UHARA HISASHI 宇原久

… Alternative Names

UHARA Hisashi 宇原久

宇原久ウハラヒサシ

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Researcher Number	40201355
Other IDs
Affiliation (Current)	2025: 札幌医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2025: 札幌医科大学, 医学部, 教授 2014 – 2015: 信州大学, 学術研究院医学系, 准教授 2013: 信州大学, 医学部, 准教授 2004 – 2006: 信州大学, 医学部附属病院, 講師 2003: 信州大学, 医学部, 講師 … More 1998: 信州大学, 医学部附属病院皮膚科, 講師 1997: 信州大学, 医学部附属病院・皮膚科, 講師 1995: 信州大学, 医学部・皮膚科, 講師 1994: 信州大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related / Dermatology / Dermatology Except Principal Investigator Dermatology / Basic Section 53050:Dermatology-related
Keywords	Principal Investigator メラノーマ / 悪性黒色腫 / リキッドバイオプシー / 遺伝子 / 皮膚腫瘍 / 遺伝子パネル / ctDNA / 個別化医療 / デジタルPCR / 免疫チェックポイント … More / シングルセルRNA-Seq / MAPK / MAPK経路 / 次世代シークエンス / バーコード / シングルセルシークエンス / ＭＡＰＫ / BRAF / RNA / Circulating marker / mRNA / MART-1 / モニタリング / 血液循環腫瘍RNA / PPAR / サイトカイン / 痤瘡様皮疹 / 皮疹 / ゲフィチニブ / NFκB / エルロチニブ / COX-2 / NFkappaB / PPARγ / SEB-1 / 脂腺細胞 / ざ瘡様皮疹 / EGFR阻害剤 / melanoma / Comparative genomic hybridization(CGH) / HSH法 / CGH法 / モノクローナリティ / アンドロゲル受容体遺伝子 / X染色体不活化 / スプライシング / エラスチン遺伝子 … More Except Principal Investigator メラノーマ / 循環腫瘍細胞 / コピー数多型 / ドライバー変異 / 構造多型 / cationic liposome / interferon beta / gene therapy / malignant melanoma / 免疫遺伝子治療 / 臨床研究 / 正電荷リポソーム / インターフェロンβ遺伝子 / 遺伝子治療 / 悪性黒色腫 / circulating tumor DNA / バイオマーカー / NRAS / BRAF / ctDNA Less

メラノーマ患者の末梢血中からの個別化変異遺伝子の検出によるモニタリング法の確立Principal Investigator
- Principal Investigator
  
  宇原久
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Sapporo Medical University
Preemptive medicine for Japanese melanoma through comprehensive analysis of tumor genome and circulating tumor cells
- Principal Investigator
  
  肥田時征
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Sapporo Medical University
メラノーマにおける複数の変異遺伝子を候補とした個別化リキッドバイオプシー法の確立Principal Investigator
- Principal Investigator
  
  宇原久
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Sapporo Medical University
Characterization of the intratumoral ecosystem in melanoma by single-cell RNA-seq analysisPrincipal Investigator
- Principal Investigator
  
  UHARA HISASHI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Sapporo Medical University
Establishment of monitoring by circulating tumour RNA in patients with metastatic melanomaPrincipal Investigator
- Principal Investigator
  
  UHARA Hisashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Sapporo Medical University
Gene analysis in melanoma patients using circulating tumor DNA
- Principal Investigator
  
  ASHIDA Atsuko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Shinshu University
the pathogenic mechanisms of EGFR inhibitor-induced rash and establishment of system for constructing medical treatmentPrincipal Investigator
- Principal Investigator
  
  UHARA Hisashi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Shinshu University
Phase I/IIa clinical trial of gene therapy for advanced melanoma using cationic liposomes containing interferon beta gene
- Principal Investigator
  
  SAIDA Toshiaki
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Shinshu University
CGH法による悪性黒色腫の早期病変における遺伝子変化の検索Principal Investigator
- Principal Investigator
  
  宇原久
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  Shinshu University
X染色体不活化の検出による皮膚前癌病変におけるクローナリティに関する研究Principal Investigator
- Principal Investigator
  
  宇原久
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  Shinshu University
各種皮膚疾患におけるエラスチンm-RNAのスプライシングの違いに関する研究Principal Investigator
- Principal Investigator
  
  宇原久
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  Shinshu University

All 2018 2017 2016 2015 2013 2004

All Journal Article Presentation Book

[Book] カレントテラピー「メラノーマ基礎から最新薬物療法まで」2016
- Author(s)
  芦田敦子、木庭幸子、宇原久
- Total Pages
  90
- Publisher
  ライフメディコム
- Data Source
  KAKENHI-PROJECT-26461687
[Book] メラノーマー基礎から最新薬物治療までー　分子異常2016
- Author(s)
  芦田敦子、木庭幸子、宇原久
- Publisher
  カレントテラピー
- Data Source
  KAKENHI-PROJECT-26461687
[Book] 家族性腫瘍ー家族性腫瘍の最新研究動向ーFamilial atypical multiple mole melanoma syndrome2015
- Author(s)
  芦田敦子、宇原久
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-26461687
[Book] Derma メラノーマ最新情報「日本人におけるMAPK系の遺伝子変異率と遺伝子検査の実際」2015
- Author(s)
  芦田敦子、宇原久
- Total Pages
  76
- Publisher
  全日本病院出版会
- Data Source
  KAKENHI-PROJECT-26461687
[Book] 家族性腫瘍2015
- Author(s)
  芦田敦子、宇原久
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-26461687
[Journal Article] Recent advances in therapeutic strategies for unresectable or metastatic melanoma and real-world data in Japan2018
- Author(s)
  Uhara H
- Journal Title
  
  Int J Clin Oncol
  
  Volume: Electronic Issue: 12 Pages: 1508-1514
- DOI
  10.1007/s10147-018-1246-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10150
[Journal Article] Circulating Tumour DNA for Monitoring Treatment Response to Anti-PD-1 Immunotherapy in Melanoma Patients2017
- Author(s)
  Ashida A、Sakaizawa K、Uhara H、Okuyama R
- Journal Title
  
  Acta Dermato Venereologica
  
  Volume: 97 Issue: 10 Pages: 1212-1218
- DOI
  10.2340/00015555-2748
- NAID
  120007100119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10150, KAKENHI-PROJECT-17H04240
[Journal Article] Detection of BRAFV600K mutant tumor-derived DNA in the pleural effusion from a patient with metastatic melanoma2017
- Author(s)
  Sakaizawa K, Ashida A, Uhara H, Okuyama R.
- Journal Title
  
  Clin Chem Lab Med
  
  Volume: 55 Issue: 4 Pages: 92-95
- DOI
  10.1515/cclm-2016-0634
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461686, KAKENHI-PROJECT-26461687, KAKENHI-PROJECT-15K19685, KAKENHI-PROJECT-16K10150, KAKENHI-PROJECT-17H04240
[Journal Article] Quantitative analysis of the BRAF <sup>V600E</sup> mutation in circulating tumor-derived DNA in melanoma patients using competitive allele-specific TaqMan PCR.2016
- Author(s)
  Ashida A, Sakaizawa K, Mikoshiba A, Uhara H, Okuyama R.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 21 Issue: 10 Pages: 981-988
- DOI
  10.1111/1346-8138.13367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10150
[Journal Article] Inhibition of epidermal growth factor receptor sinduces tumor necrosis factor-a via activation of peroxisome proliferator-activated receptor-g and nuclear factor-kB in sebocytes: A possible pathogenesis of papulopustular rash2016
- Author(s)
  Atsuko Ashida, Eisaku Ogawa,, Hisashi Uhara, Tomonobu Koizumi, Ryuhei Okuyama
- Journal Title
  
  J Dermatol Sci
  
  Volume: 82 Issue: 1 Pages: 53-56
- DOI
  10.1016/j.jdermsci.2015.12.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461687, KAKENHI-PROJECT-25461666
[Journal Article] Melanoma with BRAF Mutation in Circulating Cell-free DNA despite no Mutation in the Primary Lesion: A Case Report2016
- Author(s)
  Atsuko Ashida, Hisashi Uhara, Asuka Mikoshiba, Kaori Sakaizawa, Naomi Kumagai, Hiroshi Koga and Ryuhei Okuyama
- Journal Title
  
  Acta Derm Venereol
  
  Volume: 96 Issue: 1 Pages: 128-129
- DOI
  10.2340/00015555-2194
- NAID
  120007100151
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461687, KAKENHI-PROJECT-16K10150
[Journal Article] Quantitative analysis of the BRAFV600E mutation in circulating tumor-derived DNA using competitive allele-specific TaqMan PCR in melanoma patients2016
- Author(s)
  Ashida A, Sakaizawa K, Mikoshiba A, Uhara H, Okuyama R
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 21 Issue: 5 Pages: 981-988
- DOI
  10.1007/s10147-016-0976-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461686, KAKENHI-PROJECT-26461687
[Journal Article] Clinical characteristics associated with BRAF, NRAS and KIT mutations in Japanese melanoma patients.2015
- Author(s)
  Sakaizawa K, Ashida A, Uchiyama A, Ito T, Fujisawa Y, Ogata D, Matsushita S, Fujii K, Fukushima S, Shibayama Y, Hatta N, Takenouchi T, Uehara J, Okuyama R, Yamazaki N, Uhara H.
- Journal Title
  
  J Dermatol Sci.
  
  Volume: 80 Issue: 1 Pages: 33-37
- DOI
  10.1016/j.jdermsci.2015.07.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09772, KAKENHI-PROJECT-26461686, KAKENHI-PROJECT-26461687, KAKENHI-PROJECT-15K19685, KAKENHI-PROJECT-25461703
[Journal Article] Histopathological improvement of scleroderma induced by paclitaxel in a patient with breast cancer2015
- Author(s)
  Ohashi A, Minagawa A, Ashida A, Koga H, Uhara H, Okuyama R
- Journal Title
  
  J Dermatol
  
  Volume: 42 Issue: 12 Pages: 1198-1199
- DOI
  10.1111/1346-8138.13085
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461686, KAKENHI-PROJECT-26461687
[Journal Article] NRAS mutations in primary and metastatic melanomas of Japanese patients2013
- Author(s)
  Uhara H, Ashida A, Koga H, Uchiyama A, Uchiyama R, Hayashi K, Kiniwa Y, Okuyama R
- Journal Title
  
  Int J Clin Oncol
  
  Volume: - Issue: 3 Pages: 544-548
- DOI
  10.1007/s10147-013-0573-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591616, KAKENHI-PROJECT-26461686, KAKENHI-PROJECT-26461687
[Journal Article] Number of acquired melanocytic nevi in Japanese melanoma patients and control subjects2004
- Author(s)
  Rokuhara S, Saida T, et al.
- Journal Title
  
  J Am Acad Dermatol 50
  
  Pages: 695-700
- Data Source
  KAKENHI-PROJECT-15390340
[Presentation] 皮膚がん治療のこれから2017
- Author(s)
  宇原　久
- Organizer
  409回日本皮膚科学会北海道地方会
- Place of Presentation
  札幌医科大学記念ホール(北海道札幌市)
- Invited
- Data Source
  KAKENHI-PROJECT-16K10150
[Presentation] 末梢血中の腫瘍由来DNAを用いた悪性黒色腫に対するニボルマブ治療効果の評価2017
- Author(s)
  芦田敦子、境澤香里、宇原久、奥山隆平
- Organizer
  第193回日本皮膚科学会信州地方会
- Place of Presentation
  松本市（信州大学）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-26461687
[Presentation] 血液循環腫瘍DNAよりBRAF変異を検出した進行期悪性黒色腫症例2016
- Author(s)
  芦田敦子、御子柴飛鳥、境澤香里、古賀弘志、熊谷尚美、宇原久、奥山隆平
- Organizer
  第115回日本皮膚科学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-26461687
[Presentation] 胸水中のcell-free DNAよりBRAFV600Kを検出できた進行期悪性黒色腫の１例2016
- Author(s)
  境澤香里、芦田敦子、宇原久、奥山隆平
- Organizer
  80回日本皮膚科学会東部支部学術大会
- Place of Presentation
  アクトシティ浜松(静岡県浜松市)
- Year and Date
  2016-10-29
- Data Source
  KAKENHI-PROJECT-16K10150
[Presentation] Quantitative analysis of the BRAFV600E in circulating tumor-drived DNA using competitive allele-specific TaqMan PCR in melanoma patients2016
- Author(s)
  芦田敦子、境澤香里、宇原久、奥山隆平
- Organizer
  第30回表皮細胞研究会
- Place of Presentation
  弘前市（アートホテル弘前シティ）
- Year and Date
  2016-11-12
- Data Source
  KAKENHI-PROJECT-26461687
[Presentation] 胸水中のcell-free DNAよりBRAFV600Kを検出できた進行期悪性黒色腫の１例2016
- Author(s)
  境澤香里、芦田敦子、宇原久、奥山隆平
- Organizer
  第80回日本皮膚科学会東部支部学術大会
- Place of Presentation
  浜松市（アクトシティ浜松）
- Year and Date
  2016-10-29
- Data Source
  KAKENHI-PROJECT-26461687
[Presentation] Quantitative analysis of the BRAFV600E in circulating tumor-drived DNA using competitive allele-specific TaqMan PCR in melanoma patients2016
- Author(s)
  芦田敦子、境澤香里、宇原久、奥山隆平
- Organizer
  30回表皮細胞研究会
- Place of Presentation
  アートホテル弘前シティ(青森県弘前市)
- Data Source
  KAKENHI-PROJECT-16K10150
[Presentation] 血液循環腫瘍DNAよりBRAF変異を検出した進行期悪性黒色腫の１例2016
- Author(s)
  芦田敦子、御子柴飛鳥、境澤香里、古賀弘志、熊谷尚美、宇原久、奥山隆平
- Organizer
  第115回日本皮膚科学会学術総会
- Place of Presentation
  京都市（国立京都国際会館）
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-26461687
[Presentation] Evaluation of response to nivolumab treatment in patients with metastatic melanoma using circulating tumor DNA2016
- Author(s)
  芦田敦子、境澤香里、宇原久、奥山隆平
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜市（パシフィコ横浜）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-26461687
[Presentation] Evaluation of response to nivolumab treatment in patients with metastatic melanoma using circulating tumor DNA2016
- Author(s)
  芦田敦子、境澤香里、宇原久、奥山隆平
- Organizer
  75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K10150
[Presentation] 日本人の悪性黒色腫のBRAF, NRAS, KIT変異率と臨床所見2015
- Author(s)
  境澤香里、芦田敦子、伊東孝通、藤澤康弘、緒方大、松下茂人、藤井一恭、福島聡、柴山慶継、八田尚人、竹之内辰也、上原治朗、奥山隆平、山﨑直也、宇原久
- Organizer
  第114回日本皮膚科学会総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-26461687
[Presentation] 皮膚癌の術後出血が診断の契機となった後天性13因子欠乏症の１例2015
- Author(s)
  三宅知美、芦田敦子、宇原久、奥山隆平、福澤正男
- Organizer
  第114回日本皮膚科学会総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-26461687
[Presentation] Epidermal growth factor receptor inhibitor induces tumor necrosis factor-α via activation of the PPARκ and NF-kappa B from sebocytes.2015
- Author(s)
  Atsuko Ashida, Eisaku Ogawa, Ryuhei Uchiyama, Hisashi Uhara, Ryuhei Okuyama
- Organizer
  第40回日本研究皮膚科学会学術大会総会
- Place of Presentation
  岡山コンベンションセンター（岡山県岡山市）
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-25461666
[Presentation] Epidermal growth factor receptor inhibitor induces tumor necrosis factor-alpha; via activation of the PPARgamma; and NF-kB from sebocytes2015
- Author(s)
  Atsuko Ashida, Eisaku Ogawa, Ryuhei Uchiyama, Hisashi Uhara, Ryuhei Okuyama
- Organizer
  第40回日本研究皮膚科学会学術大会総会
- Place of Presentation
  岡山コンベンションセンター（岡山市）
- Year and Date
  2015-12-08
- Data Source
  KAKENHI-PROJECT-26461687
[Presentation] Analysis of EGF receptor(EGFR) inhibitor-induced inflammation in sebaceous cells2013
- Author(s)
  芦田敦子、木庭幸子、高沢裕子、内山龍平、宇原久、小川英作、奥山隆平
- Organizer
  第4回最新医療研究会
- Place of Presentation
  松本市
- Data Source
  KAKENHI-PROJECT-25461666

1. ASHIDA Atsuko (00596786)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
2. OKUYAMA Ryuhei (80292332)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
3. SAIDA Toshiaki (10010381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. MATSUMOTO Kazuhiko (40165882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KUBO Hitomi (60234481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 肥田時征 (90464487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 井戸川雅史 (00404749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUKUSHIMA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

UHARA HISASHI 宇原 久

UHARA Hisashi 宇原 久

宇原 久 ウハラ ヒサシ

Research Projects

Research Products

Co-Researchers

メラノーマ患者の末梢血中からの個別化変異遺伝子の検出によるモニタリング法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Preemptive medicine for Japanese melanoma through comprehensive analysis of tumor genome and circulating tumor cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

メラノーマにおける複数の変異遺伝子を候補とした個別化リキッドバイオプシー法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of the intratumoral ecosystem in melanoma by single-cell RNA-seq analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of monitoring by circulating tumour RNA in patients with metastatic melanomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene analysis in melanoma patients using circulating tumor DNA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

the pathogenic mechanisms of EGFR inhibitor-induced rash and establishment of system for constructing medical treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Phase I/IIa clinical trial of gene therapy for advanced melanoma using cationic liposomes containing interferon beta gene

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CGH法による悪性黒色腫の早期病変における遺伝子変化の検索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

X染色体不活化の検出による皮膚前癌病変におけるクローナリティに関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

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各種皮膚疾患におけるエラスチンm-RNAのスプライシングの違いに関する研究Principal Investigator

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[Book] カレントテラピー「メラノーマ基礎から最新薬物療法まで」2016

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[Book] メラノーマー基礎から最新薬物治療までー 分子異常2016

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UHARA HISASHI 宇原久

UHARA Hisashi 宇原久

宇原久ウハラヒサシ

[Book] メラノーマー基礎から最新薬物治療までー　分子異常2016