Kuwano Kazuyoshi 桑野和善

… Alternative Names

KUWANO Kazuyoshi 桑野和善

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Researcher Number	40205266
Other IDs
External Links
Affiliation (Current)	2025: 国際医療福祉大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023: 国際医療福祉大学, 医学部, 教授 2021 – 2022: 東京慈恵会医科大学, 医学部, 教授 2007 – 2018: Jikei University School of Medicine, School of Medicine, Department of Internal Medicine, Professor 2006: Kyushu University, Graduate School of Medical Sciences, Associate Professor, 大学院医学研究院, 助教授 2003 – 2005: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Assistant Prof, 大学院・医学研究院, 助教授 … More 2002: Kyushu University, Graduate School of Medical Sciences, lecturer, 医学部附属病院, 講師 2000 – 2001: KYUSHU UNIVERSITY, Faculty of Med, Ass.Prof., 医学部・附属病院, 講師 1995 – 1999: 九州大学, 医学部, 講師 1994: 九州大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine
Keywords	Principal Investigator アポトーシス / 肺線維症 / 肺損傷 / apoptosis / pulmonary fibrosis / lung injury / 特発性肺線維症 / 細胞老化 / オートファジー / 慢性閉塞性肺疾患 … More / EMT / SUMO1 / MDM2 / p53 / エクソソーム / マイクロRNA / 老化 / PPARα / IPF / COPD / senotherapy / 加齢 / PPAR / TFEB / 繊維芽細胞 / 気道上皮細胞 / microRNA / マイクロＲＮＡ / ミトコンドリア / bleomycin / 特発性間質性肺炎 / TGF-beta / ブレオマイシン / ER stress / ERストレス / 急性肺損傷 / 肺維症 / 小胞体ストレス / proteasome / ubiquitin / プロテアソーム / ユビキチン / カスパーゼ / Fasリガンド / Fas抗原 / 呼吸器疾患 / micro RNA / ｌｕｎｇ　ｉｎｊｕｒｙ / ｅｘｏｓｏｍｅ / ｍｉｃｒｏ　ＲＮＡ / ｓｅｎｅｓｃｅｎｃｅ / ｐｕｌｍｏｎａｒｙ　ｆｉｂｒｏｓｉｓ / ＣＯＰＤ / 肺線維芽細胞 / 肺上皮細胞 / 幹細胞 / 細気管支上皮細胞 / ナノテクノロジー / 再生 / 細気管支 / 肺傷害 … More Except Principal Investigator p21 / apoptosis / Fas / アポトーシス / 肺線維症 / 細胞老化 / pulmonary fibrosis / TGF-beta / 慢性閉塞性肺疾患 / amphiregulin / EGFR / lung injury / 肺損傷 / TNF-alpha / mitochondria / 肺線維化 / caspase / PCNA / p53 / オートファジー / ラミンB1 / Deptor / Lamin B1 / ｍTOR / 特発性肺線維症 / PGE-MUM / 間質性肺炎 / SASP / Bcl-2 / PDL-1 / MICA / 老化細胞除去 / 線維芽細胞 / COPD / 線維化 / IPF / 喫煙 / ミトコンドリア / マイトファジー / インフラマソーム / ブレオマイシン / 肺腺維症 / Chemokine / Vitamin A / Pulmonary emphysema / サイトカイン / シゲナル伝達 / ケモカイン / ビタミンA / 肺気腫 / lung fibroblast / lung epithelium / FLIP / アデノウイルス / p27 / 肺線維芽細胞 / 肺上皮細胞 / bronchiolar epithelial cell / 肺傷害 / 細気管支上皮 / カスパーゼ / 細気管支上皮細胞 / TGF-β / lung cancer / IIP / Fas・Fas Lシステム / 癌抑制遺伝子p53 / Fas抗原 / 肺癌 / 特発性間質性肺炎 / 心血管疾患 / 糖尿病 / 基礎疾患 / 酸化ストレス / 全身性炎症 / 好中球 / 好酸球 / 血管透過性 / トロンボキサン / 神経因性炎症 / タキキニン / タバコ煙 / 気道過敏性 Less

The development of therapeutic strategy against IPF and COPD through TFEB activationPrincipal Investigator
- Principal Investigator
  
  Kuwano Kazuyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  International University of Health and Welfare
  Jikei University School of Medicine
Role of senescent cell removal mechanism in the pathogenesis of idiopathic pulmonary fibrosis
- Principal Investigator
  
  Haruhiko Yanagisawa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Intracellular communication mediated by exosomal micro RNA in aging-related lung diseasesPrincipal Investigator
- Principal Investigator
  
  Kuwano Kazuyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Clinical evaluation of PGE-MUM as a biomarker in IPF
- Principal Investigator
  
  Hara Hiromichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Involvement of Lamin B1 reduction in accelerated cellular senescence during COPD pathogenesis.
- Principal Investigator
  
  Jun Araya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Role of mitophagy in inflammasome activation during COPD pathogenesis.
- Principal Investigator
  
  Shimizu Kenichiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
The significance of signaling pathways by exososme in lung injury and fibrosisPrincipal Investigator
- Principal Investigator
  
  KUWANO Kazuyoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
The cell fate regulated by autophagy and ER stress in idiopathic pulmonary fibrosis.
- Principal Investigator
  
  ARAYA Jun
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
The effect of comorbidity, systemic inflammation and oxidative stress on the prognosis in COPD patients.
- Principal Investigator
  
  NAKAYAMA Katsutoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Molecular mechanisms and roles of cell senescence in lung injury and repairPrincipal Investigator
- Principal Investigator
  
  KUWANO Kazuyoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
The role of small airways in lung injury and regeneration, and the treatment strategy using nanotechnologyPrincipal Investigator
- Principal Investigator
  
  KUWANO Kazuyoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
EGFR ligand as a new therapeutic target for lung injury and pulmonary fibrosis.
- Principal Investigator
  
  HAMADA Naoki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyushu University
Investigation and regulation of molecular mechanisms of epithelial mesenchymal transition in pulmonary fibrosisPrincipal Investigator
- Principal Investigator
  
  KUWANO Kazuyoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  KYUSHU UNIVERCITY
Investigation of p21 in the molecular mechanisms of lung injury and pulmonary fibrosis
- Principal Investigator
  
  FUJITA Masaki, 萩本直樹
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Involvement of ER stress in the molecular mechanisms of lung injury and pulmonary fibrosisPrincipal Investigator
- Principal Investigator
  
  KUWANO Kazuyoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  KYUSHU UNIVERSITY
The role of chronic inflammation on the pathogenesis for COPD, focusing on TNF-alpha.
- Principal Investigator
  
  FUJITA Masaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyushu University
To investigate the molecular mechanisms of pulmonary fibrosis and the development of treatment strategy
- Principal Investigator
  
  HARA Nobuyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyushu University
Ubiquitin-proteasome system in the molecular mechanisms of lung injury and pulmonary fibrosisPrincipal Investigator
- Principal Investigator
  
  KUWANO Kazuyoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyushu University
The mechanisms of TGF-beta-induced apoptosis on lung epithelial cells
- Principal Investigator
  
  HAGIMOTO Naoki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Bronchiolar and alveolar epithelial cell apoptosis in pulmonary fibrosisPrincipal Investigator
- Principal Investigator
  
  KUWANO Kazuyoshi
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Study of cell proliferation and oncogenesis in pulmonary fibrosis. Kyushu University Research Institute for Diseases of the Chest
- Principal Investigator
  
  HARA Nobuyuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyushu University
タバコ煙により引き起こされる気道炎症・気道過敏性についての研究
- Principal Investigator
  
  相沢久道
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyushu University
肺線維化に関与する細胞のアポトーシスに関する研究Principal Investigator
- Principal Investigator
  
  桑野和善
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyushu University

[Book] Annuall Reiew 呼吸器2013
- Author(s)
  荒屋　潤、　原　弘道、桑野和善
- Total Pages
  8
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23591162
[Book] Annual Review呼吸器2011呼吸器系の生物学インテグリンと呼吸器疾患.p22-322011
- Author(s)
  荒屋潤、中山勝敏、桑野和善
- Total Pages
  276
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21590972
[Book] ARDSとアポトーシス別冊・医学の歩み最新ARDSのすべて2010
- Author(s)
  桑野和善
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-21591004
[Book] Modern insights into disease from molecule to man : Apoptosis in lung diseases2010
- Author(s)
  Kuwano K, Nakayama K, Araya J
- Total Pages
  650
- Publisher
  Science Pub Inc(In press)
- Data Source
  KAKENHI-PROJECT-21590972
[Book] Modern insights into disease from molecule to man : Apoptosis in lung diseases.2010
- Author(s)
  Kuwano K, Nakayama K, et al
- Total Pages
  650
- Publisher
  Science Pub Inc
- Data Source
  KAKENHI-PROJECT-21590972
[Book] 特発性肺線維症今日の治療指針2010年版-私はこう治療している2010
- Author(s)
  桑野和善
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21591004
[Book] Apoptosis in lung diseases Modern Insights Into Disease2009
- Author(s)
  Kuwano K, Nakayama K, Araya J
- Publisher
  Apoptosis Science Publishers
- Data Source
  KAKENHI-PROJECT-21591004
[Book] COPDのすべて類縁疾患症例から学ぶ鑑別診断のポイント3. 間質性肺炎2008
- Author(s)
  桑野和善
- Total Pages
  5
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-19390225
[Book] Annual Review呼吸器20062006
- Author(s)
  桑野和善
- Total Pages
  8
- Publisher
  中外医学社、東京
- Data Source
  KAKENHI-PROJECT-18590858
[Book] Annual Review Respirology 2006.2006
- Author(s)
  K. Kuwano
- Total Pages
  8
- Publisher
  CHUGAI-IGAKUSHA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590858
[Book] Annual Review 呼吸器20062006
- Author(s)
  桑野和善
- Total Pages
  8
- Publisher
  中外医学社、東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590858
[Book] Annual Review 呼吸器 20062006
- Author(s)
  桑野和善
- Total Pages
  8
- Publisher
  中外医学社、東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590793
[Book] Recent Research Developments in Physiology2004
- Author(s)
  Kuwano K et al.
- Publisher
  Research Signpost
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Book] Recent Research Developments in Physiology2004
- Author(s)
  Kuwano K et al.
- Publisher
  Research Signpost
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Drugs against metabolic diseases as potential senotherapeutics for aging-related respiratory diseases2023
- Author(s)
  Matsubayashi Sachi、Ito Saburo、Araya Jun、Kuwano Kazuyoshi
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 14 Pages: 1-15
- DOI
  10.3389/fendo.2023.1079626
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16123, KAKENHI-PROJECT-21K08213
[Journal Article] Fibroblast-Derived Extracellular Vesicles Induce Lung Cancer Progression in the IPF Microenvironment2023
- Author(s)
  Fujita Yu、Fujimoto Shota、Miyamoto Atsushi、Kaneko Reika、Kadota Tsukasa、Watanabe Naoaki、Kizawa Ryusuke、Kawamoto Hironori、Watanabe Junko、Utsumi Hirofumi、Wakui Hiroshi、Minagawa Shunsuke、Araya Jun、Ohtsuka Takashi、Ochiya Takahiro、Kuwano Kazuyoshi
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: online ahead of print Issue: 1 Pages: 34-44
- DOI
  10.1165/rcmb.2022-0253oc
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08213, KAKENHI-PROJECT-21H02930, KAKENHI-PROJECT-20K08578
[Journal Article] Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4.2017
- Author(s)
  Tsubouchi K, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Sato N, Yoshida M, Kurita Y, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Nakanishi Y, Kuwano K.
- Journal Title
  
  Autophagy
  
  Volume: 13(8) Issue: 8 Pages: 1420-1434
- DOI
  10.1080/15548627.2017.1328348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09231, KAKENHI-PROJECT-15K09233
[Journal Article] Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy.2017
- Author(s)
  Kurita Y, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Tsubouchi K, Sato N, Yoshida M, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Kuwano K.
- Journal Title
  
  Respir Res.
  
  Volume: 18(1) Issue: 1 Pages: 114-114
- DOI
  10.1186/s12931-017-0600-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09231, KAKENHI-PROJECT-15K09233
[Journal Article] 2. Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia.2017
- Author(s)
  Horikiri T, Hara H, Saito N, Araya J, Takasaka N, Utsumi H, Yanagisawa H, Hashimoto M, Yoshii Y, Wakui H, Minagawa S, Ishikawa T, Shimizu K, Numata T, Arihiro S, Kaneko Y, Nakayama K, Matsuura T, Matsuura M, Fujiwara M, Okayasu I, Ito S, Kuwano K.
- Journal Title
  
  Respir Med.
  
  Volume: 122 Pages: 43-50
- DOI
  10.1016/j.rmed.2016.11.017
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09194, KAKENHI-PROJECT-15K09233, KAKENHI-PROJECT-16K09558
[Journal Article] Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis.2015
- Author(s)
  Fujita Y, Araya J, Ito S, Kobayashi K, Kosaka N, Yoshioka Y, Kadota T, Hara H, Kuwano K, Ochiya T.
- Journal Title
  
  J Extracell Vesicles
  
  Volume: 4 Issue: 1 Pages: 28388-28399
- DOI
  10.3402/jev.v4.28388
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09232
[Journal Article] PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.2015
- Author(s)
  Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, Hara H, Minagawa S, Wakui H, Fujii S, Kojima J, Shimizu K, Numata T, Kawaishi M, Odaka M, Morikawa T, Harada T, Nishimura SL, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Autophagy.
  
  Volume: 11 Issue: 3 Pages: 547-59
- DOI
  10.1080/15548627.2015.1017190
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233, KAKENHI-PROJECT-25461198
[Journal Article] Intercellular communication by extracellular vesicles and their microRNAs in asthma.2014
- Author(s)
  Fujita Y, Yoshioka Y, Ito S, Araya J, Kuwano K, Ochiya T.
- Journal Title
  
  Clin Ther.
  
  Volume: 36 Issue: 6 Pages: 873-81
- DOI
  10.1016/j.clinthera.2014.05.006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591178
[Journal Article] Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence2014
- Author(s)
  Takasaka N, Araya J, Hara H, Ito S, Kobayashi K, Kurita Y, Wakui H, Yoshii Y, Yumino Y, Fujii S, Minagawa S, Tsurushige C, Kojima J, Numata T, Shimizu K, Kawaishi M, Kaneko Y, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K.
- Journal Title
  
  J Immunol
  
  Volume: 192(3) Pages: 958-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162
[Journal Article] Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.2014
- Author(s)
  Takasaka N, Nakayama K, et al.
- Journal Title
  
  J Immunol
  
  Volume: 192 Issue: 3 Pages: 958-968
- DOI
  10.4049/jimmunol.1302341
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591139, KAKENHI-PROJECT-24591178, KAKENHI-PROJECT-25860660, KAKENHI-PROJECT-25860661
[Journal Article] The impact of extracellular vesicle-encapsulated circulating microRNAs in lung cancer research.2014
- Author(s)
  Fujita Y, Kuwano K, Ochiya T, Takeshita F.
- Journal Title
  
  Biomed Res Int.
  
  Volume: 2014 Pages: 486413-486413
- DOI
  10.1155/2014/486413
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591178
[Journal Article] Autophagy in the pathogenesis of pulmonary disease.2013
- Author(s)
  Araya J, Hara H, Kuwano K.
- Journal Title
  
  Intern Med
  
  Volume: 52(20) Pages: 2295-303
- NAID
  130003383668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162
[Journal Article] Apoptosis inhibitor of macrophage (AIM) expression in alveolar macrophages in COPD2013
- Author(s)
  Kojima J, Araya J, Hara H, Ito S, Takasaka N, Kobayashi K, Fujii S, Tsurushige C, Numata T, Ishikawa T, Shimizu K, Kawaishi M, Saito K, Kamiya N, Hirano J, Odaka M, Morikawa T, Hano H, Arai S, Miyazaki T, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Respir Res.
  
  Volume: 14 Pages: 30-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162
[Journal Article] Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence2013
- Author(s)
  Hara H, Araya J, Ito S, Kobayashi K, Takasaka N, Yoshii Y, Wakui H, Kojima J, Shimizu K, Numata T, Kawaishi M, Kamiya N, Odaka M, Morikawa T, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 305(10)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162
[Journal Article] Insufficient autophagy in idiopathic pulmonary fibrosis.2013
- Author(s)
  ARAYA J, KUWANO K, KOJIMA J ET AL.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 304 Issue: 8 Pages: 56-69
- DOI
  10.1152/ajplung.00337.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591178
[Journal Article] Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence.2013
- Author(s)
  Hara H, Araya J, Ito S, Kobayashi K, Takasaka N, Yoshii Y, Wakui H, Kojima J, Shimizu K, Numata T, Kawaishi M, Kamiya N, Odaka M, Morikawa T, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 305(10) Issue: 10 Pages: L737-L746
- DOI
  10.1152/ajplung.00146.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162, KAKENHI-PROJECT-24591139, KAKENHI-PROJECT-25860661
[Journal Article] Insufficient autophagy in idiopathic pulmonary fibrosis2013
- Author(s)
  Araya J, Kojima J, Takasaka N, Ito S, Fujii S, Hara H, Yanagisawa H, Kobayashi K, Tsurushige C, Kawaishi M, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Kawabata Y, Hano H, Nakayama K, Kuwano K.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 304(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162
[Journal Article] Insufficient autophagic clearance promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease.2012
- Author(s)
  Fujii S, Hara H, Araya J, Takasaka N, Kojima J, Ito S, Minagawa S, Yumino Y, Ishikawa T, Kawaishi M, Kamiya K, Hirano J, Odaka M, Morikawa T, Stephen L Nishimura S, Nakayama K, Kuwano K
- Journal Title
  
  Oncoimmunology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Involvement of creatine kinase B in cigarette smoke induced-bronchial epithelial cell senescence2012
- Author(s)
  Hara H, Araya J, Takasaka N, Fujii S, Kojima J, Yumino Y, Shimizu K, Ishikawa T, Numata T, Kawaishi M, Saito K, Hirano J, Odaka M, Morikawa T, Hano H, Nakayama K, Kuwano K
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 46 Pages: 306-312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease2012
- Author(s)
  Fujii S, Hara H, Araya J, Takasaka N, Kojima J, Ito S, Minagawa S, Yumino Y, Ishikawa T, Numata T, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K.
- Journal Title
  
  Oncoimmunology
  
  Volume: 1(5) Pages: 630-641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162
[Journal Article] エイジングと間質性肺炎2011
- Author(s)
  桑野和善、荒屋潤、原弘道
- Journal Title
  
  呼吸と循環
  
  Volume: 59 Pages: 577-585
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Accelerated epithelial senescence in IPF and the inhibitory role of SIRT6 in TGF-beta-induced senescence of bronchial epithelila cells2011
- Author(s)
  Minagawa Y, Araya J, Kuwano K, et al
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 300 Pages: 391-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] I.呼吸器系の生物学4.インテグリンと呼吸器疾患2011
- Author(s)
  荒屋潤、中山勝敏、桑野和義
- Journal Title
  
  Annual Review呼吸器2011
  
  Pages: 22-32
- Data Source
  KAKENHI-PROJECT-21590972
[Journal Article] Accelerated Epithelial Cell Senescence in IPF and the Inhibitory Role of SIRT6 in TGF-{beta}-induced Senescence of Human Bronchial Epithelial Cells2011
- Author(s)
  Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Insulin Dependent Phosphatidylinositol 3-Kinase/Akt and ERK Signaling Pathways Inhibit TLR3-Mediated Human Bronchial Epithelial Cell Apoptosis2011
- Author(s)
  Numata T, Araya J, Fujii S, Hara H, Takasaka N, Kojima J, Minagawa S, Yumino Y, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K
- Journal Title
  
  J Immunol
  
  Volume: 187 Pages: 510-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] IPFに対する分子標的治療2010
- Author(s)
  桑野和善、荒屋潤、原弘道
- Journal Title
  
  呼吸と循環
  
  Volume: 58 Pages: 979-85
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Amphiregulin attenuates bleomycin-induced pneumopathy in mice.2010
- Author(s)
  Kuwano K, Nakanishi Y, et al.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol. 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells.2009
- Author(s)
  Yoshida M., Nakayama K., Kuwano K, et al.
- Journal Title
  
  Respirology 14
  
  Pages: 1027-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] 間質性肺炎に対するステロイド薬の使い方2009
- Author(s)
  桑野和善、河石真、荒屋潤
- Journal Title
  
  Modern Physician
  
  Volume: 26 Pages: 603-607
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] 分子病態から見た肺線維症2009
- Author(s)
  桑野和善、皆川俊介、荒屋潤
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 98 Pages: 1134-1139
- NAID
  10024934837
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] 特発性肺線維症の薬物療法2009
- Author(s)
  桑野和善、皆川俊介、荒屋潤
- Journal Title
  
  呼吸と循環
  
  Volume: 57 Pages: 575-580
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] 高齢者の間質性肺炎2009
- Author(s)
  桑野和善、木下陽、中山勝敏
- Journal Title
  
  日本老年医学会雑誌
  
  Volume: 46 Pages: 93-100
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Recombinant human erythropoietin reduces epithelial cell apoptosis and attenuates bleomycin-induced pneumonitis in mice2008
- Author(s)
  Yoshimi M, Hamada N, Kuwano K et.al.
- Journal Title
  
  Respirology 13
  
  Pages: 639-45
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] Dual-immunohistochemistry provides little evidence for epithelial-mesenchymal transition in pulmonary fibrosis2008
- Author(s)
  Yamada M, Kuwano K, Hamada N, et.al.
- Journal Title
  
  Histochem Cell Biol 129
  
  Pages: 453-62
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] Epithelial cell fate following lung injury2008
- Author(s)
  Kuwano K, Araya J., et al.
- Journal Title
  
  Expert Rev Respir Med 2
  
  Pages: 573-582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] Dual-immunohistochemistry provides little evidence for epithelial-mesenchymal transition in pulmonary fibr OSIS.2008
- Author(s)
  Kuwano K Hamada N, et al
- Journal Title
  
  Histochem Cell Biol 129
  
  Pages: 453-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] The role of collagenases in experimental pulmonary fibrosis2008
- Author(s)
  Ouchi H, Kuwano K, et al.
- Journal Title
  
  Pulm Pharmacol Ther 21
  
  Pages: 401-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] Involvement of epithelial cell apoptosis in interstitial lung diseases2008
- Author(s)
  Kuwano K.
- Journal Title
  
  Intern Med 47
  
  Pages: 345-353
- NAID
  130000079691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] Involvement of epithelial cell apoptosis in interstitial lung diseases2008
- Author(s)
  Kuwano K
- Journal Title
  
  Intern Med 47
  
  Pages: 345-53
- NAID
  130000079691
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] The role of collagenases in experimental pulmonary fibrosis2008
- Author(s)
  Ouchi H, Fujita M,Kuwano K, et.al.
- Journal Title
  
  Pulm Pharmacol Ther 21
  
  Pages: 401-8
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] Recombinant human erythropoietin reduces epithelial cell apoptosis and attenuates bleomycin-induced pneumonitis in mice2008
- Author(s)
  Yoshimi M, Kuwano K, et al.
- Journal Title
  
  Respirology 13
  
  Pages: 639-645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] Epithelial cell fate following lung injury2008
- Author(s)
  Kuwano K, Araya J, Nakayama K
- Journal Title
  
  Expert Rev Respir Med 2
  
  Pages: 573-582
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] The Role of High Mobility Group boxl in Pulmonary Fibrosis2008
- Author(s)
  Hamada N, Kuwano K, et al.
- Journal Title
  
  Am J Respir Cell Mol Biol 39
  
  Pages: 440-447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] Dual-immunohistochemistry provides little evidence for epithelial-mesenchymal transition in pulmonary fibrosis.2008
- Author(s)
  Yamada M, Kuwano K, Maeyama T, Hamada N, et. al.
- Journal Title
  
  Histochem Cell Biol 129
  
  Pages: 453-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] The role of collagenases in experimental pulmonary fibrosis.2008
- Author(s)
  Ouchi H, Kuwano K, et. al.
- Journal Title
  
  Pulmon Pharmacol Ther. 21
  
  Pages: 401-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation attenuates lung injury and fibrosis.2007
- Author(s)
  Yamada M, Kuwano K, Hamada N et al.
- Journal Title
  
  Journal of Chincal Pothology 59 (In press)
- Data Source
  KAKENHI-PROJECT-18590858
[Journal Article] Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation attenuates lung injury and fibrosis2007
- Author(s)
  Yamada M, Kuwano K, et. al.
- Journal Title
  
  J Clin Pathol 60(8)
  
  Pages: 916-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590858
[Journal Article] Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation attenuates lung injury and fibrosis2007
- Author(s)
  Yamada M, Kuwano K, Maeyama T, et.al.
- Journal Title
  
  J Clin Pathol 60(8)
  
  Pages: 916-20
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation attenuates lung injury and fibrosis2007
- Author(s)
  Yamada M, Kuwano K, Maeyama T, et. al.
- Journal Title
  
  Journal of Clinical Pathology 60
  
  Pages: 916-920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] Epithelial cell apoptosis and lung remodeling2007
- Author(s)
  Kuwano K
- Journal Title
  
  Cell Mol Immunol 4
  
  Pages: 419-29
- Data Source
  KAKENHI-PROJECT-19390225
[Journal Article] Editorials. PTEN as anew agent in the fight against fobrogenesis2006
- Author(s)
  K. Kuwano
- Journal Title
  
  Am J Respir Crit Care Med 173
  
  Pages: 5-6
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590858
[Journal Article] Editorials. PTEN as a new agent in the fight against fibrogenesis.2006
- Author(s)
  Kuwano K
- Journal Title
  
  Am J Respir Crit Care Med 173
  
  Pages: 5-6
- Data Source
  KAKENHI-PROJECT-18590858
[Journal Article] Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice.2006
- Author(s)
  Fujita M, Ye Q, Ouchi H, Harada E, Inoshima I, Kuwano K, Nakanishi Y
- Journal Title
  
  Antimicrobial Agents Ch 50
  
  Pages: 739-743
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] 肺線維症におけるアポトーシスの役割2006
- Author(s)
  桑野和善, 吉見通洋, 中西洋一
- Journal Title
  
  呼吸と循環 54
  
  Pages: 43-48
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] A pregnant woman with complications of lymphangioleiomyomatosis and idiopathic thrombocytopenic purpura.2006
- Author(s)
  Toyoda K, Kuwano K, et al.
- Journal Title
  
  Internal Medicine 45
  
  Pages: 1097-100
- NAID
  130000076430
- Data Source
  KAKENHI-PROJECT-18590858
[Journal Article] Doxycycline attenuates puimonary fibrosis induced by bleomycin in mice2006
- Author(s)
  Fujita M, Kuwano K, et al.
- Journal Title
  
  Antimicrobial Agents Ch 50
  
  Pages: 739-743
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] A pregnant woman with complications of lymphangioleiomyomatosis and idiopathic thrombocytopenic purpura.2006
- Author(s)
  Toyoda K, Matsumoto K, Inoue H, Komori M, Fujita M, Hashimoto S, Kuwano K, Nakanishi Y.
- Journal Title
  
  Intern Med. 45
  
  Pages: 1097-100
- NAID
  130000076430
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] PTEN as a new agent in the light against fibrogenesis (editorials)2006
- Author(s)
  Kuwano K
- Journal Title
  
  Am J Respir Crit Care Med 173
  
  Pages: 5-6
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation attenuates lung injury and fibrosis.2006
- Author(s)
  Yamada M, Kuwano K et al.
- Journal Title
  
  Journal of Clincal Pathology 59(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] Editorials. PTEN as anew agent in the fight against fobrogenesis.2006
- Author(s)
  Kuwano K.
- Journal Title
  
  Am J Respir Crit Care Med 173
  
  Pages: 5-6
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590858
[Journal Article] A pregnant woman with complications of lymphangioleiomyomatosis and idiopathic thrombocytopenic purpura.2006
- Author(s)
  Toyoda K, Kuwano K, et al.
- Journal Title
  
  Internal Medicine 45
  
  Pages: 1097-1100
- NAID
  130000076430
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice.2006
- Author(s)
  Fujita M., Kuwano K, et al.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 50
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice.2006
- Author(s)
  Fujita M, Kuwano K, et al.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 50
  
  Pages: 739-743
- Data Source
  KAKENHI-PROJECT-18590858
[Journal Article] Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice.2006
- Author(s)
  Fujita M, Kuwano K, et al.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 50
  
  Pages: 739-743
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] Editorials. PTEN as a new agent in the fight against fibrogenesis.2006
- Author(s)
  Kuwano K
- Journal Title
  
  Am J Respir Crit Care Med 173
  
  Pages: 5-6
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation attenuates lung injury and fibrosis.2006
- Author(s)
  Yamada M, Kuwano K, Maeyama T, Yoshimi M, Hamada N, Fukumoto J, Egashira K, Hiasa K, Takayama K, Nakanishi Y.
- Journal Title
  
  J Clin Pathol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] The p53-Mdm2 association in epithelial cells in idiopathic pulmonary fibrosis and non-specific interstitial pneumonia.2005
- Author(s)
  Nakashima N, Kuwano K, et al.
- Journal Title
  
  Journal of Clinical Pathology 58
  
  Pages: 583-589
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice2005
- Author(s)
  Hamada N, Kuwano K, et al.
- Journal Title
  
  J Immunol 175
  
  Pages: 1224-1231
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] Apoptosis signaling pathways in lung diseases.2005
- Author(s)
  Kuwano K, Yoshimi M, Maeyama T, Hamada N, Yamada M, Nakanishi Y
- Journal Title
  
  Medicinal Chemistry 1
  
  Pages: 49-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice.2005
- Author(s)
  Hamada N, Kuwano K, et al.
- Journal Title
  
  Journal of Immunology 175
  
  Pages: 1224-1231
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice.2005
- Author(s)
  Hamada N, Kuwano K, Yamada M, Hagimoto N, Hiasa K, Egashira K, Nakashima N, Maeyama T, Yoshimi M, Nakanishi Y.
- Journal Title
  
  J Immunol 175
  
  Pages: 1224-1231
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] Apoptosis signaling pathways in lung diseases.2005
- Author(s)
  Kuwano K, Yoshimi M, Maeyama T, Hamada N, Yamada M, Nakanishi Y
- Journal Title
  
  Medicinal Chemistry 1
  
  Pages: 49-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] The p53-Mdm2 association in epithelial cells in idiopathic pulmonary fibrosis and non-specific interstitial pneumonia.2005
- Author(s)
  Nakashima N, Kuwano K, Maeyama T, Hagimoto N, Yoshimi M, Hamada N, Yamada M, Nakanishi Y.
- Journal Title
  
  J Clin Pathol 58
  
  Pages: 583-589
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590793
[Journal Article] The role of apoptosis in pulmonary fibrosis.2004
- Author(s)
  Kuwano K., Hagimoto N., Nakanishi Y
- Journal Title
  
  Histol Histopathol 19
  
  Pages: 867-881
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Induction of CDK inhibitor p21 gene as a new therapeutic strategy against pulmonary fibrosis.2004
- Author(s)
  Inoshima I, Kuwano K, Hamada N, Yoshimi M, Maeyama T, Hagimoto N, Nakanishi Y, Hara N
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Apoptosis signaling pathways as therapeutic targets in lung injury.2004
- Author(s)
  Kuwano K, Hagimoto N, Yoshimi M, Maeyama T, Nakanishi Y
- Journal Title
  
  Letters in Drug Design & Discovery 1
  
  Pages: 263-268
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Induction of CDK inhibitor p21 gene as a new therapeutic strategy against pulmonary fibrosis.2004
- Author(s)
  Inoshima I, Kuwano K, Hamada N, Yoshimi M, Maeyama T, Hagimoto N, Nakanishi Y, Hara N
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice.2004
- Author(s)
  Inoshima I, Kuwano K, Hamada N, Hagimoto N, Yoshimi M, Maeyama T, Takeshita A, Kitarnoto S, Egashira K, Hara N
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] The role of apoptosis in pulmonary fibrosis.2004
- Author(s)
  Kuwano K., Hagimoto N., Nakanishi Y
- Journal Title
  
  Histol Histopathol 19
  
  Pages: 867-881
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Cytoprotective strategy against pulmonary fibrosis.2004
- Author(s)
  Kuwano K, Hagimoto N, Yoshimi M, Maeyama T, Nakanishi Y
- Journal Title
  
  Drug Design Reviews 1
  
  Pages: 29-35
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] The perforin-mediated apoptotic pathway in lung injury and fibrosis.2004
- Author(s)
  Miyazaki H, Kuwano K, Yoshida K, Maeyama T, Yoshimi M, Fujita M, Hagimoto N, Yoshida R, Nakanishi Y
- Journal Title
  
  J Clin Pathol 57
  
  Pages: 1292-1298
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Retinoic acid fails to reverse emphysema in adult mouse models.2004
- Author(s)
  Fujita M, Ye Q, Ouchi H, Nakashima N, Hamada N, Hagimoto N, Kuwano K, Mason RJ, Nakanishi Y.
- Journal Title
  
  Thorax 59
  
  Pages: 224-230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Retinoic acid fails to reverse emphysema in adult mouse models.2004
- Author(s)
  Fujita M, Ye Q, Ouchi H, Nakashima N, Hamada N, Hagimoto N, Kuwano K, Mason RJ, Nakanishi Y.
- Journal Title
  
  Thorax 59
  
  Pages: 224-230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice.2004
- Author(s)
  Inoshima I, Kuwano K, Hamada N, Hagimoto N, Yoshimi M, Maeyama T, Takeshita A, Kitarnoto S, Egashira K, Hara N
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Apoptosis signaling pathways as therapeutic targets in lung injury.2004
- Author(s)
  Kuwano K, Hagimoto N, Yoshimi M, Maeyama T, Nakanishi Y
- Journal Title
  
  Letters in Drug Design & Discovery 1
  
  Pages: 263-268
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] The perforin-mediated apoptotic pathway in lung injury and fibrosis.2004
- Author(s)
  Miyazaki H, Kuwano K, Yoshida K, Maeyama T, Yoshimi M, Fujita M, Hagimoto N, Yoshida R, Nakanishi Y
- Journal Title
  
  J Clin Pathol 57
  
  Pages: 1292-1298
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Cytoprotective strategy against pulmonary fibrosis.2004
- Author(s)
  Kuwano K, Hagimoto N, Yoshimi M, Maeyama T, Nakanishi Y
- Journal Title
  
  Drug Design Reviews 1
  
  Pages: 29-35
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Serum CC-10 in Inflammatory Lung Diseases.2004
- Author(s)
  Ye Q, Fujita M, Ouchi H, Inoshima I, Maeyama T, Kuwano K, Horiuchi Y, Hara N, Nakanishi Y.
- Journal Title
  
  Respiration 71
  
  Pages: 505-510
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Serum CC-10 in Inflammatory Lung Diseases.2004
- Author(s)
  Ye Q, Fujita M, Ouchi H, Inoshima I, Maeyama T, Kuwano K, Horiuchi Y, Hara N, Nakanishi Y.
- Journal Title
  
  Respiration 71
  
  Pages: 505-510
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias2003
- Author(s)
  Kuwano K et al.
- Journal Title
  
  Eur Respir J 21
  
  Pages: 232-240
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias.2003
- Author(s)
  Kuwano K.Hagimoto N, Nakashima N, Fujita M, Yoshimi M, Maeyama T, Inoshima I, Hamada N, Watanabe K, Hara N
- Journal Title
  
  Eur Respir J 21
  
  Pages: 232-240
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias2003
- Author(s)
  Kuwano K et al.
- Journal Title
  
  Eur Respir J 21
  
  Pages: 232-240
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias.2003
- Author(s)
  Kuwano K.Hagimoto N, Nakashima N, Fujita M, Yoshimi M, Maeyama T, Inoshima I, Hamada N, Watanabe K, Hara N
- Journal Title
  
  Eur Respir J 21
  
  Pages: 232-240
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice.
- Author(s)
  Hamada N, Kuwano K, Yamada M, Hagimoto N, Hiasa K, Egashira K, Nakashima N, Maeyama T, Yoshimi M, Nakanishi Y
- Journal Title
  
  J Immunol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Understanding the mechanisms of drug-associated interstitial lung disease.
- Author(s)
  Higenbottam T, Kuwano K, Nemery B, Fujita Y
- Journal Title
  
  Brit J Cancer 91(Suppl 2)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] The p53-Mdm2 association in epithelial cells in idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia
- Author(s)
  Nakashima N, Kuwano K, Maeyama T, Hagimoto N, Yoshimi M, Hamada N, Yamada M, Nakanishi Y
- Journal Title
  
  J Clin Pathol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice.
- Author(s)
  Hamada N, Kuwano K, Yamada M, Hagimoto N, Hiasa K, Egashira K, Nakashima N, Maeyama T, Yoshimi M, Nakanishi Y
- Journal Title
  
  J Immunol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] The p53-Mdm2 association in epithelial cells in idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia
- Author(s)
  Nakashima N, Kuwano K, Maeyama T, Hagimoto N, Yoshimi M, Hamada N, Yamada M, Nakanishi Y
- Journal Title
  
  J Clin Pathol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Understanding the mechanisms of drug-associated interstitial lung disease.
- Author(s)
  Higenbottam T, Kuwano K, Nemery B, Fujita Y
- Journal Title
  
  Brit J Cancer 91(Suppl 2)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Patent] 呼吸器疾患治療剤2022
- Inventor(s)
  荒屋潤、桑野和善、伊藤三郎、松林沙知
- Industrial Property Rights Holder
  荒屋潤、桑野和善、伊藤三郎、松林沙知
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-059884
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K08213
[Patent] 呼吸器疾患治療剤2022
- Inventor(s)
  荒屋　潤、桑野和善、伊藤三郎、松林沙知
- Industrial Property Rights Holder
  荒屋　潤、桑野和善、伊藤三郎、松林沙知
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K08213
[Presentation] TFEBによるオートファジー・リソソーム制御の喫煙誘導性細胞老化およびCOPD病態への関与2022
- Author(s)
  松林沙知, 保坂悠介, 伊藤三郎, 荒屋潤, 佐々木諒子, 藤本祥太, 川本浩徳, 伊藤晶彦, 渡邉直昭, 門田宰, 藤田雄, 橋本典生, 竹越大輔, 皆川俊介, 原弘道, 沼田尊功, 桑野和善
- Organizer
  第63回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K08213
[Presentation] Myofibroblasts derived extracellular vesicles promotes epithelial cell senescence in idiopathic pulmonary fibrosis.2017
- Author(s)
  3.Tsukasa Kadota, Yusuke Yoshioka, Yu Fujita, Jun Araya, Kazuyoshi Kuwano, Takahiro Ochiya
- Organizer
  ISEV2017Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09232
[Presentation] SIRT6によるオートファジーの制御2013
- Author(s)
  高坂直樹、荒屋　潤、桑野和善、等
- Organizer
  日本呼吸器学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591178
[Presentation] Insufficient autophagy is involved in accelerated cellular senescence in the pathophysiology of COPD2011
- Author(s)
  Fujii S, Hara H, Araya J, Takasaka N, Yumino Y, Kojima J, Ishikawa T, Numata T, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nakayama K, Kuwano K
- Organizer
  European Respiratory Society Annual Congress 2011 Amsterdam
- Place of Presentation
  Netherland
- Data Source
  KAKENHI-PROJECT-21590972
[Presentation] 加齢と肺の線維化2011
- Author(s)
  桑野和善
- Organizer
  第13回東海分子呼吸器研究会
- Place of Presentation
  名古屋
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-21591004
[Presentation] SIRT6-induced activation of autophagy inhibits CSE-induced bronchial epithelial senescence2011
- Author(s)
  Takasaka N, Arava J, Kuwano K, el al
- Organizer
  European Respiratory Society Congress
- Place of Presentation
  オランダアムステルダム
- Year and Date
  2011-09-25
- Data Source
  KAKENHI-PROJECT-21591004
[Presentation] 加齢と肺の線維化2011
- Author(s)
  桑野和善
- Organizer
  第18回福岡びまん性肺疾患研究会
- Place of Presentation
  福岡
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PROJECT-21591004
[Presentation] The evaluation of systemic inflammation in COPD patients comorbided with cardiovascular diseases or diabetes mellitus2011
- Author(s)
  Yumino Y, Fujii S, Takasaka N, Kojima J, Hara H, Numata T, Ishikawa T, Kawaishi M, Saito K, Araya J, Nakayama K, Kuwano K
- Organizer
  European Respiratory Society Annual Congress 2011 Amsterdam
- Place of Presentation
  Netherland
- Data Source
  KAKENHI-PROJECT-21590972
[Presentation] Involvement of aberrant re-epithelialization with cellular senescence in IPF pathogenesis2010
- Author(s)
  Minagawa S, Araya J, Kuwano K, et al.
- Organizer
  アメリカ胸部疾患学会
- Place of Presentation
  ニューオーリンズ
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21591004
[Presentation] The study on the clinical conditions of chronic obstructive pulmonary disease(COPD) patients comorbided with cardiovascular diseases or diabetes mellitus in Japan2010
- Author(s)
  Yumino Y, Nojiri S, Minagawa S, Kojima J, Numata T, Hara H, Kawaishi M, Araya J, Nakayama K, Kuwano K
- Organizer
  American Thoracic Society 2010 International Conference
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-21590972
[Presentation] 間質性肺炎とCOPD2010
- Author(s)
  桑野和善
- Organizer
  呼吸器疾患フォーラムin福岡
- Place of Presentation
  福岡
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-21591004
[Presentation] 間質性肺炎におけるアポトーシスと老化(シンポジウム)2009
- Author(s)
  桑野和善
- Organizer
  第49回日本呼吸器学会総会
- Place of Presentation
  東京
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21591004
[Presentation] 間質性肺炎におけるアポトーシスと老化2009
- Author(s)
  桑野和善
- Organizer
  第49回日本呼吸器学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591004
[Presentation] 間質性肺炎とCOPDにおけるリモデリング2009
- Author(s)
  桑野和善
- Organizer
  第22回近畿呼吸器疾患談話会
- Place of Presentation
  大阪
- Year and Date
  2009-02-28
- Data Source
  KAKENHI-PROJECT-21591004
[Presentation] An inhibitor of HMG-CoA reductase, pitavastatin, inhibits rhinovirus infection in human tracheal epithelial cells2009
- Author(s)
  Nakayama K, Sasaki T, Yumino Y, Minagawa S, Nojiri S, Yoshida M, Numata T, Hara H, Kawaishi M, Araya J, Yamaya M, Kuwano K
- Organizer
  European Respiratory Society 2009 Annual Congress
- Place of Presentation
  Vienna
- Data Source
  KAKENHI-PROJECT-21590972
[Presentation] 高齢者におけるツベルクリン反応と感染症およびその予後との関連2009
- Author(s)
  中山勝敏、沼田尊功、大類孝、海老原孝枝、弓野陽子、荒屋潤、荒井啓行、桑野和善
- Organizer
  第49回日本呼吸器医学会学術講演会
- Place of Presentation
  東京フォーラム
- Data Source
  KAKENHI-PROJECT-21590972
[Presentation] Effects of pro-inflammatory cytokines on the cellular senescence in the human bronchial epithelial cells cultured in air-liquid interface methods2009
- Author(s)
  Yumino Y, Nojiri S, Minagawa S, Numata T, Hara H, Kawaishi M, Araya J, Nakayama K, Kuwano K
- Organizer
  European Respiratory Society 2009 Annual Congress
- Place of Presentation
  Vienna
- Data Source
  KAKENHI-PROJECT-21590972
[Presentation] Lung injury, repair, and remodeling -Mechanisms of apoptosis in lung diseases-2008
- Author(s)
  Kazuyoshi Kuwano
- Organizer
  6th European Respiratory Society Lung Science Conference
- Place of Presentation
  Estoril,Portugal
- Data Source
  KAKENHI-PROJECT-19390225
[Presentation] Lung injury, repair, and remodeling-Mechanisms of apoptosis in lung diseases2008
- Author(s)
  Kuwano K
- Organizer
  6^<th> ERS Lung Science Conference
- Place of Presentation
  Estoril, Portugal (Invited Lecture)
- Data Source
  KAKENHI-PROJECT-19390225
[Presentation] Symposium- Mechanisms of pulmonary fibrosis. Alveolar cell injury and apoptosis.2007
- Author(s)
  K. Kuwano
- Organizer
  European Respiratory Society Annual Congress 2007
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2007-09-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590858
[Presentation] Mechanisms of pulmonary fibrosis. Alveolar cell injury and apoptosis2007
- Author(s)
  Kuwano K
- Organizer
  European Respiratory Society Annual Congress
- Place of Presentation
  Stockholm (symposium)
- Data Source
  KAKENHI-PROJECT-19390225
[Presentation] Symposium : Mechanisms of pulmonary fibrosis. Alveolar cell injury and apoptosis.2007
- Author(s)
  Kuwano K.
- Organizer
  European Respiratory Society Annual Congress 2007
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2007-09-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590858
[Presentation] Cytocrome c levels in serum and bronchoalveolar lavage fluid in lung injury.2006
- Author(s)
  Kuwano K., et al.
- Organizer
  European Respiratory Society Annual Congress 2006
- Place of Presentation
  Munich, Germany
- Year and Date
  2006-09-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590858

1. ARAYA Jun (90468679)

# of Collaborated Projects: 8 results

# of Collaborated Products: 31 results
2. HAGIMOTO Naoki (50315074)

# of Collaborated Projects: 7 results

# of Collaborated Products: 20 results
3. FUJITA Masaki (50325461)

# of Collaborated Projects: 7 results

# of Collaborated Products: 15 results
4. MAEYAMA Takashige (40380456)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
5. NAKAYAMA Katsutoshi (40321989)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
6. HAMADA Naoki (00423567)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
7. HARA Nobuyuki (90038802)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KAWASAKI Masayuki (90264051)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. Hara Hiromichi (70398791)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. KAWASHIMA Yoshiaki (30082978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMAMOTO Hiromitu (30275094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TAKAVAMA Koichi (50274444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKANISHI Yoichi (20172356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SUEISHI Katsuo (70108710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Shimizu Kenichiro (80385327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Haruhiko Yanagisawa (00773425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 相沢久道 (90175711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 井上博雅 (30264039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 吉見通洋 (30372759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 猪島一朗 (90380419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. YUMINO Yoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
22. NOJIRI Satoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
23. Ito Saburo

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
24. Saito Nayuta

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. Kaneko Yumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. 松元幸一郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 田中拓夫

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kuwano Kazuyoshi 桑野 和善

KUWANO Kazuyoshi 桑野 和善

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Co-Researchers

The development of therapeutic strategy against IPF and COPD through TFEB activationPrincipal Investigator

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Intracellular communication mediated by exosomal micro RNA in aging-related lung diseasesPrincipal Investigator

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The significance of signaling pathways by exososme in lung injury and fibrosisPrincipal Investigator

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Molecular mechanisms and roles of cell senescence in lung injury and repairPrincipal Investigator

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The role of small airways in lung injury and regeneration, and the treatment strategy using nanotechnologyPrincipal Investigator

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Investigation and regulation of molecular mechanisms of epithelial mesenchymal transition in pulmonary fibrosisPrincipal Investigator

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Kuwano Kazuyoshi 桑野和善

KUWANO Kazuyoshi 桑野和善