HAGIWARA Kennichi 萩原健一

… Alternative Names

Researcher Number	40192265
Other IDs	https://orcid.org/0000-0002-1948-6034
External Links
Affiliation (Current)	2021: 国立感染症研究所, 細胞化学部, 主任研究官
Affiliation (based on the past Project Information) *help	2018 – 2019: 国立感染症研究所, 細胞化学部, 室長 2006 – 2007: 国立感染症研究所, 細胞化学部, 第一室室長 2005: 国立感染症研究所, 細胞化学部・第一室, 室長 1994: 東京大学, 薬学部, 助手 1992: 東京大学, 薬学部, 助手 1988 – 1990: 東京大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator 医薬分子機能学 / Physical pharmacy / Biological pharmacy / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related Except Principal Investigator Biological pharmacy / Physical pharmacy
Keywords	Principal Investigator プリオン / クモ毒 / ペプチド / アミノ酸配列 / マダガスカル / 神経毒 / 走化性 / 走化性ペプチド / ハチ毒 / 好中球 … More Except Principal Investigator JSTX / NMR / NOESY / 神経毒性物質 / 南米産ハチ毒・クモ毒 / パプアニューギニア産ハチ毒 / マダガスカル産クモ毒 / G蛋白質修飾物質 / ペプチド毒 / HPLC分析 / GABAアゴニスト / グルタミン酸レセプタ- / グルタミン酸 / クモ毒素 / GTP結合蛋白 / 小脳 / 海馬 / 脳虚血 / グルタミン酸レセプター / アビジン・ビオチン / 1-ナフチルアセチルスペルミン / 標識化クモ毒素 / アフィニティーカラム / Glutamate Receptor / Glutamic acid / Spider Toxin / GTP Binding Protein / Cerebellum / Hippocampus / Brain Ischemia / クモ毒 / ポリアミントキシン / 1-アセチルナフチルスペルミン / 構造活性相関 / コンホ-メイション解析 / Zn錯体 / アシルポリアミン / 1-ナフチルアセチルポリアミン / アザクラウン / ORD / spider toxin / polyamine toxin / l-naphthylacetyl spermine / structure-activity relationship / conformational analysis / Zn-complex Less

Investigation of the folding mechanism of PrPC to PrPSc and assembly of prion agents, and interpretation of the of the beta helix scaffold modelPrincipal Investigator
- Principal Investigator
  
  萩原健一
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  National Institute of Infectious Diseases
プリオンへの感染および異常型プリオン蛋白質の産生におけるスフィンゴ糖脂質の役割Principal Investigator
- Principal Investigator
  
  萩原健一
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Infectious Diseases
走化性ペプチドにより惹起される好中球の細胞内動的変化の可視化と解析Principal Investigator
- Principal Investigator
  
  萩原健一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo
本邦産クモ由来の神経毒ペプチド(アジェレニン)の高次構造の解析Principal Investigator
- Principal Investigator
  
  萩原健一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
新しい節足動物神経毒の探索
- Principal Investigator
  
  NAKAJIMA Terumi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Identification of the Glutamate Receptor and its Application for the Research in Neurological Diseases
- Principal Investigator
  
  KAWAI Nobufumi
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Tokyo Metropolitan Institute for Neurosciences
Physico-chemical studies on the blocking mechanism of glutamate receptors by spider toxin
- Principal Investigator
  
  NAKAJIMA Terumi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo

All 2019 2007 2005

All Journal Article Presentation

[Journal Article] Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys2019
- Author(s)
  Hagiwara Ken’ichi、Sato Yuko、Yamakawa Yoshio、Hara Hideyuki、Tobiume Minoru、Okemoto-Nakamura Yuko、Sata Tetsutaro、Horiuchi Motohiro、Shibata Hiroaki、Ono Fumiko
- Journal Title
  
  PLOS ONE
  
  Volume: 14
- DOI
  10.1371/journal.pone.0216807
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06621, KAKENHI-PROJECT-18K07499
[Journal Article] A PRNP-disrupted human neuroblastoma cell line and its stable transformants expressing prion protein variants2019
- Author(s)
  Okemoto-Nakamura Yuko、Tanida Isei、Yamaji Toshiyuki、Hanada Kentaro、Hagiwara Ken’ichi
- Journal Title
  
  BPB Reports
  
  Volume: 2 Pages: 73-79
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06621
[Journal Article] Prevention of Prion Propagation by Dehydrocholesterol Reductase Inhibitors in Cultured Cells and a Therapeutic Trial in Mice2007
- Author(s)
  K.Hagiwara, Y.Nakamura, M.Nishijima, Y.Yamakawa
- Journal Title
  
  Biol. Pharm. Bull. 30
  
  Pages: 835-838
- Data Source
  KAKENHI-PROJECT-17659024
[Journal Article] Accumulation of mono-glycosylated form-rich,plaque-forming PrP^<Sc> in the second atypical bovine spongiform encephalopathy case in Japan2007
- Author(s)
  Ken'ichi Hagiwara(第1著者)
- Journal Title
  
  Jpn.J.Infect.Dis. 60
  
  Pages: 305-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659024
[Journal Article] Prevention of prion Propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice2007
- Author(s)
  Ken'ichi Hagiwara(第1著者)
- Journal Title
  
  Biol.Pharm.Bull. 30
  
  Pages: 835-838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659024
[Journal Article] 異常型プリオン蛋白質(PrPSc)と感染性2005
- Author(s)
  萩原健一, 山河芳夫
- Journal Title
  
  医学のあゆみ 215
  
  Pages: 887-890
- Data Source
  KAKENHI-PROJECT-17659024
[Presentation] Atypical BSE cases in Japan2007
- Author(s)
  Ken'ichi Hagiwara(単独)
- Organizer
  Taiwan and Japan BSE Prevention and Control Conference
- Place of Presentation
  淡水、台湾
- Data Source
  KAKENHI-PROJECT-17659024

1. NAKAJIMA Terumi (50012597)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KAWAI Nobufumi (00073065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SHIMAZAKI Kuniko (40142153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MIWA Akiko (60142155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SAITO Hiroshi (00012625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHUDO Koichi (50012612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐原資謹 (40206008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 原英之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAGIWARA Kennichi 萩原 健一

萩原 健一 ハギワラ ケンイチ

Research Projects

Research Products

Co-Researchers

Investigation of the folding mechanism of PrPC to PrPSc and assembly of prion agents, and interpretation of the of the beta helix scaffold modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

プリオンへの感染および異常型プリオン蛋白質の産生におけるスフィンゴ糖脂質の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

走化性ペプチドにより惹起される好中球の細胞内動的変化の可視化と解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

本邦産クモ由来の神経毒ペプチド(アジェレニン)の高次構造の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新しい節足動物神経毒の探索

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of the Glutamate Receptor and its Application for the Research in Neurological Diseases

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Physico-chemical studies on the blocking mechanism of glutamate receptors by spider toxin

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A PRNP-disrupted human neuroblastoma cell line and its stable transformants expressing prion protein variants2019

Author(s)

Journal Title

Data Source

[Journal Article] Prevention of Prion Propagation by Dehydrocholesterol Reductase Inhibitors in Cultured Cells and a Therapeutic Trial in Mice2007

Author(s)

Journal Title

Data Source

[Journal Article] Accumulation of mono-glycosylated form-rich,plaque-forming PrP^<Sc> in the second atypical bovine spongiform encephalopathy case in Japan2007

Author(s)

Journal Title

Data Source

[Journal Article] Prevention of prion Propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice2007

Author(s)

Journal Title

Data Source

[Journal Article] 異常型プリオン蛋白質(PrPSc)と感染性2005

Author(s)

Journal Title

Data Source

[Presentation] Atypical BSE cases in Japan2007

Author(s)

Organizer

Place of Presentation

Data Source

HAGIWARA Kennichi 萩原健一

萩原健一ハギワラケンイチ