NOMA Takafumi 野間隆文

… Alternative Names

Researcher Number	40189428
Other IDs
Affiliation (Current)	2019: 徳島大学, 大学院医歯薬学研究部(歯学域), 教授
Affiliation (based on the past Project Information) *help	2019: 徳島大学, 大学院医歯薬学研究部(歯学域), 教授 2016 – 2017: 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 2015: 徳島大学, 大学院医歯薬学研究部, 教授 2014: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 2011 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 教授 … More
Review Section/Research Field	Principal Investigator Functional basic dentistry / General medical chemistry / Pathobiological dentistry/Dental radiology / Basic Section 57020:Oral pathobiological science-related Except Principal Investigator Functional basic dentistry / General medical chemistry / Conservative dentistry / Basic Section 57010:Oral biological science-related
Keywords	Principal Investigator ミトコンドリア / アデニル酸キナーゼ / アイソザイム / FRET / ATP / Sp6 / 歯原性上皮細胞 / 鉄代謝 / テトラサイクリン遺伝子誘導系 / 細胞内輸送 … More Except Principal Investigator ゴーシェ病 / 口腔粘膜線維芽細胞 / cDNA / C230 / 再生医学 / 幹細胞 / クローン / 分化 / 細胞外基質 / 遺伝学 / 疾患特異的iPS細胞 / 口腔粘膜線維芽細胞の特性 / 疾患特異的口腔粘膜由来iPS細胞 / Bリンパ球 / VDJ組換 / 骨髄多分化能細胞 / ストロ-マ細胞 / リコンビナ-ゼ / ショウジョウバエ / SーS組換え / 環状DNA / 抗体遺伝子再構成 / DNA結合タンパク質 / cDNAクローニング / integrase family / transgenic mouse / double isotype expression / trans splicing / ヒト抗体V_H鎖遺伝子 / 骨髄細胞からのリンパ球への分化 / クラススイッチ / IgM^+IgG^+B細胞 / IL-2 / IL-2R / トランスジュニックマウス / NK細胞 / 抗体遺伝子D断片 / Bリンパ球の分化 / IL-4 / IL-2リセプター / トランスジェーニックマウス / 染色体マップ / IL-4遺伝子 / IL-5遺伝子 / 免疫グロブリン遺伝子 / リンフォカイン遺伝子 / 人工突然変異 / インターロイキン2の受容体 / インターロイキン5 / エンハンサー / ナトリウムチャネル / テトロドトキシン / トラフグ / ナトリウムチヤネル / フグ / Sodium channel / Tetrodotoxin / Puffer fish / プロモーター / ベクター / 培養細胞 / カテコール / ベペクター / プロモ-タ- / ベクタ- / カテュ-ル / Promoter / Vector / Cultured cells / Catechol / exome解析 / モディファイヤー検索 / intact cell GCase assay / エクソーム解析 / データマイニング / GCase活性調節タンパク質 / SiRNA スクリーニング / in cell 酵素活性解析 / GCase結合タンパク質 / SiRNA / ハイスループット酵素活性測定系 / 細胞内局在 / GBA / RNAエピジェネティクス / 翻訳制御機構 / モディファイヤー Less

ゴーシェ病の治療標的探索：RNAエピジェネティクスによるGBA翻訳制御機構の解明Ongoing
- Principal Investigator
  
  三好圭子
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  The University of Tokushima
好中球分化におけるシグナル標的の同定Principal InvestigatorOngoing
- Principal Investigator
  
  野間隆文
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  The University of Tokushima
Study on elucidation of the pathophysiology of rare intractable diseases (reticular dysgenesis) with severe combined immunodeficiency and development of therapeutic methodsPrincipal Investigator
- Principal Investigator
  
  NOMA Takafumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  The University of Tokushima
Characterization of Gaucher disease by new gene mutation using patient-derived oral mucosa fibroblasts
- Principal Investigator
  
  MIYOSHI Keiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
Establishment of disease model system using patient-derived oral mucosa fibroblast-iPSCs and development of new therapy
- Principal Investigator
  
  MIYOSHI Keiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
Elucidation of the pathological mechanism on abnormal iron metabolism using a rat modelPrincipal Investigator
- Principal Investigator
  
  NOMA Takafumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
歯原性上皮細胞および歯髄細胞を用いた歯質再建のための細胞療法の開発
- Principal Investigator
  
  松尾敬志
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Development of sensors for monitoring intracellular ATP and GTP.Principal Investigator
- Principal Investigator
  
  NOMA Takafumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
ANALYSIS OF TISSUE-SPECIFIC AND DEVELOPMENTALLY REGULATD EXPRESSION OF THE GENE ENCODING ADENYLATEKINASEISOZYMESPrincipal Investigator
- Principal Investigator
  
  NOMA Takafumi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  YAMAGUCHI UNIVERSITY
Construction of promoter-detection plasmid in animal cells by using the metapyrocatechase gene
- Principal Investigator
  
  NAKAZAWA Atsushi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Yamaguchi University
Structure and function of the tetrodotoxin-resistant sodium channel
- Principal Investigator
  
  NAKAZAWA Atsushi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Yamaguchi University
免疫系における多様性発現機構の分子遺伝学的研究
- Principal Investigator
  
  本庶佑
- Project Period (FY)
  1986 – 1990
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Kyoto University

All 2018 2017 2016 2015 2014 2013 2012 2011 2005 Other

All Journal Article Presentation

[Journal Article] Human AK2 links intracellular bioenergetics redistribution to the fate of hematopoietic progenitors.2018
- Author(s)
  Oshima Koichi、Watanabe Akira、Nakahata Tatsutoshi、Saito Megumu K. et al.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 497 Pages: 719-719
- DOI
  10.1016/j.bbrc.2018.02.139
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0108, KAKENHI-PROJECT-17K12900, KAKENHI-PROJECT-16H05194, KAKENHI-PROJECT-15H05581, KAKENHI-PROJECT-15J06514, KAKENHI-PROJECT-15K06921, KAKENHI-PROJECT-15K09640, KAKENHI-PROJECT-15K11072, KAKENHI-PROJECT-16K14709
[Journal Article] Gene signature of human oral mucosa fibroblasts: comparison with dermal fibroblasts and induced pluripotent stem cells.2015
- Author(s)
  Miyoshi K, Horiguchi T, Tanimura A, Hagita H, Noma T.
- Journal Title
  
  BioMed Res Int.
  
  Volume: 印刷中
- Acknowledgement Compliant / Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592801
[Journal Article] Gene signature of human oral mucosa fibroblasts: comparison with dermal fibroblasts and induced pluripotent stem cells.2015
- Author(s)
  Miyoshi K, Horiguchi T, Tanimura A, Hagita H, Noma T.
- Journal Title
  
  Biomed Res Int.
  
  Volume: 2015 Pages: 1-19
- DOI
  10.1155/2015/121575
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K11041
[Journal Article] Ctip2-mediated Sp6 transcriptional regulation in dental epithelium-derived cells2014
- Author(s)
  Adiningrat A, Tanimura A, Miyoshi K, Yanuaryska RD, Hagita H, Horiguchi T, and Noma T
- Journal Title
  
  J Med Invest
  
  Volume: 61 Pages: 126-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592735
[Journal Article] Sp6 regulation of Rock1 promoter activity in dental epithelial cells2014
- Author(s)
  Ryna Dwi Yanuaryska, Keiko Miyoshi, Arya Adiningrat, Taigo Horiguchi, Ayako Tanimura, Hiroko Hagita and Takafumi Noma
- Journal Title
  
  The Journal of Medical Investigation
  
  Volume: ―
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592735
[Journal Article] Ctip2-mediated Sp6 transcriptional regulation in dental epithelium-derived cells2014
- Author(s)
  Arya Adiningrat, Ayako Tanimura, Keiko Miyoshi, Ryna Dwi Yanuaryska, Hiroko Hagita, Taigo Horiguchi, and Takafumi Noma
- Journal Title
  
  The Journal of Medical Investigation
  
  Volume: 61 Pages: 126-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592735
[Journal Article] Sp6 regulation of Rock1 promoter activity in dental epithelial cells2014
- Author(s)
  Yanuaryska RD, Miyoshi K, Adiningrat A, Horiguchi T, Tanimura A, Hagita H, and Noma T.
- Journal Title
  
  J Med Invest
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592735
[Journal Article] Novel genetic linkage of rat Sp6 mutation to Amelogenesis imperfect2012
- Author(s)
  Muto T, Miyoshi K et al
- Journal Title
  
  Orphanet Journal of Rare Diseases
  
  Volume: Jun 7 Pages: 1-11
- DOI
  10.1186/1750-1172-7-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592735
[Journal Article] iPS細胞を用いた臨床応用の基礎と課題2012
- Author(s)
  野間隆文
- Journal Title
  
  四国歯学会雑誌
  
  Volume: 24 Pages: 59-68
- Data Source
  KAKENHI-PROJECT-23592735
[Journal Article] Dynamics of nucleotide metabolism as a supporter of life phenomena.2005
- Author(s)
  Noma, T.
- Journal Title
  
  The Journal of Medical Investigation 52
  
  Pages: 127-136
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591858
[Presentation] GBA 遺伝子5´側バリアントの発現パターン解析2017
- Author(s)
  三好圭子, 萩田浩子, 谷村綾子, 堀口大吾, 野間隆文
- Organizer
  2017 年度生命科学系学会合同年次大会ConBio 2017 （神戸、兵庫）
- Data Source
  KAKENHI-PROJECT-15K11041
[Presentation] CRISPR/Cas9を用いたAK2の段階的欠損による細胞代謝への影響2017
- Author(s)
  谷村綾子、三好圭子、堀口大吾、藤沢浩一、野間隆文
- Organizer
  第２回日本ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-15K11072
[Presentation] ミトコンドリアがUPR活性をコントロールして免疫細胞分化の方向を決定づける2017
- Author(s)
  谷村綾子、三好圭子、堀口大吾、萩田浩子、藤沢浩一、野間隆文
- Organizer
  第17回日本ミトコンドリア学会
- Data Source
  KAKENHI-PROJECT-15K11072
[Presentation] From Molecular Structure and Mechanisms to Cellular Bioenergetics in Health and Disease2017
- Author(s)
  Tanimura A, Miyoshi K, Horiguchi T, Hagita H, Fujisawa K, Noma T
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11072
[Presentation] Potential and application of oral mucosa in regenerative medicine2016
- Author(s)
  野間　隆文
- Organizer
  NATIONAL COLLOQUIUM ON STEM CELL RESEARCH 2016
- Place of Presentation
  コタバル市、マレーシア
- Year and Date
  2016-03-07
- Data Source
  KAKENHI-PROJECT-15K11072
[Presentation] 転写因子SP6の構造と機能解析2013
- Author(s)
  三好圭子, Yanuaryska Dwi Ryna, Adiningrat Arya, 萩田浩子, 谷村綾子, 堀口大吾, 野間隆文
- Organizer
  第54回日本生化学会中国・四国支部例会
- Place of Presentation
  徳島大学大塚講堂（徳島県徳島市）
- Data Source
  KAKENHI-PROJECT-23592735
[Presentation] P6 and AP2 regulate Rock1 expression in dental epithelial cells2013
- Author(s)
  Ryna Dwi Yanuaryska, Keiko Miyoshi, Taigo Horiguchi, Ayako Tanimura, Hiroko Hagita and Takafumi Noma
- Organizer
  第54回日本生化学会中国・四国支部例会
- Place of Presentation
  徳島大学大塚講堂（徳島県徳島市）
- Data Source
  KAKENHI-PROJECT-23592735
[Presentation] SP6 Positiyvely Regulates Rock1 Promoter Activity in Dental Epithelial Cells2013
- Author(s)
  Yanuaryska Dwi Ryna, Keiko Miyoshi, Taigo Horiguchi, Ayako Tanimura, Adiningrat Arya and Takafumi Noma
- Organizer
  第55回歯科基礎医学会
- Place of Presentation
  岡山コンベンションセンター（岡山県岡山市）
- Data Source
  KAKENHI-PROJECT-23592735
[Presentation] SP6 and AP2 regulate Rock1 expression in dental epithelial cells2013
- Author(s)
  Yanuaryska RD, Miyoshi K, Horiguchi T, Tanimura A, Hagita H, and Noma T
- Organizer
  第54回日本生化学会中国・四国支部例会
- Place of Presentation
  徳島大学大塚講堂(徳島県)
- Year and Date
  2013-06-01
- Data Source
  KAKENHI-PROJECT-23592735
[Presentation] Role of Ctip2 in Sp6 gene regulation2013
- Author(s)
  Adiningrat A, Tanimura A, Miyoshi K, Yanuaryska RD, Horiguchi T, Hagita H, and Noma T
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-23592735
[Presentation] Role of Ctip2 in Sp6 gene regulation2013
- Author(s)
  Adiningrat Arya, Ayako Tanimura, Keiko Miyoshi, Yanuaryska Dwi Ryna, Taigo Horiguchi, 萩田浩子 and Takafumi Noma
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-23592735
[Presentation] SP6 Positively Regulates Rock1 Promoter Activity in Dental Epithelial Cells2013
- Author(s)
  Yanuaryska RD, Miyoshi K, Horiguchi T, Tanimura A, Adiningrat A, and Noma T
- Organizer
  第55回歯科基礎医学会
- Place of Presentation
  岡山コンベンションセンター(岡山県)
- Year and Date
  2013-09-21
- Data Source
  KAKENHI-PROJECT-23592735
[Presentation] エナメル質形成不全症の新規遺伝子の発見2012
- Author(s)
  三好圭子,武藤太郎,堀口大吾、萩田浩子、野間隆文
- Organizer
  第57回日本人類遺伝学会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-23592735
[Presentation] Sp6トランスジェニックラットに見られた鉄代謝異常2011
- Author(s)
  野間隆文
- Organizer
  第35回日本鉄バイオサイエンス学会
- Place of Presentation
  徳島文理大学国際会議場（徳島市）
- Data Source
  KAKENHI-PROJECT-23592735
[Presentation] SP6 stability and functional linkage during amelogenesis2011
- Author(s)
  Utami TW, Miyoshi K, Hagita H, Yanuaryska RD, Horiguchi T, and Noma T
- Organizer
  第84回日本生化学会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23592735
[Presentation] Identification of SP6 target genes in rat dental epithelial cell2011
- Author(s)
  Yanuaryska RD, Miyoshi K, Utami TW, Horiguchi T, and Noma T
- Organizer
  第53回歯科基礎医学会
- Place of Presentation
  長良川国際会議場(岐阜県)
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-23592735
[Presentation] Gaucher disease caused by possible atypical mechanism.
- Author(s)
  Miyoshi K, Horiguchi T, Tanimura A, Hagita H, Toda Y, Kagami S, Mori K, Tsuji D, Itoh K, and Noma T.
- Organizer
  Gordon Research Conference, Lysosomal Diseases
- Place of Presentation
  Galveston, TX, USA
- Year and Date
  2015-03-15 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-24592801
[Presentation] 皮膚線維芽細胞, iPS細胞との網羅的遺伝子発現の比較解析.
- Author(s)
  三好圭子, 堀口大吾, 谷村綾子，萩田浩子, 野間隆文.
- Organizer
  第14回日本再生医療学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-03-19 – 2015-03-21
- Data Source
  KAKENHI-PROJECT-24592801

1. MIYOSHI Keiko (20304537)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. HORIGUCHI Taigo (70304532)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
3. NAKAZAWA Atsushi (90025594)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. YAMADA Mamoru (30174741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 松尾敬志 (30173800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 本庶佑 (80090504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 清水章 (00162694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 川市正史 (00195041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 佐辺寿孝 (40187282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松浪伯禎 (40192752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 木梨達雄 (30202039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 川上敏明 (60143418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 武田俊一 (60188191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 伴隆志 (50101069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 谷村綾子 (10610199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
16. 萩田浩子 (30512123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KUMAHARA Hiromi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. WATANABE Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. KANEKO Shin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. HOTTA Akitsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. IMAI Kohsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. IMAMURA Hiromi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NOMA Takafumi 野間 隆文

野間 隆文 ノマ タカフミ

Research Projects

Research Products

Co-Researchers

ゴーシェ病の治療標的探索：RNAエピジェネティクスによるGBA翻訳制御機構の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

好中球分化におけるシグナル標的の同定Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on elucidation of the pathophysiology of rare intractable diseases (reticular dysgenesis) with severe combined immunodeficiency and development of therapeutic methodsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of Gaucher disease by new gene mutation using patient-derived oral mucosa fibroblasts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of disease model system using patient-derived oral mucosa fibroblast-iPSCs and development of new therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the pathological mechanism on abnormal iron metabolism using a rat modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

歯原性上皮細胞および歯髄細胞を用いた歯質再建のための細胞療法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of sensors for monitoring intracellular ATP and GTP.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ANALYSIS OF TISSUE-SPECIFIC AND DEVELOPMENTALLY REGULATD EXPRESSION OF THE GENE ENCODING ADENYLATEKINASEISOZYMESPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Construction of promoter-detection plasmid in animal cells by using the metapyrocatechase gene

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure and function of the tetrodotoxin-resistant sodium channel

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

免疫系における多様性発現機構の分子遺伝学的研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Human AK2 links intracellular bioenergetics redistribution to the fate of hematopoietic progenitors.2018

Author(s)

Journal Title

DOI

NOMA Takafumi 野間隆文

野間隆文ノマタカフミ