Tanabe Genzoh 田辺元三

… Alternative Names

TANABE Genzoh 田辺元三

田辺元三タナベゲンゾウ

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Researcher Number	40217104
Other IDs
Affiliation (Current)	2025: 近畿大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 近畿大学, 薬学部, 教授 2011 – 2013: 近畿大学, 薬学部, 准教授 2007 – 2009: Kinki University, 薬学部, 准教授 2004: Kinki University, School of Pharmaceutical Sciences, Lecturer, 講師 2001 – 2004: Kinki University School of Pharmacy Lecturer, 薬学部, 講師 1999 – 2000: 近畿大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Chemical pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator サラシノール / salacinol / α-グルコシダーゼ阻害剤 / Salacinol / サラシア / チオ糖 / 糖尿病治療薬 / 結核 / ラムノシダーゼ阻害剤 / Neosalacinol … More / 抗結核薬 / ガラクトシダーゼ阻害剤 / スルホニウム塩 / α-グルコシダーゼ阻害薬 / ジアステレオ選択的合成 / スルホニウム塩合成 / total synthesis / Diabetes / SAR study / Salacia / α-glucosidase inhibitor / neokotalanol / 構造活性相関 / 3'-O-アルキル化 / αーグルコシダーゼ阻害剤 / Salacia reticulata / カップリング反応 / 環状硫酸エステル / スルホニウム硫酸分子内塩 / Salacia reticalata … More Except Principal Investigator coupling reaction / cyclic sulfate / α-glucosidase inhibitor / salacinol / thiosugar / Salacia reticulata / sulfonium sulfate inner salt / antidiabetic agents / epoxide / antidiabetic agent / Salacia reticula / 抗転移剤 / がん細胞選択的細胞死 / メラノーマ / ERK MAPKシグナル / がん遺伝子中毒 / 構造活性相関 / DUSP / 細胞死 / ケミカルゲノミクス / 細胞内シグナル伝達 / 細胞死制御機構 / ERK MAPK / アポトーシス / 抗がん剤 / KRAS変異 / ACA-28 / 膵臓がん / リン酸化プロテオミクス / ERK依存的細胞死 / ring opening reaction / azasuga / sulfation / suldonium sulfate inner aslt / azasugar Less

新規作用機序の抗結核薬開発を志向したスルホニウム塩型ラムノシダーゼ阻害剤の創生Principal Investigator
- Principal Investigator
  
  田辺元三
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kindai University
Mechanisms of cancer-specific apoptosis induction targeting ERK hyperactivation
- Principal Investigator
  
  Sugiura Reiko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kindai University
Synthesis and evaluation of di-cationic sulfonium-type alpha-glucosidase inhibitors based on the structure of salacinolPrincipal Investigator
- Principal Investigator
  
  Tanabe Genzoh
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kindai University
Synthesis and evaluation of sulfonium-type alpha-glucosidase inhibitors based on the structure of salacinolPrincipal Investigator
- Principal Investigator
  
  TANABE Genzoh
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kinki University
Synthesis and evaluation of new α-glucosidase inhibitors having thiosugar-sulfonium salt structure based on salacinolPrincipal Investigator
- Principal Investigator
  
  TANABE Genzoh
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kinki University
Synthesis and Biological Evaluation of New α-Glucosidase inhibitors Designated on the Basis of the Structure of Salacinol
- Principal Investigator
  
  MURAOKA Osamu
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kinki University
Synthetic Studied on Thiosugar Suronium Sulfate Inner Salt,a Potent α-Glucosidase Inhibitor
- Principal Investigator
  
  MURAOKA Osamu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kinki University

All 2023 2022 2021 2020 2019 2018 2017 2013 2012 2011 2009 2004 2003 Other

All Journal Article Presentation Patent

[Journal Article] ACAGT‐007a, an anti‐cancer compound that modulates ERK MAPK signaling, induces nuclear enrichment of phosphorylated ERK in T3M4 pancreatic cancer cells2023
- Author(s)
  Khandakar Golam Iftakhar、Miyamoto Yoichi、Satoh Ryosuke、Kishimoto Kenta、Xie Mingzuo、Shih Mengyu、Takasaki Teruaki、Tanabe Genzoh、Oka Masahiro、Sugiura Reiko
- Journal Title
  
  Genes to Cells
  
  Volume: - Issue: 6 Pages: 457-465
- DOI
  10.1111/gtc.13026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0111, KAKENHI-PROJECT-19H03376, KAKENHI-PROJECT-20H03444, KAKENHI-PROJECT-20K06455, KAKENHI-PROJECT-23K27373
[Journal Article] Down‐regulation of dual‐specificity phosphatase 6, a negative regulator of oncogenic ERK signaling, by ACA‐28 induces apoptosis in NIH/3T3 cells overexpressing HER2/ErbB22021
- Author(s)
  Kanda Yuki、Mizuno Ayami、Takasaki Teruaki、Satoh Ryosuke、Hagihara Kanako、Masuko Takashi、Endo Yuichi、Tanabe Genzoh、Sugiura Reiko
- Journal Title
  
  Genes to Cells
  
  Volume: 26 Issue: 2 Pages: 109-116
- DOI
  10.1111/gtc.12823
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06494, KAKENHI-PROJECT-19H03376, KAKENHI-PROJECT-20J15403
[Journal Article] Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-282020
- Author(s)
  Satoh Ryosuke、Hamada Naoya、Yamada Ami、Kanda Yuki、Ishikawa Fumihiro、Takasaki Teruaki、Tanabe Genzoh、Sugiura Reiko
- Journal Title
  
  Bioorganic Chemistry
  
  Volume: 103 Pages: 104137-104137
- DOI
  10.1016/j.bioorg.2020.104137
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06494, KAKENHI-PROJECT-19H03376, KAKENHI-PROJECT-20J15403
[Journal Article] Facile synthesis of neokotalanol, a potent α-glycosidase inhibitor isolated from the Ayurvedic tradi-tional medicine “Salacia”2019
- Author(s)
  Genzoh Tanabe, Satoshi Ueda, Kazuho Kurimoto, Naoki Sonoda, Shinsuke Marumoto, Fumihiro Ishikawa, Weijia Xie, Osamu Muraoka
- Journal Title
  
  ACS Omega
  
  Volume: 4 Issue: 4 Pages: 7533-7542
- DOI
  10.1021/acsomega.9b00610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08377
[Journal Article] Synthesis of salacinol-d4 as an internal standard for mass-spectrometric quantitaatiion of salacinol, a potent alpha-glucosidase inhibitor found in a traditiional ayurvedic medicine "Salacia"2018
- Author(s)
  G. Tanabe, S. Teramae, Y. Kunikata, S. Marumoto, S. Okugawa, F. Ishikawa, W. Xie, T. Morikawa, and Osamu Muraoka
- Journal Title
  
  Heterocycles
  
  Volume: 97 Issue: 1 Pages: 314-332
- DOI
  10.3987/com-18-s(t)21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08377, KAKENHI-PUBLICLY-17H05438
[Journal Article] Diastereoselective Synthesis of Salacinol-Type α-Glucosidase Inhibitors2017
- Author(s)
  Ishikawa Fumihiro、Jinno Kazumi、Kinouchi Eri、Ninomiya Kiyofumi、Marumoto Shinsuke、Xie Weijia、Muraoka Osamu、Morikawa Toshio、Tanabe Genzoh
- Journal Title
  
  Journal of Organic Chemistry
  
  Volume: 83 Issue: 1 Pages: 185-193
- DOI
  10.1021/acs.joc.7b02566
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08313, KAKENHI-PROJECT-17K08377, KAKENHI-PUBLICLY-17H05438, KAKENHI-PROJECT-15K08008
[Journal Article]2012
- Author(s)
  G. Tanabe, S. Nakamura, N. Tsutsui, G. Balakishan, W. Xie, S. Tsuchiya, J. Akaki, T. Morikawa, K. Ninomiya, I. Nakanishi, M.Yoshikawa, O. Muraoka
- Journal Title
  
  Chem. Commun
  
  Volume: 48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590140
[Journal Article] In silico design, synthesis and evaluation of 3′-O-benzylated analogs of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine “Salacia”2012
- Author(s)
  G. Tanabe, S. Nakamura, N.Tsutsui, G. Balakishan, W. Xie, S.Tsuchiya, J. Akaki, T. Morikawa, K. Ninomiya, I. Nakanishi, M.Yoshikawa, O. Muraoka
- Journal Title
  
  Chem. Commun.
  
  Volume: 48 Issue: 69 Pages: 8646-8648
- DOI
  10.1039/c2cc34144a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590140, KAKENHI-PROJECT-24590037
[Journal Article]2011
- Author(s)
  G. Tanabe, T. Otani, W. Cong, T. Minematsu, K. Ninomiya, M. Yoshikawa and O. Muraoka
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 21
- Data Source
  KAKENHI-PROJECT-23590140
[Journal Article] サラシノールの3’-O-アルキル化類縁体のα-グルコシダーゼ阻害活性評価2011
- Author(s)
  田邉元三，大谷　徹，叢文英, 二宮清文，峯松敏江，吉川雅之，村岡修
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 21 Issue: 10 Pages: 3159-3162
- DOI
  10.1016/j.bmcl.2011.02.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590140
[Patent] Cyclic Onium Compounds and Glucosidase Inhibitors2004
- Inventor(s)
  村岡修, 吉川雅之, 田邉元三, 松田久司
- Industrial Property Rights Holder
  学校法人近畿大学
- Filing Date
  2004-05-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572023
[Patent] 環状オニウム化合物およびグルコシダーゼ阻害剤2003
- Inventor(s)
  村岡修, 吉川雅之, 田邉元三, 松田久司
- Industrial Property Rights Holder
  学校法人近畿大学
- Industrial Property Number
  2003-167786
- Filing Date
  2003-06-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572023
[Presentation] サラシノール型チオ糖スルホニウム塩構造を基盤とするガラクトシダーゼ阻害剤の合成研究2023
- Author(s)
  古部聖也、高島克輝、石川文洋、田邉元三
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-22K06541
[Presentation] スルホニウム塩構造を基盤とするガラクトシダーゼ阻害剤の合成研究2022
- Author(s)
  古部聖也、石川文洋、高島克輝、田邉元三
- Organizer
  第72回　日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-22K06541
[Presentation] ACA-28とその誘導体ACAGT-007aはがん細胞におけるERK MAPKシグナルのさらなる活性化を介してアポトーシスを誘導する2022
- Author(s)
  佐藤亮介, カンダカールイフタカール, 石川文洋, 高崎輝恒, 田邉元三, 杉浦麗子
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03376
[Presentation] ACAGT-007a, A NEW ERK MAPK SIGNALING MODULATOR, WHEN COMBINED WITH AKT SIGNALING INHIBITOR, INHIBITS CELL GROWTH AND TRIGGERS APOPTOSIS IN PANCREATIC CANCER CELLS2022
- Author(s)
  Golam Iftakhar Khandakar, Ryosuke Satoh, Teruaki Takasaki, Kana Fujitani, Shih Mengyu, Genzoh Tanabe, Kazuko Sakai, Kazuto Nishio, Yoichi Miyamoto, Masahiro Oka, Reiko Sugiura
- Organizer
  The Protein Phosphatases Conference Jointly hosted by FASEB and the Japanese Association for Protein Phosphatase Research (JAPPR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03376
[Presentation] ERK MAPKシグナル調節薬ACA-28による活性化ERKの細胞内動態の可視化とExportinの関わり2022
- Author(s)
  謝明作, カンダカールゴラムイフタカール, 岸本健太, 佐藤亮介, 高崎輝恒, 田邉元三, 杉浦麗子
- Organizer
  第142回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-19H03376
[Presentation] ACAGT-007a, an ERK MAPK Signaling Modulator, when combined with AKT Signaling Inhibitor, Promotes Antitumor Activity in Pancreatic Cancer Cells2021
- Author(s)
  Golam Khandakar, Ryosuke Satoh, Teruaki Takasaki, Kana Fujitani, Genzo Tanabe, Reiko Sugiura
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03376
[Presentation] 新規ERKシグナル調節薬ACA-28の適応拡大と細胞死誘導機構の解析2020
- Author(s)
  濵田直弥、佐藤亮介、髙崎輝恒、田邉元三、足立淳、朝長毅、杉浦麗子
- Organizer
  第70回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-19H03376
[Presentation] 新規ERKシグナル調節薬ACA-28のERK活性化がん細胞に対するアポトーシス誘導活性とその作用機構の解析2020
- Author(s)
  濵田直弥、佐藤亮介、髙崎輝恒、田邉元三、足立淳、朝長毅、杉浦麗子
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03376
[Presentation] ERK経路の活性化によりヒトメラノーマのアポトーシスを強力かつ選択的に誘導する新規ベンズヒドロール誘導体の発見2020
- Author(s)
  佐藤亮介、濵田直弥、石川文洋、髙崎輝恒、田邉元三、杉浦麗子
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03376
[Presentation] Impacts of ACA-28 derivatives on the ERK MAPK & PI3K/AKT signaling pathways in pancreatic cancer cells2020
- Author(s)
  Golam Iftakhar Khandakar, Ayami Mizuno, Ryosuke Satoh, Teruaki Takasaki Genzo Tanabe, Reiko Sugiura
- Organizer
  The 14th International Conference on Protein Phosphatase
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03376
[Presentation] Chemical genetic screen in fission yeast identified ACA-28 and its potent derivative compound, which preferentially kill several cancer cells2019
- Author(s)
  Naoya Hamada, Ryosuke Satoh, Genzoh Tanabe, Fumihiro Ishikawa, Teruaki Takasaki, Reiko Sugiura
- Organizer
  10th International Fission Yeast Meeting (pombe 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03376
[Presentation] ERK MAPK活性化を利用したがん細胞選択的アポトーシス誘導化合物の開発2019
- Author(s)
  佐藤亮介、濱田直弥、石川文洋、高崎輝恒、田邉元三、杉浦麗子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03376
[Presentation] Highly Diastereoselective Synthesis of an alpha-Glucosidase Inhibitor, neokotalaniols from Ayurvedic Traditional Medicine “Salacia” Using S-Alkylation of Thiosugar with Epoxide2019
- Author(s)
  上田哲志、小林祐喜、石川　文洋、村岡　修、田邉　元三
- Organizer
  日本薬学会第 139 年会
- Data Source
  KAKENHI-PROJECT-17K08377
[Presentation] 新規ERKシグナル調節薬ACA-28が多様なERK活性化癌細胞に対してERK依存的細胞死を引き起こす分子機構についての解析2019
- Author(s)
  濱田直弥、佐藤亮介、高崎輝恒、田邉元三、益子高、杉浦麗子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03376
[Presentation] 新規ERKシグナル調節薬ACA-28が多様なERK活性化癌細胞に対してERK依存的細胞死を引き起こす分子機構についての解析2019
- Author(s)
  濵田直弥、佐藤亮介、高崎輝恒、田邉元三、杉浦麗子
- Organizer
  第136回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-19H03376
[Presentation] Highly Diastereoselective Synthesis of Salacinol-type alpha-Glucosidase Inhibitors and Evaluation of Their in vivo alpha-Glucosidase Inhibitory Activity2018
- Author(s)
  F. Ishikawa, K. Jinno, N. Sonoda, E. Kinouchi, J.Akaki, K. Ninomiya, S. Marumoto, O. Muraoka, T. Morikawa, G. Tanabe
- Organizer
  The 28th International Symposium on the Organic Chemistry of Sulfur (ISOCS-28)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08377
[Presentation] チオ糖とエポキシドとのS-アルキル化を鍵反応に用いるサラシア”由来,サラシノール型α-グルコシダーゼ阻害剤の高ジアステレオ選択的合成2017
- Author(s)
  石川　文洋，神農　佳澄，薗田　直樹，村岡　修，田邉　元三
- Organizer
  第43回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08377
[Presentation] 天然薬物 ”サラシア”由来サラシノール類縁体のジアステレオ選択的合成及び in vivo α-グルコシダーゼ阻害活性評価2017
- Author(s)
  石川文洋，神農佳澄，薗田直樹，木内恵里，赤木淳二，二宮清文, 村岡修，吉川雅之，森川敏生，田邉元三
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08377
[Presentation] アーユルベーダ天然薬物“サラシア” 由来スルホニウム塩類のジアステレオ選択的合成及びin vivo α-グルコシダーゼ阻害活性評価2017
- Author(s)
  石川　文洋、神農　佳澄、薗田　直樹、木内　恵里、赤木　淳二、二宮　清文、村岡　修、吉川　雅之、森川　敏生、田邉　元三
- Organizer
  第59回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-17K08377
[Presentation] α-グルコシダーゼ阻害剤, Salacinolの構造活性相関研究―トルイル酸型置換基による3’位疎水化の効果2013
- Author(s)
  田邉元三，中村真也，筒井　望，赤木淳二，森川敏生，二宮清文，仲西　功，吉川雅之，村岡　修
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  アステールプラザ（広島市中区)
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Salacinolをシードとするスルホニウム塩型α-グルコシダーゼ阻害剤のin silico設計,合成および評価:3'位アルキル化の効果2013
- Author(s)
  田邉元三,國方雄介,中村真也,筒井望,赤木淳二,森川敏生,二宮清文,仲西功,吉川雅之,村岡修
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] α-グルコシダーゼ阻害剤、salacinolの構造活性相関研究:トルイル酸型置換基による3'位疎水化の効果2013
- Author(s)
  田邉元三,中村真也,國方雄介,筒井望,赤木淳二,森川敏生,二宮清文,仲西功,吉川雅之,村岡修
- Organizer
  第63回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都
- Year and Date
  2013-10-12
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Structure Activity Relationship Study on Salacinol, a Potentα-Glucosidase Inhibitor from Ayurvedic Traditional Medicine"Salacia": Effect of 3'-O-Aralkylation with Toluic Acid2013
- Author(s)
  G. Tanabe, S. Nakamura, N. Tsutsui, J. Akaki, T. Morikawa, K. Ninomiya, I. Nakanishi, M. Yoshikawa, O. Muraoka
- Organizer
  9th AFMS International Medicinal Chemistry Symposium (AIMECS13)
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] α-グルコシダーゼ阻害剤, Salacinolの構造活性相関研究―トルイル酸型置換基による3'位疎水化の効果―2013
- Author(s)
  田邉元三,中村真也,筒井望,赤木淳二,森川敏生,二宮清文,仲西功,吉川雅之,村岡修
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  広島
- Year and Date
  2013-11-22
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] α-グルコシダーゼ阻害剤、salacinolの構造活性相関研究:3'位脂溶性化が活性に及ぼす効果2013
- Author(s)
  田邉元三,中村真也,國方雄介,筒井望,赤木淳二,森川敏生,二宮清文,仲西功,吉川雅之,村岡修
- Organizer
  第5回食品薬学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2013-11-02
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Structure Activity Relationship Study on Salacinol, a Potent α-Glucosidase Inhibitor from Ayurvedic Traditional Medicine “Salacia”: Effect of 3’-O-Aralkylation with Toluic Acid2013
- Author(s)
  G. Tanabe, S. Nakamura, N. Tsutsui, J. Akaki, T. Morikawa, K. Ninomiya, I. Nakanishi, M. Yoshikawa, O. Muraoka
- Organizer
  9th AFMS International Medicinal Chemistry Symposium (AIMECS13)
- Place of Presentation
  Grand Hotel (Taipei, Taiwan)
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] α-グルコシダーゼ阻害剤、salacinolの構造活性相関研究：トルイル酸型置換基による3'位疎水化の効果2013
- Author(s)
  田邉元三，中村真也，國方雄介，筒井　望，赤木淳二，森川敏生，二宮清文，仲西　功，吉川雅之，村岡　修
- Organizer
  第63回日本薬学会近畿支部大会
- Place of Presentation
  同志社女子大学京田辺キャンパス(京都府京田辺市）
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] α-グルコシダーゼ阻害剤、salacinolの構造活性相関研究：3'位脂溶性化が活性に及ぼす効果2013
- Author(s)
  田邉元三，中村真也，國方雄介，筒井　望，赤木淳二，森川敏生，二宮清文，仲西　功，吉川雅之，村岡　修
- Organizer
  第5回食品薬学シンポジウム
- Place of Presentation
  京都大学大学院薬学研究科・記念講堂（京都市左京区）
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Salacinolをシードとするスルホニウム塩型α-グルコシダーゼ阻害剤のin silico設計,合成および評価2012
- Author(s)
  田邉元三,中村真也,筒井望,赤木淳二,森川敏生,二宮清文,仲西功,吉川雅之,村岡修
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation]2012
- Author(s)
  G. Tanabe, S. Nakamura, N. Tsutsui, Masahiro Yoshinaga, Y. Kunikata, J. Akaki, T. Morikawa, K. Ninomiya,I. Nakanishi, M. Yoshikawa, O. Muraoka
- Organizer
  The 12^<th> International Kyoto Conference on New Aspects of Organic Chemistry
- Place of Presentation
  IKCOC-12, Kyoto, Japan
- Year and Date
  2012-11-15
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] α-Glucosidase阻害剤salacinolの3'位アルキル化体の合成および活性評価:3'位疎水性置換基が活性に及ぼす効果2012
- Author(s)
  田邉元三, Balakishan Gorre, 筒井望, 中村真也, 仲西功, 吉川雅之, 村岡修
- Organizer
  生物分子システムに基づく創薬科学フロンティア研究成果発表会
- Place of Presentation
  京都
- Year and Date
  2012-02-18
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Salacinolをシードとするスルホニウム塩型α-グルコシダーゼ阻害剤のin silico設計,合成及び評価2012
- Author(s)
  田邉元三,中村真也,國方雄介,土屋聡史,吉長正紘,筒井望,赤木淳二,森川敏生,二宮清文,仲西功,吉川雅之,村岡修
- Organizer
  第62回日本薬学会近畿支部大会
- Place of Presentation
  武庫川
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] α-Glucosidase阻害剤salacinolの構造活性相関:3'位ベンジル化の効果2012
- Author(s)
  田邉元三, 土屋聡史, 筒井望, 峯松敏江, 赤木淳二, 中村真也, 仲西功, 吉川雅之, 村岡修
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Salacinolをシードとするスルホニウム塩型α-グルコシダーゼ阻害剤のin silico設計,合成及び評価2012
- Author(s)
  田邉元三,中村真也,吉長正紘,筒井望,Gorre Balakishan,赤木淳二,森川敏生,二宮清文,仲西功,吉川雅之,村岡修
- Organizer
  第54回天然有機化合物討論会
- Place of Presentation
  東京
- Year and Date
  2012-09-18
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Biological Evaluation of 3'-O-Alkylated Analogs of Salacinol, the Role of Hydrophobic Alkyl Group at 3'Position in the Side Chain on theα-Glucosidase Inhibitory Activity2011
- Author(s)
  G. Tanabe, N. Tsutsui, M. Oka, B. Gorre, W. Xie, S. Nakamura, I. Nakanishi, M. Yoshikawa, O. Muraoka
- Organizer
  8^<th > AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science"
- Place of Presentation
  Tokyo
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Biological Evaluation of 3'-O-Alkylated Analogs of Salacinol, the Role of Hydrophobic Alkyl Group at 3'Position in the Side Chain on theα-Glucosidase Inhibitory Activity2011
- Author(s)
  G. Tanabe, T. Otani, N. Tsutsui, H. Takemura, W. Xie, B. Gorre, M. Yoshikawa, O. Muraoka
- Organizer
  23rd International Congress on Heterocyclic Chemistry
- Place of Presentation
  Glasgow, Scotland
- Year and Date
  2011-08-01
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Synthesis and Biological Evaluation of 3'-O-Alkylated Salacinols asα-Glucosidase Inhibitors2011
- Author(s)
  G. Tanabe, T. Otani, H. Takemura, S. Tsuchiya, N. Tsutsui, B. Gorre, M. Yoshikawa, O. Muraoka
- Organizer
  22^<nd> French- Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  Rouen, France
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Salacinolをシードとするスルホニウム塩型α-グルコシダーゼ阻害剤のin silico設計,合成及び評価2011
- Author(s)
  田邉元三,中村真也,國方雄介,土屋聡史,吉長正紘,筒井望,赤木淳二,森川敏生,二宮清文,仲西功,吉川雅之,村岡修
- Organizer
  第19回天然薬物の開発と応用シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2011-11-01
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] α-Glucosidase阻害剤salacinolの3'位疎水化の活性に及ぼす効果2011
- Author(s)
  田邉元三, 土屋聡史, 筒井望, 赤木淳二, 中村真也, 仲西功, 吉川雅之, 村岡修
- Organizer
  第61回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] 非環式salacinol類縁体の合成とそのα-glucosidase阻害活性評価2009
- Author(s)
  田邉元三
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19590111
[Presentation] 非環式salacinol類縁体の合成とその α-glucosidase阻害活性評価2009
- Author(s)
  田邉元三、長山麻衣子、赤木淳二、峯松敏江、吉川雅之、村岡修
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19590111
[Presentation] α-Glucosidase 阻害剤 salacinol の3’位疎水化の活性に及ぼす効果
- Author(s)
  田邉元三、土屋聡史、筒井望、赤木淳二、中村真也、仲西功、吉川雅之、村岡修
- Organizer
  第６１回日本薬学会近畿支部大会
- Place of Presentation
  神戸学院大学薬学部（大阪）
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] In Silico Design, Synthesis and Evaluation of 3′-O-Benzylated Analogs of Salacinol, a Potent α-Glucosidase Inhibitor from Ayurvedic Traditional Medicine “Salacia”
- Author(s)
  Genzoh Tanabe, Shinya Nakamura, Nozomi Tsutsui, Masahiro Yoshinag, Yusuke Kunikata, Junji Akaki, Toshio Morikawa, Kiyofumi Ninomiya, Isao Nakanishi, Masayuki Yoshikawa, Osamu Muraoka
- Organizer
  The Twelfth International Kyoto Conference on New Aspect of Organic Chemistry
- Place of Presentation
  リーガロイヤルホテルKYOTO（京都）
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Salacinol をシードとする新規 α-グルコシダーゼ阻害剤の in silico 設計, 合成および評価
- Author(s)
  田邉元三, 中村真也,　筒井望,　赤木淳二, 森川敏生, 二宮清文, 仲西功, 吉川雅之, 村岡修
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  タワーホテル船堀（東京）
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Salacinol をシードとするスルホニウム塩型α-グルコシダーゼ阻害剤の in silico 設計, 合成及び評価
- Author(s)
  田邉元三, 中村真也, 吉長正絋, 筒井　望, Gorre Balakishan, 赤木淳二, 森川敏生, 二宮清文,　仲西　功,　吉川雅之, 村岡　修
- Organizer
  第５４回天然有機化合物用論会
- Place of Presentation
  東京農業大学世田谷キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Salacinolをシードとするスルホニウム塩型α-グルコシダーゼ阻害剤のin silico設計、合成及び評価
- Author(s)
  田邉元三、中村真也、國方雄介、土屋聡史、吉長正絋、筒井　望、赤木淳二、森川敏生、二宮清文、仲西　功、吉川雅之、村岡　修
- Organizer
  第62回日本薬学会近畿支部大会
- Place of Presentation
  武庫川女子大学薬学部（武庫川）
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] Salacinol をシードとするスルホニウム塩型α-グルコシダーゼ阻害剤のin silico 設計, 合成及び評価
- Author(s)
  田邉元三, 中村真也, 國方雄介, 土屋聡史, 吉長正絋, 筒井　望, 赤木淳二, 森川敏生, 二宮清文, 吉川雅之, 仲西　功, 村岡　修
- Organizer
  第19回天然薬物の開発と応用シンポジウム
- Place of Presentation
  大阪大学（大阪）
- Data Source
  KAKENHI-PROJECT-23590140
[Presentation] α-Glucosidase 阻害剤 salacinol の構造活性相関：3’位ベンジル化の効果
- Author(s)
  田邉元三、土屋聡史、筒井望、峯松敏江、赤木淳二、中村真也、仲西功、吉川雅之、村岡修
- Organizer
  日本薬学会第１３２年会
- Place of Presentation
  北海道大学札幌キャンパス（札幌）
- Data Source
  KAKENHI-PROJECT-23590140

1. MINEMATSU Toshie (60088151)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. MURAOKA Osamu (20142599)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. Sugiura Reiko (90294206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
4. SATOH Ryosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. NINOMIYA kiyofumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 宮本洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 森川敏生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tanabe Genzoh 田辺 元三

TANABE Genzoh 田辺 元三

田辺 元三 タナベ ゲンゾウ

Research Projects

Research Products

Co-Researchers

新規作用機序の抗結核薬開発を志向したスルホニウム塩型ラムノシダーゼ阻害剤の創生Principal Investigator

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Review Section

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Mechanisms of cancer-specific apoptosis induction targeting ERK hyperactivation

Principal Investigator

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Review Section

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Synthesis and evaluation of di-cationic sulfonium-type alpha-glucosidase inhibitors based on the structure of salacinolPrincipal Investigator

Principal Investigator

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Synthesis and evaluation of sulfonium-type alpha-glucosidase inhibitors based on the structure of salacinolPrincipal Investigator

Principal Investigator

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Synthesis and evaluation of new α-glucosidase inhibitors having thiosugar-sulfonium salt structure based on salacinolPrincipal Investigator

Principal Investigator

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Synthesis and Biological Evaluation of New α-Glucosidase inhibitors Designated on the Basis of the Structure of Salacinol

Principal Investigator

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Research Institution

Synthetic Studied on Thiosugar Suronium Sulfate Inner Salt,a Potent α-Glucosidase Inhibitor

Principal Investigator

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Research Institution

[Journal Article] ACAGT‐007a, an anti‐cancer compound that modulates ERK MAPK signaling, induces nuclear enrichment of phosphorylated ERK in T3M4 pancreatic cancer cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Down‐regulation of dual‐specificity phosphatase 6, a negative regulator of oncogenic ERK signaling, by ACA‐28 induces apoptosis in NIH/3T3 cells overexpressing HER2/ErbB22021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-282020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Facile synthesis of neokotalanol, a potent α-glycosidase inhibitor isolated from the Ayurvedic tradi-tional medicine “Salacia”2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of salacinol-d4 as an internal standard for mass-spectrometric quantitaatiion of salacinol, a potent alpha-glucosidase inhibitor found in a traditiional ayurvedic medicine "Salacia"2018

Author(s)

Journal Title

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[Journal Article] Diastereoselective Synthesis of Salacinol-Type α-Glucosidase Inhibitors2017

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[Journal Article]2012

Author(s)

Tanabe Genzoh 田辺元三

TANABE Genzoh 田辺元三

田辺元三タナベゲンゾウ