA / 3T3-L1脂肪細胞 / 炎症性アディポサイトカイン / 脂肪分解調節 / 3T3-L1白色脂肪細胞 / シアリダーゼ阻害剤 / シアリダーゼNEU1 / leukemia / hematonietic cell differentiation / acetylation / phosphorylation / 白血病 / 血液細胞分化 / アセチル化 / リン酸化 / 赤白血球 / 転写調節 / 赤白血病 / 転写因子 / 胚性腫瘍細胞 … More
Except Principal Investigator
PU.1 / アポトーシス / apoptosis / 分化 / 細胞増殖 / 細胞分化 / 転写因子 / 白血病 / Gfi-1 / Ets-1 / hematopoiesis / HoxC13 / Elf-1 / 血球分化 / PU.l / マウス赤白血病(MEL) / CBP / transcription factor / AMY-1 / C-MYC / MSSP / がん遺伝子 / Ets / cross-talk / GfilB / ETS / transcription factors / bax / 増殖 / 赤血球 / 骨髄球 / Gfi-1B / クロストーク / physical interaction / functional interaction / homeodomain proteins / Ets family transcription factors / 物理酌相互作用 / 物理的相互作用 / 機能的相互作用 / ホメオドメイン蛋白質 / Etsファミリー転写因子 / cell growth / murine erythroleukemia(MEL) / calcium-calmodulin-dependent kinase I-like kinase (CKLiK) / CKLiK / CKLiK gene / lineage switch / differentiation inhibition / murine erythroleukemia (MEL) / CKLiK遺伝子 / CKLiKi遺伝子 / 分化のスイッチ / 分化の抑制 / Differential Display / cell differentiation / erythroleukemia / Differential Display(DD)法 / 赤白血球 / Defferential Display法 / Diffrential Display法 / 赤白血病 / GATA-1 / oncogene / Ets family / differentiation / leukemia / 白血球 / HDAC / extinction / gene expression / hybrids / cell fusion / B細胞 / Etsファミリー / ネガティブ制御 / lck / TCR / T細胞 / 遺伝子発現 / 雑種細胞 / 細胞融合 / DNA BINDING PROTEINS / YEAST / CELL CYCLE / TRANSCRIPTION / REPLICATION / 核移行阻止 / DNAポリメラーゼα / DNAポリメラーゼ / DNA結合タンパク / 酵母 / 細胞周期 / 転写 / 複製 / Spi-1 / Etsがん遺伝子 / マウス / cDNAライブラリー / 核局在性 / エピトープタグ / Rb遺伝子 / アデノウイルス / SV40 Less
  • Research Projects

    (15 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (18 People)
  •  糖鎖分解酵素NEU1による脂肪分解抑制のメカニズムの解明Principal Investigator

    • Principal Investigator
      根岸 文子
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Teikyo University
  •  Cross-talks between ETS and GFI family of transcription factors in hematopoietic cell differentiation

    • Principal Investigator
      OIKAWA Tsuneyuki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Health Sciences University of Hokkaido
      Sasaki Institute
  •  Functional roles of interaction between Ets family transcription factors and homeodomain proteins.

    • Principal Investigator
      YAMADA Toshiyuki
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Hirosaki University
      Sasaki Institute
  •  The effects of phosphorylation and acetylation-mediated modification on functional activity of PU.12Principal Investigator

    • Principal Investigator
      NEGISHI Fumiko
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Sasaki institute
  •  Isolation and identification of the gene induced by Ets family transcription factor PU.1 in murine erythroleukemia cells

    • Principal Investigator
      YAMADA Toshiyuki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Sasaki Institute
  •  Analysis of mechanisms of the differentiation inhibition in erythroid cells induced by Ets transcription factor PU. I

    • Principal Investigator
      YAMADA Toshiyuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Sasaki Institute
  •  PU.1 過剰発現による赤白血病細胞の分化阻害とアポトーシス誘導の分子機構

    • Principal Investigator
      及川 恒之
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Sasaki Institute
  •  PU.1による赤白血病細胞文化の阻害の分子機構の解析Principal Investigator

    • Principal Investigator
      根岸 文子
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Sasaki Institute
  •  Molecular Mechanisms of Inhibition of Erythroid Differentiation by Overexpression of Ets Family Oncogenes in MEL cells

    • Principal Investigator
      OIKAWA Tsuneyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Sasaki Institute
  •  Isolation of the genes involved in the process of differentiation inhibition and apoptosis induced by PU.1 in murine erythroleukemia cells

    • Principal Investigator
      YAMADA Toshiyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Sasaki Institute
  •  赤血球系細胞の増殖・分化・アポトーシスに関わるetsファミリーがん遺伝子

    • Principal Investigator
      OIKAWA Tsuneyuki
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Sasaki Institute
  •  Extinction of hematopoietic specific transcription factor genes in cell hybrids between hematopoietic and non-hematopoietic cells

    • Principal Investigator
      OIKAWA Tsuneyuki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Sasaki Institute
  •  未分化胚性腫瘍細胞特異的転写調節因子の解析Principal Investigator

    • Principal Investigator
      根岸 文子
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Developmental biology
    • Research Institution
      Sasaki Institute
  •  MOLECULAR MECHANISMS OF THE CELL CYCLE REGULATION BY REPLICATION/TRANSCRIPTION FACTORS,MSSP

    • Principal Investigator
      ARIGA Sanae
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  SV40T抗原による細胞遺伝子発現の変化

    • Principal Investigator
      菅野 純夫
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo

All 2023 2022 2007 2006 2005 Other

All Journal Article Presentation

  • [Journal Article] A Complex of Type I Platelet-Activating Factor Acetylhydrolase (PAF-AH) Catalytic Subunits Switches from α1/α2 Heterodimer to α2/α2 Homodimer during Adipocyte Differentiation of 3T3-L1 Cells2023

    • Author(s)
      Nakamura Y, Kihara-Negishi F, karasawa K.et al.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 46 Issue: 2 Pages: 257-262

    • DOI

      10.1248/bpb.b22-00666

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2023-02-01
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06550
  • [Journal Article] Nobiletin and 3′-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation2022

    • Author(s)
      Kihara-Negishi F, Ohkura N, Takahashi Y, Fujita T, Nakamura Y, Maruyama K, Oshitari T, Yamaguchi S.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 45 Issue: 4 Pages: 528-533

    • DOI

      10.1248/bpb.b21-00988

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2022-04-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K02339, KAKENHI-PROJECT-21K06550, KAKENHI-PROJECT-21K06535
  • [Journal Article] Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes.2022

    • Author(s)
      Fujita T, Kihara-Negishi F, Yamaguchi S. et al.
    • Journal Title

      Front Physiol.

      Volume: 8:13 Pages: 1030621-1030621

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06550
  • [Journal Article] Thyroid stimulating hormone suppressesth expression and activity of cytosolic sulfotransferase 1a1 in thyrocytes.2022

    • Author(s)
      Nakamura Y, Kihara-Negishi F, Suzuki K.et al.
    • Journal Title

      Endocr J .

      Volume: 69(10) Pages: 1261-1269

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06550
  • [Journal Article] Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression2007

    • Author(s)
      Nakazawa Y, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncogene 26(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Negative cross-talk between hematopoietic transcription factors PU.1 and Gfi-1B2007

    • Author(s)
      Manabe N, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncogene (subumitted)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Cooperative interaction between ETSl and GFI1 transcription factors in the repression of Bax gene expression2007

    • Author(s)
      Nakazawa Y, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncogene 26

      Pages: 3541-3550

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Site-specific DNA methylation by a complex of PU.l and Dnmt3a/b2006

    • Author(s)
      Suzuki M, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncogene 25

      Pages: 2477-2488

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b2006

    • Author(s)
      Suzuki M, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncogene 25

      Pages: 2477-2488

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Ets family of transcription factors in normal hematopoiesis and in leukemogenesis2005

    • Author(s)
      Oikawa T, Kihara-Negishi F. et al.
    • Journal Title

      Molecular Genetics of Cancer Book

      Pages: 119-148

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Classification of neural differentiation-associated genes in P19 embryonal carcinoma cells by their expression patterns induced after cell aggregation and/or retinoic acid treatment.2005

    • Author(s)
      Teramoto S, Kihara-Negishi F, Sakurai T, Yamada T, Oikawa Y.
    • Journal Title

      Oncol.Rep. 14

      Pages: 1231-1238

    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Impaired repressor activity and biological functions of PU.1 in MEL cells induced by mutations in the acetylation motif2005

    • Author(s)
      Kihara=NeEgishi F, Oikawa T. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 335

      Pages: 477-484

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Impaired repressor activity and biological functions of PU. 1 in MEL cells induced by mutations in the acetylation motif2005

    • Author(s)
      Kihara=Negishi F, Oikawa T. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 335

      Pages: 477-484

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Impaired represser activity and biological functions of PU.1 in MEL cells induced by mutations in the acetylation motifs within the ETS domain.2005

    • Author(s)
      Kihara-Negishi F
    • Journal Title

      Biochem.Biophys.Res.Commun. 335

      Pages: 477-484

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590967
  • [Journal Article] Ets family of transcription factros in normal hematopoiesis and in leukemogenesis.2005

    • Author(s)
      Oikawa T, Yamada T, Kihara-Negishi F, Sakurai T.
    • Journal Title

      Molecular Genetics of Cancer Research Signpost

      Pages: 119-148

    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Impaired repressor activity and biological functions of PU.1 in MEL cells induced by mutations in the acetylation motifs within the ETS domain.2005

    • Author(s)
      Kihara-Negishi F
    • Journal Title

      Biochem.Biophys.Res.Commun. 335

      Pages: 477-484

    • Data Source
      KAKENHI-PROJECT-16590967
  • [Journal Article] Impaired repressor activity and biological functions of PU.1 in MEL cells induced by mutations in the acethylation motifs within the ETS domain.2005

    • Author(s)
      Kihara-Negishi F, Suzuki M, Yamada T, Sakurai T, Oikawa T.
    • Journal Title

      Biochem.Biophys.Res.Com. 335

      Pages: 477-484

    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Classification of neural differentiation-associated genes in P19 embryonic carcinoma cells2005

    • Author(s)
      Teramoto S, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncol. Rep. 14

      Pages: 1231-1238

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b.2005

    • Author(s)
      Suzuki M, Yamada T, Kihara-Negishi F, Tenen DG, Hozumi N, Oikawa T.
    • Journal Title

      Oncogene

    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Ets family of transcription factors in normal hematopoiesis and in leukemogenesis (Review)2005

    • Author(s)
      Oikawa T, Kihara-Negishi F. et al.
    • Journal Title

      In "Molecular Genetics of Cancer".(ed by Sinnet D.)( Research Signpost, India)

      Pages: 119-148

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Impaired repressor activity and biological functions of PU.l in MEL cells induced by mutations in the acetylation motifs within the ETS domain.2005

    • Author(s)
      Kihara-Negishi F
    • Journal Title

      Biochem. Biophys. Res. Commun. 335

      Pages: 477-484

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590967
  • [Journal Article] Negative cross-talk between hematopoietic transcription factors PU.1 and GFi-lB

    • Author(s)
      Manabe N, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncogene, submitted

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Presentation] 甲状腺細胞においてTSHは硫酸転移酵素SULT1A1の発現を制御する2023

    • Author(s)
      中村康宏、吉原彩、桐谷光夫、川島晃、谷川和也、藤原葉子、丸山桂司、渡辺茂和、根岸文子、鈴木幸一
    • Organizer
      第6回帝京大学研究交流シンポジウム
    • Data Source
      KAKENHI-PROJECT-21K06550
  • [Presentation] ノビレチンによるマウス褐色脂肪細胞の熱産生およびブラウンアディポカイン分泌促進の機構解析2022

    • Author(s)
      根岸文子、大藏直樹、中村康宏,丸山桂司,高橋由佳、忍足鉄太
    • Organizer
      第95回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-21K06550
  • 1.  YAMADA Toshiyuki (20183981)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 2.  YAMAMOTO Hitomi (30290977)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  OIKAWA Tsuneyuki (80150241)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 15 results
  • 4.  ARIGA Sanae (90184283)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  KITAURA Hirotake (10281817)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  ARIGA Hiroyoshi (20143505)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KONDOH Nobuo (40202072)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  OHTA Toru (10223835)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  菅野 純夫 (60162848)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  余郷 嘉明 (60092376)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  山口 宣生 (90012723)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  鈴木 光浩 (00321662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  大藏 直樹 (60349256)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 14.  GALLI Ivo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  WANG Teresa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  WANG Teresa S.-F.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  IVO Galli
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  TERESA S.ーF.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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