HAGIWARA Kennichi 萩原健一

… Alternative Names

Researcher Number	40192265
Other IDs
External Links
Affiliation (Current)	2019: 国立感染症研究所, 細胞化学部, 室長
Affiliation (based on the past Project Information) *help	2018: 国立感染症研究所, 細胞化学部, 室長 2006 – 2007: 国立感染症研究所, 細胞化学部, 第一室室長 2005: 国立感染症研究所, 細胞化学部・第一室, 室長 1994: 東京大学, 薬学部, 助手 1992: 東京大学, 薬学部, 助手 1988 – 1990: 東京大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Physical pharmacy / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Biological pharmacy / 医薬分子機能学 Except Principal Investigator Physical pharmacy / Biological pharmacy
Keywords	Principal Investigator プリオン / アミノ酸配列 / マダガスカル / 生体分子 / スフィンゴ糖脂質 / クモ毒 / カルシウムイオン / コレステロール / 感染症 / コンフォメーション … More Except Principal Investigator JSTX / NOESY / NMR / アザクラウン / グルタミン酸レセプター / 脳虚血 / 海馬 / GTP結合蛋白 / アフィニティーカラム / 南米産ハチ毒・クモ毒 / ペプチド毒 / 構造活性相関 / クモ毒 / ポリアミントキシン / アビジン・ビオチン / l-naphthylacetyl spermine / アシルポリアミン / Hippocampus / HPLC分析 / 1-ナフチルアセチルスペルミン / Glutamic acid / spider toxin / Zn-complex / G蛋白質修飾物質 / クモ毒素 / グルタミン酸 / conformational analysis / パプアニューギニア産ハチ毒 / Brain Ischemia / Cerebellum / コンホ-メイション解析 / polyamine toxin / 1-ナフチルアセチルポリアミン / GTP Binding Protein / グルタミン酸レセプタ- / 小脳 / Zn錯体 / 神経毒性物質 / Glutamate Receptor / マダガスカル産クモ毒 / structure-activity relationship / Spider Toxin / 1-アセチルナフチルスペルミン / GABAアゴニスト / ORD / 標識化クモ毒素 Less

Investigation of the folding mechanism of PrPC to PrPSc and assembly of prion agents, and interpretation of the of the beta helix scaffold modelPrincipal InvestigatorOngoing
- Principal Investigator
  
  萩原健一
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  National Institute of Infectious Diseases
プリオンへの感染および異常型プリオン蛋白質の産生におけるスフィンゴ糖脂質の役割Principal Investigator
- Principal Investigator
  
  萩原健一
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Infectious Diseases
走化性ペプチドにより惹起される好中球の細胞内動的変化の可視化と解析Principal Investigator
- Principal Investigator
  
  萩原健一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo
本邦産クモ由来の神経毒ペプチド(アジェレニン)の高次構造の解析Principal Investigator
- Principal Investigator
  
  萩原健一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
新しい節足動物神経毒の探索
- Principal Investigator
  
  NAKAJIMA Terumi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Identification of the Glutamate Receptor and its Application for the Research in Neurological Diseases
- Principal Investigator
  
  KAWAI Nobufumi
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Tokyo Metropolitan Institute for Neurosciences
Physico-chemical studies on the blocking mechanism of glutamate receptors by spider toxin
- Principal Investigator
  
  NAKAJIMA Terumi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo

All 2007 2005

All Journal Article Presentation

[Journal Article] Prevention of Prion Propagation by Dehydrocholesterol Reductase Inhibitors in Cultured Cells and a Therapeutic Trial in Mice2007
- Author(s)
  K.Hagiwara, Y.Nakamura, M.Nishijima, Y.Yamakawa
- Journal Title
  
  Biol. Pharm. Bull. 30
  
  Pages: 835-838
- Data Source
  KAKENHI-PROJECT-17659024
[Journal Article] Accumulation of mono-glycosylated form-rich,plaque-forming PrP^<Sc> in the second atypical bovine spongiform encephalopathy case in Japan2007
- Author(s)
  Ken'ichi Hagiwara(第1著者)
- Journal Title
  
  Jpn.J.Infect.Dis. 60
  
  Pages: 305-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659024
[Journal Article] Prevention of prion Propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice2007
- Author(s)
  Ken'ichi Hagiwara(第1著者)
- Journal Title
  
  Biol.Pharm.Bull. 30
  
  Pages: 835-838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659024
[Journal Article] 異常型プリオン蛋白質(PrPSc)と感染性2005
- Author(s)
  萩原健一, 山河芳夫
- Journal Title
  
  医学のあゆみ 215
  
  Pages: 887-890
- Data Source
  KAKENHI-PROJECT-17659024
[Presentation] Atypical BSE cases in Japan2007
- Author(s)
  Ken'ichi Hagiwara(単独)
- Organizer
  Taiwan and Japan BSE Prevention and Control Conference
- Place of Presentation
  淡水、台湾
- Data Source
  KAKENHI-PROJECT-17659024

1. NAKAJIMA Terumi (50012597)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KAWAI Nobufumi (00073065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SHIMAZAKI Kuniko (40142153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MIWA Akiko (60142155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 佐原資謹 (40206008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SAITO Hiroshi (00012625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHUDO Koichi (50012612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HAGIWARA Kennichi 萩原 健一

萩原 健一 ハギワラ ケンイチ

Research Projects

Research Products

Co-Researchers

Investigation of the folding mechanism of PrPC to PrPSc and assembly of prion agents, and interpretation of the of the beta helix scaffold modelPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

プリオンへの感染および異常型プリオン蛋白質の産生におけるスフィンゴ糖脂質の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

走化性ペプチドにより惹起される好中球の細胞内動的変化の可視化と解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

本邦産クモ由来の神経毒ペプチド(アジェレニン)の高次構造の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新しい節足動物神経毒の探索

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of the Glutamate Receptor and its Application for the Research in Neurological Diseases

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Physico-chemical studies on the blocking mechanism of glutamate receptors by spider toxin

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Prevention of Prion Propagation by Dehydrocholesterol Reductase Inhibitors in Cultured Cells and a Therapeutic Trial in Mice2007

Author(s)

Journal Title

Data Source

[Journal Article] Accumulation of mono-glycosylated form-rich,plaque-forming PrP^<Sc> in the second atypical bovine spongiform encephalopathy case in Japan2007

Author(s)

Journal Title

Data Source

[Journal Article] Prevention of prion Propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice2007

Author(s)

Journal Title

Data Source

[Journal Article] 異常型プリオン蛋白質(PrPSc)と感染性2005

Author(s)

Journal Title

Data Source

[Presentation] Atypical BSE cases in Japan2007

Author(s)

Organizer

Place of Presentation

Data Source

HAGIWARA Kennichi 萩原健一

萩原健一ハギワラケンイチ