Hishinuma Akira 菱沼昭

… Alternative Names

HISHINUMA Akira 菱沼昭

菱沼昭ヒシヌマアキラ

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Researcher Number	40201727
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2014 – 2019: 獨協医科大学, 医学部, 教授 2007 – 2009: Dokkyo Medical University, Department Clinical Laboratory Medicine, Associate Professor 1998 – 2006: 獨協医科大学, 医学部, 助教授 1993: 独協医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Laboratory medicine / Laboratory medicine / 内分泌・代謝学 Except Principal Investigator Laboratory medicine / Basic Section 54040:Metabolism and endocrinology-related / Laboratory medicine
Keywords	Principal Investigator サイログロブリン / thyroglobulin / 甲状腺腫 / 小胞体貯蔵病 / 創始者効果 / 遺伝子異常症 / molecular chaperone / missense mutation / goiter / rdwラット … More / 分子シャペロン / ミスセンス変異 / 甲状腺 / 甲状腺癌 / 甲状腺腫瘍 / single nucleotide polymorphism / de novo mutation / founder effect / mutation / haplotype analysis / サイログブリン / SNPs / ハプロタイプ解析 / Endoplasmic Storage Disease / Founder Effect / SNP Analysis / Cretin / BRAF Gene / Thyroid Cancer / Thyroglobulin / Thyroid / RETキメラ遺伝 / 新生児マスクリーニング / 甲状腺ホルモン合成障害 / SNP解析 / クレチン症 / BRAF遺伝子 / quatitative RT-PCR / intracellular transport / cDNA array / misfolding / hereditary hypothyroidism / マクロアレイ法 / 定量的PCR / マイクロアレイ法 / 細胞内輸送 / 先天性甲状腺機能低下症 / 定量的RT-PCR / cDNAアレイ / 細胞内輸送障害 / 先天性甲状腺機能低下 / hypothyroidism / rdw rat / polymorphism / ER storage disease / endoplasmic storage disease / アリル発現頻度 / 腺腫様甲状腺腫 / 先天性甲状腺腫 / 分子シャベロン / 遺伝子解析 / ポリモルフィズム / 甲状腺種 / 発癌機序 / 転移 / 乳頭癌 / 未分化癌 / 濾胞癌 / 免疫染色 / サイログロブリン異常症 / 細胞増殖関連遺伝子 / 遺伝子 / 発癌 / 腫瘍 / トランスクリプトーム / 病理診断 / 甲状腺濾胞癌 / HMGA2 / ノーザンブロット / 癌遺伝子 … More Except Principal Investigator サイログロブリン / 甲状腺癌 / サイログロブリン遺伝子異常症 / T1560 gene / tissue specificity / quantitative reverse transcription-polymerase chain reaction / thyroid / thyroid transcription factor-2 / thyroid dysgenesis / Cretinism / アラニン反復回数 / 遺伝発現 / サブトラクションPCR法 / 定量的PCR法 / マイクロアレイ / cDNAアレイ / TTF-2転写因子 / 甲状腺原基 / 甲状腺形成異状 / T1560遺伝子 / 組織特異性 / 定量的RT-PCR法 / マイクロアレイ法 / 甲状腺 / TTF-2遺伝子 / 甲状腺形成異常 / クレチン症 / AKT阻害剤 / ヨード・トランスポーター / 蛋白質合成阻害剤 / 胃癌細胞 / ナトリウム・ヨード共輸送体 / 放射性ヨード治療 / 胃癌細胞株 / 遺伝子発現誘導 / ナトリウム/ヨード共輸送体 / レチノイン酸 / 胃癌 / レチノイド / ヨードトランスポーター / 分子シャペロン / 小胞体貯蔵病 / 甲状腺腫 / 遺伝子異常症 / アポトーシス / MEK-MAPK経路 / 細胞増殖 / 遺伝子発現 / 定量RT-PCR / 細胞内輸送障害 / びまん性甲状腺腫 / 甲状腺ホルモン合成障害 / サイログロブリン異常症 Less

地域集積性サイログロブリン遺伝子異常症の臨床像解析と甲状腺癌発症機構の解明
- Principal Investigator
  
  中山修一
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kochi University
Reguration mechanism of a new gene HMGA2 in thyroid tumorsPrincipal Investigator
- Principal Investigator
  
  Hishinuma Akira
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Dokkyo Medical University
Induction and Enhancement of Iodide Transporter Expression in Gastric Cancer Cells
- Principal Investigator
  
  KOGAI Takahiko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Dokkyo Medical University
Mechanisms of Goiter Development in Patients with Thyroglobulin Mutations
- Principal Investigator
  
  IEIRI Tamio
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Dokkyo Medical University
Origin of thyroglobulin mutations in Japan studied by haplotype analysisPrincipal Investigator
- Principal Investigator
  
  HISHINUMA Akira
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Dokkyo Medical University
Mechanisms of Thyroid Cancer Development in Patients with Thyroglobulin MutationsPrincipal Investigator
- Principal Investigator
  
  HISHINUMA Akira
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Dokkyo Medical University
Analysis of thyroid transcription factor-2 (TTF-2) gene and cloning of causative genes for Cretinism
- Principal Investigator
  
  IEIRI Tamio
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Dokkyo University School of Medicine
Analysis of endoplasmic stroage disease caused by thyroglobulin gene mutations and elucidation of the mechanisms of intracellular transport of proteinsPrincipal Investigator
- Principal Investigator
  
  HISHINUMA Akira
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Dokkyo University School of Medicine
Analysis of Thyroglobulin Gene in Patients with Congenital Goiter and Elucidation of Molecular MechanismsPrincipal Investigator
- Principal Investigator
  
  HISHINUMA Akira
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Dokkyo University School of Medicine
ヒト培養甲状腺腫瘍細胞株の癌遺伝子発現Principal Investigator
- Principal Investigator
  
  菱沼昭
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Dokkyo Medical University

All 2017 2016 2015 2014 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] 甲状腺疾患診療マニュアル(田上哲也、西川光重、伊藤公一、成瀬光栄編, 小児Basedow病)2009
- Author(s)
  菱沼昭
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-19590569
[Book] 内分泌病理学最近の進歩2008 ホルモンと臨床 2009秋季増刊号(上條桂一編, サイログロブリン遺伝子異常一細胞内輸送異常と甲状腺癌-2009
- Author(s)
  菱沼昭, 家人蒼生夫
- Publisher
  医学の世界社
- Data Source
  KAKENHI-PROJECT-19590569
[Book] 甲状腺疾患診療マニュアル(田上哲也、西川光重、伊藤公一、成瀬光栄編, 先天性甲状腺疾患)2009
- Author(s)
  菱沼昭
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-19590569
[Book] 臨床検査増刊号ホルモンの病態異常と臨床検査 52(ll)(サイログロブリン遺伝子異常と甲状腺腫)2008
- Author(s)
  菱沼昭, 家人蒼生夫
- Total Pages
  1183
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19590569
[Book] Hot Thyroidology(Emerging new features of patients with thyroglobulin mutations, including increased incidence of thyroid cancer.)2007
- Author(s)
  Hishinuma A, Fukata S, Ieiri T.
- Publisher
  European Thyroid Associatlon
- Data Source
  KAKENHI-PROJECT-19590569
[Journal Article] PTEN mutation in a Japanese boy with autonomously functioning thyroid nodule2017
- Author(s)
  Nyuzuki Hiromi、Kogai Takahiko、Hishinuma Akira、Ogawa Yohei、Saitoh Akihiko、Nagasaki Keisuke
- Journal Title
  
  Pediatrics International
  
  Volume: 59 Issue: 11 Pages: 1223-1224
- DOI
  10.1111/ped.13427
- Data Source
  KAKENHI-PROJECT-26460684
[Journal Article] A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter2016
- Author(s)
  Nishihara E, Hishinuma A, Kogai T, Takada N, Hirokawa M, Fukata S, Ito M, Yabuta T, Nishikawa M, Nakamura H, Amino N, Miyauchi A
- Journal Title
  
  Front Endocrinol
  
  Volume: 7 Pages: 131-131
- DOI
  10.3389/fendo.2016.00131
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460684
[Journal Article] Iodide Transport Defect and Breast Milk Iodine2016
- Author(s)
  Mizokami T, Fukata S, Hishinuma A, Kogai T, Hamada K, Maruta T, Higashi K1, Tajiri J
- Journal Title
  
  Eur Thyroid J
  
  Volume: 5 Issue: 2 Pages: 145-148
- DOI
  10.1159/000446496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460684
[Journal Article] DICER1遺伝子に胚細胞性変異を認めた多結節性甲状腺腫の一家系2016
- Author(s)
  深田修司、菱沼昭、小飼貴彦、廣川満良、西原永潤、舛岡裕雄、宮内昭
- Journal Title
  
  日本甲状腺学会雑誌
  
  Volume: 7 Pages: 50-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460684
[Journal Article] Identification of activated protein C as a ghrelin endopeptidase in bovine plasma.2015
- Author(s)
  Satou M, Nishi Y, Hishinuma A, Hosoda H, Kangawa K, Sugimoto H.
- Journal Title
  
  J Endocrinol.
  
  Volume: 224 Issue: 1 Pages: 61-73
- DOI
  10.1530/joe-14-0529
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590358, KAKENHI-PROJECT-25461570, KAKENHI-PROJECT-26460684
[Journal Article] Familial hypocalciuric hypercalcemia with a de novo heterozygous mutation of calcium-sensing receptor.2015
- Author(s)
  Taki K, Kogai T, Sakumoto J, Namatame T, Hishinuma A
- Journal Title
  
  Endocrinol Diabetes Metab Case Rep
  
  Volume: 2015 Pages: 150016-150016
- DOI
  10.1530/edm-15-0016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460684
[Journal Article] Prevalence of thyrotropin receptor germline mutations and clinical courses in 89 hyperthyroid patients with diffuse goiter and negative anti-thyrotropin receptor antibodies.2014
- Author(s)
  Nishihara E, Fukata S, Hishinuma A, Amino N, Miyauchi A
- Journal Title
  
  Thyroid
  
  Volume: 24 Issue: 5 Pages: 789-795
- DOI
  10.1089/thy.2013.0431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460684
[Journal Article] サイログロブリン遺伝子異常-細胞内輸送異常と甲状腺癌-2009
- Author(s)
  菱沼昭, 家入蒼生夫
- Journal Title
  
  ホルモンと臨床秋季増刊号
  
  Pages: 73-79
- Data Source
  KAKENHI-PROJECT-19590569
[Journal Article]2009
- Author(s)
  菱沼昭
- Journal Title
  
  甲状腺疾患診療マニュアル(診断と治療社)
  
  Pages: 82-83
- Data Source
  KAKENHI-PROJECT-19590569
[Journal Article]2009
- Author(s)
  菱沼昭, 家入蒼生夫
- Journal Title
  
  内分泌病理学最近の進歩2008(医学の世界社)
  
  Pages: 73-79
- Data Source
  KAKENHI-PROJECT-19590569
[Journal Article] 家系内に集積したサイログロブリン(Tg)遺伝子異常症2008
- Author(s)
  深田修司, 菱沼昭, 窪田純久, 隈寛二、網野信行, 宮内昭
- Journal Title
  
  日本内分泌学会雑誌 84(Suppl)
  
  Pages: 38-41
- NAID
  10021263018
- Data Source
  KAKENHI-PROJECT-19590569
[Journal Article] A novel homozygous missense mutation of the dual oxidase 2 (DUOX2) gene in an adult patient with large goiter.2008
- Author(s)
  Ohye H, Fukata S, Hishinuma A, Kudo T, Nishihara E, ItoM, Kubota S, Amino N, Ieiri T, Kuma K, Miyauchi A
- Journal Title
  
  Thyroid 10(5)
  
  Pages: 561-566
- Data Source
  KAKENHI-PROJECT-19590569
[Journal Article] 特集臨床検査:現状と展望トピックスII. 各論-実地医家に必要な新しい検査と重要な検査項目- 6. 内分泌・代謝疾患2008
- Author(s)
  家人蒼生夫, 菱沼昭, 竹越一博
- Journal Title
  
  日本内科学会雑誌 97(12)
  
  Pages: 2983-2990
- Data Source
  KAKENHI-PROJECT-19590569
[Journal Article] A NOVEL HOMOZYGOUS MISSENSE MUTATION OF THE DUAL OXIDASE 2(DUOX2) GENE IN AN ADULT PATIENT WITH LARGE GOITER2008
- Author(s)
  Ohye H, Fukata S, Hishinuma A, Kudo T, Nishihara E, Ito M, Kubota S, Amino N, Ieiri T, Kuma K, Miyauchi, A
- Journal Title
  
  Thyroid (in print)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] Endemic goiter due to thyroglobulin gene abnormality and social ostracism2007
- Author(s)
  Fukata S, Hishinuma A, Kuma K, Miyauchi A, Sugawara, M
- Journal Title
  
  Endocrine J 54
  
  Pages: 485-486
- NAID
  130004770048
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] Emerging new features of patients with thyroglobulin mutations, including increased incidence of thyroid cancer2007
- Author(s)
  Hishinuma A, Fukata S, Ieiri, T
- Journal Title
  
  Hot Thyroidology(European Thyroid Association)
  
  Pages: 1-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] Letter to the Editor Endemic goiter due to thyroglobulin gene abnormality and social ostracism.2007
- Author(s)
  Fukata S, Hishinuma A, Kuma K, Miyauchi A, Sugawara M
- Journal Title
  
  Endocrine J. 54(3)
  
  Pages: 485-486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590569
[Journal Article] Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroldal type 2 10dothyronine delodinase activity.2007
- Author(s)
  Kanou Y, Hishinuma A, Tsunekawa K, Seki K, MIzuno Y, Fujisawa H, Imai T, Miura Y, Nagasaka T, Yamada C, Ieiri T, Murakami A, Murata Y.
- Journal Title
  
  J Clin EndocrinoI Metab 92(4)
  
  Pages: 1451-1457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590569
[Journal Article] A Novel Thyrotropin Receptor Germline Mutation(Asp617Tyr) Causing Hereditary Hyperthyroidism2007
- Author(s)
  Nishihara E, Nagayama Y, Amino N, Hishinuma A, Takano T, Yoshida H, Kubota S, Fukata S, Kuma K, Miyauchi, A
- Journal Title
  
  Endocrine J 54
  
  Pages: 927-934
- NAID
  10021263788
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] Emerging new features of patients with thyroglobulin mutations,including increased incidence of thyroid cancer2007
- Author(s)
  Hishinuma, A., et. al.
- Journal Title
  
  Hot Thyroidology 2
  
  Pages: 1-10
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are. associated with increased thyroidal type 2 iodothyronine deiodinase activity2007
- Author(s)
  Kanou Y, Hishinuma A, Tsunekawa K, Seki K, Mizuno Y, Fujisawa H, Imai T, Miura Y, Nagasaka T, Yamada C, Ieiri T, Murakami M, Murata, Y
- Journal Title
  
  J Clin Endocrinol Metab 92
  
  Pages: 1451-1457
- NAID
  120000975200
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] サイログロブリン遺伝子異常症2006
- Author(s)
  深田修司, 菱沼昭
- Journal Title
  
  別冊日本臨床内分泌症候群第2版
- NAID
  10016926011
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels2006
- Author(s)
  Kitanaka S, Takeda A, Sato U, Miki Y, Hishinuma A, Ieiri T, Igarashi, T
- Journal Title
  
  J Hum Genet 51
  
  Pages: 379-382
- NAID
  10017479993
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] サイログロブリン遺伝子異常症2006
- Author(s)
  深田修司、菱沼昭
- Journal Title
  
  別冊日本臨床内分泌症候群第2版
  
  Pages: 363-366
- NAID
  10016926011
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] ヨード有機化障害2006
- Author(s)
  菱沼昭, 他
- Journal Title
  
  別冊日本臨床内分泌症候群第2版
  
  Pages: 360-362
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] Haplotype analysis reveals founder effects of thyroglobulin gene mutations C1058R and C1977S in Japan2006
- Author(s)
  Hishinuma A, Fukata S, Nishiyama S, Nishi Y, Oh-Ishi M, Murata Y, Ohyama Y, Matsuura N, Kasai K, Harada S, Kitanaka S, Takamatsu J, Kiwaki K, Ohye H, Uruno T, Tomoda C, Tajima T, Kuma K, Miyauchi A, Ieiri, T
- Journal Title
  
  J Clin Endocrinol Metab 91
  
  Pages: 3100-3104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] サイログロブリン異常、組胞内輸送障害、癌化2006
- Author(s)
  菱沼昭
- Journal Title
  
  ホルモンと臨床 54
  
  Pages: 711-728
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] Sporadic congenital hyperthyroidism due to a germline mutation in the thyrotropin receptor gene(Leu512G1n) in a Japanese patient2006
- Author(s)
  Nishihara E, Fukata S, Hishinuma A, Kudo T, Ohye H, Ito M, Kubota S, Amino N, Kuma K, Miyauchi, A
- Journal Title
  
  Endocrine J 53
  
  Pages: 735-740
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] サイログロブリン異常、細胞内輸送障害、癌化2006
- Author(s)
  菱沼昭
- Journal Title
  
  ホルモンと臨床 54(8)
  
  Pages: 711-723
- NAID
  10018072101
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] 特集これだけは知りたい甲状腺疾患の臨床検査 6.先天性甲状腺疾患の遺伝子検査 1)サイログロブリン異常症、甲状腺ペルオキシダーゼ異常症2006
- Author(s)
  菱沼昭
- Journal Title
  
  Medical Technology 34(4)
  
  Pages: 375-378
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590462
[Journal Article] 先天性甲状腺疾患の遺伝子検査 1)サイログロブリン異常症、甲状腺ペルオキシダーゼ異常症2006
- Author(s)
  菱沼昭
- Journal Title
  
  Medical Technology 34(4):375-378 34
  
  Pages: 375-378
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] Haplotype analysis reveals founder affects of thyroglobulin gene mutations C1058R and C1977S in Japan2006
- Author(s)
  Hishinuma A. et al.
- Journal Title
  
  J Clin Endocrinol Metab 91(8)
  
  Pages: 3100-3104
- Data Source
  KAKENHI-PROJECT-18590537
[Journal Article] サイログロブリン遺伝子異常症2005
- Author(s)
  菱沼昭
- Journal Title
  
  内分泌・糖尿病科 20(4)
  
  Pages: 419-426
- NAID
  10016926011
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590462
[Journal Article] サイログロブリン遺伝子の異常2005
- Author(s)
  菱沼昭
- Journal Title
  
  臨床内分泌学3-甲状腺・副甲状腺・骨内分泌代謝系-(日本臨床社) 63巻増刊号
  
  Pages: 31-35
- Data Source
  KAKENHI-PROJECT-16590462
[Journal Article] サイログロブリン遺伝子の異常2005
- Author(s)
  菱沼昭, 他
- Journal Title
  
  日本臨床社 63巻増刊号
  
  Pages: 31-35
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590462
[Journal Article] サイログロブリン遺伝子異常症2005
- Author(s)
  菱沼昭
- Journal Title
  
  臨床病理 53(10)
  
  Pages: 935-941
- NAID
  10016926011
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590462
[Journal Article] サイログロブリン遺伝子異常症のupdate2005
- Author(s)
  菱沼昭
- Journal Title
  
  Laboratory and Clinical Practice 23(1)
  
  Pages: 12-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590462
[Journal Article] High Incidence of Thyroid Cancer in Long-standing Goiters with Thyroglobulin Mutations.2005
- Author(s)
  Hishinuma, A., et al.
- Journal Title
  
  Thyroid 15(9)
  
  Pages: 1079-1084
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590462
[Journal Article] High Incidence of Thyroid Cancer in Long-standing Goiters with Tyroglobulin Mutations.2005
- Author(s)
  Hishinuma, A.et al.
- Journal Title
  
  Thyroid 15(9)
  
  Pages: 1079-1084
- Data Source
  KAKENHI-PROJECT-16590462
[Journal Article] TTF-2 stimulates expression of 17 genes, including one novel thyroid-specific gene which might be involved in thyroid development.2004
- Author(s)
  Hishinuma, A., et al.
- Journal Title
  
  Mol Cell Endocrinol 221(1-2):
  
  Pages: 33-46
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590462
[Journal Article] 甲状腺転写因子TTF-2により発現増加する遺伝子群の同定2004
- Author(s)
  菱沼昭, 他
- Journal Title
  
  ホルモンと臨床 52(3)
  
  Pages: 253-260
- NAID
  10012648922
- Data Source
  KAKENHI-PROJECT-16590462
[Journal Article] TTF-2 stimulates expression of 17 genes, including one novel thyroid-specific gene which might be involved in thyroid development2004
- Author(s)
  Hishinuma, A., et al.
- Journal Title
  
  Mol Cell Endocrinol 221(1-2)
  
  Pages: 33-46
- Data Source
  KAKENHI-PROJECT-16590462
[Journal Article] TTF-2 stimulates expression of 17 genes, including one novel thyroid-specific gene which might be involved in thyroid development.2004
- Author(s)
  Hishinuma, A., et al.
- Journal Title
  
  Mol Cell Endocrinol 221(1-2)
  
  Pages: 33-46
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590462
[Presentation] 成人のDUOX2遺伝子異常症における甲状腺腫大について2017
- Author(s)
  深田修司、菱沼昭、小飼貴彦、西原栄潤、工藤工、吉岡和佳、久門真子、笠原俊彦、中村友彦、工藤充、西川重光、中村浩淑、宮内昭
- Organizer
  第60回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-26460684
[Presentation] Expression of a Cell Differentiation Marker HMGA2 in Thyroid Cancer Tissues in Japan2017
- Author(s)
  Kogai T, Hirokawa M, Fukushima M, Sakumoto J, Kobayashi K, Fukata F, Akira Miyauchi A, Hirabayashi H, Hishinuma A
- Organizer
  The 12th Asia and Oceania Thyroid Association Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460653
[Presentation] POTENTIAL OF HMGA2 IMMUNO-HISTOCHEMICAL STAINING AS A PROGNOSTIC MARKER OF METASTATIC RECURRENCE IN FOLLICULAR THYROID CANCER2017
- Author(s)
  Kogai T, Sakumoto J, Konno W, Kanaya H, Hirabayashi H, Hishinuma A.
- Organizer
  87th Annual Metting of the American Thyroid Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460653
[Presentation] Expression of a cell differentiation marker HMGA2 in thyroid cancer tissues in Japan.2017
- Author(s)
  Takahiko Kogai, Mitsuyoshi Hirokawa, Mitsuhiro Fukushima, Junko Sakumoto, Kaoru Kobayashi, Shuji Fukata, Akira Miyauchi, Hideki Hirabayashi, Akira Hishinuma
- Organizer
  2017 Asia Oceania Thyroid Association (AOTA) Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460684
[Presentation] PTEN胚細胞変異を同定した4歳発症の機能性甲状腺結節の1例2017
- Author(s)
  長崎啓祐、入月浩美、鳴海覚志、小飼貴彦、菱沼昭
- Organizer
  第60回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-26460684
[Presentation] Potential of HMGA2 Immuno-histochemical Staining as a Prognostic Marker of Metastatic Recurrence in Follicular Thyroid Cancer2017
- Author(s)
  Kogai, Takahiko; Sakumoto, Junko; Konno, Wataru; Kanaya, Hiroaki; Hirabayashi, Hideki; Hishinuma, Akira
- Organizer
  Annual Meeting of the American Thyroid Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460684
[Presentation] 蛋白質合成阻害剤シクロヘキシミドによるヨード・トランスポーター NIS の発現誘導2016
- Author(s)
  小飼貴彦、Gregory A Brent、菱沼昭
- Organizer
  日本内分泌学会学術総会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26460684
[Presentation] DICER1遺伝子に胚細胞性変異を認めた家族性腺腫様甲状腺腫の一家系2015
- Author(s)
  深田修司、菱沼昭、廣川満良、西原永潤、小飼貴彦、吉岡和佳、姜信午、久門真子、井手茜、工藤工、伊藤充、西川光重、中村浩淑、網野信行、宮内昭
- Organizer
  日本甲状腺学会学術集会
- Place of Presentation
  福島県文化センター
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-26460684
[Presentation] 胃癌細胞におけるヨード・トランスポーター NIS の発現誘導2015
- Author(s)
  小飼貴彦、斉藤司、Yan-Yun Liu,　影近弘之、Gregory Brent, 菱沼昭
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  ホテルニューオータニ東京
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26460684
[Presentation] 甲状腺機能亢進症を合併したPendred症候群の１例2015
- Author(s)
  溝上哲也、菱沼昭、小飼貴彦、濱田勝彦、丸田哲史、東輝一朗、田尻淳一
- Organizer
  日本甲状腺学会学術集会
- Place of Presentation
  福島県文化センター
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-26460684
[Presentation] 甲状腺癌における細胞分化マーカーHMGA2の発現の検討2014
- Author(s)
  小飼貴彦、廣川満良、福島光浩、作本順子、小林　薫、深田修司、宮内　昭、菱沼　昭
- Organizer
  第57回日本甲状腺学会
- Place of Presentation
  大阪
- Year and Date
  2014-11-14
- Data Source
  KAKENHI-PROJECT-26460653
[Presentation] 甲状腺癌における細胞分化マーカーHMGA2の発現の検討2014
- Author(s)
  小飼貴彦、廣川満良、福島光浩、作本順子、小林　薫、深田修司、宮内　昭、菱沼　昭
- Organizer
  第61回日本臨床検査医学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2014-11-23
- Data Source
  KAKENHI-PROJECT-26460653
[Presentation] Genomic microdeletion of 6,675 nucleotides encompassing exon 28 and 29 of thyroglobulin(Tg)gene was found with a compound heterozygous occurrence of single nucleotide deletion7890delT2010
- Author(s)
  菱沼昭, et al.
- Organizer
  14th International Congress of Endocrinology
- Place of Presentation
  Kyoto
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] Dyshormonogenesis by thyroglobulin mutation in basic and clinical aspects2010
- Author(s)
  Hishinuma A
- Organizer
  Thyroid Satellite Symposium of 14th lntemational Congress of Endocrinology (CE2010)
- Place of Presentation
  Kyoto
- Year and Date
  2010-03-25
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] Dyshormonogenesis by thyroglobulin mutation in basic and clinical aspects2010
- Author(s)
  菱沼昭
- Organizer
  Thyroid Satellite Symposium of 14th International Congress of Endocrinology
- Place of Presentation
  Kyoto
- Year and Date
  2010-03-25
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] Genomic microdeletion of 6, 675 nucleotides encompassing exon 28 and 29 0f thyroglobulin (Tg) gene was found with a compound heterozygous occurrence of single nucleotide deletion7890delT2010
- Author(s)
  Hishinuma A, Fukata S, Ohmika N, Hayama N, Namatame T, Ieiri T
- Organizer
  14th lntemational Congress of Endocrinology (ICE2010)
- Place of Presentation
  Kyoto
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] サイログロブリン異常と甲状腺癌の特徴2009
- Author(s)
  菱沼昭, 他
- Organizer
  第82回日本内分泌学会学術総会
- Place of Presentation
  前橋
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] クリニカルアワー4特殊な甲状腺機能克進症の治療小児におけるバセドゥ病2009
- Author(s)
  菱沼昭
- Organizer
  第19回臨床内分泌代謝Update
- Place of Presentation
  東京
- Year and Date
  2009-03-14
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] Novel compound heterozygous occurrence of single nucleotide deletion 7890delT and genomic microdeletion encompassing exon 28 and 29 of thyroglobulin gene causes multinodular goiter2009
- Author(s)
  菱沼昭, et al.
- Organizer
  9th Asia and Oceania Thyroid Association Congress
- Place of Presentation
  Nagoya
- Year and Date
  2009-11-02
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] Novel compound heterozygous occurrence of single nucleotide deletion 7890delT and genomlc microdeletion encompassing exon 28 and 29 0f thyroglobulin gene causes multinodular goiter.2009
- Author(s)
  Hishinuma A, Fukata S, Ohmika N, HayamaN, NamatameT, Ieiri T
- Organizer
  9th Asia and Oceania Thyroid Association Congress
- Place of Presentation
  Nagoya
- Year and Date
  2009-11-02
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] 公募シンポジウム8甲状腺癌の分子生物学の新知見と応用サイログロブリン異常と甲状腺癌の特徴2009
- Author(s)
  菱沼昭, 深田修司, 宮内昭, 家人蒼生夫
- Organizer
  第82回日本内分泌学会学術総会
- Place of Presentation
  前橋
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] シンポジウム4遺伝子異常による甲状腺疾患甲状腺ホルモン合成障害をきたす遺伝子異常2008
- Author(s)
  菱沼昭
- Organizer
  第81回日本内分泌学会
- Place of Presentation
  青森
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] シンポジウム4 遺伝子異常による甲状腺疾患甲状腺ホルモン合成障害をきたす遺伝子異常2008
- Author(s)
  菱沼昭
- Organizer
  第81回日本内分泌学会
- Place of Presentation
  青森
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] New Aspects of Thyroglobulin Mutations-Clinical Features,Pathogenesis,and High Incidence of Cancer2007
- Author(s)
  菱沼昭
- Organizer
  Autumn Meeting of Korean Endocrine Society 2007
- Place of Presentation
  Muju Resort,Korea
- Year and Date
  2007-11-03
- Data Source
  KAKENHI-PROJECT-18590537
[Presentation] Genetic thyroid diseases in Japan featured by thyroglobulin mutations2007
- Author(s)
  菱沼昭
- Organizer
  第50回日本甲状腺学会
- Place of Presentation
  神戸
- Year and Date
  2007-11-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Presentation] シンポジウム「甲状腺疾患の病理と臨床のさらなる融合-」サイログロブリン遺伝子異常症一細胞内輸送異常と甲状腺癌2007
- Author(s)
  菱沼昭, 家人蒼生夫
- Organizer
  第11回日本内分泌病理学会
- Place of Presentation
  札幌
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] サイログロブリン遺伝子異常症-細胞内輸送異常と甲状腺癌2007
- Author(s)
  菱沼昭, 他
- Organizer
  第11回日本内分泌病理学会
- Place of Presentation
  札幌
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] サイログロブリン遺伝子異常症-細胞内輸送異常と甲状腺癌2007
- Author(s)
  菱沼昭、家入蒼生夫
- Organizer
  第11回日本内分泌病理学会
- Place of Presentation
  札幌
- Year and Date
  2007-10-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Presentation] 国際分子甲状腺学シンポジウムGenetic thyroid diseases in Japan featured by thyroglobulin mutations2007
- Author(s)
  菱沼昭
- Organizer
  第50回日本甲状腺学会
- Place of Presentation
  神戸
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] New Aspects of Thyroglobulin Mutations-Clinical Features,Pathogenesis,and High Incidence of Cancer2007
- Author(s)
  Hishinuma, A.
- Organizer
  Autumn Meeting of Korean Endocrine Society 2007
- Place of Presentation
  Muju,Korea
- Year and Date
  2007-11-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Presentation] Symposium (II)-Update ln Clinical Thyroidology- New Aspects of Thyroglobulin Mutations-Clinical Features2007
- Author(s)
  Hishinuma A
- Organizer
  Pathogenesis, and High Incidence of Cancer- Autum Meeting of Korean Endocrine Soclety
- Year and Date
  2007-11-03
- Data Source
  KAKENHI-PROJECT-19590569
[Presentation] 母体ヨード過剰摂取とともにTHOX2遺伝子変異の関与も背景と推測される先天性甲状腺機能低下症の1例2007
- Author(s)
  成相昭吉、菱沼昭
- Organizer
  第41回日本小児内分泌学会
- Place of Presentation
  横浜
- Year and Date
  2007-11-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Presentation] ]Symposium(II)-Update in Clinical Thyroidology-New Aspects of Thyroglobulin Mutations-Clinical Features, Pathogenesis, and High Incidence of Cancer-2007
- Author(s)
  Hishinuma, A
- Organizer
  Autumn Meeting of Korean Endocrine Society
- Place of Presentation
  Muju Resort, Korea
- Year and Date
  2007-11-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Presentation] 日本におけるサイログロブリン遺伝子異常と創始者効果2006
- Author(s)
  菱沼昭, 他
- Organizer
  第13回遺伝子診療学会大会
- Place of Presentation
  東京
- Year and Date
  2006-07-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Presentation] A novel homozygous missense mutation in the thyroid oxidase 2(THOX2)gene in an adult patient with large goiter2006
- Author(s)
  Ohye H, Fukata S, Kudo T, Nishihara E, Ito M, Kubota S, Amino N, Kuma K, Miyauchi A, Hishinuma A, Ieiri, T
- Organizer
  The Endocrine Society's 88th Annual Meeting
- Place of Presentation
  Boston, USA
- Year and Date
  2006-06-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590537
[Presentation] 胃癌細胞におけるヨード・トランスポーター NIS の発現誘導
- Author(s)
  小飼貴彦、斉藤司、Yan-Yun Liu,　影近弘之、Gregory Brent, 菱沼昭
- Organizer
  日本内分泌学会学術集会
- Place of Presentation
  ホテルニューオータニ東京
- Year and Date
  2015-04-23 – 2015-04-25
- Data Source
  KAKENHI-PROJECT-26460684

1. IEIRI Tamio (80049220)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. KOGAI Takahiko (40711693)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
3. 中山修一 (20457394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 西山充 (50315008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SATOU Motoyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 杉本博之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hishinuma Akira 菱沼 昭

HISHINUMA Akira 菱沼 昭

菱沼 昭 ヒシヌマ アキラ

Research Projects

Research Products

Co-Researchers

地域集積性サイログロブリン遺伝子異常症の臨床像解析と甲状腺癌発症機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Reguration mechanism of a new gene HMGA2 in thyroid tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction and Enhancement of Iodide Transporter Expression in Gastric Cancer Cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of Goiter Development in Patients with Thyroglobulin Mutations

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Origin of thyroglobulin mutations in Japan studied by haplotype analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of Thyroid Cancer Development in Patients with Thyroglobulin MutationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of thyroid transcription factor-2 (TTF-2) gene and cloning of causative genes for Cretinism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of endoplasmic stroage disease caused by thyroglobulin gene mutations and elucidation of the mechanisms of intracellular transport of proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of Thyroglobulin Gene in Patients with Congenital Goiter and Elucidation of Molecular MechanismsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト培養甲状腺腫瘍細胞株の癌遺伝子発現Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 甲状腺疾患診療マニュアル(田上哲也、西川光重、伊藤公一、成瀬光栄 編, 小児Basedow病)2009

Author(s)

Publisher

Data Source

[Book] 内分泌病理学 最近の進歩2008 ホルモンと臨床 2009秋季増刊号(上條桂一編, サイログロブリン遺伝子異常一細胞内輸送異常と甲状腺癌-2009

Author(s)

Publisher

Data Source

[Book] 甲状腺疾患診療マニュアル(田上哲也、西川光重、伊藤公一、成瀬光栄 編, 先天性甲状腺疾患)2009

Author(s)

Publisher

Data Source

[Book] 臨床検査 増刊号 ホルモンの病態異常と臨床検査 52(ll)(サイログロブリン遺伝子異常と甲状腺腫)2008

Author(s)

Hishinuma Akira 菱沼昭

HISHINUMA Akira 菱沼昭

菱沼昭ヒシヌマアキラ

[Book] 甲状腺疾患診療マニュアル(田上哲也、西川光重、伊藤公一、成瀬光栄編, 小児Basedow病)2009

[Book] 内分泌病理学最近の進歩2008 ホルモンと臨床 2009秋季増刊号(上條桂一編, サイログロブリン遺伝子異常一細胞内輸送異常と甲状腺癌-2009

[Book] 甲状腺疾患診療マニュアル(田上哲也、西川光重、伊藤公一、成瀬光栄編, 先天性甲状腺疾患)2009

[Book] 臨床検査増刊号ホルモンの病態異常と臨床検査 52(ll)(サイログロブリン遺伝子異常と甲状腺腫)2008

[Journal Article] 特集臨床検査:現状と展望トピックスII. 各論-実地医家に必要な新しい検査と重要な検査項目- 6. 内分泌・代謝疾患2008