Oyama Fumitaka 小山文隆

… Alternative Names

Researcher Number	40194641
Other IDs	https://orcid.org/0000-0002-1095-8306
Affiliation (Current)	2022: 工学院大学, 先進工学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2018: 工学院大学, 先進工学部, 教授 2009 – 2010: Kogakuin University, 工学部, 教授 2006 – 2008: 独立行政法人理化学研究所, 構造神経病理研究チーム, 研究員 2003: RIKEN (The Institute of Physical and Chemical Research), Brain Science Institute, Laboratory for Structural Neuropathology, Research Scientist, 構造神経病理研究チーム, 研究員 2002: 理化学研究所, 構造神経病理研究チーム, 研究員 … More
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / 老化(加齢) / Nerve anatomy/Neuropathology / Applied biochemistry Except Principal Investigator Biological Sciences / 物質生物化学
Keywords	Principal Investigator アルツハイマー病 / tau / lysosome / タウ / クロロキンミオパチー / Alzheimer's disease / ダウン症候群 / APP / ナトリウムチャネルベータ4 / ハンチントン病 … More Except Principal Investigator フィブロネクチン / RNAスプライシング / 癌胎児性変化 / 肝細胞癌 / アルツハイマー病 / 神経原線維変化 / IIIa / 細胞外基質 / 肺癌 / 腎癌 / テネイシン / 免疫組織化学 / βアミロイド / PHF / βーアミロイド蛋白質前駆体 / タウ / 選択的スプライシング / 脳 / アルツハイマ-病 / 老人 / 家族性アルツハイマー病 / ポジショナルクローニング / 連鎖解析 / 第14染色体 / アポリポタンパクE / アミロイド / ダウン症 / アミロイド前駆体タンパク / 神経成長抑制因子 / アポリポタンパクE4 / 第21染色体 / タウ蛋白 / 神経細胞死 / Alzheimer's disease / Tau / Neurofibrillary tangles / Neuronal death / フォンビルブラント因子 / 血小板凝集 / 血小板膜GPlb / 血小板膜GPIIb / ボトロセチン / リストセチン / 単クロ-ン抗体 / アスパラギン結合糖鎖 / 血小板膜GPIb / 血小板膜GPIIb@IIIa / フォルビルブラント因子 / 血小板膜糖タンパク質(GP)Ib / アミノ酸配列 / ジスルヒド結合 / モノクロナール抗体 / エピトープ / フォンビルラント因子 / 血小板膜糖タンパク質 / 血液凝固第VIII因子結合ドメイン / ヘパリン結合ドメイン / コラーゲン結合ドメイン / トレオニン / セリン結合糖鎖 / von Willebrand Factor / Platelet Aggregation / Glycoprotein(GP)Ib / Glycoprotein(GP)IIb / Botrocetin / Ristocetin / Monoclonal Antibody / Asparagine(N)-linked Sugar Chain Less

Is acidic mammalian chitinase a major glycosidase in the stomachs of mouse and porcine?Principal Investigator
- Principal Investigator
  
  Oyama Fumitaka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Kogakuin University
Downregulation of sodium channel β4 subunit in Huntington Disease transgenic micePrincipal Investigator
- Principal Investigator
  
  OYAMA Fumitaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research
Pathological roles of sodium channel β4 subunit in Huntington disease transgenic micePrincipal Investigator
- Principal Investigator
  
  OYAMA Fumitaka
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research
Identification of novel genes closely related to Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  OYAMA Fumitaka
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  RIKEN (The Institute of Physical and Chemical Research)
Hyperphosphorylation and aggregation of tau protein, and neuronal death
- Principal Investigator
  
  IHARA Yasuo
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tokyo
Studies on the tau lysosomal proteolytic pathwayPrincipal Investigator
- Principal Investigator
  
  OYAMA Fumitaka
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  University of Tokyo
Studies on the tau lysosomal proteolytic pathwayPrincipal Investigator
- Principal Investigator
  
  OYAMA Fumitaka
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  The University of Tokyo
アルツハイマー病原因遺伝子のヒト組織における発現制御Principal Investigator
- Principal Investigator
  
  小山文隆
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  The University of Tokyo
クロロキンミオパチーにおける細胞死の研究Principal Investigator
- Principal Investigator
  
  小山文隆
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
ダウン症候群患者脳におけるアルツハイマー病関連遺伝子の発現制御Principal Investigator
- Principal Investigator
  
  小山文隆
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokyo
APPとタウ遺伝子のダウン症候群患者脳における発現制御Principal Investigator
- Principal Investigator
  
  小山文隆
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokyo
アルツハイマー病の分子遺伝学的研究
- Principal Investigator
  
  辻省次
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Niigata University
ヒト癌における組織特異的alternative splicingの脱制御の検証
- Principal Investigator
  
  関口清俊
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fujita Health University
アルツハイマ-病関連タンパク質mRNA前駆体の選択的スプライシングの脳での制御
- Principal Investigator
  
  TITANI Koiti
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Fujita Health University
ヒト癌におけるalternative splicingの脱制御の検証
- Principal Investigator
  
  SEKIGUCHI Kiyotoshi
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fujita Health University
Studies on platelet aggregation by structural analysis of von Willebrand factor
- Principal Investigator
  
  TITANI Koiti
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  物質生物化学
- Research Institution
  Fujita Health University

All 2019 2018 2017 2016 2010 2009 2008 2007 2006 2004 2000

All Journal Article Presentation

[Journal Article] High expression of acidic chitinase and chitin digestibility in the stomach of common marmoset (Callithrix jacchus), an insectivorous nonhuman primate2019
- Author(s)
  Tabata， E.， Kashimura， A.， Uehara， M.， Wakita， S.， Sakaguchi， M.， Sugahara， Y.， Yurimoto， T.， Sasaki， E.， Matoska， V.， Bauer， P. O. & Oyama， F.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Pages: 159-159
- DOI
  10.1038/s41598-018-36477-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18J23382, KAKENHI-PROJECT-16K07699
[Journal Article] Chitin digestibility is dependent on feeding behaviors, which determine acidic chitinase mRNA levels, in stomachs of mammal and poultry2018
- Author(s)
  Tabata, E., Kashimura, A., Kikuchi, A., Masuda, H., Miyahara, R., Hiruma, Y., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Matoska, V., Bauer, P. O. and Oyama, F.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 1461-1461
- DOI
  10.1038/s41598-018-19940-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699, KAKENHI-PROJECT-18J23382
[Journal Article] Chitinase mRNA Levels Determined by QPCR in Crab-Eating Monkey (Macaca fascicularis) Tissues: Species-Specific Expression of Acidic Mammalian Chitinase and Chitotriosidase2018
- Author(s)
  Uehara, M., Tabata, E., Ishii, K., Sawa, A., Ohno, M., Sakaguchi, M., Matoska, V., Bauer, P. O. & Oyama, F.
- Journal Title
  
  Genes (Basel)
  
  Volume: 9 Pages: 244-244
- DOI
  10.3390/genes9050244
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Journal Article] Acidic Chitinase-Chitin Complex Is Dissociated in a Competitive Manner by Acetic Acid: Purification of Natural Enzyme for Supplementation Purposes2018
- Author(s)
  Tabata, E., Kashimura, A., Wakita, S., Sakaguchi, M., Sugahara, Y., Imamura, Y., Shimizu, H., Matoska, V., Bauer, P. O. and Oyama, F.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Pages: 362-362
- DOI
  10.3390/ijms19020362
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699, KAKENHI-PROJECT-18J23382
[Journal Article] Improved fluorescent labeling of chitin oligomers: chitinolytic properties of acidic mammalian chitinase under somatic tissue pH conditions.2017
- Author(s)
  Wakita, S., Kimura, M., Kato, N., Kashimura, A., Kobayashi, S., Kanayama, N., Ohno, M., Honda, S., Sakaguchi, M., Sugahara, Y., Bauer, P.O. and Oyama, F.
- Journal Title
  
  Carbohydr. Polym.
  
  Volume: 164 Pages: 145-153
- DOI
  10.1016/j.carbpol.2017.01.095
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Journal Article] Gastric and intestinal proteases resistance of chicken acidic chitinase nominates chitin-containing organisms for alternative whole edible diets for poultry.2017
- Author(s)
  Tabata, E., Kashimura, A., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Kino, Y., Matoska, V., Bauer, P.O. and Oyama, F.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 6662-6662
- DOI
  10.1038/s41598-017-07146-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699, KAKENHI-PROJECT-16K09683
[Journal Article] Mouse acidic mammalian chitinase exhibits transglycosylation activity at somatic tissue pH.2017
- Author(s)
  Wakita S, Kobayashi S, Kimura M, Kashimura A, Honda S, Sakaguchi M, Sugahara Y, Kamaya M, Matoska V, Bauer PO, and Oyama F.
- Journal Title
  
  FEBS Lett.
  
  Volume: 591 Pages: 3310-3318
- DOI
  10.1002/1873-3468.12798
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Journal Article] Protease resistance of porcine acidic mammalian chitinase under gastrointestinal conditions implies that chitin-containing organisms can be sustainable dietary resources2017
- Author(s)
  Tabata, E., Kashimura, A., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Imamura, Y., Seki, S., Ueda, H., Matoska, V., Bauer, P. O. and Oyama, F.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 12963-12963
- DOI
  10.1038/s41598-017-13526-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699, KAKENHI-PROJECT-17K07412
[Journal Article] Acidic mammalian chitinase is a proteases-resistant glycosidase in mouse digestive system.2016
- Author(s)
  Ohno, M.; Kimura, M.; Miyazaki, H.; Okawa, K.; Onuki, R.; Nemoto, C.; Tabata, E.; Wakita, S.; Kashimura, A.; Sakaguchi, M.; Sugahara, Y.; Nukina, N.; Bauer, P. O.; Oyama, F.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Pages: 37756-37756
- DOI
  10.1038/srep37756
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Journal Article] Functional properties of mouse chitotriosidase expressed in the periplasmic space of Escherichia coli.2016
- Author(s)
  Kimura, M.; Wakita, S.; Ishikawa, K.; Sekine, K.; Yoshikawa, S.; Sato, A.; Okawa, K.; Kashimura, A.; Sakaguchi, M.; Sugahara, Y.; Yamanaka, D.; Ohno, N.; Bauer, P. O.; Oyama, F.
- Journal Title
  
  PLoS One
  
  Volume: 11
- DOI
  10.1371/journal.pone.0164367
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Journal Article] Loss and gain of human acidic mammalian chitinase activity by nonsynonymous SNPs.2016
- Author(s)
  Okawa, K.; Ohno, M.; Kashimura, A.; Kimura, M.; Kobayashi, Y.; Sakaguchi, M.; Sugahara, Y.; Kamaya, M.; Kino, Y.; Bauer, P. O.; Oyama, F.
- Journal Title
  
  Mol. Biol. Evol.
  
  Volume: 33 Pages: 3183-3193
- DOI
  10.1093/molbev/msw198
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Journal Article] Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth.2010
- Author(s)
  Brackenbury W.J., Calhoun J.D., Chen C., Miyazaki H., Nukina N., Oyama F., Ranscht B., Isom L.L.
- Journal Title
  
  Proc.Natl.Acad.Sci. USA. 107
  
  Pages: 2283-2288
- Data Source
  KAKENHI-PROJECT-20500329
[Journal Article] Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth.2010
- Author(s)
  Brackenbury, W.J., Calhoun, J.D., Chen, C., Miyazaki, H., Nukina, N., Oyama, F., Ranscht, B., Isom, L.L.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA.
  
  Volume: 107 Pages: 2283-2288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500329
[Journal Article] Inhibition of rho-kinases enhances the degradation of mutant huntingtin.2009
- Author(s)
  Bauer P.O., Wong HK., Oyama F., Goswami A., Okuno M., Kino Y., Miyazaki H., Nukina N.
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 13153-13164
- Data Source
  KAKENHI-PROJECT-20500329
[Journal Article] Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy.2009
- Author(s)
  Remme C.A., Scicluna B.S., Verkerk A.O., Amin A.S., Van Brunschot S., Beekman L., Deneer V.H.M., Chevalier C., Oyama F., Miyazaki H., Nukina N., Wilders R., Escande D., Houlgatte R., Wilde A.A.M., Tan H.L., Veldkamp M.W., de Bakker J.M.T., Bezzina C.R.
- Journal Title
  
  Circulation Res. 104
  
  Pages: 1283-1292
- Data Source
  KAKENHI-PROJECT-20500329
[Journal Article] A functional null mutation of SCN1B in a patient with Dravet syndrome.2009
- Author(s)
  Patino G.A., Claes L.R., Lopez-Santiago L.F., Slat E.A., Dondeti R.S., Chen C., O'Malley H.A., Gray C.B., Miyazaki H., Nukina N., Oyama F., De Jonghe P., Isom L.L.
- Journal Title
  
  J.Neurosci. 29
  
  Pages: 10764-10778
- Data Source
  KAKENHI-PROJECT-20500329
[Journal Article] Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.2008
- Author(s)
  Kaminosono S., Saito T., Oyama F., Ohshima T., Asada A., Nagai Y., Nukina N., Hisanaga S.
- Journal Title
  
  J.Neurosci. 28
  
  Pages: 8747-8755
- Data Source
  KAKENHI-PROJECT-20500329
[Journal Article] Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor.2008
- Author(s)
  Yamanaka T., Miyazaki H., Oyama F., Kurosawa M., Washizu C., Doi H., Nukina N.
- Journal Title
  
  EMBO J. 27
  
  Pages: 827-839
- Data Source
  KAKENHI-PROJECT-20500329
[Journal Article] Floxed allele for conditional inactivation of the voltage-gated sodium channel β1 subunit Scnlb.2007
- Author(s)
  Chen, C., Dickendesher, T. L., Oyama, F., Miyazaki, H., Nukina, N., Isom, L. L.
- Journal Title
  
  Genesis. 45
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Journal Article] N. : BACEI modulates filopodia-like protrusions induced by sodium channel β4 subunit.2007
- Author(s)
  Miyazaki, H., Oyama, F., Wong, HK., Sakurai, T., Tamaoka, A., Nukina
- Journal Title
  
  Biochem. Biophys. Res. Commun. 361
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Journal Article] Sodium channel beta4 subunit : down-regulation and possible involvement in neuritic degeneration in Huntington's disease transgenic mice2006
- Author(s)
  Oyama et al.
- Journal Title
  
  Journal of Neurochemistry 98
  
  Pages: 518-529
- Data Source
  KAKENHI-PROJECT-18500284
[Journal Article] N. : Sodium channel β4 : downregulated expression and possible involvement of neuritic degeneration in Huntington Disease transgenic mice.2006
- Author(s)
  Oyama, F., Miyazaki, H., Sakamoto, N., Ikeda, T., Becquet, C., Machida, Y., Kaneko, K., Uchikawa, C., Suzuki, T., Kurosawa M., Tamaoka, A., Sakurai, T., Nukina
- Journal Title
  
  J. Neurochem. 98
  
  Pages: 519-529
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Journal Article] N. : rAAV-mediated shRNA reversed neuropathology in HD model mouse.2006
- Author(s)
  Machida, Y., Okada, T., Kurosawa, M., Oyama, F., Ozawa, K., Nukina
- Journal Title
  
  Biochem. Biophys. Res. Commun. 343
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Journal Article] Sodium channel beta4 subunit : down-regulation and possible involvement in neuritic degeneration in Huntington's disease transgenic mice2006
- Author(s)
  Oyama, et. al.
- Journal Title
  
  Journal of Neurochemistry 98
  
  Pages: 518-529
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500284
[Journal Article] Gem GTPase and tau : morphological changes induced by Gem GTPase in CHO cells are antagonized by tau.2004
- Author(s)
  Oyama F, Kotliarova S, Harada A, Ito M, Miyazaki H, Ueyama Y, Hirokawa N, Nukina N, Ihara Y
- Journal Title
  
  J Biol Chem 279
  
  Pages: 27272-27277
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210005
[Journal Article] Gem GTPase and tau : morphological changes induced by gem GTPase in cho cells are antagonized by tau.2004
- Author(s)
  Oyama F, et al.
- Journal Title
  
  J Biol Chem 279・26
  
  Pages: 27272-27277
- Data Source
  KAKENHI-PROJECT-12210005
[Journal Article] Gem GTPase and tau : morphological changes induced by Gem GTPase in CHO cells are antagonized by tau.2004
- Author(s)
  Oyama F, et al.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 27272-27277
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210005
[Journal Article] Mutant-presenilin 2-transgenic mice : A large increase in the levels of Aβ42 is presumably associated with the low-density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin.2000
- Author(s)
  Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Ito M, Oyama F, Ando S, Ihara Y
- Journal Title
  
  J Biol Chem 275
  
  Pages: 27901-27908
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210005
[Presentation] ブタ酸性キチナーゼは，消化器系プロテアーゼに耐性で，キチン分解酵素として機能する2019
- Author(s)
  小山文隆、樫村昭徳、脇田悟誌、菅原康里、田畑絵理
- Organizer
  日本農芸化学会2019年度(H31年度)大会
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] Gene expression analysis of chitinases in crab-eating monkey: species-specific expression of acidic mammalian chitinase and chitotriosidase2018
- Author(s)
  Uehara, M., Tabata, E., Ohno, M., Sakaguchi, M., Oyama, F.
- Organizer
  14th International Chitin and Chitosan Conference (14th ICCC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] Acidic chitinase mRNA levels and their chitinolytic activity are affected by the feeding behavior, which may determine chitin digestibility in animals2018
- Author(s)
  Tabata, E., Kashimura, A., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Oyama, F.
- Organizer
  14th International Chitin and Chitosan Conference (14th ICCC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] Acidic mammalian chitinase is a major chitinase in stomach resistant to pepsin and trypsin/chymotrypsin digestion2018
- Author(s)
  Oyama, F., Kimura, M., Okawa, K., Onuki, R., Nemoto, C., Tabata, E., Wakita, S., Kashimura, A., Sakaguchi, M., Sugahara, Y., Ohno, M.
- Organizer
  14th International Chitin and Chitosan Conference (14th ICCC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] Gene expression analysis of mammalian chitinases in common marmoset (Callithrix jacchus) tissue.2018
- Author(s)
  Tabata, E., Kashimura, A., Uehara, M. Wakita, S., Sakaguchi, M., Sugahara, Y., Yurimoto, T., Sasaki, E., Oyama, F.
- Organizer
  The 67th Annual Meeting of the American Society of Human Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] Feeding behaviors determine acidic chitinase mRNA levels in mammalian and poultry stomachs.2018
- Author(s)
  Oyama, F., Kashimura, A., Kikuchi, A., Masuda, H., Miyahara, R., Hiruma, Y., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Tabata, E.
- Organizer
  The 67th Annual Meeting of the American Society of Human Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] ヒト酸性ほ乳類キチナーゼの nonsynonymous SNPs による活性の調節2018
- Author(s)
  小山文隆，大野美紗，樫村昭徳，木村将大，坂口政吉，菅原康里，大川一明
- Organizer
  日本農芸化学会2018年度大会[名古屋]
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] Quantification of chitinases mRNA levels by qPCR in crab-eating monkey tissues: Comparison with mouse and human2018
- Author(s)
  Uehara, M., Tabata, E., Ohno, M., Sakaguchi, M., Oyama, F.
- Organizer
  The 67th Annual Meeting of the American Society of Human Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] ニワトリ酸性キチナーゼの消化酵素としての機能解析2018
- Author(s)
  田畑絵理，樫村昭德，脇田悟誌，大野美紗，坂口政吉，菅原康里，小山文隆
- Organizer
  日本農芸化学会2018年度大会[名古屋]
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] 2種類のマウスほ乳類キチナーゼのキチナーゼ活性比較2018
- Author(s)
  木村将大，梅山隆敏，脇田悟誌，大川一明，坂口政吉，小山文隆
- Organizer
  日本農芸化学会2018年度大会[名古屋]
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] Mechanistic insight of inactivation of mouse chitinase-like protein Ym12017
- Author(s)
  Oyama, F., Sakaguchi, M., Sugahara, Y., Okawa, K.
- Organizer
  The 67th Annual Meeting of the American Society of Human Genetics (ASHG) (Orlando)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] ヒト酸性ほ乳類キチナーゼの活性喪失とその活性化2017
- Author(s)
  小山文隆
- Organizer
  第6回医薬工3大学包括連携推進シンポジウム　特別講演（東京薬科大学）
- Invited
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] キチンオリゴ糖蛍光標識法を用いた酸性ほ乳類キチナーゼの特性解析2017
- Author(s)
  脇田悟誌，木村将大, 樫村明徳, 坂口政吉, 菅原康里, 小山文隆
- Organizer
  第31回日本キチン・キトサン学会大会
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] Chitinases mRNA levels quantified by qPCR in crab-eating monkey tissues.2017
- Author(s)
  Kimura, M., Umeyama, T., Wakita, S., Okawa, K., Sakaguchi, M., Oyama, F.
- Organizer
  The 67th Annual Meeting of the American Society of Human Genetics (ASHG) (Orlando)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] Gene expression analysis and enzyme function of pig mammalian chitinase2017
- Author(s)
  Tabata, E., Kashimura, A., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Oyama, F.
- Organizer
  The 67th Annual Meeting of the American Society of Human Genetics (ASHG) (Orlando)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] ニワトリ酸性キチナーゼの遺伝子発現解析とその酵素機能2017
- Author(s)
  田畑絵理，樫村昭徳，脇田悟志，大野美紗，菅原康里，坂口政吉，小山文隆
- Organizer
  第31回日本キチン・キトサン学会大会
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] カニクイザルにおけるキチナーゼ遺伝子の発現解析2017
- Author(s)
  上原麻衣子，田畑絵里，大野美紗，坂口政吉，小山文隆
- Organizer
  第31回日本キチン・キトサン学会大会
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] ヒト酸性ほ乳類キチナーゼの進化学的解析2017
- Author(s)
  小山文隆，大野美紗，樫村昭徳，木村将大，坂口政吉，菅原康里，大川一明
- Organizer
  第31回日本キチン・キトサン学会大会
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] マウスほ乳類キチナーゼの比較解析2017
- Author(s)
  木村将大, 梅山隆敏, 脇田悟誌, 大川一明, 坂口政吉, 小山文隆
- Organizer
  第31回日本キチン・キトサン学会大会
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] ニワトリ組織におけるキチナーゼ遺伝子発現レベルとその酵素学的機能の解析2017
- Author(s)
  田畑絵理，樫村昭德，大野美紗，坂口政吉，小山文隆
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都市
- Year and Date
  2017-03-18
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] マウス胃における酸性ほ乳類キチナーゼの発現と生産細胞の同定2016
- Author(s)
  小山文隆，大野美紗，木村将大，大川一明，田畑絵理，脇田悟誌，樫村昭徳，坂口政吉，菅原康里
- Organizer
  第30回日本キチン・キトサン学会大会
- Place of Presentation
  川越市
- Year and Date
  2016-08-19
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] Inactivation of mouse AMCase by introducing amino acid substitutions encoded by single-nucleotide polymorphisms in human AMCase gene.2016
- Author(s)
  Oyama, F., Okawa, K., Ohno, M., Kashimura, A. Kobayashi, Y. Sakaguchi, M., Sugahara, Y.
- Organizer
  The 66th Annual Meeting of the American Society of Human Genetics (ASHG)
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2016-10-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] Gene expression analysis of mammalian chitinase transcripts in pig tissues.2016
- Author(s)
  Tabata, E., Ohno, M., Sakaguchi, M., Oyama, F.
- Organizer
  The 66th Annual Meeting of the American Society of Human Genetics (ASHG)
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2016-10-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] ブタ組織におけるキチナーゼ遺伝子発現レベルの解析2016
- Author(s)
  田畑絵理，大野美紗，坂口政吉，小山文隆
- Organizer
  第30回日本キチン・キトサン学会大会
- Place of Presentation
  川越市
- Year and Date
  2016-08-18
- Data Source
  KAKENHI-PROJECT-16K07699
[Presentation] Correlation of nuclear accumulation of expanded polyglutamine and dysregulation of sodium channel beta4 subunit in Huntington disease transgenic mice2009
- Author(s)
  F.Oyama, H. Miyazaki, M. Yamada, M. Kurosawa, Y. Kino, N. Nukina
- Organizer
  The 59th Annual Meeting of the American Society of Human Genetics
- Place of Presentation
  アメリカ合衆国、ハワイ州ホノルル市
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20500329
[Presentation] ポリグルタミン病の治療ターゲット探索のためのトランスジェニックマウスの開発・解析に関する研究厚生労働科学研究費補助金運動失調症に関する調査研究2009
- Author(s)
  小山文隆、宮崎晴子、山田みず樹、黒沢大、貫名信行
- Organizer
  平成20年度班会議
- Place of Presentation
  東京
- Year and Date
  2009-01-16
- Data Source
  KAKENHI-PROJECT-20500329
[Presentation] Correlation of nuclear accumulation of expanded polyglutamine and dysregulation of sodium channel beta4 subunit in Huntington disease transgenic mice2009
- Author(s)
  Oyama, et al.
- Organizer
  The 54th Annual Meeting of The American Society of Human Genetics
- Place of Presentation
  Honolulu, Hawai, USA
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20500329
[Presentation] Downregulation of sodium channel β4 subunit in Huntington Disease transgenic mice2008
- Author(s)
  Oyama, et al.
- Organizer
  The 58th Annual Meeting of The American Society of Human Genetics
- Place of Presentation
  Philadelphia, Pennsylvalnia, USA
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-20500329
[Presentation] Downregulation of sodium channel β4 in Huntington Disease transgenic mice.2008
- Author(s)
  小山文隆、宮崎晴子、黒沢大、山田みず樹、貫名信行
- Organizer
  第31回日本神経科学大会、第31回大会
- Year and Date
  2008-07-16
- Data Source
  KAKENHI-PROJECT-20500329
[Presentation] Downregulation of sodium channel β4 subunit in Huntington Disease transgenic mice.2008
- Author(s)
  F.Oyama, H. Miyazaki, M. Kurosawa, M. Yamada, N. Nukina
- Organizer
  The 58th Annual Meeting of The American Society of Human Genetics
- Place of Presentation
  アメリカ合衆国ペンシルバニア州フィラデルフィア市
- Year and Date
  2008-11-12
- Data Source
  KAKENHI-PROJECT-20500329
[Presentation] ハンチントン病トランスジェニックマウスにおけるナトリウムチャネルβ4サブユニットの発現抑制2008
- Author(s)
  小山文隆, 他
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20500329
[Presentation] ハンチントン病モデルマウスにおけるナトリウムチャネルβ4サブユニットの発現抑制2007
- Author(s)
  小山文隆, 他
- Organizer
  第30回日本神経科学学会
- Place of Presentation
  横浜市
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-18500284
[Presentation] BACE1 cleavage mediates neurite morphology induced by sodium channel β4 subunit.2007
- Author(s)
  宮崎晴子、小山文隆、Hon-Kit Wong、金子貢巳、櫻井隆、玉岡晃、貫名信行
- Organizer
  日本神経科学大会、第30回大会
- Place of Presentation
  横浜市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Presentation] Dysregulation of β4 Gene Transcription in the Striatum of Huntington Disease Transgenic Mice2007
- Author(s)
  Fumitaka Oyama, et. al.
- Organizer
  The 57th Annual Meeting of The American Society of Human Genetics
- Place of Presentation
  San Diego,California,
- Data Source
  KAKENHI-PROJECT-18500284
[Presentation] BACE1 cleavage mediates neurite morphology induced by sodium channel β4 subunit.2007
- Author(s)
  H. Miyazaki, F. Oyama. Hon-Kit Wong, K. Kaneko, T. Sakurai, A. Tamaoka, N. Nukina
- Organizer
  The 30th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Presentation] Dysregulation of β4 Gene Transcription in the Striatum of Huntington Disease Transgenic Mice2007
- Author(s)
  Fumitaka Oyama, et. al.
- Organizer
  The 57th Annual Meeting of The American Society of Human Genetics
- Place of Presentation
  San Diego, California, USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Presentation] Dysregulation of sodium channel β4 expression in the striatum of Huntington Disease transgenic mice.2007
- Author(s)
  F. Oyama, H. Miyazaki, M. Kurosawa, Takeshi Kaneko, Nobuyuki Nukina
- Organizer
  The 57th Annual Meeting of The American Society of Human Genetics
- Place of Presentation
  San Diego, California
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Presentation] Dysregulation of β4 gene transcription in the striatum of Huntington Disease transgenic mice.2007
- Author(s)
  小山文隆、宮崎晴子、黒沢大、玉岡晃、金子武嗣、貫名信行
- Organizer
  日本神経科学大会、第30回大会、
- Place of Presentation
  横浜市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Presentation] Dysregulation of β4 gene transcription in the striatum of Huntington Disease transgenic mice.2007
- Author(s)
  F. Oyama, H. Miyazaki, M. Kurosawa, A. Tamaoka, Takeshi Kaneko, Nobuyuki Nukina
- Organizer
  The 30th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Presentation] Dysregulation of Sodium Channel β4 Subunit by Expanded Polyglutamine.2006
- Author(s)
  F. Oyama, H. Miyazaki, K. Okamura, Y. Machida, M. Kurosawa, T. Sakurai, N. Nukina
- Organizer
  The 56th Annual Meeting of The American Society of Huamn Genetics
- Place of Presentation
  New Orleans, Louisiana
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Presentation] Dysregulation of Sodium Channel β4 Subunit by Expanded Polyglutamine in Huntington Disease Transgenic Mice2006
- Author(s)
  小山文隆、宮崎晴子、岡村和政、町田陽子、黒沢大、櫻井隆、貫名信行
- Organizer
  日本神経科学大会、第29回大会
- Place of Presentation
  京都市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Presentation] Dysregulation of Sodium Channel β4 Subunit by Expanded Polyglutamine,2006
- Author(s)
  Fumitaka Oyama, et. al.
- Organizer
  The 56th Annual Meeting of The American Society of Human Genetics
- Place of Presentation
  New Orleans, Louisiana, USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500284
[Presentation] Dysregulation of Sodium Channel β4 Subunit by Expanded Polyglutamine in Huntington Disease Transgenic Mice.2006
- Author(s)
  F. Oyama, H. Miyazaki, K. Okamura, Y. Machida, M. Kurosawa, T. Sakurai, N. Nukina
- Organizer
  The 29th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500284

1. IHARA Yasuo (60114386)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
2. SEKIGUCHI Kiyotoshi (50187845)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. TITANI Koiti (60179942)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MORISHIMA Maho (50204722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. FUNAMOTO Satoru (10345043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MIYASAKA Tomohiro (90342857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ITO Mamoru (00176364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. FUJITA Shinobu (30092323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FUJIMURA Yoshihiro (80118033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MATSUI Taei (90183946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MIZUOCHI Tsuguo (90133149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 広橋説雄 (70129625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 坂元亨宇 (40221270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 嶋田裕之 (60113487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 辻省次 (70150612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大木操 (00158792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 田平武 (80112332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 吉川和明 (30094452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 榊佳之 (10112327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 三木哲郎 (00174003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 宮武正 (50048998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 元永耕三 (20345044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 山崎恒夫 (80200658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 岡澤均 (50261996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 原田彰広 (40251441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 前田利長

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KINO Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 上田均

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oyama Fumitaka 小山 文隆

OYAMA Fumitaka 小山 文隆

Research Projects

Research Products

Co-Researchers

Is acidic mammalian chitinase a major glycosidase in the stomachs of mouse and porcine?Principal Investigator

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Downregulation of sodium channel β4 subunit in Huntington Disease transgenic micePrincipal Investigator

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Pathological roles of sodium channel β4 subunit in Huntington disease transgenic micePrincipal Investigator

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Identification of novel genes closely related to Alzheimer's diseasePrincipal Investigator

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Hyperphosphorylation and aggregation of tau protein, and neuronal death

Principal Investigator

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Review Section

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Studies on the tau lysosomal proteolytic pathwayPrincipal Investigator

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Studies on the tau lysosomal proteolytic pathwayPrincipal Investigator

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アルツハイマー病原因遺伝子のヒト組織における発現制御Principal Investigator

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クロロキンミオパチーにおける細胞死の研究Principal Investigator

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ダウン症候群患者脳におけるアルツハイマー病関連遺伝子の発現制御Principal Investigator

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APPとタウ遺伝子のダウン症候群患者脳における発現制御Principal Investigator

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アルツハイマー病の分子遺伝学的研究

Principal Investigator

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ヒト癌における組織特異的alternative splicingの脱制御の検証

Principal Investigator

Project Period (FY)

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Research Institution

Oyama Fumitaka 小山文隆

OYAMA Fumitaka 小山文隆