YAMAZAKI Yoshimitu 山崎義光

… Alternative Names

YAMASAKI Yoshimitsu 山崎義光

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Researcher Number	40201834
Other IDs
Affiliation (based on the past Project Information) *help	1999 – 2005: Osaka University Medical School, Associate Professor, 医学系研究科, 助教授 1993 – 1998: 大阪大学, 医学部, 助手 1992 – 1993: Osaka Univ. Medicine Assistant Teacher, 医学部・第一内科, 助手 1992: The First Dept. of Med. Osaka Univ. Med. School, 医学部第一内科, 助手 1989 – 1991: 大阪大学, 医学部, 助手 … More 1987: First Department of Medicine, Osaka University Medical School, 医学部, 助手 1986: 大阪大学, 医学部付属病院, 医員 1986: Osaka University Hospital, 医学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Metabolomics / Metabolomics / 内分泌・代謝学 / Biological Sciences Except Principal Investigator 内分泌・代謝学 / Metabolomics / 内科学一般
Keywords	Principal Investigator 糖尿病 / 転写因子 / PDX-1 / Rho-kinase / diabetes / PAX6 / PAX4 / transcription factor / oxidative stress / インスリン … More / トランスジェニックマウス / アデノウイルス / 酸化ストレス / Foxol / insulin / JNK pathway / pancreatic beta-cells / 核外移行 / 膵beta細胞 / RhoA / Foxo1 / JNK経路 / 膵β細胞 / transdifferentiation / development / pancreas / β-cell differentiation / 形質転換 / 発生 / 膵臓 / β細胞分化 / stress activated protein kinase / glucose toxicity / transgenic mouse / antioxidative enzyme / diabetes mellitus / インスリン非依存型糖尿病 / インスリン非依存性糖尿病 / ブドウ糖毒性 / 抗酸化酵素 / molecular biology / polymorphism / transcription / inslin gene / 多型性 / 選択的スプライシング / IPF1 / インスリン遺伝子 / 転写調節 / 遺伝子多型性 / 骨髄 / インターフェロン / 膵管細胞 / β細胞 / 分化転換 / Ptfla / 再生医療 / 遺伝子治療 / インスリン生合成 / 膵β細胞障害 / 2型糖尿病 / p21 … More Except Principal Investigator 糖尿病 / インスリン遺伝子 / PDX-1 / 転写因子 / transcription factor / insulin gene / GCMS / 自己燐酸化 / 遺伝子発現調節 / インスリン / 膵β細胞 / glycemic control / artificial pancreas / data base / expert system / artificial intelligence / コンパートメント・モデル / エキスパート・システム / 血糖値クランプ / コンパートメントモデル / 人工知能 / エキスパートシステム / closed-loop system / telemetry / wearable artificial endocrine pancreas / needle-type glucose sensor / ノイズ・フィルター / 生体適合膜 / ブドウ糖センサ / 微小針型センサ / 血糖モニター・システム / antioxidant / glucose toxicity / type 2 diabetes / 抗酸化剤 / ブドウ糖毒性 / インスリン非依存型糖尿病 / pancreatic betacell / molecular biology / gene therapy / 遺伝子導入 / 筋芽細胞 / グルコキナーゼ遺伝子 / 分子生物学 / 遺伝子治療 / Baculovirus / Phospho-tyrasine phosphatise (PTPase) / Antophosphorylation / Insulin receptor / バキュロウイルス / バキュロウィルス / PTPase / インスリンレセプター / ^<19>F-Glucose / ^<13>C-Glucose / Stable Isotope / Hepatic Glucose Uptake / Non-invasive Measurement / Glucose Clamp / ^<19>FーMRS / クランプ法 / 人工膵B細胞 / ^<19>F標識ブドウ糖 / ^<13>C標識ブドウ糖 / 安定同位体 / 肝糖取り込み / 非侵襲的計測 / 血糖クランプ / artophosphorylation / insulin-EGF chimeric receptor / Insulin biosensor / 燐酸化 / キメラ / EGF / インスリンEGFキメラ受容体 / インスリン免疫センサ / Gluco corticoid / Expression / Insulin Receptor / Type A インスリン抵抗性 / グルココルチコイド / レセプタ- / 培養リンパ球 / グルココルチマイド / 発現調節 / インスリン結合 / インスリンレセプタ- / Gelatin / Collagen / Recombinant DNA / Artificial skin / Insulin genes / Diabetes mellitus / 血糖値 / インシュリン / ゼラチン / コラ-ゲン / 遺伝子組換え / 人工皮膚 / 核外移行シグナル / JNK / 核内外移行 / 酸化ストレス / 膵β細胞糖毒性 / ブドウ糖負荷試験 / インスリン分泌 / 肥満 / 耐糖能異常 / 膵島構造異常 / 早期インスリン分泌障害 / ノックアウトマウス / Cre-loxP / STAT3 / シグナル伝達 / IGF-I / STAT / 小人症 / 成長ホルモン Less

Role of oxidative stress and the JNK pathway in diabetesPrincipal Investigator
- Principal Investigator
  
  MATSUHISA Munehide, 山崎義光
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
糖尿病再生医療に向けた類β細胞化の標的となりうる組織幹細胞の同定と解析Principal Investigator
- Principal Investigator
  
  山崎義光
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
ブドウ糖毒性の分子メカニズム解明に向けた転写因子PDX-1の細胞内局在変化の研究
- Principal Investigator
  
  梶本佳孝
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
Role of Pax4/Pax6 in pancreatic β-cell differentiation and maintaining its functionPrincipal Investigator
- Principal Investigator
  
  YAMASAKI Yoshimitsu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
膵β細胞の再生・機能維持とSTAT3:Cre-loxPマウスを用いた検討
- Principal Investigator
  
  梶本佳孝
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
細胞周期制御因子p21が糖尿病性膵β細胞障害に関わる可能性の検討Principal Investigator
- Principal Investigator
  
  山崎義光
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
Molecular Mechanism of Pancreatic β-cell Glucose Toxicity in Anti-oxidative Enzyme Overexpressing Transgenic db/db Obese Diabetic Mice.Principal Investigator
- Principal Investigator
  
  YAMASAKI Yoshimitsu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
Investigation of transcription factors involved in the β-cell glucose toxicity
- Principal Investigator
  
  KAJIMOTO Yoshitaka
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
成長ホルモンの成長作用発現の分子メカニズムの解析-ドミナントネガティブSTAT分子を用いた解析-Principal Investigator
- Principal Investigator
  
  山崎義光, 渡曾隆夫
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
Introduction of glucose-responsive insulin secretion machinery to non-pancreatic beta cells
- Principal Investigator
  
  KAWAMORI Ryuzo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Juntendo Univ., Dept.of Med.
Evaluation of the amino-acid polymorphism identified in the insulin gene transcription factor A1Principal Investigator
- Principal Investigator
  
  YAMASAKI Yoshimitsu, 森島豊彦
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
The mechanisis of decreased autophosphorylation of the insulin receptor in diabetes mellitus
- Principal Investigator
  
  KAWAMORI Ryuzo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
Development of insulin sensor using biotechnology Insulin-EGF chimera receptor
- Principal Investigator
  
  AWAMORI Ryuzo
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Osaka University
INVIVO NON-INVASIVE MEASUREMENT OF GLUCOSE DYNAMICS APPLICATION OF GLUCOSE CLAMP AND STABLE ISOTOPE
- Principal Investigator
  
  MORISHIMA Toyohiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
Analysis of protein regulating expression of insulin receptor gene.
- Principal Investigator
  
  KAWAMORI Ryuzo
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
treatment of diabetes mellitus by cultured skin transfected with insulin genes
- Principal Investigator
  
  YOSHIZATO Katutoshi
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  内科学一般
- Research Institution
  Hiroshima University
  Tokyo Metropolitan University
Development of adaptive glycemic control system using artificial intelligence - application of expert system -
- Principal Investigator
  
  KAWAMORI Ryuzo, 鮴谷桂和
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University Medical School
The development of wrist-watch type glucose monitoring system and its clinical applications
- Principal Investigator
  
  KAWAMORI Ryuzo
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University

All 2006

All Journal Article

[Journal Article] Marked increase of insulin gene transcription by suppression of the Rho/Rho-kinase pathway.2006
- Author(s)
  Nakamura Y, Kaneto H, Miyatsuka T, Matsuoka T, Matsuhisa M, Node K, Hori M, Yamasaki Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 350・1
  
  Pages: 68-73
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390263
[Journal Article] Marked increase of insulin gene transcription by suppression of the Rho/Rho-kinase pathway2006
- Author(s)
  Nakamura Y, Kaneto H, Miyatsuka T, Matsuoka T, Matsuhisa M, Node K, Hori M, Yamasaki Y.
- Journal Title
  
  Biochem.Biophys.Res.Commu. 350(1)
  
  Pages: 68-73
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390263
[Journal Article] The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation.2006
- Author(s)
  Kawamori D, Kaneto H, Nakatani Y, Matsuoka T, Matsuhisa M, Hori M, Yamasaki Y
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages: 1091-1098
- Data Source
  KAKENHI-PROJECT-17390263
[Journal Article] The forkhead transcription factor Foxol bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation.2006
- Author(s)
  Kawamori D, Kaneto H, Nakatani Y, Matsuoka T, Matsuhisa M, Hori M, Yamasaki Y
- Journal Title
  
  J. BioL Chem. 281
  
  Pages: 1091-1098
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390263
[Journal Article] The forkhead transcription factor Foxol bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation2006
- Author(s)
  Kawamori D, Kaneto H, Nakatani Y, Matsuoka T, Matsuhisa M, Hori M, Yamasaki Y
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages: 1091-1098
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390263

1. KAWAMORI Ryuzo (00116021)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. KAJIMOTO Yoshitaka (60301256)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. MATSUHISA Munehide (60362737)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
4. MORISHIMA Toyohiko (50221635)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. IWAMA Norimichi

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. UMAYAHARA Yutaka

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. WATARAI Takao

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. GORIYA Yoshikazu (20144462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SHICHIRI Motoaki (00028515)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. YOSHIZATO Katutoshi (20095516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MUKAI Ryozaburo (90133040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MOCHIZUKI Kentaro (40266044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ARISAKA Tomoyuki (30266043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MATSUOKA Takaaki (10379258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. 渡曾隆夫 (90271022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 伊藤孝仁 (60362703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YOSHIKAWA Etuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KUBOTA Masashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. IMANO Eiichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SHIBA Yuichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 綿田裕孝

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 藤谷与士夫

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 佐々木澄志

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 野村誠

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MONURA Makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMAZAKI Yoshimitu 山崎 義光

YAMASAKI Yoshimitsu 山崎 義光

Research Projects

Research Products

Co-Researchers

Role of oxidative stress and the JNK pathway in diabetesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

糖尿病再生医療に向けた類β細胞化の標的となりうる組織幹細胞の同定と解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Pax4/Pax6 in pancreatic β-cell differentiation and maintaining its functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞周期制御因子p21が糖尿病性膵β細胞障害に関わる可能性の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Mechanism of Pancreatic β-cell Glucose Toxicity in Anti-oxidative Enzyme Overexpressing Transgenic db/db Obese Diabetic Mice.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

成長ホルモンの成長作用発現の分子メカニズムの解析-ドミナントネガティブSTAT分子を用いた解析-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of the amino-acid polymorphism identified in the insulin gene transcription factor A1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

YAMAZAKI Yoshimitu 山崎義光

YAMASAKI Yoshimitsu 山崎義光