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Hagiwara Ken'ichi  萩原 健一

… Alternative Names

萩原 健一  ハギワラ ケンイチ

HAGIWARA Kennichi  萩原 健一

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Researcher Number 40192265
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1948-6034
External Links
Affiliation (Current) 2025: 国立健康危機管理研究機構, 国立感染症研究所 細胞科学部, 主任研究員
Affiliation (based on the past Project Information) *help 2021 – 2023: 国立感染症研究所, 細胞化学部, 主任研究官
2018 – 2020: 国立感染症研究所, 細胞化学部, 室長
2006 – 2007: 国立感染症研究所, 細胞化学部, 第一室室長
2005: 国立感染症研究所, 細胞化学部・第一室, 室長
1994: 東京大学, 薬学部, 助手
1992: 東京大学, 薬学部, 助手
1988 – 1990: 東京大学, 薬学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Biological pharmacy / Physical pharmacy / 医薬分子機能学
Except Principal Investigator
Physical pharmacy / Biological pharmacy
Keywords
Principal Investigator
プリオン / 感染症 / 神経変性疾患 / コンフォメーション / ベータへリックス / βへリックス / 光架橋反応 / 蛋白質凝集 / βヘリックス / アミロイド … More / neuro2a / コレステロール / スフィンゴ糖脂質 / 脳・神経 / 蛋白質 / 生体分子 / 脳神経疾患 / プリオン病 / 情報伝達 / 活性酸素 / カルシウムイオン / 好中球 / ハチ毒 / 走化性ペプチド / 走化性 / 神経毒 / マダガスカル / アミノ酸配列 / ペプチド / クモ毒 … More
Except Principal Investigator
NOESY / NMR / JSTX / Zn-complex / conformational analysis / structure-activity relationship / l-naphthylacetyl spermine / polyamine toxin / spider toxin / ORD / アザクラウン / 1-ナフチルアセチルポリアミン / アシルポリアミン / Zn錯体 / コンホ-メイション解析 / 構造活性相関 / 1-アセチルナフチルスペルミン / ポリアミントキシン / クモ毒 / Brain Ischemia / Hippocampus / Cerebellum / GTP Binding Protein / Spider Toxin / Glutamic acid / Glutamate Receptor / アフィニティーカラム / 標識化クモ毒素 / 1-ナフチルアセチルスペルミン / アビジン・ビオチン / グルタミン酸レセプター / 脳虚血 / 海馬 / 小脳 / GTP結合蛋白 / クモ毒素 / グルタミン酸 / グルタミン酸レセプタ- / GABAアゴニスト / HPLC分析 / ペプチド毒 / G蛋白質修飾物質 / マダガスカル産クモ毒 / パプアニューギニア産ハチ毒 / 南米産ハチ毒・クモ毒 / 神経毒性物質 Less
  • Research Projects

    (7 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (7 People)
  •  Investigation of the folding mechanism of PrPC to PrPSc and assembly of prion agents, and interpretation of the of the beta helix scaffold modelPrincipal Investigator

    • Principal Investigator
      Hagiwara Ken'ichi
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
    • Research Institution
      National Institute of Infectious Diseases
  •  プリオンへの感染および異常型プリオン蛋白質の産生におけるスフィンゴ糖脂質の役割Principal Investigator

    • Principal Investigator
      萩原 健一
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Infectious Diseases
  •  走化性ペプチドにより惹起される好中球の細胞内動的変化の可視化と解析Principal Investigator

    • Principal Investigator
      萩原 健一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      The University of Tokyo
  •  本邦産クモ由来の神経毒ペプチド(アジェレニン)の高次構造の解析Principal Investigator

    • Principal Investigator
      萩原 健一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      The University of Tokyo
  •  新しい節足動物神経毒の探索

    • Principal Investigator
      NAKAJIMA Terumi
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  Identification of the Glutamate Receptor and its Application for the Research in Neurological Diseases

    • Principal Investigator
      KAWAI Nobufumi
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Research Institution
      Tokyo Metropolitan Institute for Neurosciences
  •  Physico-chemical studies on the blocking mechanism of glutamate receptors by spider toxin

    • Principal Investigator
      NAKAJIMA Terumi
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      The University of Tokyo

All 2023 2019 2007 2005

All Journal Article Presentation

  • [Journal Article] Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys2019

    • Author(s)
      Hagiwara Ken’ichi、Sato Yuko、Yamakawa Yoshio、Hara Hideyuki、Tobiume Minoru、Okemoto-Nakamura Yuko、Sata Tetsutaro、Horiuchi Motohiro、Shibata Hiroaki、Ono Fumiko
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 5 Pages: e0216807-e0216807

    • DOI

      10.1371/journal.pone.0216807

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06621, KAKENHI-PROJECT-18K07499
  • [Journal Article] A PRNP-disrupted human neuroblastoma cell line and its stable transformants expressing prion protein variants2019

    • Author(s)
      Okemoto-Nakamura Yuko、Tanida Isei、Yamaji Toshiyuki、Hanada Kentaro、Hagiwara Ken’ichi
    • Journal Title

      BPB Reports

      Volume: 2 Pages: 73-79

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06621
  • [Journal Article] Prevention of Prion Propagation by Dehydrocholesterol Reductase Inhibitors in Cultured Cells and a Therapeutic Trial in Mice2007

    • Author(s)
      K.Hagiwara, Y.Nakamura, M.Nishijima, Y.Yamakawa
    • Journal Title

      Biol. Pharm. Bull. 30

      Pages: 835-838

    • Data Source
      KAKENHI-PROJECT-17659024
  • [Journal Article] Accumulation of mono-glycosylated form-rich,plaque-forming PrP^<Sc> in the second atypical bovine spongiform encephalopathy case in Japan2007

    • Author(s)
      Ken'ichi Hagiwara(第1著者)
    • Journal Title

      Jpn.J.Infect.Dis. 60

      Pages: 305-308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17659024
  • [Journal Article] Prevention of prion Propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice2007

    • Author(s)
      Ken'ichi Hagiwara(第1著者)
    • Journal Title

      Biol.Pharm.Bull. 30

      Pages: 835-838

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17659024
  • [Journal Article] 異常型プリオン蛋白質(PrPSc)と感染性2005

    • Author(s)
      萩原 健一, 山河 芳夫
    • Journal Title

      医学のあゆみ 215

      Pages: 887-890

    • Data Source
      KAKENHI-PROJECT-17659024
  • [Presentation] Elucidation of the mechanism of prion disease progression by comparison of histopathological lesions in transmission of atypical (L-type) BSE prions to cynomolgus macaques before and after the onset of the disease.2023

    • Author(s)
      Okudaira T, Shibata H, Tobiume M, Nakano N, Sato Y, Hagiwara K, Kimura N, Hanari K, Ogawa H, Ohto K, Terao K, Sata T, Ono F.
    • Organizer
      Asian Pacific Prion Symposium 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06621
  • [Presentation] Atypical BSE cases in Japan2007

    • Author(s)
      Ken'ichi Hagiwara(単独)
    • Organizer
      Taiwan and Japan BSE Prevention and Control Conference
    • Place of Presentation
      淡水、台湾
    • Data Source
      KAKENHI-PROJECT-17659024
  • 1.  NAKAJIMA Terumi (50012597)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  KAWAI Nobufumi (00073065)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  SHIMAZAKI Kuniko (40142153)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  MIWA Akiko (60142155)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  佐原 資謹 (40206008)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  SAITO Hiroshi (00012625)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  SHUDO Koichi (50012612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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