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HAGIWARA Kennichi  萩原 健一

… Alternative Names

萩原 健一  ハギワラ ケンイチ

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Researcher Number 40192265
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1948-6034
External Links
Affiliation (Current) 2022: 国立感染症研究所, 細胞化学部, 主任研究官
Affiliation (based on the past Project Information) *help 2018 – 2020: 国立感染症研究所, 細胞化学部, 室長
2006 – 2007: 国立感染症研究所, 細胞化学部, 第一室室長
2005: 国立感染症研究所, 細胞化学部・第一室, 室長
1994: 東京大学, 薬学部, 助手
1992: 東京大学, 薬学部, 助手
1988 – 1990: 東京大学, 薬学部, 助手
Review Section/Research Field
Principal Investigator
医薬分子機能学 / Physical pharmacy / Biological pharmacy / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Except Principal Investigator
Biological pharmacy / Physical pharmacy
Keywords
Principal Investigator
プリオン / クモ毒 / ペプチド / アミノ酸配列 / マダガスカル / 神経毒 / 走化性 / 走化性ペプチド / ハチ毒 / 好中球 … More / カルシウムイオン / 活性酸素 / 情報伝達 / プリオン病 / 感染症 / 脳神経疾患 / 生体分子 / 蛋白質 / 脳・神経 / スフィンゴ糖脂質 / コレステロール / neuro2a / アミロイド / βヘリックス / βへリックス / ベータへリックス / コンフォメーション / 神経変性疾患 … More
Except Principal Investigator
JSTX / NMR / NOESY / 神経毒性物質 / 南米産ハチ毒・クモ毒 / パプアニューギニア産ハチ毒 / マダガスカル産クモ毒 / G蛋白質修飾物質 / ペプチド毒 / HPLC分析 / GABAアゴニスト / グルタミン酸レセプタ- / グルタミン酸 / クモ毒素 / GTP結合蛋白 / 小脳 / 海馬 / 脳虚血 / グルタミン酸レセプター / アビジン・ビオチン / 1-ナフチルアセチルスペルミン / 標識化クモ毒素 / アフィニティーカラム / Glutamate Receptor / Glutamic acid / Spider Toxin / GTP Binding Protein / Cerebellum / Hippocampus / Brain Ischemia / クモ毒 / ポリアミントキシン / 1-アセチルナフチルスペルミン / 構造活性相関 / コンホ-メイション解析 / Zn錯体 / アシルポリアミン / 1-ナフチルアセチルポリアミン / アザクラウン / ORD / spider toxin / polyamine toxin / l-naphthylacetyl spermine / structure-activity relationship / conformational analysis / Zn-complex Less
  • Research Projects

    (7 results)
  • Research Products

    (7 results)
  • Co-Researchers

    (8 People)
  •  Investigation of the folding mechanism of PrPC to PrPSc and assembly of prion agents, and interpretation of the of the beta helix scaffold modelPrincipal Investigator

    • Principal Investigator
      萩原 健一
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
    • Research Institution
      National Institute of Infectious Diseases
  •  プリオンへの感染および異常型プリオン蛋白質の産生におけるスフィンゴ糖脂質の役割Principal Investigator

    • Principal Investigator
      萩原 健一
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Infectious Diseases
  •  走化性ペプチドにより惹起される好中球の細胞内動的変化の可視化と解析Principal Investigator

    • Principal Investigator
      萩原 健一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      The University of Tokyo
  •  本邦産クモ由来の神経毒ペプチド(アジェレニン)の高次構造の解析Principal Investigator

    • Principal Investigator
      萩原 健一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      The University of Tokyo
  •  新しい節足動物神経毒の探索

    • Principal Investigator
      NAKAJIMA Terumi
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  Identification of the Glutamate Receptor and its Application for the Research in Neurological Diseases

    • Principal Investigator
      KAWAI Nobufumi
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Research Institution
      Tokyo Metropolitan Institute for Neurosciences
  •  Physico-chemical studies on the blocking mechanism of glutamate receptors by spider toxin

    • Principal Investigator
      NAKAJIMA Terumi
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      The University of Tokyo

All 2019 2007 2005

All Journal Article Presentation

  • [Journal Article] Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys2019

    • Author(s)
      Hagiwara Ken’ichi、Sato Yuko、Yamakawa Yoshio、Hara Hideyuki、Tobiume Minoru、Okemoto-Nakamura Yuko、Sata Tetsutaro、Horiuchi Motohiro、Shibata Hiroaki、Ono Fumiko
    • Journal Title

      PLOS ONE

      Volume: 14

    • DOI

      10.1371/journal.pone.0216807

    • NAID

      120006812014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06621, KAKENHI-PROJECT-18K07499
  • [Journal Article] A PRNP-disrupted human neuroblastoma cell line and its stable transformants expressing prion protein variants2019

    • Author(s)
      Okemoto-Nakamura Yuko、Tanida Isei、Yamaji Toshiyuki、Hanada Kentaro、Hagiwara Ken’ichi
    • Journal Title

      BPB Reports

      Volume: 2 Pages: 73-79

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06621
  • [Journal Article] Prevention of Prion Propagation by Dehydrocholesterol Reductase Inhibitors in Cultured Cells and a Therapeutic Trial in Mice2007

    • Author(s)
      K.Hagiwara, Y.Nakamura, M.Nishijima, Y.Yamakawa
    • Journal Title

      Biol. Pharm. Bull. 30

      Pages: 835-838

    • Data Source
      KAKENHI-PROJECT-17659024
  • [Journal Article] Accumulation of mono-glycosylated form-rich,plaque-forming PrP^<Sc> in the second atypical bovine spongiform encephalopathy case in Japan2007

    • Author(s)
      Ken'ichi Hagiwara(第1著者)
    • Journal Title

      Jpn.J.Infect.Dis. 60

      Pages: 305-308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17659024
  • [Journal Article] Prevention of prion Propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice2007

    • Author(s)
      Ken'ichi Hagiwara(第1著者)
    • Journal Title

      Biol.Pharm.Bull. 30

      Pages: 835-838

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17659024
  • [Journal Article] 異常型プリオン蛋白質(PrPSc)と感染性2005

    • Author(s)
      萩原 健一, 山河 芳夫
    • Journal Title

      医学のあゆみ 215

      Pages: 887-890

    • Data Source
      KAKENHI-PROJECT-17659024
  • [Presentation] Atypical BSE cases in Japan2007

    • Author(s)
      Ken'ichi Hagiwara(単独)
    • Organizer
      Taiwan and Japan BSE Prevention and Control Conference
    • Place of Presentation
      淡水、台湾
    • Data Source
      KAKENHI-PROJECT-17659024
  • 1.  NAKAJIMA Terumi (50012597)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  KAWAI Nobufumi (00073065)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  SHIMAZAKI Kuniko (40142153)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  MIWA Akiko (60142155)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  SAITO Hiroshi (00012625)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  SHUDO Koichi (50012612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  佐原 資謹 (40206008)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  原 英之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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