Kawahara Masahiro 川原正博

… Alternative Names

KAWAHARA Masahiro 川原正博

川原正博カワハラマサヒロ

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Researcher Number	40224828
Other IDs
External Links
Affiliation (Current)	2025: 武蔵野大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2025: 武蔵野大学, 薬学部, 教授 2018 – 2021: 武蔵野大学, 薬学部, 教授 2014 – 2017: 武蔵野大学, 薬学研究所, 教授 2003 – 2011: 九州保健福祉大学, 薬学部, 教授 2002: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 … More 2001 – 2002: 東京都神経科学総合研究所, 主事研究員 2001: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 主事研究員 2000 – 2001: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 主事研究員 1999: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 主事研究員 1997 – 1998: (財)東京都神経科学総合研究所, 神経生化学研究部門, 主事研究員 1994 – 1995: (財)東京都神経科学総合研究所, 神経生化学研究部門, 主事研究員 1991 – 1993: 東京都神経科学総合研究所, 神経生化学研究部門, 主事研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / 医薬分子機能学 / Environmental pharmacy / Neurochemistry/Neuropharmacology / Environmental and hygienic pharmacy Except Principal Investigator Intelligent mechanics/Mechanical systems / Drug development chemistry / Biological pharmacy / Chemical biology / Nerve anatomy/Neuropathology / Biological Sciences
Keywords	Principal Investigator アルツハイマー病 / プリオン病 / 亜鉛 / 銅 / アポトーシス / カルシウム / 小胞体ストレス / 神経細胞死 / カルノシン / プリオン … More / チャネル / イオンチャネル / Alzheimer's disease / 微量元素 / membrane lipid / calcium homeostasis / 神経ステロイド / 膜脂質 / HPLC / カルシウムホメオスタシス / 神経毒性 / コンフォメーション / イメージング / 無機金属毒性 / 中毒学 / βアミロイド蛋白 / zinc / 金属 / アミロイド / 過酸化 / シナプス / 酸化ストレス / cell culture / apoptosis / copper / prion disease / カルシウムホメオスタシス / 細胞死 / 高次構造 / カルシウムホメオスタシ / パーキンソン / プリ / アルツハイマー / アルミニウム / 培養神経細胞 / シヌクレイン / プリオン蛋白 / 細胞培養 / ペプチド / cholesterol / development / culture / Parkinson's disease / Prion disease / コレステロール / イオンチャンネル / 性ホルモン / GT1-7細胞 / 細胞内カルシウム変動 / Alzheimer / dementia / anserine / amyloid / Zn / ER stress / carnosine / 運動能力 / 抗酸化 / 肺疾患 / ARDS / 老年性認知症 / 脳血管性認知症 / RT-PCR / 小胞体 / 虚血性神経細胞死 / p8 / patch-clamp / Western blotting / 免疫組織化学 / 培養大脳皮質・海馬神経細胞 / iron / Aggregation / desferrioxamine / Amyloid β protein / Aluminium … More Except Principal Investigator 大脳皮質 / PACAP / カルシウム / VIP / 神経科学 / プロテオーム / アミロイド / 光反応 / BDNF / アルツハイマー病 / 神経細胞死 / シナプス再形成 / シナプス可塑性 / 記憶強化 / 薬物スクリーニング / 再生医療 / 組織工学 / ドラッグスクリーニング / 薬剤スクリーニング / 組織チップ / マイクロデバイス / peptide polymerization / screening / panning / proteome / amyloid / antibody-displayed phage / diazirine / photoreaction / ペプチド多量化 / スクリーニング / パニング / 抗体提示ファージ / ジアジリン / Gene expression / Apoptosis / Calcium / Neurotrophin / プロテオミクス / DNAマイクロアレイ / ニユーロトロフィン / 脳由来神経栄養因子(BDNF) / 遺伝子発現 / ポリグルタミン病 / アポトーシス / 脳由来神経栄養因子 / ニューロトロフィン / バイオテクノロジー / 分析化学 / 薬学 / 糖鎖 / 開裂と閉環 / ペプチド合成 / 神経細胞 / アスパラギン酸 / ジケトピペラチン / 異性化 / アミロイドペプチド / ERK / グリア / cAMP / アストログリア細胞株 / GFRα1 / TrkB-T1 / アストログリア / ニューロン / GDNF / 免疫細胞染色 / 神経初代培養細胞 / 共焦点レーザー走査顕微鏡 / シナプス脱落 / βアミロイド / 蛍光色素モニター / カルシウム流入 / MAP1B / シナプス形成 / ラット大脳皮質培養細胞 / プロテインキナーゼ阻害剤・K-252b / アデノシン / 細胞内カルシウム / 培養神経細胞 / LTP / 高頻度刺激 / 発火パターン / Synchronous oscillation / 時空間パターン / 培養ニューロン / 記憶 / ニューロン回路 / トレーシング回路 / ニューロン閉回路 / パッチクランプ法 / 電気活動 / 健忘 / トレ-シング回路 / ニュ-ロン閉回路 / 海馬 / 連想記憶 Less

有機フッ素化合物(PFAS)による神経内分泌毒性メカニズム解明Principal Investigator
- Principal Investigator
  
  川原正博
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Musashino University
Effects of metals on oligomerization, channel formation, and neurotoxicity of amyloidogenic proteinsPrincipal Investigator
- Principal Investigator
  
  Kawahara Masahiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Musashino University
Neural tissue array with blood brain barrier (BBB) for the drug screening assay
- Principal Investigator
  
  Negishi Midori
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Intelligent mechanics/Mechanical systems
- Research Institution
  Musashino University
Neuroprotective mechanism of carnosine against zinc-induced neurotoxicity: a possible drug for vascular dementiaPrincipal Investigator
- Principal Investigator
  
  Kawahara Masahiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Musashino University
Molecular mechanism of zinc-induced neurotoxicity : involvement of Ca and ER stressPrincipal Investigator
- Principal Investigator
  
  KAWAHARA Masahiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Kyushu University of Health and Welfare
Development of the photochemical panning adapted to low affinity ligands and analysis of neural carbohydrates' functions
- Principal Investigator
  
  SADAKANE Yutaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Kyushu University of Health and Welfare
Involvement of calcium homeostasis in the apoptotic neuronal death induced by zincPrincipal Investigator
- Principal Investigator
  
  KAWAHARA Masahiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Kyushu University of Health and Welfare
Development of screening system for antibody-displayed phages by photo panning method : isolation of anti-amyloid antibody
- Principal Investigator
  
  SADAKANE Yutaka
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyushu University of Health and Welfare
神経グリア間におけるニューロトロフィン遺伝子発現応答ネットワークの解析
- Principal Investigator
  
  TSUDA Masaaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Toyama
  Toyama Medical and Pharmaceutical University
アルツハイマーAβペプチドの新規自己開裂・閉環現象の解明と応用
- Principal Investigator
  
  SADAKANE Yutaka
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Kyushu University of Health and Welfare
Formation of ion chyannels by amyloidogenic proteins and screening for protective substancesPrincipal Investigator
- Principal Investigator
  
  KAWAHARA Masahiro
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
  Tokyo Metropolitan Organization for Medical Research
Calcium-mediated activation of gene expression in neurons and a survey for drugs preventing neurodegenerative disorders
- Principal Investigator
  
  TSUDA Masaaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
培養神経細胞を用いたシナプス再形成・機能修復実験系の分子機構解明
- Principal Investigator
  
  黒田洋一郎
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Effects of membrane lipids on the incorporation of Alzheimer's β-amyloid protein into membranes and neurotoxicityPrincipal Investigator
- Principal Investigator
  
  KAWAHARA Masahiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
培養神経細胞を用いたシナプス再形成・機能修復実験系の開発と分子機構解明
- Principal Investigator
  
  黒田洋一郎
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
培養下神経回路網を用いた興奮の時空間パターンの単一ニューロン・レベルでの相関解析
- Principal Investigator
  
  黒田洋一郎
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
培養神経細胞を用いたシナプス再形成・機能修復実験系の開発と分子機構解明
- Principal Investigator
  
  黒田洋一郎
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
アルツハイマー・アミロイド前駆体蛋白質の培養神経細胞間シナプス形成に対する作用Principal Investigator
- Principal Investigator
  
  川原正博
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
アルツハイマー・アミロイドβ蛋白の初代培養神経細胞に対する神経毒性:Aggregationによる構造変化と毒性との関係Principal Investigator
- Principal Investigator
  
  川原正博
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
コバリアンス学習におけるシナプス結合可塑性の細胞・分子機構
- Principal Investigator
  
  黒田洋一郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
in vitroシナプス形成で自己組織化された大脳皮質神経回路網の構造の機能
- Principal Investigator
  
  黒田洋一郎
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
in vitro シナプス形成で自己組織化された大脳皮質神経回路の構造と機能
- Principal Investigator
  
  黒田洋一郎
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience

[Book] 脳血管性認知症発症における亜鉛と銅のクロストーク2019
- Author(s)
  川原正博、根岸みどり、田中健一郎
- Total Pages
  10
- Publisher
  亜鉛栄養治療
- Data Source
  KAKENHI-PROJECT-17H03197
[Book] Metallomics-Recent Analytical Techniques and Applications-, (eds Ogra,Y and Hirata, T)2017
- Author(s)
  Mizuno D and Kawahara M
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26460177
[Book] Disruption of metal homeostasis and the pathogenesis of prion diseases Prion2016
- Author(s)
  Kawahara M, Tanaka K, and Mizuno D
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-26460177
[Book] Aluminum Neurotoxicity: From Subtle Molecular Lesions to Neurological Diseases2016
- Author(s)
  Kawahara M
- Publisher
  Nova publication
- Data Source
  KAKENHI-PROJECT-26460177
[Book] Carnosine: Physiological Effects and Research Insights2016
- Author(s)
  Kawahara M, Tanaka K and Mizuno D
- Publisher
  Nova Science Publishers
- Data Source
  KAKENHI-PROJECT-26460177
[Book] Oligomerization (ed by Claire Lesieur, ISBN 980-953-307-1130-3)2014
- Author(s)
  Mizuno D and Kawahara M
- Total Pages
  450
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-26460177
[Book] Disruption of calcium homeostasis in Alzheimer's disease : role of channel formation by β Amyloid Protein In "Neurodegenerative Diseases/Book 2", ISBN 979-953-307-672-9(Ed by Ivana Zach)2011
- Author(s)
  Kawahara M., Koyama H., Ohkawara S., Kato-Negishi M
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-21590145
[Book] Disruption of calcium homeostasis in Alzheimer's disease : role of channel formation byβAmyloid Protein, In "Neurodegenerative Diseases/Book 2"2011
- Author(s)
  Kawahara M., Koyama H., Ohkawara S., Kato-Negishi M.
- Data Source
  KAKENHI-PROJECT-21590145
[Book] Aluminum and human health : possible link with neurodegenerative disorders. In Metals and Neurodegeneration2010
- Author(s)
  Kawahara M
- Data Source
  KAKENHI-PROJECT-21590145
[Book] Protective substances against zinc-induced neuronal death after ischemia : carnosine as a target for drug of vascular type of dementia. In Frontiers in CNS Drug Discovery2010
- Author(s)
  Kawahara M, Konoha K, Tetsuya N and Sadakane Y
- Publisher
  Bentham Science Publishers
- Data Source
  KAKENHI-PROJECT-21590145
[Book] Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal disease by reversed-phase HPLC. In D-Amino Acids in chemistry, Life Sciences and Biotechnology2010
- Author(s)
  Sadakane Y., Konoha K., Kawahara M., Nakagomi K. Hans Bruckner and Noriko Fujii
- Data Source
  KAKENHI-PROJECT-21590145
[Book] Metals and Neurodegeneration (Editor : Shile Huang)2010
- Author(s)
  Kawahara M:
- Publisher
  Aluminum and human health : possible link with neurodegenerative disorders. (Research Signpost)
- Data Source
  KAKENHI-PROJECT-21590145
[Book] 日本薬学会物理系薬学部会・分析化学担当教員会議編、認知症予防候補物質の探索と単離・構造決定、「薬学分析科学の最前線」2009
- Author(s)
  川原正博, 定金豊
- Total Pages
  185
- Publisher
  じほう
- Data Source
  KAKENHI-PROJECT-19590133
[Book] 認知症予防候補物質の探索と単離・構造決定、「薬学分析科学の最前線」、日本薬学会物理系薬学部会・分析化学担当教員会議編2009
- Author(s)
  川原正博、定金豊
- Publisher
  じほう
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Cell fiber‐based 3D tissue array for drug response assay2022
- Author(s)
  Midori Kato‐Negishi, Jun Sawayama, Masahiro Kawahara,& ShojiTakeuchi
- Journal Title
  
  Scientific Reports
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] 神経疾患発症におけるアミロイド形成タンパク質とニューロメタルのクロストーク2022
- Author(s)
  川原正博、田中健一郎、根岸みどり
- Journal Title
  
  月刊「細胞」
  
  Volume: 54 Pages: 35-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Effects of selenium-containing compounds on Cu<sup>2+</sup>/Zn<sup>2+</sup>-induced neuronal cell death and potential application as therapeutic agents for neurological diseases2022
- Author(s)
  Tanaka Ken-ichiro、Shimoda Mikako、Kawahara Masahiro
- Journal Title
  
  Neural Regeneration Research
  
  Volume: 17 Issue: 2 Pages: 311-311
- DOI
  10.4103/1673-5374.317968
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Neurotoxicity of Aluminum and its link with neurodegenerative diseases.2022
- Author(s)
  Kawahara Masahiro, Tanaka Ken-ichiro, Kato-Negishi Midori
- Journal Title
  
  Metallomics Research
  
  Volume: 1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Cell fiber-based 3D tissue array for drug response assay2022
- Author(s)
  Midori Kato-Negishi, Jun Sawayama, Masahiro Kawahara & Shoji Takeuchi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 7870-7870
- DOI
  10.1038/s41598-022-11670-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03197, KAKENHI-PROJECT-23K21074
[Journal Article] Neurometals in the Pathogenesis of Prion Diseases2021
- Author(s)
  Kawahara Masahiro、Kato-Negishi Midori、Tanaka Ken-ichiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 3 Pages: 1267-1267
- DOI
  10.3390/ijms22031267
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Neurotoxicity of aluminum and its link to neurodegenerative diseases2021
- Author(s)
  Masahiro Kawahara, Ken-ichiro Tanaka, Midori Kato-Negishi
- Journal Title
  
  Metallomics Research
  
  Volume: 1 Issue: 1 Pages: rev-47-rev-65
- DOI
  10.11299/metallomicsresearch.MR202104
- NAID
  130008145805
- ISSN
  2436-5173
- Year and Date
  2021-12-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03197
[Journal Article] Copper as a Collaborative Partner of Zinc-Induced Neurotoxicity in the Pathogenesis of Vascular Dementia2021
- Author(s)
  Kawahara Masahiro、Tanaka Ken-ichiro、Kato-Negishi Midori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 14 Pages: 7242-7242
- DOI
  10.3390/ijms22147242
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669, KAKENHI-PROJECT-17H03197
[Journal Article] Thioredoxin-albumin fusion protein prevents urban aerosol-induced lung injury via suppressing oxidative stress-related neutrophil extracellular trap formation.2021
- Author(s)
  Tanaka KI, Kubota M, Shimoda M, Hayase T, Miyaguchi M, Kobayashi N, Ikeda M, Ishima Y, Kawahara M.
- Journal Title
  
  Environ Pollut.
  
  Volume: 268(Pt A) Pages: 115787-115787
- DOI
  10.1016/j.envpol.2020.115787
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06691, KAKENHI-PROJECT-18K06669
[Journal Article] 神経疾患と亜鉛2020
- Author(s)
  川原正博、水野大、定兼豊
- Journal Title
  
  亜鉛栄養治療
  
  Volume: 11 Pages: 158-168
- NAID
  40020474970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Carnosine suppresses neuronal cell death and inflammation induced by 6-hydroxydopamine in an in vitro model of Parkinson's disease.2020
- Author(s)
  Kubota M, Kobayashi N, Sugizaki T, Shimoda M, Kawahara M, Tanaka KI.
- Journal Title
  
  PLoS One
  
  Volume: 1 Issue: 10 Pages: e0240448-e0240448
- DOI
  10.1371/journal.pone.0240448
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Seleno-L-methionine suppresses copper-enhanced zinc-induced neuronal cell death via induction of glutathione peroxidase.2020
- Author(s)
  Nakano Y, Shimoda M, Okudomi S, Kawaraya S, Kawahara M, Tanaka KI.
- Journal Title
  
  Metallomics
  
  Volume: 12 Issue: 11 Pages: 1693-1701
- DOI
  10.1039/d0mt00136h
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Amyloids: Regulators of Metal Homeostasis in the Synapse2020
- Author(s)
  Kawahara M, Kato-Negishi M, Tanaka KI
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 6 Pages: 1441-1441
- DOI
  10.3390/molecules25061441
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669, KAKENHI-PROJECT-17H03197
[Journal Article] Carnosine and Lung Disease2020
- Author(s)
  Tanaka KI, Kawahara M.
- Journal Title
  
  Curr Med Chem
  
  Volume: 27 Issue: 11 Pages: 1714-1725
- DOI
  10.2174/0929867326666190712140545
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669, KAKENHI-PROJECT-18K06691
[Journal Article] Carnosine as a Possible Drug for Zinc-Induced Neurotoxicity and Vascular Dementia.2020
- Author(s)
  Kawahara M, Sadakane Y, Mizuno K, Kato-Negishi M, Tanaka KI.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 21 Issue: 7 Pages: 2570-2570
- DOI
  10.3390/ijms21072570
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669, KAKENHI-PROJECT-19K07031, KAKENHI-PROJECT-17H03197
[Journal Article] Protective effect of polaprezinc on cadmium-induced injury of lung epithelium.2019
- Author(s)
  Kimura K, Nakano Y, Sugizaki T, Shimoda M, Kobayashi N, Kawahara M, Tanaka KI.
- Journal Title
  
  Metallomics
  
  Volume: 11 Issue: 7 Pages: 1310-1320
- DOI
  10.1039/c9mt00060g
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] 神経系における亜鉛の役割、2019
- Author(s)
  川原正博、田中健一郎、根岸みどり
- Journal Title
  
  ClinicalNeuroscience
  
  Volume: 37 Pages: 333-337
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity.2019
- Author(s)
  Yamashita Y, Tanaka KI, Yamakawa N, Asano T, Kanda Y, Takafuji A, Kawahara M, Takenaga M, Fukunishi Y, Mizushima T.
- Journal Title
  
  Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity.
  
  Volume: 17 Issue: 15 Pages: 3339-3346
- DOI
  10.1016/j.bmc.2019.06.016
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Involvement of SAPK/JNK signaling pathway in copper enhanced zinc-induced neuronal cell death.2019
- Author(s)
  Tanaka KI1, Shimoda M1, Kasai M1, Ikeda M2, Ishima Y2, Kawahara M
- Journal Title
  
  Toxicol Sci. 2019 Feb 15. pii: kfz043. doi: 10.1093/toxsci/kfz043. [Epub ahead of print]
  
  Volume: Feb15 Issue: 1 Pages: 043-043
- DOI
  10.1093/toxsci/kfz043
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669, KAKENHI-PROJECT-18J10935, KAKENHI-PROJECT-18H02587
[Journal Article] Nickel enhances zinc-induced neuronal cell death by priming the endoplasmic reticulum stress response.2019
- Author(s)
  Tanaka KI, Kasai M, Shimoda M, Shimizu A, Kubota M, Kawahara M.
- Journal Title
  
  Oxid Med Cell Longev
  
  Volume: 17 Pages: 9693726-9693726
- DOI
  10.1155/2019/9693726
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Idebenone has preventative and therapeutic effects on pulmonary fibrosis via preferential suppression of fibroblast activity.2019
- Author(s)
  Sugizaki T, Tanaka KI, Asano T, Kobayashi D, Hino Y, Takafuji A, Shimoda M, Mogushi K, Kawahara M, Mizushima T.
- Journal Title
  
  Cell Death Discov
  
  Volume: 5 Pages: 146-146
- NAID
  130007813267
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] 脳血管性認知症発症における亜鉛と銅のクロストーク2019
- Author(s)
  川原正博、根岸みどり、田中健一郎
- Journal Title
  
  亜鉛栄養治療
  
  Volume: 9 Pages: 56-65
- NAID
  40021925031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Pyruvic acid prevents Cu2+/Zn2+-induced neurotoxicity by suppressing mitochondrial injury.2018
- Author(s)
  Tanaka KI, Shimoda M, Kawahara M.
- Journal Title
  
  Biochem Biophys Res Commun. 2018 Jan 1;495(1):1335-1341. doi: 10.1016/j.bbrc.2017.11.152. Epub 2017 Nov 24.
  
  Volume: 495 Issue: 1 Pages: 1335-1341
- DOI
  10.1016/j.bbrc.2017.11.152
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Zinc, Carnosine, and Neurodegenerative Diseases.2018
- Author(s)
  Kawahara M, Tanaka KI, Kato-Negishi M.
- Journal Title
  
  Nutrients. 2018 Jan 29;10(2). pii: E147. doi: 10.3390/nu10020147.
  
  Volume: 10 Issue: 2 Pages: 1-20
- DOI
  10.3390/nu10020147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] 亜鉛と神経疾患2018
- Author(s)
  川原正博、根岸みどり、田中健一郎
- Journal Title
  
  ファルマシア、54(7), 663-666 (2018).
  
  Volume: 54 Pages: 663-666
- NAID
  130007386939
- Data Source
  KAKENHI-PROJECT-18K06669
[Journal Article] Implications of Metal Binding and Asparagine Deamidation for Amyloid Formation.2018
- Author(s)
  Sadakane Y, Kawahara M.
- Journal Title
  
  Int J Mol Sci. 2018 Aug 19;19(8). pii: E2449. doi: 10.3390/ijms19082449.
  
  Volume: 19 Issue: 8 Pages: 1-23
- DOI
  10.3390/ijms19082449
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06669, KAKENHI-PROJECT-16K08207
[Journal Article] Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases2017
- Author(s)
  Kawahara M, Kato-Negishi M, Tanaka K
- Journal Title
  
  Metallomics
  
  Volume: 5 Issue: 6 Pages: 619-633
- DOI
  10.1039/c7mt00046d
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460177
[Journal Article] Evaluation of Lecithinized Superoxide Dismutase for the Prevention of Acute Respiratory Distress Syndrome in Animal Models2017
- Author(s)
  Tanaka KI, Tamura F, Sugizaki T, Kawahara M, Kuba K, Imai Y, Mizushima T
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 56(2) Issue: 2 Pages: 179-190
- DOI
  10.1165/rcmb.2016-0158oc
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05978, KAKENHI-PROJECT-26460177, KAKENHI-PROJECT-15K15304
[Journal Article] 神経疾患と微量元素2017
- Author(s)
  川原正博
- Journal Title
  
  臨床検査
  
  Volume: 61 Pages: 174-178
- Data Source
  KAKENHI-PROJECT-26460177
[Journal Article] Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice2017
- Author(s)
  Tanaka K, Niino T, Ishihara T, Sugizaki T, Takafuji A, Takayama T, Kanda Y, Tamura F, Kurotsu S, Kawahara M, Mizushima T
- Journal Title
  
  Scientific Reports
  
  Volume: 7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460177
[Journal Article] Preventive Effects of Carnosine on Lipopolysaccharide-induced Lung Injury.2017
- Author(s)
  Tanaka K, Sugizaki T, Kanda Y, Tamura F, Niino T, Kawahara M.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 42813-42813
- DOI
  10.1038/srep42813
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460104, KAKENHI-PROJECT-26460177
[Journal Article] 微量元素の生体機能と疾患－アルミニウムと神経疾患2016
- Author(s)
  川原正博
- Journal Title
  
  日本臨床
  
  Volume: 74 Pages: 1176-1185
- Data Source
  KAKENHI-PROJECT-26460177
[Journal Article] 微量元素と神経疾患：シナプス間隙における疾患関連タンパクと金属との相互作用2015
- Author(s)
  川原正博、水野大
- Journal Title
  
  Biomed Trace Elem Res
  
  Volume: 26 Pages: 10-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460177
[Journal Article] Quantification of horse plasma proteins altered by xylazine using the fluorogenic derivatization-liquid chromatography-tandem mass spectrometry2015
- Author(s)
  4.M.Mori, T. Ichibangase, S. Yamashita, I.Kijima-Suda, M. Kawahara, K.Imai
- Journal Title
  
  J. Equine Sci.
  
  Volume: 26 Pages: 141-146
- NAID
  130005124609
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460177
[Journal Article] Quantitative analysis of carnosine and anserine in foods by performing high performance liquid chromatography2015
- Author(s)
  Mori, D. Mizuno, K. Konoha-Mizuno, Y. Sadakane, M. Kawahara
- Journal Title
  
  Biomedical Research on Trace Elements
  
  Volume: 26 Pages: 49-53
- NAID
  130005113917
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460177
[Journal Article] Carnosine concentration in the muscle of thoroughbred horses and its implications in exercise performance2015
- Author(s)
  M.Mori, D.Mizuno, K.Konoha-Mizuno, Y.Sadakane, M.Kawahara
- Journal Title
  
  Trace Nutrients Research
  
  Volume: 32 Pages: 49-53
- NAID
  40020919697
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460177
[Journal Article] Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia.2015
- Author(s)
  Mizuno D et al
- Journal Title
  
  Metallomics
  
  Volume: 印刷中 Issue: 8 Pages: 1-7
- DOI
  10.1039/c5mt00049a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500527, KAKENHI-PROJECT-26460177
[Journal Article] Involvement of trace elements in the pathogenesis of prion diseases2014
- Author(s)
  Mizuno D, Koyama H, Ohkawara S, Sadakane Y, Kawahara M
- Journal Title
  
  Curr Pharam Biotech
  
  Volume: 15 Pages: 1049-57
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460177
[Journal Article] Carnosine: A Possible Drug for Vascular Dementia.2014
- Author(s)
  Mizuno D et al.
- Journal Title
  
  J Vasc Med Surg
  
  Volume: 2 Issue: 03 Pages: 146-146
- DOI
  10.4172/2329-6925.1000146
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500527, KAKENHI-PROJECT-26460177
[Journal Article] 神経疾患と亜鉛2014
- Author(s)
  川原正博、定金豊、水野大
- Journal Title
  
  亜鉛栄養治療
  
  Volume: 5 Pages: 4-15
- NAID
  40020474970
- Data Source
  KAKENHI-PROJECT-26460177
[Journal Article] ニューロメタルとアミロイド形成タンパク質のクロストーク2014
- Author(s)
  川原正博、水野大
- Journal Title
  
  日本衛生学雑誌
  
  Volume: 69 Pages: 155-165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460177
[Journal Article] 亜鉛と認知症:脳の中のヤヌス2012
- Author(s)
  川原正博
- Journal Title
  
  ファルマシア
  
  Volume: 48 Pages: 216-220
- NAID
  110009901048
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Zinc neurotoxicity and the pathogenesis of vascular-type dementia : Involvement of calcium dyshomeostasis and carnosine2012
- Author(s)
  Koyama H, Konoha K, Sadakane Y, Ohkawara S, Kawahara M
- Journal Title
  
  J.Clin Toxicol.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Zinc neurotoxicity and the pathogenesis of vascular-type dementia : Involvement of calcium dyshomeostasis and carnosine2012
- Author(s)
  Koyama H, Konoha K, Sadakane Y, Ohkawara S, and Kawahara M
- Journal Title
  
  J. Clin Toxicol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] 神経疾患と微量金属2012
- Author(s)
  川原正博、小山裕也、大河原晋
- Journal Title
  
  金属
  
  Volume: 82 Pages: 19-27
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-1262011
- Author(s)
  Kawahara M., Koyama H., Nagata T., Sadakane Y.
- Journal Title
  
  Metallomics (in press)
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's beta-amyloid protein2011
- Author(s)
  Kawahara M.
- Journal Title
  
  International Journal of Alzheimer's Disease.
  
  Volume: 2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's s-amyloid protein2011
- Author(s)
  Kawahara M., Ohtsuka I., Yokoyama S., Kato-Negishi M. and Sadakane Y
- Journal Title
  
  Int. J. Alzheimer Dis.
  
  Pages: 304583-304583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's β-amyloid protein2011
- Author(s)
  Kawahara M., Ohtsuka I., Yokoyama S., Kato-Negishi M., Sadakane Y.
- Journal Title
  
  Int.J.Alzheimer Dis.
  
  Volume: 2011 Pages: 304583-304583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-1262011
- Author(s)
  Kawahara M, Koyama H., Nagata T., Sadakane Y.
- Journal Title
  
  Metallomics
  
  Volume: 3 Pages: 726-734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Link between aluminum and the pathogenesis of Alzheimer's disease : the integration of the aluminum and amyloid cascade hypotheses2011
- Author(s)
  Kawahara M., Kato-Negishi M.
- Journal Title
  
  Int.J.Alzheimer Dis.
  
  Volume: 2011 Pages: 276393-276393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-1262011
- Author(s)
  Kawahara M.
- Journal Title
  
  Metallomics
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] アミロイド形成蛋白の高次構造変化と神経毒性に及ぼす金属の影響2011
- Author(s)
  川原正博、小山裕也、定金豊
- Journal Title
  
  Biomed. Res. Trace Elements
  
  Volume: 22 Pages: 7-14
- NAID
  10028117958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] アミロイド形成蛋白の高次構造変化と神経毒性に及ぼす金属の影響2011
- Author(s)
  川原正博、小山裕也、定金豊
- Journal Title
  
  Biomed.Res.Trace Elements
  
  Volume: 28 Pages: 49-53
- NAID
  10028117958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Link between aluminum and the pathogenesis of Alzheimer's disease : the integration of the aluminum and amyloid cascade hypotheses2011
- Author(s)
  Kawahara M. and Kato-Negishi M.
- Journal Title
  
  Int. J. Alzheimer Dis.
  
  Pages: 276393-276393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's beta-amyloid protein.2011
- Author(s)
  Masahiro Kawahara, Isao Ohtsuka, Shoko Yokoyama, Midori Kato-Negishi, Yutaka Sadakane
- Journal Title
  
  International Journal of Alzheimer's Disease. 2011,Article ID 304583 17
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] Ligand structure for photoaffinity labeling of carbohydrate-binding protein.2010
- Author(s)
  Sadakane Y, Otsuka I, Konoha K, Koyama H, Kawahara M, Hatanaka Y
- Journal Title
  
  Photomedicine and Photobiology 31(In press)
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Ligand structure for photoaffinity labeling of carbohydrate-binding protein2010
- Author(s)
  Sadakane Y, Otsuka I, Konoha K, Koyama H, Kawahara M, Hatanaka Y
- Journal Title
  
  Photomedicine and Photobiology
  
  Volume: 31 Pages: 9-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Effects of UV-B irradiation on the stability of amino acids and peptides.2010
- Author(s)
  Sadakane Y, Fukuhara T, Kawahara M, Nakagomi K
- Journal Title
  
  J.KUHW 11
  
  Pages: 147-152
- NAID
  110007577967
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article]2010
- Author(s)
  Kawahara M, Konoha K, Nagata T, Sadakane Y
- Journal Title
  
  Frontiers in CNS Drug Discovery(Bentham Science Publishers)
  
  Pages: 21-30
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal disease by reversed-phase HPLC2010
- Author(s)
  Sadakane Y, Konoha K., Kawahara M., Nakagomi K.
- Journal Title
  
  Chem. & Biodivers
  
  Volume: 7 Pages: 1371-1379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal disease by reversed-phase HPLC2010
- Author(s)
  Sadakane Y, Konoha K., Kawahara M., Nakagomi K
- Journal Title
  
  Chem. & Biodivers (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Role of calcium dyshomeostasis via amyloid channels in the pathogenesis of Alzheimer's disease2010
- Author(s)
  Kawahara M
- Journal Title
  
  Current Pharmaceutical Design
  
  Volume: 16 Pages: 2779-2789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Analysis of structural alternation of L-Asp and L-Asn residures in the peptides related to neuronal conformation disease2010
- Author(s)
  Sadakane Y., Konoha K., Kawahara M
- Journal Title
  
  KURRI-KR 148
  
  Pages: 1-5
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Effects of UV-B irradiation on the stability of amino acids and peptides.2010
- Author(s)
  Sadakane Y, Fukuhara T, Kawahara M, Nakagomi K
- Journal Title
  
  J.KUHW
  
  Volume: 11 Pages: 147-152
- NAID
  110007577967
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal disease by reversed-phase HPLC2010
- Author(s)
  Sadakane Y, Konoha K., Kawahara M., Nakagomi K.
- Journal Title
  
  Chem.& Biodivers
  
  Volume: 7 Pages: 1371-1379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article]2010
- Author(s)
  Kawahara M
- Journal Title
  
  Metals and Neurodegeneration (Editor : Shile Huang)(Research Signpost)
  
  Pages: 15-56
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal disease by reversed-phase HPLC.2010
- Author(s)
  Y.Sadakane, K.Konoha, M.Kawahara, K.Nakagomi
- Journal Title
  
  Chem.& Biodivers. 7
  
  Pages: 1371-1379
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] Effects of UV-B irradiation on the stability of amino acids and peptides2010
- Author(s)
  Sadakane Y, Fukuhara T, Kawahara M, Nakagomi K
- Journal Title
  
  J. KUHW
  
  Volume: 11 Pages: 147-152
- NAID
  110007577967
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Ligand structure for photoaffinity labeling of carbohydrate-binding protein.2009
- Author(s)
  Y.Sadakane, I.Otsuka, K.Konoha, H.Koyama, M.Kawahara, Y.Hatanaka
- Journal Title
  
  Photomedicine and Photobiology 31
  
  Pages: 9-10
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] Analysis of structural alternation of L-Asp and L-Asn residures in the peptides related to neuronal conformation disease2009
- Author(s)
  Sadakane Y., Konoha K., Kawahara M.
- Journal Title
  
  KURRI-KR
  
  Volume: 148 Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Calcium dyshomeostasis andneurotoxicity of Alzheimer's beta-amyloidprotein. Expert Rev.2009
- Author(s)
  Kawahara M, Negishi-Kato M, Sadakane Y
- Journal Title
  
  Neurother 9
  
  Pages: 681-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein.2009
- Author(s)
  Kawahara M, Negishi-Kato M, Sadakane Y
- Journal Title
  
  Expert Rev Neurother 9
  
  Pages: 681-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein2009
- Author(s)
  Kawahara M
- Journal Title
  
  Expert Rev Neurother. 9
  
  Pages: 681-693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein.2009
- Author(s)
  Kawahara M, Negishi-Kato M, Sadakane Y.
- Journal Title
  
  Expert Rev Neurother. 9
  
  Pages: 681-693
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein2009
- Author(s)
  Kawahara M. Negishi-Kato M, Sadakane Y.
- Journal Title
  
  Expert Rev Neurother
  
  Volume: 9 Pages: 681-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein.2009
- Author(s)
  Kawahara M., Negishi-Kato M, Sadakane Y
- Journal Title
  
  Expert Rev Neurother 9
  
  Pages: 681-693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] 宮崎の特産物から認知症のくすりを創る2008
- Author(s)
  川原正博
- Journal Title
  
  みやぎん経済研究所調査月報 3 月号
  
  Pages: 2-6
- NAID
  40015905735
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] アミロイド蛋白質の多量体化とpore形成による神経細胞死2008
- Author(s)
  川原正博
- Journal Title
  
  臨床病理 56
  
  Pages: 130-136
- NAID
  10024356088
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurosteroids block the increase in intracellular calcium level induced by Alzheimer's beta-amyloid protein in long-term cultured rat hippocampal neurons2008
- Author(s)
  Kato-Negishi M, Kawahara M
- Journal Title
  
  Neuropsychiatric Disease and Treatment 4
  
  Pages: 209-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Improvement of screening for protective substances against zinc-induced neuronal cell death2008
- Author(s)
  Sadakane Y, Konoha K, Nagata T, Kawahara M
- Journal Title
  
  Trace Nutrient Res 25
  
  Pages: 59-63
- NAID
  40016413893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Improvement of screening for protective substances against zinc-induced neuronal cell death.2008
- Author(s)
  Y.Sadakane, K.Konoha, T.Nagata, M.Kawahara
- Journal Title
  
  Trace Nutrients Res. 25
  
  Pages: 41-45
- NAID
  40016413893
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] Neurotoxicity of trace elements and the pathogenesis of senile-type dementia2008
- Author(s)
  Kawahara M
- Journal Title
  
  Biomed. Res. Trace Elements 19
  
  Pages: 25-33
- NAID
  10019586965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] アミロイド蛋白質の多量体化とpore 形成による神経細胞死2008
- Author(s)
  川原正博
- Journal Title
  
  臨床病理 vol.56, No.2
  
  Pages: 130-136
- NAID
  10024356088
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurosteroids block the increase inintracellular calcium level induced by Alzheimer's beta-amyloid protein in long-term cultured rat hippocampal neurons2008
- Author(s)
  Kato-Negishi M and Kawahara M
- Journal Title
  
  Neuropsychiatric Disease and Treatment 4
  
  Pages: 209-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurosteroids block the increase in intracellular calcium level induced by Alzheimer's beta-amyloid protein in long-term cultured rat hippocampal neurons2008
- Author(s)
  Kato-Negishi M and Kawahara M
- Journal Title
  
  Neuropsychiatric Disease and Treatment 4
  
  Pages: 209-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurotoxicity of trace elements and the pathogenesis of senile-type dementia2008
- Author(s)
  Kawahara M
- Journal Title
  
  Biomed.Res.Trace Elements 19(In press)
- NAID
  10019586965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Improvement of screening for protective substances against zinc-induced neuronal cell death.2008
- Author(s)
  Sadakane Y, Konoha K, Nagata T, Kawahara M
- Journal Title
  
  Trace Nutrient Res 25
  
  Pages: 59-63
- NAID
  40016413893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Protective substances against zinc-induced neuronal death after ischemia : camosine a target for drug of vascular type of dementia.2007
- Author(s)
  M. Kawahara, K. Konoha, T. Nagata, Y. Sadakane
- Journal Title
  
  Recent Patents on CNS Drug Discovery, (with peer review.) 2
  
  Pages: 145-149
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Neurotoxicity of zinc:the involvement of calcium homeostasis and carnosine2007
- Author(s)
  M.Kawahara, K.Konoha, Y.Sadakane
- Journal Title
  
  Biomed Res Trace Elements 18
  
  Pages: 26-34
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Protective activity of the extracts from Japanese eel(Anguilla japonica) against zinc-induced neuronal cell death : Carnosine and an unknown substance.2007
- Author(s)
  Y. Sadakane, K. Konoha, T. Nagata, M. Kawahara
- Journal Title
  
  Trace Nutrient Res.(with peer review.) 24
  
  Pages: 1-4
- NAID
  40015808263
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Aluminum and human health:its intake,bioavailability and neurotoxicity2007
- Author(s)
  M.Kawahara, K.Konoha, T.Nagata, Y.Sadakane
- Journal Title
  
  Biomed.Res.Trace Elements 18
  
  Pages: 111-120
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] アルツハイマー病の病理・病態危険因子としての非遺伝的要因アルミニウム2007
- Author(s)
  川原正博
- Journal Title
  
  アルツハイマー病-基礎研究から予防・治療の新しいパラダイム-(日本臨床増刊号) 66
  
  Pages: 205-210
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Protective activity of the extracts from Japanese eel(Anguilla japonica)against zinc-induced neuronal cell death:Carnosine and an unknown substance2007
- Author(s)
  Sadakane Y., Konoha K., Nagata T., Kawahara M
- Journal Title
  
  Trace Nutrient Res. 24
  
  Pages: 111-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Neurotoxicity of aluminum hydroxyl polymer on primary cultured neurons of rat cerebral cortex2007
- Author(s)
  Konoha K, Nagata T, Sadakane Y, Kawahara M
- Journal Title
  
  Biomed.Res.Trace Elements 18
  
  Pages: 393-397
- NAID
  10021097781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Aluminum and human health: its intake, bioavailability and neurotoxicity2007
- Author(s)
  Kawahara M., Konoha K., Nagata T., Sadakane Y.
- Journal Title
  
  Biomed. Res. Trace Elements 18
  
  Pages: 111-120
- NAID
  130004456835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] アルツハイマー病の病理・病態危険因子としての非遺伝的要因アルミニウム「アルツハイマー病-基礎研究から予防・治療の新しいパラダイム-」2007
- Author(s)
  川原正博
- Journal Title
  
  日本臨床 66
  
  Pages: 205-210
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] アルミニウム製剤の投与と副作用2007
- Author(s)
  川原正博
- Journal Title
  
  日本医事新報 No. 4341
  
  Pages: 97-98
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Protective activity of the extracts from Japanese eel(Anguilla japonica)against zinc-induced neuronal cell death:Carnosine and an unknown substance2007
- Author(s)
  Y.Sadakane, K.Konoha, T.Nagata, M.Kawahara
- Journal Title
  
  Trace Nutrient Res. 24
  
  Pages: 1-4
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] アルミニウムの生体への影響2007
- Author(s)
  川原正博
- Journal Title
  
  金属 77
  
  Pages: 279-285
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurotoxicity of aluminum hydroxyl polymer on primary cultured neurons of rat cerebral cortex2007
- Author(s)
  K.Konoha, T.Nagata, Y.Sadakane, M.Kawahara
- Journal Title
  
  Biomed.Res.Trace Elements 18
  
  Pages: 393-397
- NAID
  10021097781
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Aluminum and human health : its intake, bioavailability and neurotoxicity.2007
- Author(s)
  M. Kawahara, K. Konoha, T. Nagata, Y. Sadakane
- Journal Title
  
  Biomed. Res. Trace Elements, (with peer review.) 18
  
  Pages: 111-120
- NAID
  130004456835
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Protective substances against zinc-induced neuronal death after ischemia:carnosine a target for drug of vascular type of dementia2007
- Author(s)
  Kawahara M., Konoha K., Nagata T., Sadakane Y
- Journal Title
  
  Recent Patents on CNS Drsicovery 2
  
  Pages: 145-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurotoxicity of zinc : the involvement of calcium homeostasis and camosine.2007
- Author(s)
  M. Kawahara, K. Konoha, Y. Sadakane
- Journal Title
  
  Biomed. Res. Trace Elements, (with peer review.) 18
  
  Pages: 26-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Neurotoxicity of aluminum hydroxyl polymer on primary cultured neurons of rat cerebral cortex2007
- Author(s)
  Konoha K, Nagata T, Sadakane Y, Kawahara M
- Journal Title
  
  Biomed. Res. Trace Elements 18
  
  Pages: 395-399
- NAID
  10021097781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurotoxicity of aluminum hydroxyl polymer on primary cultured neurons of rat cerebral cortex2007
- Author(s)
  Konoha K, Nagata T, Sadakane Y, Kawahara M
- Journal Title
  
  Biomed.Res.Trace Elements 18
  
  Pages: 395-399
- NAID
  10021097781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurotoxicity of zinc: the involvement of calcium homeostasis and carnosine2007
- Author(s)
  Kawahara M., Konoha K., Sadakane Y.
- Journal Title
  
  Biomed. Res. Trace Elements 18
  
  Pages: 26-34
- NAID
  10018910865
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Aluminum and human health:its intake,bioavailability and neurotoxicity2007
- Author(s)
  Kawahara M., Konoha K., Nagata T., Sadakane Y.
- Journal Title
  
  Biomed.Res.Trace Elements 18
  
  Pages: 111-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Protective substances against zinc-induced neuronal death after ischemia: carnosine a target for drug of vascular type of dementia2007
- Author(s)
  Kawahara M., Konoha K., Nagata T., Sadakane Y.
- Journal Title
  
  Recent Patents on CNS Drug Discovery 2
  
  Pages: 145-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Protective substances against zinc-induced neuronal death after ischemia:carnosine a target for drug of vascular type of dementia2007
- Author(s)
  M.Kawahara, K.Konoha, T.Nagata, Y.Sadakane
- Journal Title
  
  Recent Patents on CNS Drug Discovery 2
  
  Pages: 145-149
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Protective activity of the extracts from Japanese eel(Anguilla japonica)against zinc-induced neuronal cell death:Carnosine and an unknown substance2007
- Author(s)
  Sadakane Y., Konoha K., Nagata T., Kawahara M
- Journal Title
  
  Trace Nutrient Res 24
  
  Pages: 98-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Protective activity of the extracts from Japanese eel (Anguilla japonica) against zinc-induced neuronal cell death: Carnosine and an unknown substance.2007
- Author(s)
  Sadakane Y., Konoha K., Nagata T., Kawahara M
- Journal Title
  
  Trace Nutrient Res. 24
  
  Pages: 98-105
- NAID
  40015808263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurotoxicity of zinc:the involvement of calcium homeostasis and carnosine2007
- Author(s)
  Kawahara M., Konoha K., Sadakane Y.
- Journal Title
  
  Biomed.Res.Trace Elements 18
  
  Pages: 26-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] アルミニウム製剤の投与と副作用2007
- Author(s)
  川原正博
- Journal Title
  
  日本医事新報 56
  
  Pages: 97-98
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] アルミニウムの生体への影響2007
- Author(s)
  川原正博
- Journal Title
  
  金属 77
  
  Pages: 279-285
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurotoxicity of aluminum hydroxyl polymer on primary cultured neurons of rat cerebral cortex.2007
- Author(s)
  K. Konoha, T. Nagata, Y. Sadakane, M. Kawahara
- Journal Title
  
  Biomed. Res. Trace Elements, (with peer review.) 18
  
  Pages: 393-397
- NAID
  10021097781
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Photoaffinity labeling of opioid-binding cell-adhesion molecule(OBCAM) by phenyldiazirine-integrated ligand.2006
- Author(s)
  Y.sadakane, E.Kitamoto, T.Tomohiro, K.Konoha, M.Kawahara, Y.Hatanaka
- Journal Title
  
  J.KUHW 8
  
  Pages: 179-185
- NAID
  110006407510
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Analysis of Structural Alternations of L-Asp and L-Asn Residues in Peptides Related to Neuronal Disease.2006
- Author(s)
  Y. Sadakane, S. Kumamoto, K. Konoha, M. Kawahara, K. Nakagomi
- Journal Title
  
  Peptide Sciences.(with peer review.) 43
  
  Pages: 284-284
- NAID
  10020529985
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Hatanaka : Phenyldiazirine unit for converting peptides, proteins, DNAs, and sugars to photoaffinity ligands2006
- Author(s)
  Y. Sadakane, M. Kaneda, H. Nakashima, T. Tomohiro, K. Konoha, M. Kawahara, Y. Hatanaka
- Journal Title
  
  Photomedicine and Photobiology(without peer review.) 28
  
  Pages: 11-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Carnosine protects GT1-7 cell against zinc-induced neurotoxicity:a possible candidate for treatment for vascular type of dementia2006
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Journal Title
  
  Trace Nutrients Research 23
  
  Pages: 1-8
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Zinc neurotoxicity and its role in neurodegenerative diseases2006
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Journal Title
  
  J. Health Sd.(with peer review.) 52
  
  Pages: 1-8
- NAID
  110006163207
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Analysis of Structural Alternations of L-Asp and L-Asn Residues in Peptides Related to Neuronal Disease2006
- Author(s)
  Y.Sadakane, S.Kumamoto, K.Konoha, M.Kawahara, K.Nakagomi
- Journal Title
  
  Peptide Sciences 43
  
  Pages: 284-284
- NAID
  10020529985
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Zinc neurotoxicity and its role in neurodegenerative diseases2006
- Author(s)
  Konoha K., Sadakane Y., Kawahara M.
- Journal Title
  
  J.Health Sci. 52
  
  Pages: 1-8
- NAID
  110006163207
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Analysis of Structural Alternations of L-Asp and L-Asn Residues in Peptides Related to Neuronal Disease.2006
- Author(s)
  Y.Sadakane, S.Kumamoto, K.Konoda, M.Kawahara, K.Nakagomi
- Journal Title
  
  Peptide Sciences 43
  
  Pages: 284-284
- NAID
  10020529985
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Zinc neurotoxicity and its role in neurodegenerative diseases2006
- Author(s)
  Konoha K., Sadakane Y., Kawahara M
- Journal Title
  
  J.Health Sci., 52
  
  Pages: 1-8
- NAID
  110006163207
- Data Source
  KAKENHI-PROJECT-16650077
[Journal Article] Photoaffinity labeling of opioid-binding cell-adhesion molecule (OBCAM) by phenyldiazirine-integrated ligand2006
- Author(s)
  Y.sadakane, E.Kitamoto, T.Tomohiro, K.Konoha, M.Kawahara, Y.Hatanaka
- Journal Title
  
  J.KUHW 8
  
  Pages: 179-185
- NAID
  110006407510
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Zinc neurotoxicity and its role in neurodegenerative diseases,2006
- Author(s)
  Konoha K., Sadakane Y., Kawahara M.
- Journal Title
  
  J.Health Sci. 52
  
  Pages: 1-8
- NAID
  110006163207
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Pore formation and distuption of calciumhomeostasis by amyloidogenic peptidesincluding Alzheimer's beta-amyloid protein, prion protein fragment peptide, and aipha-synuclein fragment.2006
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Journal Title
  
  Alzheimer r Disease : New Advances(with peer review.)
  
  Pages: 323-327
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Carnosine protects GT 1-7 cell against zinc-induced neurotoxicity : a possible candidate for treatment for vascular type of dementia.2006
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Journal Title
  
  Trace Nutrients Research, (with peer review.) 23
  
  Pages: 1-8
- NAID
  40015330447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Carnosine protects GT1-7 cell against zinc-induced neurotoxicity : a possible candidate for treatment for vascular type of dementia.2006
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Journal Title
  
  Trace Nutrients Research 23
  
  Pages: 1-8
- NAID
  40015330447
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Pore formation and distuption of calciumhomeostasis by amyloidogenic peptides including Alzheimer's beta-amyloid protein,prion protein fragment peptide, and alpha-synuclein fragment2006
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Journal Title
  
  Alzheimer's Disease:New Advances
  
  Pages: 323-327
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Zinc neurotoxicity and its role in neurodegenerative diseases2006
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Journal Title
  
  J.Health Sci. 52
  
  Pages: 1-8
- NAID
  110006163207
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Phenyldiazirine unit for converting peptides,proteins,DNAs,and sugars to photoaffinity ligands2006
- Author(s)
  Y.sadakane, M.Kaneda, H.Nakashima, T.Tomohiro, K.Konoha, M.Kawahara, Y.Hatanaka
- Journal Title
  
  Photomedicine and Photobiology 28
  
  Pages: 11-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Zinc neurotoxicity and its role in neurodegenerative diseases2006
- Author(s)
  Konoha K., Sadakane Y., Kawahara M.
- Journal Title
  
  J. Health Sci. 52
  
  Pages: 1-8
- NAID
  110006163207
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Preparation of recombinant lysosomal cysteine proteases highly expressed in mouse placenta, cathepsin-P/J and -6.2005
- Author(s)
  Y.Sadakane, T.Ito, T.Tomohiro, K.Konoha, M.Kawahara, S.Imanishi, Y.Hatanaka, K.Nakagomi
- Journal Title
  
  J.Kyushu Univ.Health Welfare 6
  
  Pages: 287-298
- NAID
  110004633177
- Data Source
  KAKENHI-PROJECT-16650077
[Journal Article] Photoaffinity identification of DNA-binding proteins : Comparison of labeling efficiency between photoreactive DNAs bearing diazirine or benzophenone.2005
- Author(s)
  Y.Sadakane, T.Takagi, T.Tomohiro, K.Tsurusawa, K.Konoha, M.Kawahara, Y.Hatanaka
- Journal Title
  
  Photomedicine and Photobiology 26
  
  Pages: 35-40
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases2005
- Author(s)
  Kawahara M
- Journal Title
  
  J. Alzheimer Disease 8
  
  Pages: 171-182
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain.2005
- Author(s)
  Yamamoto H, Hiragami Y, Murayam M, Ishizuka K, Kawahara M, Takashim A
- Journal Title
  
  J.Neurochem. 94
  
  Pages: 1438-1447
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain.2005
- Author(s)
  Yamamoto H, HiragamiY, Murayama M, Ishizuka K, Kawahara M, Takashima A
- Journal Title
  
  J. Neurochem. 94
  
  Pages: 1438-47
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Preparation of recombinant lysosomal cysteine proteases highly expressed in mouse placenta, cathepsin-P/J and -6.2005
- Author(s)
  Y.Sadakane, T.Ito, T.Tomohiro, K.Konoha, M.Kawahara, S.Imanishi, Y.Hatanaka, K.Nakagomi
- Journal Title
  
  J. Kyushu Univ. Health Welfare 6
  
  Pages: 287-298
- NAID
  110004633177
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Photoaffinity identification of DNA-binding proteins : Comparison of labeling efficiency between photoreactive DNAs bearing diazirine or benzophenone.2005
- Author(s)
  Y.Sadakane, T.Takagi, T.Tomohiro, K.Tsurusawa, K.Konoha, M.Kawahara.Y.Hatanaka
- Journal Title
  
  Photomedicine and Photobiology 26
  
  Pages: 35-40
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases2005
- Author(s)
  Kawahara M
- Journal Title
  
  J.Alzheimer Disease 8
  
  Pages: 171-182
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Peparation of recombinant lysosomal cysteine proteases highly expressed in mouse placenta, cathepsin-P/J and -6.2005
- Author(s)
  Y.Sadakane T.Ito, T.Tomohiro, K.Konoha, M.Kawahara, S.Imanishi, Y.Hatanaka, K.Nakagomi
- Journal Title
  
  J.Kyushu Univ.Health Welfare 6
  
  Pages: 287-298
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Preparation of recombinant lysosomal cysteine proteases highly expressed in mouse placenta, cathepsin-P/J and -6.2005
- Author(s)
  Y.Sadakane, T.Ito, T.Tomohiro, K.Konoha, M.Kawahara, S.Imanishi, Y.Hatanaka, K.Nakagomi
- Journal Title
  
  J.Kyushu Univ.Health Welfare 6
  
  Pages: 287-298
- NAID
  110004633177
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Photoaffinity identification of DNA-binding proteins : Comparison of labeling efficiency between photoreactive DNAs bearing diazirine or benzophenone.2005
- Author(s)
  Y.Sadakane, T.Takagi, T.Tomohiro, K.Tsurusawa, K.Konoha, M.Kawahara, Y.Hatanaka
- Journal Title
  
  Photomedicine and Photobiology 26
  
  Pages: 35-40
- Data Source
  KAKENHI-PROJECT-16650077
[Journal Article] Y. Hatanaka : Photoaffinity labeling of opioid-binding cell-adhesion molecule(OBCAM) by phenyldiazirine-integrated ligand.2005
- Author(s)
  Y. Sadakane, E. Kitamoto, T. Tomohiro, K. Konoha, M. Kawahara, Y. Hatanaka
- Journal Title
  
  J. KUHW(without peer review.) 8
  
  Pages: 179-185
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases2005
- Author(s)
  Kawahara M.
- Journal Title
  
  J.Alzheimer Disease 8
  
  Pages: 171-182
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Protective activity of mango (Mangifera indica L.) fruit against a zinc-induced neuronal cell death is independent of its antioxidant activity2005
- Author(s)
  Sadakane Y., Konoha K., Kawahara M
- Journal Title
  
  Trace Nutrients Res 22
  
  Pages: 73-79
- NAID
  40015392247
- Data Source
  KAKENHI-PROJECT-16650077
[Journal Article] Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain.2005
- Author(s)
  Yamamoto H., Hiragami Y., Murayama M., Ishizuka K., Kawahara M., Takashima A.
- Journal Title
  
  J.Neurochem. 94
  
  Pages: 1438-1447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Protective activity of mango (Mangifera indica L.) fruit against a zinc-induced neuronal cell death is independent of its antioxidant activity2005
- Author(s)
  Sadakane Y., Konoha K., Kawahara M.
- Journal Title
  
  Trace Nutrients Res. 22
  
  Pages: 73-79
- NAID
  40015392247
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Effects of gadolinium and other metal on the neurotoxicity of immortalized hypothalamic neurons induced by zinc2004
- Author(s)
  Konoha K., Sadakane Y., Kawahara M.
- Journal Title
  
  Biomed.Res.Trace Elements 15
  
  Pages: 275-277
- NAID
  10027573511
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Developmental changes of GABAergic synapses formed between Primary cultured cortical neurons2004
- Author(s)
  Kato-Negishia M., Muramoto K., Kawahara M., Kuroda Y., Ichikawa
- Journal Title
  
  Brain Res. Dev. Brain Res 152
  
  Pages: 99-108
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Developmental changes of GABAergic synapses formed between primary cultured cortical neurons2004
- Author(s)
  Kato-Negishia M., Muramoto K., Kawahara M., Kuroda Y., Ichikawa M.
- Journal Title
  
  Brain Res.Dev.Brain Res. 152
  
  Pages: 99-108
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Implications of calcium homeostasis and neurotrophic factors in neurotoxicity of aluminum on primary cultured neurons2004
- Author(s)
  Konoha K., Sadakane Y., Imamura L., Tsuda M., Kawahara M.
- Journal Title
  
  Yakugakuzassi 124,Suppl.a
  
  Pages: 63-63
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] 培養神経細胞のシナプスを数える-細胞内カルシウム濃度同時多点観察システムを用いるシナプス形成のアッセイシステム2004
- Author(s)
  川原正博, 他
- Journal Title
  
  日本薬理学雑誌 124
  
  Pages: 11-17
- NAID
  10013796597
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Effects of gadolinium and other metal on the neurotoxicity of immortalized hypothalamic neurons induced by zinc.2004
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Journal Title
  
  Biomed.Res.Trace Elements 15
  
  Pages: 275-277
- NAID
  10027573511
- Data Source
  KAKENHI-PROJECT-16650077
[Journal Article] Developmental changes of GABAergic synapses formed between primary cultured cortical neurons2004
- Author(s)
  Kato-Negishia M., Muramoto K., Kawahara M., Kuroda Y., Ichikawa M.
- Journal Title
  
  Brian Res.Dev. Brain Res 152
  
  Pages: 99-108
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Disruption of calcium homeostasis in Alzherimer's disease and other conformational disease2004
- Author(s)
  Kawahara M.
- Journal Title
  
  Current Alzheimer Research 1
  
  Pages: 87-95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] 亜鉛ホメオスタシスの異常と神経細胞死2004
- Author(s)
  木葉敬子, 定金豊, 川原正博
- Journal Title
  
  Trace Nutrients Research 21
  
  Pages: 77-83
- NAID
  40007140673
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Zinc homeostasis and neuronal death.2004
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Journal Title
  
  Trace Nutrients Research 21
  
  Pages: 77-83
- Data Source
  KAKENHI-PROJECT-16650077
[Journal Article] Neurotoxicity of aluminum on primary cultured neurons of rat cerebral cortex2004
- Author(s)
  Konoha K., Kawahara M.
- Journal Title
  
  Proceedings of the 6^<th> International symposium on plant-soil interactions at low pH
  
  Pages: 102-103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Effects of gadolinium and other metal on the neurotoxicity of immortalized hypothalamic neurons induced by zinc2004
- Author(s)
  Konoha K., Sadakane Y., Kawahara M.
- Journal Title
  
  Biomed. Res. Trace Elements 15
  
  Pages: 275-277
- NAID
  10027573511
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] アルミニウムの毒性とアルツハイマー病2004
- Author(s)
  川原正博
- Journal Title
  
  科学(岩波) 74
  
  Pages: 77-80
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] アルミニウムの毒性とアルツハイマー病2004
- Author(s)
  川原正博
- Journal Title
  
  科学(岩波) 74
  
  Pages: 77-80
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Effects of gadolinium and other metal on the neurotoxicity of immortalized hypothalamic neurons induced by zinc2004
- Author(s)
  Konoha K., Sadakane Y., Kawahara M.
- Journal Title
  
  Biomed.Res. Trace Elements 15
  
  Pages: 275-277
- NAID
  10027573511
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Aluminum maltolate inhibits brain-derived neurotrophic factor induced intracellular free calcium elevations in cultured rat hippocampal neurons2003
- Author(s)
  Konoha K., Imamura L., Tsuda M., Kawahara M.
- Journal Title
  
  Biomed.Res.Trace Elements 14
  
  Pages: 173-187
- NAID
  10027904297
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Aluminum-induced conformational change and the pathogenesis of Alzheimer's disease2003
- Author(s)
  Kawahara M.
- Journal Title
  
  J.Health Science 49
  
  Pages: 341-347
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Thyroid hormone enhances the formation of synapses between cultured neurons of rat cerebral cortex.2003
- Author(s)
  Hosoda R., Nakayama K., Kato-Negishi M., Kawahara M., Muramoto K., Kuroda Y.
- Journal Title
  
  Cellular and Molecular Neurobiolog 23
  
  Pages: 895-906
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Brain-derived neurotrophic factor protects cultured rat hippocampal neurons from aluminum maltolate neurotoxicity2003
- Author(s)
  Kawahara M., Kato-Negishi M., Hosoda R., Imamura L., Tsuda M., Kuroda Y.
- Journal Title
  
  Journal of Inorganic Biochemistry 97
  
  Pages: 124-131
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Effects of progesterone on intracellular Ca^<2+> levels of immortalized hypothalamic neurons (GT1-7) : Fluorescence imaging study2003
- Author(s)
  Sekiguchi M., Chiyo T., Kawahara M., Ohta Y.
- Journal Title
  
  Bioimages 11
  
  Pages: 67-73
- NAID
  10013894054
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Thyroid hormone enhances the formation of synapses between cultured neurons of rat cerebral cortex.2003
- Author(s)
  Hosoda R., Nakayama K., Kato-Negishi M., Kawahara M., Nuramoto K., Kuroda Y.
- Journal Title
  
  Cellular and Molecular Neurobiolog 23
  
  Pages: 895-906
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Effects of progesterone on intracellular Ca^2+ levels of immortalized hypothalamic neurons (GT1-7) : Fluorescence imaging study2003
- Author(s)
  Sekiguchi M, Chiyo T, Kawahara M, Ohta Y.
- Journal Title
  
  Bioimages 11
  
  Pages: 67-73
- NAID
  10013894054
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Aluminum-induced conformational change and the pathogenesis of Alzheimer's disease2003
- Author(s)
  Kawahara M
- Journal Title
  
  J. Health Science 49
  
  Pages: 341-347
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Bicuculline induces synapse formation on primary cultured accessory olfactory bulb neurons2003
- Author(s)
  Kato-Negishi M., Muramoto K., Kawahara M., Hosoda R., Kuroda Y., Ichikawa M.
- Journal Title
  
  Eur.J.Neurosci. 18
  
  Pages: 1343-1352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Aluminum maltolate inhibits brain-derived neurotrophic factor induced intracellular free calcium elevations in cultured rat hippocampal neurons2003
- Author(s)
  Konoha K., Imamura L., Tsuda M., Kawahara M.
- Journal Title
  
  Biomed. Res. Trace Elements 14
  
  Pages: 173-175
- NAID
  10027904297
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Disruption of calcium homeostasis in Alzheimer's disease and other conformational disease,
- Author(s)
  Kawahara M.
- Journal Title
  
  Current Alzheimer Research 1
  
  Pages: 87-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Patent] 脳血管性認知症の治療剤および該治療剤を含有する飲食物、補助食品2009
- Inventor(s)
  川原正博、定金豊、木葉敬子
- Industrial Property Rights Holder
  九州保健福祉大学
- Patent Publication Number
  2009-249335
- Filing Date
  2009-10-29
- Data Source
  KAKENHI-PROJECT-21590145
[Patent] 脳血管性認知症の治療剤および該治療剤を含有する飲食物、補助食品2008
- Inventor(s)
  川原正博, 定金豊, 木葉敬子
- Industrial Property Rights Holder
  九州保健福祉大学
- Industrial Property Number
  2008-098675
- Filing Date
  2008-04-04
- Data Source
  KAKENHI-PROJECT-19590133
[Patent] 「脳血管性認知症の治療剤および該治療剤を含有する飲食物、補助食品」2008
- Inventor(s)
  川原正博、定金豊、木葉敬子
- Industrial Property Rights Holder
  九州保健福祉大学
- Industrial Property Number
  2008-098675
- Filing Date
  2008-04-04
- Data Source
  KAKENHI-PROJECT-19590133
[Patent] 「脳血管性認知症の予防または治療用飲食物、その包装または容器ならびに脳血管性認知症の予防または治療薬」2007
- Inventor(s)
  川原正博、定金豊、木葉敬子
- Industrial Property Rights Holder
  九州保健福祉大学
- Patent Publication Number
  2007-314467
- Acquisition Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 呼吸器疾患領域におけるメタロチオネインの機能解析2022
- Author(s)
  田中健一郎, 下田実可子, 高藤綾香, 高畑南咲, 門田佳人, 川上隆茂, 鈴木真也, 川原正博
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 銅によって増強される亜鉛神経細胞死の分子メカニズム2021
- Author(s)
  川原正博、徳永汐凜、田中健一郎
- Organizer
  第32回日本微量元素学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 神経疾患発症における金属の影響：金属-金属および金属-タンパク質相互作用による神経細胞死2021
- Author(s)
  川原正博
- Organizer
  第74回日本酸化ストレス学会・第21回日本NO学会合同学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 6-hydroxydopamineによる神経細胞死・神経炎症に対するカルノシン(βAla-His)の有効性解析, , 2021年11月.2021
- Author(s)
  塩田沙智恵, 榊原緒妃菜, 久保田真帆, 下田実可子, 田中健一郎, 川原正博.
- Organizer
  新アミノ酸分析研究会第11回学術講演会
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] Screening and Structure Determination of Protective Substances Against Senile Dementia: From Analytical Chemistry to Neurochemistry2021
- Author(s)
  Kawahara Masahiro
- Organizer
  31st International Symposium on Pharamaceutical and Biomedical Analysis (PBA2021)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 銅による神経毒性増強および神経疾患の発症2021
- Author(s)
  川原正博
- Organizer
  日本薬学会第141年会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 銅による神経毒性増強および神経疾患の発症（シンポジウム「銅イオン：疾患との関連、その検出と制御」）2021
- Author(s)
  川原正博
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 胃潰瘍治療薬・ポラプレジンクの新たな薬理作用の発見2020
- Author(s)
  中野由加里、久保田真帆、杉崎俊文、川原正博、田中健一郎
- Organizer
  日本薬学会第140年会（京都、2020.03.25-28）
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 亜鉛と銅の神経毒性に対するセレノメチオニンの効果2020
- Author(s)
  田中健一郎, 下田実可子, 中野由加里, 久保田真帆, 川原正博
- Organizer
  メタルバイオサイエンス研究会
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] Seleno-L-methionineによるCu/Zn依存神経細胞死の阻害効果2020
- Author(s)
  下田実可子, 田中健一郎, 中野由加里, 久保田真帆, 川原正博
- Organizer
  第31回日本微量元素学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] ハイスループットスクリーニングのための3次元組織アレイ2020
- Author(s)
  根岸みどり、澤山淳、川原正博、竹内昌治
- Organizer
  日本薬学会第140年会（京都、2020.03.25-28）
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 6-OHDA依存の神経細胞死に影響を与える微量金属の探索2020
- Author(s)
  久保田真帆、鍋嶋友惟子、中野由加里、田中健一郎、川原正博
- Organizer
  日本薬学会第140年会（京都、2020.03.25-28）
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] カドミウム依存の肺胞上皮細胞傷害に対するメタロチオネイン誘導剤の保護効果2020
- Author(s)
  田中健一郎, 木村和真, 杉崎俊文, 中野由加里, 下田実可子, 川原正博
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] ハイスループットスクリーニングのための3次元組織アレイ2020
- Author(s)
  根岸みどり、澤山淳、川原正博、竹内昌治
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17H03197
[Presentation] アミノ酸・ペプチドから認知症の薬を創る2020
- Author(s)
  川原正博
- Organizer
  新アミノ酸分析研究会第10回学術講演会　特別講演
- Invited
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 食肉中カルノシン類のHPLCによる定量分析2020
- Author(s)
  川原正博、森　美和子、森田晃子、根岸みどり、田中健一郎
- Organizer
  第31回日本微量元素学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] Zinc neurotoxicity and the pathogenesis of vascular type dementia: synergistic interactions between copper and zinc2019
- Author(s)
  Kawahara M, Shimoda M, Kubota M, Hiroki M, Tanaka KI
- Organizer
  7th International Symposium on Metallomics (2019.06.30-07.03, Warsaw, Poland)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] Mechanisms by which copper promotes zinc-induced neuronal cell death2019
- Author(s)
  Tanaka K, Kawahara M
- Organizer
  ISTERH 2019 conference, (2019.09.22-26, Bali, Indonesia)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] :ポラプレジンク (カルノシン-亜鉛錯体)はカドミウムによる肺胞上皮細胞傷害を抑制する.2019
- Author(s)
  中野由加里、木村和真、下田実可子、田中健一郎、川原正博
- Organizer
  第１８回日本亜鉛栄養治療研究会・学術集会(2019.2.2, 大阪)
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] Carnosine as a possible drug for vascular dementia and lung diseases2019
- Author(s)
  Kawahara M, Shimoda M, Kubota M, Hiroki M, Kato-Negishi M, Tanaka KI
- Organizer
  15th International Symposium on Applied Bioinorganic Chemistry (ISABC), (2019.06.2-5, Nara, Japan)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] Therapeutic effect of idebenone on pulmonary fibrosis via preferential suppression of fibroblast activity2019
- Author(s)
  Tanaka K, Shimoda M, Takafuji A, Sugizaki T, Kawahara M.
- Organizer
  CHEST Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 亜鉛(Zn)/銅(Cu)の神経細胞死におけるSAPK/JNK経路の関与2019
- Author(s)
  田中健一郎, 下田実可子, 廣木美香, 久保田真帆, 池田真由美, 異島優, 川原正博
- Organizer
  第46回日本毒性学会学術年会 (2019.06.22-26, 徳島)
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 亜鉛による神経細胞死と老年性認知症2019
- Author(s)
  川原正博、田中健一郎：、
- Organizer
  第46回日本毒性学会学術年会シンポジウム“ニューロジンクの動態制御破綻からみた神経変性疾患研究の新展開“（2019.06.26～28、徳島）
- Invited
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] ポラプレジンクはメタロチオネイン誘導を介して、カドミウム依存の肺胞上皮細胞傷害を抑制する2019
- Author(s)
  田中健一郎，木村和真，杉崎俊文，中野由加里，下田実可子，川原正博
- Organizer
  メタルバイオサイエンス研究会2019 (2019.10.29-30, 東京理科大、東京
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] Molecular pathways of zinc-induced neurotoxicity: involvements in the pathogenesis of vascular dementia2019
- Author(s)
  Kawahara M, Shimoda M, Kubota M, Hiroki M, Tanaka KI
- Organizer
  The 6th meeting of International Society of Zinc Biology (ISZB2019), (2019.09.09-13, Kyoto, Japan)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 健康食品で認知症を予防する－亜鉛とカルノシン－2018
- Author(s)
  川原正博
- Organizer
  神戸薬科大学　第26回健康食品講座　（2018.10.27、神戸）
- Invited
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 亜鉛とニッケルの相互作用による神経細胞死の促進.2018
- Author(s)
  下田実可子、葛西美里、清水綾音、川原正博、田中健一郎
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2018（2018.8.25, 福岡）
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] Preventive effect of Thioredoxin-Albumin Fusion Protein against Copper enhanced Zinc-induced neuronal cell death.2018
- Author(s)
  Shimoda M, Tanaka K, Ishida T, Ishima Y, Kawahara M.
- Organizer
  SRM2018 (2018.6.29-30, 宮城)
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] Preventive effect of Thioredoxin-Albumin Fusion Protein against Copper enhanced Zinc-induced Neurotoxicity.2018
- Author(s)
  Shimoda M, Shimizu A, Takafuji A, Ishida T, Ishima Y, Kawahara M, Tanaka K.
- Organizer
  WCP2018 (2018.7.1-6,京都)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 急性肺傷害発症後の抗酸化ペプチド・カルノシンの有効性解析2018
- Author(s)
  高藤綾香、木村和真、田中健一郎、川原正博
- Organizer
  第35回日本微量栄養素学会学術集会 (2018.6.9, 京都)
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 鉄の生理機能と神経疾患2018
- Author(s)
  川原正博
- Organizer
  第41回栄養アセスメント研究会教育セミナー（2018.06.30、東京）
- Invited
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] ニッケルは酸化ストレスを介して亜鉛による神経細胞死を促進する.2018
- Author(s)
  田中健一郎、葛西美里、下田実可子、清水綾音、久保田真帆、川原正博
- Organizer
  第6回メタロミクス研究フォーラム (2018.11.1-2, 東京)
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 亜鉛/ニッケルの相互作用による神経細胞死の促進とその促進機構の解明.2018
- Author(s)
  田中健一郎、葛西美里、下田実可子、清水綾音、久保田真帆、川原正博
- Organizer
  メタルバイオサイエンス研究会2018(2018.10.11-14, 宮城)
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 金属-金属相互作用による神経細胞死に対するカルノシンの有効性の解析.2018
- Author(s)
  久保田真帆、田中健一郎、下田実可子、葛西美里、清水綾音、川原正博
- Organizer
  新アミノ酸分析研究会第8回学術講演会(2018.12.17, 東京)
- Data Source
  KAKENHI-PROJECT-18K06669
[Presentation] 食品中カルノシンのcarbon カラムHPLC による定量分析2017
- Author(s)
  田中健一郎, 森美和子, 水野大, 定金豊, 川原正博
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（仙台）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] LPS急性肺傷害に対する抗酸化ペプチド・カルノシンの予防効果の検討2017
- Author(s)
  神田侑季、川原正博、田中健一郎
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] 亜鉛による神経細胞死における金属間相互作用2016
- Author(s)
  川原正博、田中健一郎
- Organizer
  第27回日本微量元素学会学術集会
- Place of Presentation
  京都大学（京都）
- Year and Date
  2016-07-30
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] 食品中カルノシンおよびアンセリンのHPLCによる定量分析2016
- Author(s)
  桒原奈緒美、森　美和子、水野　大、田中健一郎、川原正博
- Organizer
  第33回日本微量栄養素学会学術集会
- Place of Presentation
  京都リサーチパーク（京都）
- Year and Date
  2016-06-25
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] 食品中カルノシンの定量分析および肺障害に対する効果2016
- Author(s)
  田中健一郎、川原正博
- Organizer
  新アミノ酸分析研究会第6回学術講演会
- Place of Presentation
  武田先端知センター（東京）
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] Metal-metal interactions in zinc-induced neurotoxicity: the possible involvements in the pathogenesis of vascular dementia2016
- Author(s)
  Kawahara M, Mizuno D, Tanaka K.
- Organizer
  Neuroscience 2016
- Place of Presentation
  SanDiegoConvention center (San Diego, U.S.A.)
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] サラブレッド筋肉中のカルノシン濃度：筋肉種による差異と運動能力との関連2016
- Author(s)
  森美和子、川原正博
- Organizer
  第58回競争馬に関する調査研究発表会
- Place of Presentation
  東京大学（東京）
- Year and Date
  2016-11-28
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] カルノシンによる神経細胞保護メカニズムの解析2015
- Author(s)
  川原正博、水野大
- Organizer
  日本微量元素学会
- Place of Presentation
  北海道大学（札幌）
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] Molecular Mechanism of Neuroprotective activity by Carnosine and Anserine2015
- Author(s)
  Mizuno D, Mori M, Asakawa N, Murohisa K, Yamamoto R, and Kawahara M
- Organizer
  第25回金属の関与する生体関連反応シンポジウム(SRM2015)
- Place of Presentation
  長崎大学（長崎）
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] カルノシンの神経保護作用及び筋肉中含量の解析2015
- Author(s)
  森美和子、木葉―水野敬子、水野大、定金豊、川原正博
- Organizer
  第32回日本微量栄養素学会
- Place of Presentation
  京都
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] 筋肉中カルノシンおよびアンセリンの順相HPLCによる定量分析2015
- Author(s)
  森美和子、水野大、水野－木葉敬子、定金豊、川原正博
- Organizer
  新アミノ酸分析研究会
- Place of Presentation
  東京大学（東京）
- Year and Date
  2015-12-07
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] カルノシンおよびアンセリンのHPLCによる定量分析およびその神経保護作用機構の解析2015
- Author(s)
  森美和子、水野大、定金豊、川原正博
- Organizer
  第28回バイオメディカル分析化学シンポジウム
- Place of Presentation
  長崎大学（長崎）
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] 脳内のヤヌス～神経疾患発症における亜鉛の役割～2014
- Author(s)
  川原正博
- Organizer
  第9回近畿亜鉛栄養治療研究会
- Place of Presentation
  シノテスト（大阪）
- Year and Date
  2014-08-02
- Invited
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] 金属が脳内アミロイド蛋白のコンフォメーション変化及び神経毒性に及ぼす影響2014
- Author(s)
  川原正博、水野大
- Organizer
  第41回日本毒性学会学術年会シンポジウム
- Place of Presentation
  神戸国際会議場（神戸市）
- Year and Date
  2014-07-02
- Invited
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] カルノシン、アンセリン類の順相HPLCによる分離分析およびその神経細胞死抑制機構の解析2014
- Author(s)
  水野　大、菅亜由美、小林清美、小山裕也、定金豊、川原正博
- Organizer
  第4回新アミノ酸分析研究会
- Place of Presentation
  東京大学（東京都）
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] PrP106-126の高次構造変化に重要な配列2012
- Author(s)
  小山裕也,坂口哲陛,大河原晋,定金豊,川原正博
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] アルツハイマーβペプチドのN末側アミノ酸の構造的変化と線維化への影響2012
- Author(s)
  定金豊,小山裕也,川原正博
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Molecular Mechanism of zinc-induced neurotoxicity2011
- Author(s)
  Kawahara M
- Organizer
  ISTERH (International Society for Trace Element Research in Humans)
- Place of Presentation
  Antalya, Turkey
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] アルミニウムの神経毒性と神経疾患との関連2011
- Author(s)
  川原正博、小山裕也
- Organizer
  第22回日本微量元素学会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2011-07-02
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] 創薬シーズとしてのカルノシン2011
- Author(s)
  川原正博
- Organizer
  第4回薬学研究フォーラムin東京-九州からの情報発信による企業との共同研究マッチング-」日本薬学会九州支部・九州薬科学研究教育連合主催
- Place of Presentation
  東京
- Year and Date
  2011-01-02
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Molecular Mechanism of zinc-induced neurotoxicity2011
- Author(s)
  Kawahara M.
- Organizer
  ISTERH(International Society for Trace Element Research in Humans)
- Place of Presentation
  Antalya, Turkey
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-1262011
- Author(s)
  Koyama H, Okahara M, Sakaguchi T, Sadakane Y and Kawahara M
- Organizer
  5th International Conference on Metals and Genetics
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] 創薬シーズとしてのカルノシン2011
- Author(s)
  川原正博
- Organizer
  第4回薬学研究フォーラムin東京-九州からの情報発信による企業との共同研究マッチング-
- Place of Presentation
  東京
- Year and Date
  2011-01-23
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] PrP断片ペプチドに対する亜鉛および銅の影響2011
- Author(s)
  小山裕也,永田哲也,定金豊,川原正博
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Effects of trace elements on the conformational changes of amyloidogenic proteins and their neurotoxicity2011
- Author(s)
  Kawahara M.
- Organizer
  5th International Conference on Metals and Genetics
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] コンフォメーション病に関与するペプチド中のアスanti-stressanti-oxidantanti-glycationanti-painanti-crosslink(Alzheimer, prion) pHbalanceCarnosineCH2CH2CNHOCHCCH2OHONNHH2Nパラギンおよびアスパラギン酸残基の構造変化と生理活性2011
- Author(s)
  定金豊,小山裕也,川原正博
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] プリオンペプチド断片(106-126)中のアスパラギン残基の自発的構造変化と生理機能2010
- Author(s)
  定金豊,小山裕也、大塚功、川原正博
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Alterations of gene expressions during neuronal death after zinc exposure : implications of calcium dyshomeostasis2010
- Author(s)
  Kawahara M., Koyama H., Sadakane Y.
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Effects of zinc and copper on conformational changes and neurotoxicity of prion fragment peptide (PrP106-126)2010
- Author(s)
  小山裕也、定金豊、大塚功、川原正博
- Organizer
  第20回金属の関与する生体関連反応シンポジウム(SRM2010)
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] カルノシンって何?-宮崎の食で認知症を防ぐ-2010
- Author(s)
  川原正博
- Organizer
  都市エリア産学官連携事業第8回浜辺のセミナー
- Place of Presentation
  延岡
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Effects of zinc and copper on conformational changes and neurotoxicity of prion fragment peptide (PrP106-126)2010
- Author(s)
  小山裕也、定金豊、大塚功、川原正博
- Organizer
  第20回金属の関与する生体関連反応シンポジウム(SRM2010)
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Effects of zinc and copper on conformational changes and neurotoxicity of prion fragment peptide(PrP106-126)2010
- Author(s)
  小山裕也、定金豊、大塚功、川原正博
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] 認知症から脳を保護するカルノシン2010
- Author(s)
  川原正博
- Organizer
  都市エリア産学官連携事業第9回浜辺のセミナー
- Place of Presentation
  宮崎
- Year and Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] プリオン蛋白断片ペプチドのコンフォメーション変化と神経毒性に及ぼす微量金属の影響2010
- Author(s)
  川原正博、小山裕也、定金豊
- Organizer
  第2回メタロミクス研究フォーラム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 微量金属の神経毒性と神経変性疾患2010
- Author(s)
  川原正博
- Organizer
  第130年会日本薬学会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] PrP断片ペプチドの神経毒性に対する亜鉛および銅の影響2010
- Author(s)
  小山裕也、永田哲也、定金豊、川原正博
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] carnosine誘導体合成とGT1-7系における神経細胞保護効果2010
- Author(s)
  鳥や尾篤、宮越辰則、反田和宏,渡邉暁子、坂本正徳、木葉敬子、定金豊、川原正博、山崎哲郎
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] カルノシンって何?-宮崎の食で認知症を防ぐ2010
- Author(s)
  川原正博
- Organizer
  都市エリア産学官連携事業第8回浜辺のセミナー
- Place of Presentation
  延岡
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] 微量金属の神経毒性と神経変性疾患2010
- Author(s)
  川原正博
- Organizer
  第130年会日本薬学会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] 糖鎖機能の効率的化未明を目指した光反応性糖鎖リガンドの製作2010
- Author(s)
  定金豊,大塚功,川原正博,畑中保丸
- Organizer
  第32回日本光医学・光生物学会
- Place of Presentation
  東京
- Year and Date
  2010-07-30
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 糖鎖機能の効率的化未明を目指した光反応性糖鎖リガンドの製作2010
- Author(s)
  定金豊,大塚功,川原正博,畑中保丸
- Organizer
  第32回日本光医学・光生物学会
- Place of Presentation
  東京
- Year and Date
  2010-07-30
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] プリオンペプチド断片(106-126)中のAsn残基の構造的変化と生理活性について2010
- Author(s)
  定金豊,小山裕也,大塚功,木葉敬子,川原正博
- Organizer
  第6回D-アミノ酸研究会学術講演会
- Place of Presentation
  富山
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] 認知症から脳を保護するカルノシン2010
- Author(s)
  川原正博
- Organizer
  都市エリア産学官連携事業第9回浜辺のセミナー
- Place of Presentation
  宮崎
- Year and Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] プリオン蛋白断片ペプチドのコンフォメーション変化と神経毒性に及ぼす微量金属の影響2010
- Author(s)
  川原正博、小山裕也、定金豊
- Organizer
  第2回メタロミクス研究フォーラム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Alterations of gene expressions during neuronal death after zinc exposure : implications of calcium dyshomeostasis2010
- Author(s)
  Kawahara M., Koyama H., Sadakane Y.
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 微量金属の神経毒性と神経変性疾患2010
- Author(s)
  川原正博,定金豊,小山裕也
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] プリオン蛋白による培養細胞に対する亜鉛および銅の影響2010
- Author(s)
  小山裕也,永田哲也,定金豊,大塚功,戸泉文江,横山祥子,川原正博
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Analysis of Alternation of A-Asp and L-Asn residures in peptides related to conformational disease2009
- Author(s)
  Sadakane Y, Konoha K, Kawahara M, Nakagomi K
- Organizer
  International D-amino acid Research (IDAR2009)
- Place of Presentation
  Awaji Irland, Japan
- Year and Date
  2009-07-01
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] プリオン蛋白断片ペプチドPrP106-126 のコンフォーメーションの違いによる細胞膜中における糖脂質認識能について-原子間力顕微法による直接観察2009
- Author(s)
  大塚功,永田哲也,木葉敬子,定金豊,川原正博,横山祥子
- Organizer
  日本薬学会第129 回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 糖鎖結合タンパク質に適した光化学的スクリーニング法の開発2009
- Author(s)
  定金豊,木葉敬子,川原正博,畑中保丸
- Organizer
  第26回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 宮崎県産海産物から老年性認知症予防・治療薬を探索する2009
- Author(s)
  川原正博
- Organizer
  第3回薬学研究フォーラムin東京-九州からの情報発信-
- Place of Presentation
  東京
- Year and Date
  2009-11-03
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] 微量元素の神経毒性と老年性認知症の発症メカニズム2009
- Author(s)
  川原正博, 永田哲也, 大塚功, 木葉敬子, 定金豊, 横山祥子
- Organizer
  日本薬学会シンポジウム「金属の関与する生命科学(II) トキシコメタロミクス研究の新展開~最新分析法開発から創薬、診断、治療へのアプローチ」
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 宮崎県産海産物から老年性認知症予防・治療薬を探索する2009
- Author(s)
  川原正博
- Organizer
  第3回薬学研究フォーラムin東京-九州からの情報発信-
- Place of Presentation
  東京
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] Analysis of Alternation of A-Asp and L-Asn residures in peptides related to conformational disease2009
- Author(s)
  Sadakane Y, Konoha K, Kawahara M, Nakagomi K
- Organizer
  International D-amino acid Research
- Place of Presentation
  Awazi Inland, Japan
- Year and Date
  2009-07-05
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] HPLC によるラット脳内カルノシンの定量2009
- Author(s)
  木葉敬子,定金豊,永田哲也,川原正博
- Organizer
  日本薬学会第129 回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 微量元素の神経毒性と老年性認知症の発症メカニズム2009
- Author(s)
  川原正博, 永田哲也, 大塚功, 木葉敬子, 定金豊, 横山祥
- Organizer
  日本薬学会第129回年会シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Analysis of Alternation of A-Asp and L-Asn residures in peptides related to conformational disease.2009
- Author(s)
  Y.Sadakane, K.Konoha, M.Kawahara, K.Nakagomi
- Organizer
  International D-amino acid Research (IDAR2009)
- Place of Presentation
  Awazi Inland, Japan
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] Carnosine inhibits s-sheet formation of PrP106-126 and protects against its neurotoxicity2009
- Author(s)
  Kawahara M, T. Nagata, K. Konoha, Y. Sadakane
- Organizer
  International Conference on Alzheimer's disease and related disorders
- Place of Presentation
  Wien
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] HPLCによるラット脳内カルノシンの定量2009
- Author(s)
  木葉敬子, 定金豊, 永田哲也, 川原正博
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 中枢神経保護作用を目的としたL-carnosine 誘導体の合成2009
- Author(s)
  宮越辰則,鳥ヤ尾篤,渡邉暁子,坂本正徳,木葉敬子,定金豊,川原正博,山崎哲郎
- Organizer
  日本薬学会第129 回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 環状L-carnosine誘導体の合成とその生物学的評価2009
- Author(s)
  鳥や尾篤, 宮越辰則, 渡邉暁子, 坂本正徳, 木葉敬子, 定金豊, 川原正博, 山崎哲郎
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 老年性認知症治療薬の開発に向けて2009
- Author(s)
  川原正博
- Organizer
  都市エリア産学官連携事業浜辺のセミナー
- Place of Presentation
  宮崎
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] プリオン蛋白断片ペプチドPrP106-126のコンフォーメーションの違いによる細胞膜中における糖脂質認識能について-原子間力顕微法による直接観察2009
- Author(s)
  大塚功, 永田哲也, 木葉敬子, 定金豊, 川原正博, 横山祥子
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] アミロイド形成蛋白の高次構造変化と神経毒性に及ぼす金属の影響2009
- Author(s)
  川原正博
- Organizer
  第20回日本微量元素学会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-07-02
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 微量元素の神経毒性と老年性認知症の発症メカニズム2009
- Author(s)
  川原正博,永田哲也,大塚功,木葉敬子,定金豊,横山祥子
- Organizer
  日本薬学会シンポジウム「金属の関与する生命科学(II)トキシコメタロミクス研究の新展開～最新分析法開発から創薬、診断、治療へのアプローチ」
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 糖鎖結合タンパク質に適した光化学的スクリーニング法の開発2009
- Author(s)
  定金豊,木葉敬子,川原正博,畑中保丸
- Organizer
  第26回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Carnosine inhibits β-sheet formation of PrP106-126 and protects against its neurotoxicity.2009
- Author(s)
  Kawahara M, Nagata T, Konoha K, Sadakane Y
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease 2009
- Place of Presentation
  Wien, Austria
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] Carnosine inhibits B-sheet formation of PrP106-126 and protects against its neurotoxicity2009
- Author(s)
  Kawahara M
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease 2009
- Place of Presentation
  オーストリア
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] プリオン蛋白断片ペプチドPrP106-126のコンフォーメーションの違いによる細胞膜中における糖脂質認識能について-原子間力顕微法による直接観察2009
- Author(s)
  大塚功,永田哲也,木葉敬子,定金豊,川原正博,横山祥子
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 中枢神経保護作用を目的としたL-carnosine誘導体の合成2009
- Author(s)
  宮越辰則, 鳥ヤ尾篤, 渡邉暁子, 坂本正徳, 木葉敬子, 定金豊, 川原正博, 山崎哲郎
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 環状 L-carnosine 誘導体の合成とその生物学的評価2009
- Author(s)
  鳥や尾篤,宮越辰則,渡邉暁子,坂本正徳,木葉敬子,定金豊,川原正博,山崎哲郎
- Organizer
  日本薬学会第129 回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Carnosine inhibits β-sheet formation of PrP106-126 and protects against its neurot oxicitv2009
- Author(s)
  Kawahara M, Nagata T, Konoha K, Sadakane Y
- Organizer
  International Conference of Alzheimer's Disease (ICAD2009)
- Place of Presentation
  Wien, Austria
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Inhibitory mechanism of metal ionsonzinc-induced neurotoxicity of culturedneuronal cells.2008
- Author(s)
  K. Konoha, Y. Sadakane, T. Nagata, M. Kawahara
- Organizer
  128th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] プリオン断片蛋白PrP106-126のコンフォーメーシヨンの違いによるGM1への認識能の変化-原子間力顕微法による直接観察2008
- Author(s)
  大塚功, 永田哲也, 木葉敬子, 定金豊, 川原正博, 横山祥子
- Organizer
  第25回日本薬学会九州支部大会
- Place of Presentation
  宮崎(延岡)
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン蛋白による培養神経細胞に対する毒性メカニズムの検討2008
- Author(s)
  永田哲也、木葉敬子、定金豊、川原正博
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 亜鉛による培養神経細胞死に対する金属イオンの阻害メカニズムの検討2008
- Author(s)
  木葉敬子,永田哲也、定金豊,川原正博
- Organizer
  日本薬学会第128 年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Zinc-induced neuronal cell death : inhibitory activity of citric acid and its Zinc-inducedmechanism.2008
- Author(s)
  Y. Sadakane, K. Konoha, T. Nagata, M.Kawahara
- Organizer
  128th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] プリオン蛋白による培養神経細胞に対する毒性メカニズムの検討2008
- Author(s)
  永田哲也, 定金豊, 木葉敬子, 川原正博
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Effects of trace elements on prion-induced neurotoxicity of primary cultured hippocampal neurons2008
- Author(s)
  M. Kawahara, 他
- Organizer
  Neuroscience 2008
- Place of Presentation
  米国ワシントン
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 魚介類水抽出液からの脳血管認知症予防物質の単離と同定2008
- Author(s)
  定金豊、木葉敬子、永田哲也、川原正博
- Organizer
  日本微量栄養素学会第25 回学術集会
- Place of Presentation
  京都
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] L-Carnosine誘導体の合成と生理作用について2008
- Author(s)
  宮越辰則、鳥や尾篤、渡邉暁子、坂本正徳、木葉敬子、定金豊、川原正博、山崎哲郎
- Organizer
  第25 回日本薬学会九州支部大会
- Place of Presentation
  延岡
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 亜鉛による神経細胞死を抑制する成分:魚介類バイオマスからの単離と同定2008
- Author(s)
  木葉敬子、定金豊、永田哲也、川原正博
- Organizer
  第21 回バイオメディカル分析科学シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 亜鉛による神経細胞死:クエン酸の抑制活性とそのメカニズムについて2008
- Author(s)
  定金豊, 木葉敬子, 永田哲也, 川原正博
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 亜鉛による培養神経細胞死に対する金属イオンの阻害メカニズムの検討2008
- Author(s)
  木葉敬子, 永田哲也, 定金豊, 川原正博
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] マウス神経株化細胞を用いた亜鉛による神経細胞死メカニズムの解明2008
- Author(s)
  定金豊、木葉敬子、永田哲也、川原正博
- Organizer
  第18 回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 農産物・魚介類中に認知症の治療予防薬を探索する2008
- Author(s)
  川原正博
- Organizer
  薬学フォーラムin東京2008
- Place of Presentation
  東京
- Year and Date
  2008-03-14
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] L-Carnosine誘導体の合成と生理作用について2008
- Author(s)
  宮越辰則, 鳥や尾篤, 渡邉暁子, 坂本正徳, 木葉敬子, 定金豊, 川原正博, 山崎哲郎
- Organizer
  第25回日本薬学会九州支部大会
- Place of Presentation
  宮崎(延岡)
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] YOKOYAMA Effects of trace elements on prion-induced neurotoxicity of primary cultured hippocampal neurons2008
- Author(s)
  M.KAWAHARA, T.NAGATA1, OHTSUKA, K.KONOHA, Y.SADAKANE, S
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington D.C., U.S.A.
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 亜鉛による神経細胞死を抑制する成分 : 魚介類バイオマスからの単離と同定2008
- Author(s)
  木葉敬子, 定金豊, 永田哲也, 川原正博
- Organizer
  第21回バイオメディカル分析科学シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] GTl-7マウス神経株化細胞を用いた亜鉛による神経細胞死メカニズムの解明2008
- Author(s)
  定金豊, 木葉敬子, 永田哲也, 川原正博
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] アミロイド形成タンパクの高次構造変化と神経毒性に及ぼす金属の影響2008
- Author(s)
  川原正博
- Organizer
  第1 回メタロミクス研究フォーラム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン蛋白による培養神経細胞に対する亜鉛および銅の影響2008
- Author(s)
  永田哲也, 木葉敬子, 定金豊, 川原正博
- Organizer
  第19回日本微量元素学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Effects of trace elements on prion-induced neurotoxicity of primary cultured hippocampal neurons2008
- Author(s)
  M. KAWAHARA, T. NAGATAl, OHTSUKA, K. KONOHA, Y. SADAKANE, S. YOKOYAMA
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington D. C., U. S. A
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 脳血管性認知症予防物質の農産物・魚介類由来バイオマス中におけるスクリーニングと構造解析2008
- Author(s)
  川原正博
- Organizer
  日本学術会議九州・沖縄地区会議学術講演会
- Place of Presentation
  宮崎
- Year and Date
  2008-01-22
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン蛋白による培養神経細胞に対する毒性メカニズムの検討2008
- Author(s)
  永田哲也、定金豊,木葉敬子、川原正博
- Organizer
  日本薬学会第128 年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン断片蛋白PrP106-126のコンフォーメーションの違いによるGM1への認識能の変化-原子間力顕微法による直接観察2008
- Author(s)
  大塚功、永田哲也、木葉敬子、定金豊、川原正博、横山祥子
- Organizer
  第25回日本薬学会九州支部大会
- Place of Presentation
  (延岡)
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] プリオン断片蛋白PrP106-126 のコンフォーメーションの違いによるGM1 への認識能の変化-原子間力顕微法による直接観察2008
- Author(s)
  大塚功、永田哲也、木葉敬子、定金豊、川原正博、横山祥子
- Organizer
  第25 回日本薬学会九州支部大会
- Place of Presentation
  延岡
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Molecular mechanism of neurotoxicity induced by prion protein peptide.2008
- Author(s)
  T. Nagata, Y.Sadakane, K. Konoha, M.Kawahara
- Organizer
  128th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 亜鉛による培養神経細胞死に対する金属イオンの阻害メカニズムの検討2008
- Author(s)
  木葉敬子、定金豊、永田哲也、川原正博
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 魚介類水抽出液からの脳血管認知症予防物質の単離と同定2008
- Author(s)
  定金豊, 木葉敬子, 永田哲也, 川原正博
- Organizer
  日本微量栄養素学会第25回学術集会
- Place of Presentation
  京都
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 亜鉛による神経細胞死:クエン酸の抑制活性とそのメカニズムについて2008
- Author(s)
  定金豊,木葉敬子,永田哲也、川原正博
- Organizer
  日本薬学会第128 年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン蛋白による培養神経細胞に対する亜鉛および銅の影響2008
- Author(s)
  永田哲也、木葉敬子、定金豊、川原正博
- Organizer
  第19 回日本微量元素学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] アミロイド形成タンパクの高次構造変化と神経毒性に及ぼす金属の影響2008
- Author(s)
  川原正博
- Organizer
  第1回メタロミクス研究フォーラム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Effects of trace elements on prion-induced neurotoxicity of primary cultured hippocampal neurons2008
- Author(s)
  M. KAWAHARA, T. NAGATA, OHTSUKA, K. KONOHA, Y. SADAKANE, S. YOKOYAMA
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington D.C., U.S.A.
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] L-β-アスパラギン酸含有ペプチドの逆相HPLC定量法によるアスパラギン酸残基の異性化速度の解析:タンパク質の高次構造との関係2007
- Author(s)
  定金豊, 木葉敬子, 永田哲也, 川原正博, 中込和哉, 藤井紀子
- Organizer
  第3回D-アミノ酸研究会
- Place of Presentation
  徳島
- Year and Date
  2007-09-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] クエン酸による神経細胞死抑制活性とその作用機構の解明2007
- Author(s)
  定金豊,木葉敬子,永田哲也、川原正博
- Organizer
  第24 回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Mechanism for zinc-induced neuronal cell death.2007
- Author(s)
  K. Konoha, T. Nagata, Y. Sadakane, M. Kawahara
- Organizer
  17th Symposium on Role of Metals in Biological Reactions, Biology and Medicine
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2007-06-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] クエン酸による神経細胞死抑制活性とその作用機構の解明2007
- Author(s)
  定金豊, 木葉敬子, 永田哲也, 川原正博
- Organizer
  第24回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Year and Date
  2007-12-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 亜鉛による培養神経細胞死メカニズムの検討2007
- Author(s)
  木葉敬子, 永田哲也, 定金豊, 川原正博
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 亜鉛による培養神経細胞死メカニズムの検討2007
- Author(s)
  木葉敬子、定金豊、永田哲也、川原正博
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] カルノシンによる神経細胞死抑制活性とその作用機構の解明2007
- Author(s)
  定金豊, 木葉敬子, 川原正博
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] アミロイド蛋白質の多量体化とpore 形成による神経細胞死2007
- Author(s)
  川原正博
- Organizer
  第54 回日本臨床検査医学会および第47 回日本臨床化学会連合大会シンポジウム"アミロイドーシス"
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 「微量元素の神経毒性と老年性認知症発症に関する研究」2007
- Author(s)
  川原正博
- Organizer
  第18 回日本微量元素学会研究学術賞(浜理薬品賞)受賞講演
- Place of Presentation
  福井
- Year and Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Zinc-induced apoptosis of GT1-7 cells are protected by mango(Mangifera indica L.)fruit:a candidate for treatment of neurodegeneration after ischemia2007
- Author(s)
  M.Kawahara, K.Konoha, T.Nagata, Y.Sadakane
- Organizer
  Neuroscience 2007
- Place of Presentation
  San Diego,USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] マンゴー(Mangifera indica L.)果実抽出液の神経細胞死抑制活性成分の同定2007
- Author(s)
  木葉敬子, 定金豊, 川原正博
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Characterization of inhibitory compounds in Mangifera indica L.fruit extract, which suppress the zinc-induced neurotoxicity of immortalized hypothalamic neurons.2007
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of apan
- Place of Presentation
  Toyama, Japan
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] アルミニウムのラット大脳皮質培養神経細胞に対する毒性の化学形態による比較2007
- Author(s)
  木葉敬子、定金豊、永田哲也、川原正博
- Organizer
  第18回日本微量元素学会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Zinc-induced apoptosis of GT1-7 cells are protected by mango(Mangifera indica L.)fruit: a candidate for treatment of neurodegeneration after ischemia2007
- Author(s)
  M. Kawahara, K. Konoha, T. Nagata, Y. Sadakane
- Organizer
  Neuroscience 2007(Society for Neuroscience)
- Place of Presentation
  San Diego(U.S.A.)
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 農産物・魚介類中における脳血管性認知症予防物質の探索と単離,構造解析2007
- Author(s)
  川原正博, 木葉敬子, 永田哲也, 定金豊
- Organizer
  第24回微量栄養素研究会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Zinc-induced apoptosis of GT1-7 cells are protected by mango (Mangifera indica L.) fruit: a candidate for treatment of neurodegeneration after ischemia2007
- Author(s)
  M. Kawahara, K. Konoha, T. Nagata, Y. Sadakane
- Organizer
  Neuroscience 2007 (Society for Neuroscience)
- Place of Presentation
  San Diego (U.S.A.)
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 農産物・魚介類中における脳血管性認知症予防物質の探索と単離・構造解析2007
- Author(s)
  川原正博,木葉敬子,永田哲也,定金豊
- Organizer
  第24 回微量栄養素研究会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-07
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Analysis of alternation of L-Asp residues in recombinant human alpha-crystallin by reversed-phase HPLC.2007
- Author(s)
  Y. Sadakane, K. Konoha, T. Nagata, M. Kawahara, K. Nakagomi, N. Fujii
- Organizer
  3rd D-amino acid research meeting
- Place of Presentation
  Tokushima, Japan
- Year and Date
  2007-09-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] アルミニウムのラット大脳皮質培養神経細胞に対する毒性の化学形態による比較2007
- Author(s)
  木葉敬子, 永田哲也, 定金豊, 川原正博
- Organizer
  第18回日本微量元素学会
- Place of Presentation
  福井
- Year and Date
  2007-07-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Zinc-induced apoptosis of GT1-7 cells are protected by mango(Mangifera indica L.) fruit : a candidate for treatment of neurodegeneration after ischemia.2007
- Author(s)
  M. Kawahara, K. Konoha, T. Nagata, Y. Sadakane
- Organizer
  Neuroscience 2007
- Place of Presentation
  San Diego, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 農産物・魚介類中における脳血管性認知症予防物質の探索と単離・構造解析2007
- Author(s)
  川原正博, 木葉敬子, 永田哲也, 定金豊
- Organizer
  第24回微量栄養素研究会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-07
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Inhibitory activity and mechanisms of carnosine against the zinc-induced neurotoxicity of immortalized hypothalamic neurons.2007
- Author(s)
  Y. Sadakane, K. Konoha, M. Kawahara
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of apan
- Place of Presentation
  Toyama, Japan
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 老年性認知症予防・治療薬の探索系の開発とその応用2007
- Author(s)
  川原正博
- Organizer
  野口賞受賞講演会
- Place of Presentation
  延岡
- Year and Date
  2007-11-27
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 亜鉛による培養神経細胞死メカニズムの検討2007
- Author(s)
  木葉敬子、永田哲也、定金豊、川原正博
- Organizer
  第17 回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Purification and structural determination of the suppression substance for cerebrovascular dementia in farm products and seafoods.2007
- Author(s)
  M. Kawahara, K. Konoha, T. Nagata, Y. Sadakane
- Organizer
  24th Symposium of Trace Nutrients Research
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2007-06-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] アルミニウムのラット大脳皮質培養神経細胞に対する毒性の化学形態による比較2007
- Author(s)
  木葉敬子、定金豊、川原正博
- Organizer
  第18 回日本微量元素学会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Structural comparison of Aluminum-toxicity for rat primary culture cell of cerebral cortex.2007
- Author(s)
  K. Konoha, T. Nagata, Y. Sadakane, M. Kawahara
- Organizer
  18th Japan Society for Biomedical Research on Trace Elements
- Place of Presentation
  Fukui, Japan
- Year and Date
  2007-07-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Investigation of the mechanism of zinc-induced neuronal cell death by using citrate.2007
- Author(s)
  Y. Sadakane, K. Konoha, T. Nagata, M. Kawahara
- Organizer
  24th Annual Meeting of Kyushu branch of the Pharmaceutical Society of Japan
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2007-12-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] L-AspとL-Asn残基の構造変化分析手法の開発:コンフォメーション病に関わるペプチドの分析2006
- Author(s)
  定金豊, 木葉敬子, 川原正博, 中込和哉
- Organizer
  第2回D-アミノ酸研究会
- Place of Presentation
  京都
- Year and Date
  2006-09-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 亜鉛神経毒性を指標としたスクリーニングによる脳血管性認知症予防物質の探索2006
- Author(s)
  定金豊, 木葉敬子, 川原正博
- Organizer
  第23回日本薬学会九州支部大会
- Place of Presentation
  熊本
- Year and Date
  2006-12-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 亜鉛神経毒性スクリーニングによる脳血管性認知症予防物質の探索2006
- Author(s)
  木葉敬子, 定金豊, 川原正博
- Organizer
  第23回微量栄養素研究会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2006-06-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Inhibition of neuronal apoptosis by mango fruits-utilization of immature fruit-2006
- Author(s)
  Y. Sadakane, K. Konoha, M. Kawahara
- Organizer
  5th Congress of innovation with Academia, Industry and Government
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-06-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Screening of the substances for suppression of cerebrovascular dementia using zinc-induced neuronal degradation.2006
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Organizer
  23rd Symposium of Trace Nutrients Research
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-06-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Pore formation and distuption of calciumhomeostasis by amyloidogenic peptides including Alzheimer's beta-amyloid protein, prion protein fragment peptide, and alpha-synuclein fragment.2006
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Organizer
  The 10th International Conference on Alzheimer's Disease and Related Disorders
- Place of Presentation
  Madrid, Spain
- Year and Date
  2006-07-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Analysis of Structural Alternations of L-Asp and L-Asn Residues in Peptides Related to Neuronal Disease2006
- Author(s)
  Y.Sadakane, S.Kumamoto, K.Konoha, M.Kawahara, K.Nakagomi
- Organizer
  43JPS/PEM4
- Place of Presentation
  Yokohama,Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Screening of the substances for suppression of cerebrovascular dementia and analysis for the peptide from seafood.2006
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Organizer
  19th Biomedical analytical Science Symposium
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2006-08-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 海産物由来ペプチドの分析と脳血管性認知症予防物質のスクリーニング2006
- Author(s)
  木葉敬子, 定金豊, 川原正博
- Organizer
  第19回バイオメディカル分析科学シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2006-08-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Screening of suppression substance for cerebrovascular dementia : usefulness of mango fruit and eel.2006
- Author(s)
  Y. Sadakane, K. Konoha, M. Kawahara
- Organizer
  6th OUS Forum 2006
- Place of Presentation
  Okayama, Japan
- Year and Date
  2006-11-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Analysis of Structural Alternations of L-Asp and L-Asn Residues in Peptides Related to Neuronal Disease.2006
- Author(s)
  Y. Sadakane, S. Kumamoto, K. Konoha, M. Kawahara, K. Nakagomi
- Organizer
  43JPS/PEM4
- Place of Presentation
  Yokohama, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Carnosine protects against zinc-induced apoptosis of GT1-7 cells and cultured rat hippocampal neurons:a candidate for the drugs for neurode generation after ischemia2006
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Organizer
  Neuroscience 2006
- Place of Presentation
  Atlanta,USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Development of analytical method for structure alternation of L-Asp and L-Asn : peptides concerned with conformation disease.2006
- Author(s)
  Y. Sadakane, K. Konoha, M. Kawahara, K. Nakagomi
- Organizer
  2nd D-amino acid research meeting
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-09-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Analytical method for structure alternation of L-Asp and L-Asn in the peptides concerned with conformation disease.2006
- Author(s)
  Y. Sadakane, K. Konoha, M. Kawahara, K. Nakagomi
- Organizer
  19th Biomedical analytical Science Symposium
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2006-08-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] コンフォメーション病に関わるペプチドでのL-AspとL-Asn残基の構造変化分析手法2006
- Author(s)
  定金豊, 木葉敬子, 川原正博, 中込和哉
- Organizer
  第19回バイオメディカル分析科学シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2006-08-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Pore formation and distuption of calciumhomeostasis by amyloidogenic peptides including Alzheimer's beta-amyloid protein,prion protein fragment peptide,and alpha-synuclein fragment2006
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Organizer
  The 10th International Conference on Alzheimer's Disease and Related Disorders
- Place of Presentation
  Madrid,Spain
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 脳血管性認知症の予防物質の探索:マンゴーとウナギの有用性2006
- Author(s)
  定金豊, 木葉敬子, 川原正博
- Organizer
  第6回OUSフオーラム2006
- Place of Presentation
  岡山
- Year and Date
  2006-11-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] マンゴー果実抽出液が神経細胞の自殺をくいとめる〜未熟果実の利用法2006
- Author(s)
  定金豊, 木葉敬子, 川原正博
- Organizer
  第5回産学官連携推進会議
- Place of Presentation
  京都
- Year and Date
  2006-06-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Carnosine protects against zinc-induced apoptosis of GT1-7 cells and cultured rat hippocampal neurons : a candidate for the drugs for neurodegeneration after ischemia.2006
- Author(s)
  K. Konoha Y. Sadakane, M. Kawahara
- Organizer
  Neuroscience 2006
- Place of Presentation
  Atlanta, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Screening with zinc-induced neuronal degradation for the substances for suppression of cerebrovascular dementia.2006
- Author(s)
  Y. Sadakane, K. Konoha, M. Kawahara
- Organizer
  23rd Annual Meeting of Kyushu branch of the Pharmaceutical Society of Japan
- Place of Presentation
  Kumamoto, Japan
- Year and Date
  2006-12-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 神経疾患と微量元素
- Author(s)
  川原正博、水野大
- Organizer
  日本微量元素学会第25回年会シンポジウム「疾患と微量元素」
- Place of Presentation
  岡山大学（岡山市）
- Year and Date
  2014-07-03 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] 亜鉛神経細胞死におけるカルノシンの役割
- Author(s)
  水野大、菅亜由美、川原正博
- Organizer
  第24回金属の関与する生体関連反応シンポジウム（SRM2014）
- Place of Presentation
  京都薬科大学（京都）
- Year and Date
  2014-06-17 – 2014-06-18
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] Involvement of endoplasmic reticulum stress and calcium dyshomeostasis in zinc-induced neurotoxicity
- Author(s)
  Dai MIZUNO and Masahiro KAWAHARA
- Organizer
  Neuroscience2014(Society for Neuroscience Meeting)
- Place of Presentation
  Convention Center（Washington DC, U.S.A.）
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26460177
[Presentation] 亜鉛による神経細胞死メカニズムの検討
- Author(s)
  川原正博、水野大
- Organizer
  日本微量元素学会第25回年会シンポジウム「ジンクシグナリングの最前線」
- Place of Presentation
  岡山大学（岡山市）
- Year and Date
  2014-07-03 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26460177

1. 黒田洋一郎 (30073084)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. SADAKANE Yutaka (60293304)

# of Collaborated Projects: 5 results

# of Collaborated Products: 189 results
3. KONOHA Keiko (00369175)

# of Collaborated Projects: 4 results

# of Collaborated Products: 145 results
4. TSUDA Masaaki (80132736)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TABUCHI Akiko (40303234)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OHTSUKA Isao (20389589)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
7. Negishi Midori (30300750)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 小林和夫 (80100139)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 村本和世 (10301798)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. NAGATA Tetusya (00454992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 41 results
11. KOYAMA Hironari (70567718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 26 results
12. 関野祐子 (70138866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 市川眞澄 (20124414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 安田誠 (00361965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 水野大 (70380061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 26 results
16. 尾上弘晃 (30548681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 森本雄矢 (60739233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 田中健一郎 (30555777)

# of Collaborated Projects: 1 results

# of Collaborated Products: 47 results
19. 根岸みどり(加藤みどり)

# of Collaborated Projects: 0 results

# of Collaborated Products: 17 results
20. 今井由美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawahara Masahiro 川原 正博

KAWAHARA Masahiro 川原 正博

川原 正博 カワハラ マサヒロ

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有機フッ素化合物(PFAS)による神経内分泌毒性メカニズム解明Principal Investigator

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Effects of metals on oligomerization, channel formation, and neurotoxicity of amyloidogenic proteinsPrincipal Investigator

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Neuroprotective mechanism of carnosine against zinc-induced neurotoxicity: a possible drug for vascular dementiaPrincipal Investigator

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Molecular mechanism of zinc-induced neurotoxicity : involvement of Ca and ER stressPrincipal Investigator

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Involvement of calcium homeostasis in the apoptotic neuronal death induced by zincPrincipal Investigator

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Formation of ion chyannels by amyloidogenic proteins and screening for protective substancesPrincipal Investigator

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Effects of membrane lipids on the incorporation of Alzheimer's β-amyloid protein into membranes and neurotoxicityPrincipal Investigator

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Kawahara Masahiro 川原正博

KAWAHARA Masahiro 川原正博

川原正博カワハラマサヒロ